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1. Final Research Plan: Aspirin Use to Prevent Cardiovascular Disease: Preventive Medication | United States Preventive Services Taskforce
   www.uspreventiveservicestaskforce.org/uspstf/document/final-research-plan/aspirin-use-to-prevent-cardiovascular-disease-preventive-medication
   May 14, 2020 - to In Progress page Expand All Analytic Framework Abbreviations: CRC … aspirin use in patients without known cardiovascular disease (CVD) reduce CVD and colorectal cancer (CRC … What is the effect of aspirin discontinuation on CVD, CRC, all-cause mortality, and bleeding outcomes … age ≥40 years without known CVD and at average risk for CRC or unselected for CRC risk * Other selected … The availability of other subgroups, such as those defined by CRC risk, will be audited and addressed

2. Final Research Plan: Aspirin Use to Prevent Cardiovascular Disease: Preventive Medication | United States Preventive Services Taskforce
   www.uspreventiveservicestaskforce.org/uspstf/document/final-research-plan/aspirin-to-prevent-cardiovascular-disease-preventive-medication
   May 14, 2020 - Framework Abbreviations: CRC … aspirin use in patients without known cardiovascular disease (CVD) reduce CVD and colorectal cancer (CRC … What is the effect of aspirin discontinuation on CVD, CRC, all-cause mortality, and bleeding outcomes … age ≥40 years without known CVD and at average risk for CRC or unselected for CRC risk * Other selected … The availability of other subgroups, such as those defined by CRC risk, will be audited and addressed

3. Screening for Colorectal Cancer: Consumer Guide (pdf file)
   www.uspreventiveservicestaskforce.org/home/getfilebytoken/Yuj3Md9rNMCvcktoBsWjh3
   June 01, 2016 - or of noncancerous growths that can become CRC … The main benefit of CRC screening is that it can reduce the chance that a person will die from CRC. … CRC screening also has potential harms. … Notes 1 screening Using a test to detect CRC or abnormalities that might lead to CRC. … Deciding Whether to Be Screened for CRC Evidence clearly shows that CRC screening can reduce the risk

4. Draft Research Plan: Aspirin Use to Prevent Cardiovascular Disease and Colorectal Cancer: Preventive Medication | United States Preventive Services Taskforce
   www.uspreventiveservicestaskforce.org/uspstf/document/draft-research-plan/aspirin-use-to-prevent-cardiovascular-disease-and-colorectal-cancer-preventive-medication
   January 30, 2020 - Expand All Proposed Analytic Framework Abbreviations: CRC … aspirin use in patients without known cardiovascular disease (CVD) reduce CVD and colorectal cancer (CRC … What is the effect of aspirin discontinuation on CVD, CRC, all-cause mortality, and bleeding outcomes … Category Included Excluded Aim Primary prevention of CVD, CRC, and/or all-cause mortality … CVD and at average risk for CRC or unselected for CRC risk * Other selected nongeneralizable populations

5. Draft Research Plan: Aspirin Use to Prevent Cardiovascular Disease: Preventive Medication | United States Preventive Services Taskforce
   www.uspreventiveservicestaskforce.org/uspstf/document/draft-research-plan/aspirin-use-to-prevent-cardiovascular-disease-preventive-medication
   January 30, 2020 - Expand All Proposed Analytic Framework Abbreviations: CRC … aspirin use in patients without known cardiovascular disease (CVD) reduce CVD and colorectal cancer (CRC … What is the effect of aspirin discontinuation on CVD, CRC, all-cause mortality, and bleeding outcomes … Category Included Excluded Aim Primary prevention of CVD, CRC, and/or all-cause mortality … CVD and at average risk for CRC or unselected for CRC risk * Other selected nongeneralizable populations

6. Evidence Summary: Aspirin Use to Prevent Cardiovascular Disease: Preventive Medication | United States Preventive Services Taskforce
   www.uspreventiveservicestaskforce.org/uspstf/document/final-evidence-summary/aspirin-to-prevent-cardiovascular-disease-preventive-medication
   April 26, 2022 - or were unselected for CRC risk. … benefits (KQ1) were CRC incidence and CRC mortality. … Detailed results are available in the full report. 10 CRC Outcomes CRC Incidence. … The point estimate for reductions in CRC incidence was even greater in an analysis examining only CRC … CRC Mortality.

7. Aspirin for the Primary Prevention of Cardiovascular Disease and Colorectal Cancer: A Decision Analysis for the USPSTF (pdf file)
   www.uspreventiveservicestaskforce.org/home/getfilebytoken/_SfjkGNHBnLqn8ySe7kAdg
   April 01, 2016 - , and CRC mortality. … history of cancer to determine CRC deaths prevented. … Case 4 CRC benefit = none is equivalent to setting the CRC RR = 1. … Case 4 CRC benefit = none is equivalent to setting the CRC RR = 1. … Case 4 CRC benefit = none is equivalent to setting the CRC RR = 1.

