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421. Total Worker Health® (TWH) (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/worker-health_executive.pdf
     April 01, 2016 - Total Worker Health® (TWH) 1 Comparative Effectiveness Review Number 175 Total Worker Health® Effective Health Care Program Executive Summary Background The American worksite has been a venue for both health protection and health promotion programs. Health protection programs are interventions aimed specifi…

422. Disposition of Comments Report for Treatment for Hepatitis C Virus Infection in Adults (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/hepatitis-c_disposition-comments.pdf
     November 27, 2012 - General Another point of concern is the seemingly inconsistent ratings of various trials throughout

423. Methods Guide for Comparative Effectiveness Reviews_Inclusion of Nonrandomized Studies of Interventions in Systematic Reviews of Intervention Effectiveness: An Update (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/product/pdf/methods-guide-inclusion-nonrandomized-studies.pdf
     September 01, 2022 - A chief concern raised was the perception that evidence summarized does not adequately apply to the … However, applicability may be less of a concern for some RCT designs (e.g., large simple RCTs, pragmatic … assessment requires explicit consideration of whether the Key Questions, and hence the decisional dilemmas, concern … In balancing these tradeoffs, a crucial concern pertains to the potential threats to validity of NRSIs

424. Methods Guide for Comparative Effectiveness Reviews_Inclusion of Nonrandomized Studies of Interventions in Systematic Reviews of Intervention Effectiveness: An Update (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/wysiwyg/pdf/methods-guide-inclusion-nonrandomized-studies.pdf
     September 01, 2022 - A chief concern raised was the perception that evidence summarized does not adequately apply to the … However, applicability may be less of a concern for some RCT designs (e.g., large simple RCTs, pragmatic … assessment requires explicit consideration of whether the Key Questions, and hence the decisional dilemmas, concern … In balancing these tradeoffs, a crucial concern pertains to the potential threats to validity of NRSIs

425. Disposition of Comments Report for Enzyme-Replacement Therapies for Lysosomal Storage Disease (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/lysosomal-storage-diseases-therapies_disposition-comments.pdf
     January 01, 2014 - We continue to have concern that important literature for rare diseases is categorically excluded. … presents a point of significant concern by using the word “theoretical”.

426. Disposition of Comments for Venous Thromboembolism Prophylaxis in Orthopedic Surgery (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/blood-clots-hip-knee-surgery_disposition-comments.pdf
     March 01, 2012 - bleeding risk is prohibitively high (such as spinal surgery where risk of epidural bleeding is of great concern … Our chief concern with this question is the exclusion of direct thrombin inhibitors from the list of

427. Back-Pain-Imaging Clinician (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/back-pain-imaging_clinician.pdf
     April 01, 2016 - Early Imaging for Back Pain and Clinical Outcomes in Older Adults: A Brief Summary of Findings and Key Points for Clinician-Patient Discussions KEY CLINICAL ISSUE What were the clinical outcomes and use of health care resources among older adults who received early imaging when compared with those who did not re…

428. Kravitz_ECCS2012 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/kravitz_eccs2012.pdf
     January 01, 2012 - Kravitz_ECCS2012 Slide 1: Media, Messages, and Medication: Strategies  To Reconcile What Patients  Hear, What TheyWant, andWhat They Need FromMedications   Richard  L.  Kravitz,  M.D.,  M.S.P.H. University of California, Davis, Department of…

429. Infectious Disease Including HIV/AIDS #09 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/09_infectiousdisease_potential_high_impact_june_2012.pdf
     January 01, 2012 - ES-3 Discussion Hepatitis C Virus Infection Hepatitis C virus (HCV) is a major public health concern … on ineffective therapies, thereby continuing to spread TB and creating a significant public health concern … However, one expert with a health systems perspective expressed concern that getting a high-risk individual … In addition, experts had some concern that treating patients with vancomycin for CDI might make them … One clinical expert also expressed concern about using vancomycin to treat CDI because of the possibility

430. Disposition of Comments_Comparative Effectiveness Review No. 249: Malnutrition in Hospitalized Adults: A Systematic Review (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-249-malnutrition-disposition-comments_0_0.pdf
     October 13, 2021 - Section Comment Response Peer Reviewer 4 Methods Methods: Pg. 17, line 34: Again, I want to raise concern … BMI, weight loss, serum albumin levels) experts have expressed concern that these measures are not … We understand the concern that some areas of research may be differentially funded.

