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401. S9 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/s9.pdf
     October 01, 2007 - For this reason, the continued concern surrounding any evaluation or assessment of the Part D program

402. Disposition of Comments for CER 157 Appendicitis (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/appendicitis_disposition-comments.pdf
     December 14, 2015 - We appreciate the reviewer’s concern that the size of the report may be intimidating to some readers … is what they are assessing as much as the actual problem of RLQ pain We appreciate the reviewer’s concern … I would add that the ionizing radiation concern may delay the ordering of a CT which could then lead … Public Reviewer #1 Advisory Council for General Surgery General Comments We have a concern … This is of particular concern since many publications on US in particular have been published in European

403. Disposition of Comments: CER 224, Treatment of Depression in Children and Adolescents: A Systematic Review (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-224-depression-children-comments.pdf
     April 10, 2020 - Disposition of Comments: CER 224, Treatment of Depression in Children and Adolescents: A Systematic Review Comparative Effectiveness Review Disposition of Comments Report Research Review Title: Treatment of Depression in Children and Adolescents: A Systematic Review Draft review available for publ…

404. Disposition of Comments for CER 170 Cultural Competence Health Disparities (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/cultural-competence_disposition-comments.pdf
     January 01, 2020 - Disposition of Comments for CER 170 Cultural Competence Health Disparities Comparative Effectiveness Review Disposition of Comments Report Research Review Title: Improving Cultural Competence To Reduce Health Disparities Draft review available for public comment from June 22, 2015 to July 20, 2015. Research Rev…

405. Future Research Needs for Diagnosis of Obstructive Sleep Apnea (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/sleep-apnea-diagnosis-future_research.pdf
     February 01, 2012 - Design 3D1: No randomized trials address this question. 3D2: Selection biases of major concern in available … Design 3D1: No randomized trials address this question. 3D2: Selection biases of major concern in available … The stakeholders talked about the concern among anesthesiologists and surgeons about the patients who … Loss to followup should be rare during the period of hospitalization, but may be of concern for posthospitalization … Ethical Issues There are no ethical issues of concern. 25 High Priority Future Research

406. Disposition of Comments Report for Relationship Between Use of Quality Measures and Improved Outcomes in Serious Mental Illness (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/mental-illness-outcomes_disposition-comments.pdf
     January 15, 2015 - overlap, for example in the case of functioning, but then suggest that its measurement is of greater concern

407. Obesity (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/obesity-horizon-scan-high-impact-1512.pdf
     December 01, 2015 - outcomes appear at 6 months to be better than that for all medication trials, short-term tolerance is a concern … data to show any form of durable weight loss and like any other short term treatment, there is a concern

408. Cad-Women-Treatment Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cad-women-treatment_executive.pdf
     August 01, 2012 - The generalizability of those studies to the United States may be of concern; however, the practice

409. Methods Guide for Comparative Effectiveness Reviews - Avoiding Bias in Selecting Studies (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guidance-bias_methods.pdf
     February 01, 2013 - Methods Guide for Comparative Effectiveness Reviews - Avoiding Bias in Selecting Studies Methods Guide for Comparative Effectiveness Reviews Avoiding Bias in Selecting Studies ii This report is based on research conducted by the Oregon Health & Science Uni…

410. Disposition of Comments for CER 165 Fecal Incontinence (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/fecal-incontinence_disposition-comments.pdf
     March 21, 2016 - Commentator & Affiliation Section Comment Response TEP 7 General comments The second major concern … This is a major concern for my review and represents a missed opportunity for this project. … subgroups of adults defined by their FI etiologies (when available),… TEP 7 Introduction My major concern … This is a major concern for my review and represents a missed opportunity for this project (repeated

411. Antibiotics-Respiratory-Infection Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/antibiotics-respiratory-infection_executive.pdf
     January 01, 2016 - ranges widely, from 50 to 80 percent, based on patient, provider, and setting factors.13,14 A main concern … In order to address the concern that reductions in overall prescribing might lead to undertreatment … abstracts did not identify inconsistencies in findings, suggesting that this is not a significant concern … Finally, with only 45 percent of studies conducted in the United States, there may be concern about

412. Making Healthcare Safer IV: Summary of Findings, 2023-2024 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/mhs-IV-1-year-final-report-updated-title_0.pdf
     May 01, 2024 - this PSP over one which was not, but we have uncertainty about the effectiveness of the practice or concern

413. Evidence Report on the (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/bundled-payments-quality-effects_research-protocol.pdf
     June 23, 2011 - Two types of directness, which can coexist, may be of concern.

414. Layout 1 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/sleep-apnea_executive.pdf
     July 01, 2011 - Also of concern are the high rates of perioperative and postoperative complications among OSA patients … The heavy reliance on industry support for trials of devices may lead to the concern of publication bias … However, this concern may be reduced since most of our conclusions were that the strength of evidence

415. Disposition of Comments for CER 166 Calcineurin Inhibitors (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/calcineurin-inhibitor_disposition-comments.pdf
     March 15, 2016 - Commentator & Affiliation Section Comment Response Peer Reviewer 1 General Comments My major concern … heritage as a pioneer in transplant immunosuppression, we are sharing the following comments out of concern … Immunology Astellas Pharma Global Development Medical Affairs, Americas Results The paramount concern

416. Disposition of Comments Report for Testing of CYP2C19 Variants and Platelet Reactivity for Guiding Antiplatelet Treatment (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/antiplatelet-treatment_disposition-comments.pdf
     September 25, 2013 - This would alleviate the concern about treatment being delayed. … To address this concern we have conducted analyses using alternative genetic models. … To address the reviewers’ concern, we have provided additional details on our rationale for each decision

417. Vaginal Birth After Cesarean: Developing and Prioritizing a Future Research Agenda (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/cesarean-birth-future_research.pdf
     August 09, 2012 - A concern was raised about the small number of stakeholders engaged in this activity. … Another comment expressed concern that the Discussion section highlights health systems issues more … A key concern in recruitment of participants was obtaining representation of relevant stakeholder groups

418. Treatment of Osteoarthritis of the Knee: An Update Review (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/osteoarthritis-knee-update-disposition.pdf
     May 04, 2017 - I would have some concern that it could introduce a bias in pooled estimates if it occurred commonly … While here studies were not often pooled, small study effects on the evidence synthesis are yet a concern

419. Treatment of Osteoarthritis of the Knee: An Update Review (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/osteoarthritis-knee-update-disposition-archived.pdf
     May 04, 2017 - I would have some concern that it could introduce a bias in pooled estimates if it occurred commonly … While here studies were not often pooled, small study effects on the evidence synthesis are yet a concern

420. PULMONARY with "Discussions" in Exec Summary (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pulmonary-horizon-scan-high-impact-1312.pdf
     December 01, 2013 - They did, however, express concern about antibiotic resistance with ongoing daily use. … Some experts expressed concern about antibiotic resistance.