8. Aspirin Use for the Primary Prevention of Cardiovascular Disease and Colorectal Cancer (pdf file)
   www.uspreventiveservicestaskforce.org/Home/GetFile/11/218/aspr-cvccrc-finalrsfact/pdf
   April 01, 2016 - that taking a low-dose aspirin can help prevent cardiovascular disease (CVD) and colorectal cancer (CRC … Force looked at the benefits and harms of taking aspirin for the primary prevention of both CVD and CRC … Colorectal cancer (CRC) is cancer that starts in the colon or rectum. … In addition, regular screening is an important part of preventing CRC. … Here are the Task Force’s final recommendations on aspirin to prevent CVD and CRC.

9. Aspirin Use for the Primary Prevention of Cardiovascular Disease and Colorectal Cancer: USPSTF Recommendation Statement (pdf file)
   www.uspreventiveservicestaskforce.org/home/getfilebytoken/by8VJVre6h6BmadrGxaFMM
   April 01, 2016 - In addition, it has made rec- ommendations on screening for CRC. … The time to benefit for CRC (that is, reduced CRC incidence and death) and time to harm are important … The CRC preven- tion benefit is more complex. … The sys- tematic review on aspirin use to prevent cancer other than CRC is new (4, 7). … There is evidence of a potential long-term benefit on CRC mortality.

10. Archived: Evidence Summary: NSAIDs: Aspirin/NSAIDs for Prevention of Colorectal Cancer: Preventive Medication | United States Preventive Services Taskforce
    www.uspreventiveservicestaskforce.org/uspstf/document/evidence-summary-nsaids/aspirin-nsaids-for-prevention-of-colorectal-cancer-preventive-medication
    March 15, 2007 - Included studies addressed the incidence of colorectal adenomas, CRC, or both and CRC-related death or … A CRC-related death in 1 cohort study 21 was reported. … , and CRC-related death. … We found no observational data on the effect of COX-2 inhibitors on CRC incidence or CRC-related death … Cohort studies (NSAID: 1 adenoma, 4 CRC): 5.

11. Decision Analysis: Aspirin Use to Prevent Cardiovascular Disease and Colorectal Cancer: Preventive Medication | United States Preventive Services Taskforce
    www.uspreventiveservicestaskforce.org/uspstf/document/decision-analysis-for-aspirin/aspirin-to-prevent-cardiovascular-disease-and-cancer
    April 11, 2016 - , and CRC mortality. … model's natural history of cancer to determine CRC deaths prevented. … Case 4 CRC benefit = none is equivalent to setting the CRC RR = 1. … Case 4 CRC benefit = none is equivalent to setting the CRC RR = 1. … Case 4 CRC benefit = none is equivalent to setting the CRC RR = 1.

12. Archived: Decision Analysis: Aspirin Use to Prevent Cardiovascular Disease and Colorectal Cancer: Preventive Medication | United States Preventive Services Taskforce
    www.uspreventiveservicestaskforce.org/uspstf/document/decision-analysis-for-aspirin/aspirin-to-prevent-cardiovascular-disease-and-cancer-april-2016
    April 11, 2016 - , and CRC mortality. … model's natural history of cancer to determine CRC deaths prevented. … Case 4 CRC benefit = none is equivalent to setting the CRC RR = 1. … Case 4 CRC benefit = none is equivalent to setting the CRC RR = 1. … Case 4 CRC benefit = none is equivalent to setting the CRC RR = 1.

13. Archived: Evidence Summary: NSAIDs: Aspirin/NSAIDs for Prevention of Colorectal Cancer: Preventive Medication | United States Preventive Services Taskforce
    www.uspreventiveservicestaskforce.org/uspstf/document/evidence-summary-nsaids/aspirin-nsaids-for-prevention-of-colorectal-cancer-preventive-medication-2007
    March 15, 2007 - Included studies addressed the incidence of colorectal adenomas, CRC, or both and CRC-related death or … A CRC-related death in 1 cohort study 21 was reported. … , and CRC-related death. … We found no observational data on the effect of COX-2 inhibitors on CRC incidence or CRC-related death … Cohort studies (NSAID: 1 adenoma, 4 CRC): 5.

14. Evidence Summary: Aspirin Use to Prevent Cancer: Aspirin Use to Prevent Cardiovascular Disease and Colorectal Cancer: Preventive Medication | United States Preventive Services Taskforce
    www.uspreventiveservicestaskforce.org/uspstf/document/evidence-summary-aspirin-to-prevent-cancer/aspirin-to-prevent-cardiovascular-disease-and-cancer
    April 11, 2016 - Data on non-CRC cancer types and subgroups were limited. … CRC Mortality Rothwell and colleagues reported data on long-term CRC mortality (median follow-up, 18.3 … CRC Incidence Data on CRC incidence came from 2 IPD meta-analyses by Rothwell and colleagues 67 , … CRC deaths k = 2; n = 7588; 216 incident CRC cases Primary CVD prevention studies AAA, … CRC = colorectal cancer.

