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www.uspreventiveservicestaskforce.org/uspstf/document/modeling-study/colorectal-cancer-screening-june-2016
June 15, 2016 - developed within the National Cancer Institute–funded Cancer Intervention and Surveillance Modeling … (CRC-SPIN). … Cancer Intervention and Surveillance Modeling Network (CISNET) Model Registry. … Mandelblatt JS, Cronin KA, Bailey S, et al; Breast Cancer Working Group of the Cancer Intervention and … 28
28
27
Abbreviations: CRC, colorectal cancer; CRC-SPIN, CRC Simulated Population
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www.uspreventiveservicestaskforce.org/uspstf/recommendation/aspirin-to-prevent-cardiovascular-disease-preventive-medication
April 26, 2022 - Treatment or Intervention
The benefits of aspirin for CVD prevention appear similar for a low dose … Although the WHS reported a lower incidence of CRC at 17.5 years of follow-up (Peto OR, 0.82 [95% CI, … Overall, only a small number of trials reported on CRC outcomes. … by 1 trial conducted in women only, and the evidence on CRC mortality is limited by few CRC deaths. … assumed no effect of aspirin on CRC incidence.
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www.uspreventiveservicestaskforce.org/uspstf/about-uspstf/methods-and-processes/use-decision-models-development-evidence-based-clinical-preventive-services-recommendations
May 01, 2019 - seek to make inferences about the cause of disease, decision models assess the benefits and harms of intervention … Indirect evidence comprises evidence for a series of linkages that connect the intervention to health … outcomes, with adequate evidence that the intervention changes health outcomes ( Figure 1 ), steps … modeling results, the USPSTF assesses how well the model captures both the benefits and harms of the intervention … often evaluate benefits over longer time horizons—perhaps the entire lifetime of persons who have the intervention
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www.uspreventiveservicestaskforce.org/home/getfilebytoken/EppFbhnDEX5UtYWrTkLEhT
March 01, 2007 - Included studies addressed the
incidence of colorectal adenomas, CRC, or both and CRC-
related death … We extracted data by
using the PICOS (participant, intervention and exposure,
comparator, outcome, and … not shown but included were acetylsalicylic acid (ASA) studies or studies that considered more than 1 intervention … Mea-
suring the dose effect depended on the intervention dose,
the frequency and duration of use, and … , and CRC-related death.
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www.uspreventiveservicestaskforce.org/uspstf/document/evidence-summary-aspirin/aspirin-nsaids-for-prevention-of-colorectal-cancer-preventive-medication
March 15, 2007 - with approximately 90% of cases occurring after age 50, 1 aspirin may be a particularly attractive intervention … The PICOS (participant, intervention/exposure, comparator, outcome and study design) approach was applied … observational phase, which could have introduced several forms of bias, including contamination by intervention … In the setting of colorectal cancer chemoprevention with aspirin, depending on the age at which the intervention … No relevant intervention = 31.
No relevant outcome = 17.
Not an eligible study design = 135.
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www.uspreventiveservicestaskforce.org/uspstf/document/evidence-summary-aspirin/aspirin-nsaids-for-prevention-of-colorectal-cancer-preventive-medication-2007
March 15, 2007 - with approximately 90% of cases occurring after age 50, 1 aspirin may be a particularly attractive intervention … The PICOS (participant, intervention/exposure, comparator, outcome and study design) approach was applied … observational phase, which could have introduced several forms of bias, including contamination by intervention … In the setting of colorectal cancer chemoprevention with aspirin, depending on the age at which the intervention … No relevant intervention = 31.
No relevant outcome = 17.
Not an eligible study design = 135.
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www.uspreventiveservicestaskforce.org/home/getfilebytoken/vw-LTWCTZ_N5pAaydcNQTx
June 21, 2016 - (CRC-SPIN). … Two models (SimCRC and CRC-SPIN) also pre-
dicted CRC incidence reductions that were within the trial … : CRC, colorectal cancer; CRC-SPIN, CRC Simulated Population
Model for Incidence and Natural History; … Cancer Intervention and Surveillance Modeling
Network (CISNET) Model Registry. … Mandelblatt JS, Cronin KA, Bailey S, et al;
Breast Cancer Working Group of the Cancer
Intervention and
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www.uspreventiveservicestaskforce.org/home/getfilebytoken/LPaUxRbrTshfsYVVTzenEQ
April 26, 2022 - The systematic review also investigated the
effect of aspirin use on colorectal cancer (CRC) incidence … Treatment or Intervention
The benefits of aspirin for CVD prevention appear similar for a low dose
(� … Overall, only a small
number of trials reported on CRC outcomes. … weighted by 1 trial conducted in women only, and the evidence on
CRC mortality is limited by few CRC … assumed no effect of as-
pirin on CRC incidence.
