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1. Comparative Effectiveness of Fecal DNA Testing in Screening for Colorectal Cancer in Average-Risk Adults | Effective Health Care (EHC) Program
   effectivehealthcare-admin.ahrq.gov/products/colorectal-cancer-screening/research-protocol
   December 01, 2019 - Outcomes KQ 1: Final Health Outcomes CRC-specific or all-cause mortality CRC incidence … with CRC. … Persons at high risk for CRC include persons with a strong family history of CRC including syndrome-related … KQ 5: Any established CRC-screening modality. … Outcomes KQ 1: CRC incidence (or advanced neoplasia incidence if CRC incidence is not reported),

2. Evidence-based Practice Center Systematic Review Protocol (pdf file)
   effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/colorectal-cancer-screening_research-protocol.pdf
   May 18, 2011 - Outcomes KQ 1: Final Health Outcomes 1) CRC-specific or all-cause mortality 2) CRC incidence … with CRC. … Persons at high risk for CRC include persons with a strong family history of CRC including syndrome … Outcomes KQ 1: CRC incidence (or advanced neoplasia incidence if CRC incidence is not reported), all-cause … mortality, and CRC-specific mortality.

3. Evidence Summary: Management of Colonic Diverticulitis (pdf file)
   effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/cer-233-diverticulitis-evidence-summary.pdf
   October 01, 2020 - various treatment options, preventive options for long- term recurrence, and detection strategies for CRC … with recent diverticulitis, those who undergo colonoscopy may, ultimately, have similar rates of CRC … diagnoses as those who did not; however, no studies evaluated comparative risks of CRC death. … ; however, no studies evaluated comparative risks of CRC death. … Among these patients, about 2 percent have CRC, 7 percent have advanced colonic neoplasia (CRC or advanced

4. Comparative Effectiveness of Fecal DNA Testing in Screening for Colorectal Cancer in Average Risk Adults. (pdf file)
   effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/colorectal-cancer-screening_disposition-comments.pdf
   February 01, 2012 - In our results table we calculated specificity for CRC and CRC plus advanced adenomas. … is still informative to know the specificity of CRC versus CRC plus advanced adenomas). … In our results table we calculated specificity for CRC and CRC plus advanced adenomas. … is still informative to know the specificity of CRC versus CRC plus advanced adenomas). … Thus, specificity for CRC and CRC+adenomas should take into account those weights.

5. Management of Colonic Diverticulitis | Effective Health Care (EHC) Program
   effectivehealthcare-admin.ahrq.gov/products/diverticulitis/research
   January 01, 2022 - diagnoses as those who did not; however, no studies evaluated comparative risks of CRC death. … who had complicated diverticulitis (with abscess, peritonitis, etc.) are at increased risk of having CRC … There is low SoE that patients with recent acute diverticulitis may be at increased risk of CRC compared … those who undergo colonoscopy soon after acute diverticulitis may ultimately have similar rates of CRC … Patients 50 years and older may be at increased risk of CRC (moderate SoE) or premalignant lesions (low

6. Local Therapies for Unresectable Colorectal Cancer Metastases to the Liver: A Comparative Effectiveness Review | Effective Health Care (EHC) Program
   effectivehealthcare-admin.ahrq.gov/products/colorectal-cancer-liver-metastases-therapies/research-protocol
   December 01, 2019 - Current Treatments Several liver-directed therapies have been developed to treat patients with CRC … Summary The standard of care of care for metastatic CRC confined to the liver is surgical resection … decisionmaking about the comparative benefits and harms of the various liver-directed therapies for CRC … , are candidates for liver-directed therapies to treat unresectable hepatic metastases from primary CRC … Abbreviations: CRC = colorectal cancer; KQ = key question Figure 2.