15. Archived: Evidence Summary: Aspirin Use to Prevent Cancer: Aspirin Use to Prevent Cardiovascular Disease and Colorectal Cancer: Preventive Medication | United States Preventive Services Taskforce
    www.uspreventiveservicestaskforce.org/uspstf/document/evidence-summary-aspirin-to-prevent-cancer/aspirin-to-prevent-cardiovascular-disease-and-cancer-april-2016
    April 11, 2016 - Data on non-CRC cancer types and subgroups were limited. … CRC Mortality Rothwell and colleagues reported data on long-term CRC mortality (median follow-up, 18.3 … CRC Incidence Data on CRC incidence came from 2 IPD meta-analyses by Rothwell and colleagues 67 , … CRC deaths k = 2; n = 7588; 216 incident CRC cases Primary CVD prevention studies AAA, … CRC = colorectal cancer.

16. Modeling Study: Colorectal Cancer: Screening | United States Preventive Services Taskforce
    www.uspreventiveservicestaskforce.org/uspstf/document/modeling-study/colorectal-cancer-screening
    June 15, 2016 - Screening Analysis (MISCAN) for CRC, and CRC Simulated Population Model for Incidence and Natural History … (CRC-SPIN). … Two models (SimCRC and CRC-SPIN) also predicted CRC incidence reductions that were within the trial's … Distribution of Adenomas by Location, Adenomas by Size, and CRC by Stage and Lifetime Risks of CRC Outcomes … 28 28 27   Abbreviations: CRC, colorectal cancer; CRC-SPIN, CRC Simulated Population

17. Archived: Modeling Study: Colorectal Cancer: Screening | United States Preventive Services Taskforce
    www.uspreventiveservicestaskforce.org/uspstf/document/modeling-study/colorectal-cancer-screening-june-2016
    June 15, 2016 - Screening Analysis (MISCAN) for CRC, and CRC Simulated Population Model for Incidence and Natural History … (CRC-SPIN). … Two models (SimCRC and CRC-SPIN) also predicted CRC incidence reductions that were within the trial's … Distribution of Adenomas by Location, Adenomas by Size, and CRC by Stage and Lifetime Risks of CRC Outcomes … 28 28 27   Abbreviations: CRC, colorectal cancer; CRC-SPIN, CRC Simulated Population

18. Archived: Aspirin Use to Prevent Cardiovascular Disease and Colorectal Cancer: Preventive Medication | United States Preventive Services Taskforce
    www.uspreventiveservicestaskforce.org/uspstf/recommendation/aspirin-to-prevent-cardiovascular-disease-and-cancer-april-2016
    April 11, 2016 - year CVD risk The decision to initiate low-dose aspirin use for the primary prevention of CVD and CRC … In addition, it has made recommendations on screening for CRC. … The time to benefit for CRC (that is, reduced CRC incidence and death) and time to harm are important … The CRC prevention benefit is more complex. … There is evidence of a potential long-term benefit on CRC mortality.

19. Estimation of Benefits, Burden, and Harms of Colorectal Cancer Screening Strategies: Modeling Study for the USPSTF (pdf file)
    www.uspreventiveservicestaskforce.org/home/getfilebytoken/vw-LTWCTZ_N5pAaydcNQTx
    June 21, 2016 - Screening Analysis (MISCAN) for CRC, and CRC Simulated Population Model for Incidence and Natural History … (CRC-SPIN). … Two models (SimCRC and CRC-SPIN) also pre- dicted CRC incidence reductions that were within the trial … Distribution of Adenomas by Location, Adenomas by Size, and CRC by Stage and Lifetime Risks of CRC Outcomes … : CRC, colorectal cancer; CRC-SPIN, CRC Simulated Population Model for Incidence and Natural History;

20. Nonsteroidal Anti-inflammatory Drugs and Cyclooxygenase-2 Inhibitors for Primary Prevention of Colorectal Cancer: A Systematic Review (pdf file)
    www.uspreventiveservicestaskforce.org/home/getfilebytoken/EppFbhnDEX5UtYWrTkLEhT
    March 01, 2007 - factors for colorectal adenoma or CRC, other than age). … Included studies addressed the incidence of colorectal adenomas, CRC, or both and CRC- related death … A CRC-related death in 1 cohort study (21) was re- ported. … , and CRC-related death. … We found no observational data on the effect of COX-2 inhibitors on CRC incidence or CRC-related death