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www.uspreventiveservicestaskforce.org/home/getfilebytoken/by8VJVre6h6BmadrGxaFMM
April 01, 2016 - In addition, it has made rec-
ommendations on screening for CRC. … The Community Preventive Services Task Force
recommends several intervention strategies to prevent
CVD … The time to benefit for CRC (that is, reduced CRC
incidence and death) and time to harm are important … The CRC preven-
tion benefit is more complex. … There is evidence of a potential long-term benefit
on CRC mortality.
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www.uspreventiveservicestaskforce.org/uspstf/recommendation/aspirin-to-prevent-cardiovascular-disease-and-cancer-april-2016
April 11, 2016 - In addition, it has made recommendations on screening for CRC. … The Community Preventive Services Task Force recommends several intervention strategies to prevent CVD … The time to benefit for CRC (that is, reduced CRC incidence and death) and time to harm are important … The CRC prevention benefit is more complex. … There is evidence of a potential long-term benefit on CRC mortality.
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www.uspreventiveservicestaskforce.org/uspstf/document/final-modeling-study/aspirin-to-prevent-cardiovascular-disease-preventive-medication
April 26, 2022 - the use of aspirin for the primary prevention of cardiovascular disease (CVD) and colorectal cancer (CRC … Reduced CRC incidence was considered in sensitivity analysis. … module capable of assessing primary prevention of either CRC cases or deaths. … Intervention Strategies
Two strategies for low-dose aspirin use (≤100 mg/d) were modeled. … In the base case, there was no assumed effect of aspirin use on CRC incidence.
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www.uspreventiveservicestaskforce.org/uspstf/document/final-evidence-summary19/colorectal-cancer-screening
May 18, 2021 - For KQ1, randomized clinical trials (RCTs) or nonrandomized controlled intervention studies of CRC screening … Included studies needed to report outcomes of CRC incidence, CRC-specific mortality, or all-cause mortality … incidence, CRC mortality, or both. … significant disease) or harm (unnecessary diagnostic workup or identification of condition not needing intervention … No. of studies (participants)
Rounds (intervals)
Follow-up, y
CRC incidence
CRC mortality
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www.uspreventiveservicestaskforce.org/uspstf/sites/default/files/inline-files/decision-modeling-for-uspstf_0.pdf
July 01, 2016 - seek to make inferences about
the cause of disease, decision models assess the ben-
efits and harms of intervention … Indirect evi-
dence comprises evidence for a series of linkages that
connect the intervention to health … outcomes, with ade-
quate evidence that the intervention changes health
outcomes (Figure 1, steps 2 … modeling results,
the USPSTF assesses how well the model captures both
the benefits and harms of the intervention … The population
represented, intervention delivery and performance
characteristics, adherence assumptions
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www.uspreventiveservicestaskforce.org/home/getfilebytoken/pnyU5fxhdBUtCdvJ3GyqzR
March 01, 2007 - with approximately 90% of cases occurring
after age 50 (1), aspirin may be a particularly attractive
intervention … The PICOS
(participant, intervention/exposure, comparator, outcome
and study design) approach was applied … ASA � aspirin; CRA � colorectal adenoma; CRC � colorectal cancer; RCT � randomized, controlled trial. … observational phase, which
could have introduced several forms of bias, including con-
tamination by intervention … In the
setting of colorectal cancer chemoprevention with aspirin,
depending on the age at which the intervention
-
www.uspreventiveservicestaskforce.org/home/getfilebytoken/ocULFVqnfy4STqcU2DuPzU
May 18, 2021 - For KQ1, randomized clinical trials (RCTs) or nonrandomized con-
trolled intervention studies of CRC … Included studies needed
to report outcomes of CRC incidence, CRC-specific mortality, or all-
cause mortality … incidence, CRC mortality, or both. … No. of studies
(participants)
Rounds
(intervals) Follow-up, y CRC incidence CRC mortality
Colonoscopy37,47 … significant disease) or harm
(unnecessary diagnostic workup or identification of condition not
needing intervention
-
www.uspreventiveservicestaskforce.org/home/getfilebytoken/MLeu_yFpPwzcZwKG6fw5ZY
April 26, 2022 - the use of aspirin for the primary prevention of cardiovascular disease
(CVD) and colorectal cancer (CRC … Reduced CRC incidence was
considered in sensitivity analysis. … Sensitivity
analyses showed lifetime net benefits may be higher if aspirin reduced CRC incidence or CVD … module capable of
assessing primary prevention of either CRC cases or deaths. … Intervention Strategies
Two strategies for low-dose aspirin use (�100 mg/d) were mod-
eled.