7. Health Outcomes of Biologic Agents for Metastatic Colorectal Cancer | Effective Health Care (EHC) Program
   effectivehealthcare-admin.ahrq.gov/products/colorectal-cancer-hepatic-therapy/abstract
   December 01, 2019 - and bevacizumab by studying the balance of benefits and harms of adding biologic therapy to standard CRC … chemotherapy regimens treatments for CRC. … stakeholders with a comprehensive understanding of the ramifications of integrating biologic therapy into the CRC

8. Evidence-based Practice Center Systematic Review Protocol (pdf file)
   effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/colorectal-cancer-liver-metastases-therapies_research-protocol.pdf
   September 27, 2012 - synchronous liver metastases and another 50 percent developing metachronous disease.1 Colorectal cancer (CRC … Current Treatments Several liver-directed therapies have been developed to treat patients with CRC … Summary The standard of care of care for metastatic CRC confined to the liver is surgical resection … who are candidates for liver-directed therapy as an adjunct to systemic therapy for unresectable CRC … Abbreviations: CRC = colorectal cancer; KQ = key question Transarterial embolization;

9. Colorectal-Cancer-Screening Executive (pdf file)
   effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/colorectal-cancer-screening_executive.pdf
   February 01, 2012 - Screening for Colorectal Cancer in Average-Risk Adults Executive Summary Background Colorectal cancer (CRC … the third leading cause of cancer deaths in the United States.1 Incidence and mortality rates for CRC … in reducing morbidity (CRC incidence) or mortality (all-cause or CRC-specific)? … To detect CRC? b. To detect precancerous lesion(s)? 2.2. … To detect CRC? b. To detect precancerous lesion(s)? Key Question 3. Interval of Screening.

10. Disparities-Quality-Improvement Executive (pdf file)
    effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/disparities-quality-improvement_executive.pdf
    August 01, 2012 - Lasser et al., 20112 RCT Cancer: CRC screening • Patient education • Promotion of self- management … BP = blood pressure; CRC = colorectal cancer; DBP = diastolic blood pressure; GAP = American College … CRC = colorectal cancer; QI = quality improvement; RCT = randomized controlled trial. … CRC = colorectal cancer; QI = quality improvement; RCT = randomized controlled trial. Table D. … • Patients with adequate health literacy were equally likely to pursue CRC screening when treated

11. Colorectal-Cancer-Liver-Metastases-Therapies Executive (pdf file)
    effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/colorectal-cancer-liver-metastases-therapies_executive.pdf
    December 01, 2012 - the effectiveness and harms of several local hepatic therapies for unresectable colorectal cancer (CRC … In the sections that follow, we describe CRC and its diagnosis and treatment to orient the reader to … This is followed by a discussion of the treatment of CRC liver metastasis. … Condition CRC is the fourth most frequently diagnosed cancer and the second leading cause of cancer … through a sequential process of accumulating genetic changes.2 Although the most common type of CRC

12. Local Hepatic Therapies for Metastases to the Liver From Unresectable Colorectal Cancer | Effective Health Care (EHC) Program
    effectivehealthcare-admin.ahrq.gov/products/colorectal-cancer-liver-metastases-therapies/research
    December 01, 2019 - of various local hepatic therapies for metastases to the liver from unresectable colorectal cancer (CRC … insufficient to permit conclusions on the comparative effectiveness of these therapies for unresectable CRC

13. Disposition of Comments: Management of Colonic Diverticulitis (pdf file)
    effectivehealthcare-admin.ahrq.gov/sites/default/files/diverticulitis-comments.pdf
    October 12, 2020 - o The reviewer also suggested evaluating colorectal cancer (CRC) rates found on colonoscopy by country … : The key points (5th bullet point) highlights a finding that older people are at higher risk for CRC … the reason for the age 50 cutpoint (used by 5 studies) is to match general population guidance for CRC … SoE that patients with recent diverticulitis may have an increased likelihood of having undiagnosed CRC … or advanced colonic neoplasia (CRC or advanced adenomas).”

