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www.uspreventiveservicestaskforce.org/uspstf/document/final-research-plan/aspirin-use-to-prevent-cardiovascular-disease-preventive-medication
May 14, 2020 - to In Progress page
Expand All
Analytic Framework
Abbreviations: CRC … aspirin use in patients without known cardiovascular disease (CVD) reduce CVD and colorectal cancer (CRC … What is the effect of aspirin discontinuation on CVD, CRC, all-cause mortality, and bleeding outcomes … age ≥40 years without known CVD and at average risk for CRC or unselected for CRC risk *
Other selected … medications (e.g., warfarin)
Comparisons
Placebo or no treatment
Any active substance or intervention
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www.uspreventiveservicestaskforce.org/uspstf/document/final-research-plan/aspirin-to-prevent-cardiovascular-disease-preventive-medication
May 14, 2020 - Framework
Abbreviations: CRC … aspirin use in patients without known cardiovascular disease (CVD) reduce CVD and colorectal cancer (CRC … What is the effect of aspirin discontinuation on CVD, CRC, all-cause mortality, and bleeding outcomes … age ≥40 years without known CVD and at average risk for CRC or unselected for CRC risk *
Other selected … medications (e.g., warfarin)
Comparisons
Placebo or no treatment
Any active substance or intervention
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www.uspreventiveservicestaskforce.org/uspstf/document/draft-research-plan/aspirin-use-to-prevent-cardiovascular-disease-and-colorectal-cancer-preventive-medication
January 30, 2020 - Expand All
Proposed Analytic Framework
Abbreviations: CRC … aspirin use in patients without known cardiovascular disease (CVD) reduce CVD and colorectal cancer (CRC … What is the effect of aspirin discontinuation on CVD, CRC, all-cause mortality, and bleeding outcomes … CVD and at average risk for CRC or unselected for CRC risk *
Other selected nongeneralizable populations … medications (e.g., warfarin)
Comparisons
Placebo or no treatment
Any active substance or intervention
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www.uspreventiveservicestaskforce.org/uspstf/document/draft-research-plan/aspirin-use-to-prevent-cardiovascular-disease-preventive-medication
January 30, 2020 - Expand All
Proposed Analytic Framework
Abbreviations: CRC … aspirin use in patients without known cardiovascular disease (CVD) reduce CVD and colorectal cancer (CRC … What is the effect of aspirin discontinuation on CVD, CRC, all-cause mortality, and bleeding outcomes … CVD and at average risk for CRC or unselected for CRC risk *
Other selected nongeneralizable populations … medications (e.g., warfarin)
Comparisons
Placebo or no treatment
Any active substance or intervention
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www.uspreventiveservicestaskforce.org/uspstf/document/evidence-summary-aspirin-to-prevent-cancer/aspirin-to-prevent-cardiovascular-disease-and-cancer
April 11, 2016 - † Minimum intended intervention duration. … Figure 3 displays two forest plots of studies reporting the relative risk for the intervention group … Appendix Figure 2 displays a forest plot of studies reporting the relative risk for the intervention … Appendix Figure 3 displays a forest plot of studies reporting the relative risk for the intervention … Appendix Figure 4 displays a forest plot of studies reporting the relative risk for the intervention
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www.uspreventiveservicestaskforce.org/uspstf/document/evidence-summary-aspirin-to-prevent-cancer/aspirin-to-prevent-cardiovascular-disease-and-cancer-april-2016
April 11, 2016 - † Minimum intended intervention duration. … Figure 3 displays two forest plots of studies reporting the relative risk for the intervention group … Appendix Figure 2 displays a forest plot of studies reporting the relative risk for the intervention … Appendix Figure 3 displays a forest plot of studies reporting the relative risk for the intervention … Appendix Figure 4 displays a forest plot of studies reporting the relative risk for the intervention