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www.uspreventiveservicestaskforce.org/uspstf/document/final-evidence-summary4/colorectal-cancer-screening-2008
October 15, 2008 - considered 3 types of clinical significance: high (findings that require surgical treatment, medical intervention … 95.2
CRC: 86.7
Polyp ≥10 mm: 87.5
CRC: 97.3
Polyp ≥10 mm: 97.9
CRC: 97.7 … ≥10 mm: 22.8
CRC: 96.9
Adenoma ≥ 10 mm: 97.3
CRC: 90.1
Adenoma ≥10 mm: 90.6
CRC … : 55.6
Adenoma: 30.1
CRC: 83.3
Adenoma: 50.7
CRC: 88.9
Adenoma: 54.8
CRC … 1996 46 , b ; 3365; fair
4.7
CRC: 90.9
CRC: 83.3
CRC: 71.4
CRC: 95.6
Yes
No
-
www.uspreventiveservicestaskforce.org/home/getfilebytoken/UCajZVxQEKLCgs59HV7ddE
November 01, 2008 - CRC: 79.4 CRC: 86.7 Yes Yes
Polyp �10 mm: 68.6 Polyp �10 mm: 87.5
3.0 CRC: 65.6 CRC: 97.3
Polyp �10 … Polymedco,
Cortlandt Manor, NY)
5.3 CRC: 86.5 CRC: 94.9 No No
18.8 CRC: 66.7 CRC: 83.1 No No
Advanced … : 30.1
NR CRC: 83.3 CRC and adenoma: 96.0
Adenoma: 50.7
NR CRC: 88.9 CRC and adenoma: 93.9
Adenoma: … 54.8
4.7 CRC: 90.9 CRC: 95.6 Yes No
CRC: 83.3
CRC: 71.4
8.2 CRC: 51.6 (34.8–68.0) Minor polyps: 92.4 … Internal Medicine Volume 149 • Number 9 www.annals.org
that require surgical treatment, medical intervention
-
www.uspreventiveservicestaskforce.org/home/getfilebytoken/DYFdTVu-UY3h7CWGdA7Zkh
July 20, 2021 - For KQ1, randomized clinical trials (RCTs) or nonrandomized con-
trolled intervention studies of CRC … Included studies needed
to report outcomes of CRC incidence, CRC-specific mortality, or all-
cause mortality … incidence, CRC mortality, or both. … No. of studies
(participants)
Rounds
(intervals) Follow-up, y CRC incidence CRC mortality
Colonoscopy37,47 … significant disease) or harm
(unnecessary diagnostic workup or identification of condition not
needing intervention
-
www.uspreventiveservicestaskforce.org/uspstf/draft-recommendation/colorectal-cancer-screening3
October 27, 2020 - colorectal cancer in adults younger than age 50 years. 4 Additionally, modeling performed by the Cancer Intervention … https://www.cdc.gov/cancer/colorectal/pdf/QuickFacts-BRFSS-2016-CRC-Screening-508.pdf . … There is no direct evidence evaluating effect of sDNA-FIT on CRC mortality. … No direct evidence evaluating effect of CT colonography on CRC mortality. … Abbreviations: CRC=colorectal cancer; CT=computed tomography; FIT=fecal immunochemical test; HSgFOBT