14. Fecal DNA Testing in Screening for Colorectal Cancer in Average Risk Adults | Effective Health Care (EHC) Program
    effectivehealthcare-admin.ahrq.gov/products/colorectal-cancer-screening/research
    December 01, 2019 - accuracy studies (n=5004) evaluating a multi-marker fecal DNA found differing sensitivities to detect CRC

15. EPC Systematic Review Protocol: Achieving Health Equity in Preventive Services: Systematic Evidence Review (pdf file)
    effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/health-equity-protocol.pdf
    January 01, 2020 - harms of screening Aspirin use to prevent cardiovascular disease (CVD) and colorectal cancer (CRC … 10% 10-year CVD risk Use of low-dose aspirin for prevention purposes CVD events (MI, CVD); CRC … mortality; and quality of life, harms of interventions Abbreviations: CHD=coronary heart disease; CRC … 2003 B October 2015 Aspirin use to prevent cardiovascular disease (CVD) and colorectal cancer (CRC … ): preventive medication CVD: 2007 CRC: 2009 B April 2016 Breast cancer screening 2002 B: Ages

16. Achieving Health Equity in Preventive Services: Systematic Evidence Review | Effective Health Care (EHC) Program
    effectivehealthcare-admin.ahrq.gov/products/health-equity-preventive/protocol
    August 31, 2018 - 10-year CVD risk Use of low-dose aspirin for prevention purposes CVD events (MI, CVD); CRC … ; and quality of life, harms of interventions Abbreviations: CHD=coronary heart disease; CRC … October 2015 Aspirin use to prevent cardiovascular disease (CVD) and colorectal cancer (CRC … ): preventive medication CVD: 2007 CRC: 2009 B April 2016 Breast cancer … A Current: 2015 Draft: In process Abbreviations: CVD=cardiovascular disease, CRC

17. Technical Brief 13: Gene Expression Profiling for Predicting Outcomes in Stage II Colon Cancer (pdf file)
    effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/colon-cancer-gene-profiling_technical-brief.pdf
    December 01, 2012 - Precision Therapeutics 634 Probe-set signature Formalin-fixed paraffin embedded tissue OncoDefender-CRC … ; the peer-reviewed publication24 for the fifth commercially available assay 12 (OncoDefender-CRC … Polyps and From Patients Without Polyps (Primary objective is to predict risk of colorectal cancer [CRC … ]; a secondary objective is to predict response to therapy for various stages of CRC.) … For derivation study only No ColonPRS®+ Yes No No No GeneFx® Colon Yes No No No OncoDefender-CRC

18. Cell-Free-Dna-Appendix-C (xls file)
    effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/cell-free-dna-appendix-c.xlsx
    September 01, 2024 - Presentation Cervical Cancer Diagnosis from Usual Care Screening Cervical Cancer Diagnosis from MCST CRC … Unknown Diagnosis Method CRC Diagnosis from Clinical Presentation CRC Diagnosis from Usual Care Screening … CRC Diagnosis from MCST Esophageal Cancer Unknown Diagnosis Method Esophageal Cancer Diagnosis from … 40 to 75 years including patients (N=473) diagnosed with any stage of one of the 6 types of cancers (CRC … Cancer signal of origin reporting possible for six cancer types (CRC, esophageal, liver, lung, ovarian

19. Fleisher (pdf file)
    effectivehealthcare-admin.ahrq.gov/sites/default/files/fleisher.pdf
    January 01, 2010 - credible voices from communities • Connect Web 2.0  to  online resources (e.g., Healing  Choices, CRC

20. Infectious Disease Including HIV/AIDS #09 (pdf file)
    effectivehealthcare-admin.ahrq.gov/sites/default/files/infectiousdisease_hi_impact.pdf
    December 01, 2013 - available for this patient population. 58 Screening and early treatment for colorectal cancer (CRC … Patients treated surgically for localized CRC have a long-term survival of 91%, compared with patients … common symptoms are confirmed with either barium enema radiography or colonoscopy. 64 Localized CRC … Patients attending HIV clinics for routine treatment and monitoring can be screened for CRC with anal … Pap smears to reduce the incidence of advanced CRC. 12 AHRQ Healthcare Horizon Scanning