431. Crosscutting-Horizon-Scan-High-Impact-1406 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/crosscutting-horizon-scan-high-impact-1406.pdf
     June 01, 2014 - potential benefits of wider access to propofol-mediated sedation were significant enough to offset the concern

432. Executive Summary_Systematic Review: Use of Telehealth During the COVID-19 Era (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/use-telehealth-during-COVID-19-executive-summary.pdf
     January 01, 2023 - Executive Summary_Systematic Review: Use of Telehealth During the COVID-19 Era Systematic Review Use of Telehealth During the COVID-19 Era Executive Summary Main Points Background and Purpose Telehealth is remotely delivered and synchronous medical services (e.g., telephone/audio, video vis…

433. Treatment for Restless Legs Syndrome Disposition of Comments Report (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/restless-legs_disposition-comments.pdf
     November 27, 2012 - Pg 28 Table D, pg 84 Table 13: “long-term durability of treatment benefits remains an unaddressed concern … Peer Reviewer #2 General The first major concern is calling gabapentin / pregabalin “GABA analogues

434. S58 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/s58.pdf
     October 01, 2007 - Plausibility of observed utilization patterns for subgroups of concern should be assessed, and sensitivity … birth-defect rates, which prompted a policy response in the form of an FDA safety alert.44 A related concern

435. Disposition of Comments Report for Prevention of Healthcare-Associated Infections (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/health-careassociated-infections_disposition-comments.pdf
     November 30, 2012 - My concern is of those associated with the equipment and other systems dealing with the facilities and … needed. 72 Peer Reviewer #3 Methods Outcome measure defs -- also good, although I have some mild concern … Public Reviewer #1 (Joan Blanchard) Results A concern on page 117 is the inability to compare staffing

436. Disposition of Comments for CER 182 Glasgow Coma Scale (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/field-triage-glascow-disposition-170415.pdf
     January 12, 2017 - My only concern is determining “who” assigned the quality assessment information and rated quality—was … Regarding your concern, described in the Methods section, two reviewers independently rated the quality … My only concern is determining “who” assigned the quality assessment information and rated quality—was

437. Layout 1 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/ace-inhibitor-arb-update_executive.pdf
     June 01, 2011 - Layout 1 Background Almost 75 million American adults— approximately one-third—have hypertension. The prevalence of hypertension increases with advancing age such that more than half of people 55 to 74 years old and approximately three-fourths of those age 75 years and older are affected. In addition to being the pr…

438. Management of Renal Masses and Localized Renal Cell Carcinoma: Current State of the Evidence (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/renal-cancer_clinician.pdf
     July 01, 2017 - Management of Renal Masses and Localized Renal Cell Carcinoma: Current State of the Evidence Management of Renal Masses and Localized Renal Cell Carcinoma: Current State of the Evidence Focus of This Summary This is a summary of a systematic review that evaluated the recent evidence regarding the benefits and adve…

439. Disposition of Comments_Comparative Effectiveness Review No. 262_Pharmacotherapy for Adults With Alcohol Use Disorder in Outpatient Settings: Systematic Review (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-262-pharmacotherapy-alcohol-disposition-comments.pdf
     November 07, 2023 - information on the potential contraindications of acamprosate (severe renal impairment), and the concern

440. Version 2_Risk of Reinfection From SARS-CoV-2 -- An Update of an Antibody Response Following SARS-CoV-2 Infection and Implications for Immunity: A Living Rapid Review (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/version-2-risk-of-reinfection-from-SARSCoV2_0.pdf
     December 31, 2022 - variant is reassuring, there are no data on reinfection risk with the Delta variant or other variants of concern … Centers for Disease Control and Prevention (CDC) identified four “variants of concern,” defined as … 25-36, 38, 39 These results do not, of course, rule out the possibility that another variant of concern … Of less concern, but worth noting, results do not address protection conferred by a first infection that