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www.uspreventiveservicestaskforce.org/home/getfilebytoken/Yuj3Md9rNMCvcktoBsWjh3
June 01, 2016 - The main benefit of CRC screening is that it can reduce the chance that a person will die from CRC. … CRC screening also has potential harms. … When the Task Force recommends an intervention (Grade A), it is because it has substantially more potential … Notes
1 screening
Using a test to detect CRC
or abnormalities that might
lead to CRC. … Deciding Whether to Be Screened for CRC
Evidence clearly shows that CRC screening can reduce the risk
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www.uspreventiveservicestaskforce.org/home/getfilebytoken/Xbtq4oDQwVo7KgmSjnnDbz
November 01, 2021 - Intervention: study used
an excluded intervention or screening approach. … ,60
2014
Fair Norway 50-64 Intervention:
20 572
Control:
78 220
1 NA 11.0 20.4 1.4 Intervention: 31 … 55-64 Intervention:
17 136
Control:
17 136
1 NA 11.4 8.6 1.6 Intervention: 35
Control Group:44
0.78 … Intervention:
45 642
Control:
45 557
6 2 11 2.1 1.5 Intervention: 53
Control:64
0.84
(0.71-0.99) … Funen,33
2004
Good Denmark 45-75 Intervention:
30 967
Control:
30 966
9 2 17 1.0 2.8 Intervention:
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www.uspreventiveservicestaskforce.org/uspstf/document/evidence-summary/colorectal-cancer-screening
June 15, 2016 - Summarized below are the results for CRC-specific mortality, as results for CRC incidence were consistent … with CRC mortality findings. … Intervention: study used an excluded intervention or screening approach. … , % e
No. of
CRC Deaths/
100,000
Person-Years
CRC
Mortality,
RR (95% CI … 60-64
Intervention: 34,144
Control: 34,164
2-3
1-9
19
3.8 i
2.2
Intervention: 53
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www.uspreventiveservicestaskforce.org/uspstf/document/evidence-summary/colorectal-cancer-screening-june-2016
June 15, 2016 - Summarized below are the results for CRC-specific mortality, as results for CRC incidence were consistent … with CRC mortality findings. … Intervention: study used an excluded intervention or screening approach. … , % e
No. of
CRC Deaths/
100,000
Person-Years
CRC
Mortality,
RR (95% CI … 60-64
Intervention: 34,144
Control: 34,164
2-3
1-9
19
3.8 i
2.2
Intervention: 53
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www.uspreventiveservicestaskforce.org/home/getfilebytoken/whbbEX529Ha4FyvsYv6uh6
April 26, 2022 - Health outcomes
1
Harms of
intervention
2
Aspirin
Evidence reviews for the US
Preventive Services … The primary outcomes for CRC benefits (KQ1) were CRC inci-
dence and CRC mortality. … Intervention: Study did not use an included
intervention. … Harms of Intervention
Key Question 2. … /total (%)
Intervention ControlOutcome
Cardiovascular disease
Peto OR (95% CI)
11 134 470 2511/67
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www.uspreventiveservicestaskforce.org/home/getfilebytoken/2GDCmTe7akyrAHsTMbfz72
May 06, 2022 - Health outcomes
1
Harms of
intervention
2
Aspirin
Evidence reviews for the US
Preventive Services … The primary outcomes for CRC benefits (KQ1) were CRC inci-
dence and CRC mortality. … Intervention: Study did not use an included
intervention. … Harms of Intervention
Key Question 2. … /total (%)
Intervention ControlOutcome
Cardiovascular disease
Peto OR (95% CI)
11 134 470 2511/67
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www.uspreventiveservicestaskforce.org/uspstf/document/final-evidence-summary/aspirin-to-prevent-cardiovascular-disease-preventive-medication
April 26, 2022 - English-language randomized clinical trials (RCTs) of low-dose aspirin (≤100mg/d) compared with placebo or no intervention … were eligible for inclusion if they were randomized clinical trials (RCTs), nonrandomized controlled intervention … Cancer of any type was a prespecified outcome in only 3 low-dose aspirin RCTs. 6 , 45 , 53
Benefits of Intervention … Harms of Intervention
Key Question 2. … Intervention: Study did not use an included intervention.
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www.uspreventiveservicestaskforce.org/uspstf/document/decision-analysis-for-aspirin/aspirin-to-prevent-cardiovascular-disease-and-cancer
April 11, 2016 - Intervention: Low-dose aspirin (≤100 mg/d). … , and CRC mortality. … Choice of Intervention
Findings from the 3 coordinated, companion systematic evidence reviews were … Cardiology/American Heart Association risk calculator to specify baseline CVD risk in the model. 16
Intervention … Case 4 CRC benefit = none is equivalent to setting the CRC RR = 1.
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www.uspreventiveservicestaskforce.org/uspstf/document/decision-analysis-for-aspirin/aspirin-to-prevent-cardiovascular-disease-and-cancer-april-2016
April 11, 2016 - Intervention: Low-dose aspirin (≤100 mg/d). … , and CRC mortality. … Choice of Intervention
Findings from the 3 coordinated, companion systematic evidence reviews were … Cardiology/American Heart Association risk calculator to specify baseline CVD risk in the model. 16
Intervention … Case 4 CRC benefit = none is equivalent to setting the CRC RR = 1.
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www.uspreventiveservicestaskforce.org/home/getfilebytoken/_SfjkGNHBnLqn8ySe7kAdg
April 01, 2016 - Intervention: Low-dose aspirin (≤100 mg/d). … , and CRC mortality. … Choice of Intervention
Findings from the 3 coordinated, companion sys-
tematic evidence reviews were … Intervention Effects
Effects from using aspirin for primary prevention
were modeled as RR modifications … Case 4 CRC benefit = none is equivalent to setting the CRC RR = 1.
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www.uspreventiveservicestaskforce.org/home/getfilebytoken/Njxn2r3qtWKdBf2_VhS2Aw
April 01, 2016 - Does the effect of aspirin vary by delivery of intervention (e.g., dose, frequency, duration, formulation … Does the effect of aspirin vary by delivery of intervention (e.g., dose, frequency, duration, formulation … Does the effect of aspirin vary by delivery of intervention (e.g., dose, frequency, duration, formulation … Does the effect of aspirin vary by delivery of intervention (e.g., dose, frequency, duration, formulation … Does the effect of aspirin vary by delivery of intervention (e.g., dose, frequency, duration, formulation
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www.uspreventiveservicestaskforce.org/uspstf/document/evidence-summary-nsaids/aspirin-nsaids-for-prevention-of-colorectal-cancer-preventive-medication
March 15, 2007 - We extracted data by using the PICOS (participant, intervention and exposure, comparator, outcome, and … Measuring the dose effect depended on the intervention dose, the frequency and duration of use, and whether … , and CRC-related death. … not shown but included were acetylsalicylic acid (ASA) studies or studies that considered more than 1 intervention … No relevant intervention = 31.
No relevant outcome = 17.
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www.uspreventiveservicestaskforce.org/uspstf/document/evidence-summary-nsaids/aspirin-nsaids-for-prevention-of-colorectal-cancer-preventive-medication-2007
March 15, 2007 - We extracted data by using the PICOS (participant, intervention and exposure, comparator, outcome, and … Measuring the dose effect depended on the intervention dose, the frequency and duration of use, and whether … , and CRC-related death. … not shown but included were acetylsalicylic acid (ASA) studies or studies that considered more than 1 intervention … No relevant intervention = 31.
No relevant outcome = 17.
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www.uspreventiveservicestaskforce.org/uspstf/document/modeling-study/colorectal-cancer-screening
June 15, 2016 - developed within the National Cancer Institute–funded Cancer Intervention and Surveillance Modeling … (CRC-SPIN). … Cancer Intervention and Surveillance Modeling Network (CISNET) Model Registry. … Mandelblatt JS, Cronin KA, Bailey S, et al; Breast Cancer Working Group of the Cancer Intervention and … 28
28
27
Abbreviations: CRC, colorectal cancer; CRC-SPIN, CRC Simulated Population