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201. Disposition of Comments for CER 176 Management of Gout (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/gout-management-disposition-160721.pdf
     March 15, 2016 - Thus, the theoretical concern about reducing serum urate to 6mg/dL or below has not acknowledged the … There doesn’t, therefore, seem to be a major compelling supportive argument for the concern raised … The concern about lowering SUA to less than 6 is not the physiologic effects on the body but rather … TEP Reviewer #6 Analytic Frameworks I have an extremely high level concern using the term “chronic … However, the concern about lowering SUA to less than 6 is not the physiologic effects on the body

202. Renal Artery Stenosis Management Strategies: An Updated Comparative Effectiveness Review (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/renal-update_disposition-comments.pdf
     August 16, 2016 - No concern about search strategy. Outcome measures are adequately defined. … The review should note that it did not include stenting of arteries with ARAS in whom there was concern … My major concern is about statements asserting bias toward lower-risk patients in the newer RCT’s. … The review should note that it did not include stenting of arteries with ARAS in whom there was concern

203. Research White Paper_Outcome Measure Harmonization and Data Infrastructure for Patient-Centered Outcomes Research in Depression: Data Use and Governance Toolkit (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/outcomes-research-depression.pdf
     October 01, 2021 - to such registries, considerations of identifiability and benefits to patients may be of particular concern

204. Assessing the Risk of Bias of Individual Studies in Systematic Reviews of Health Care Interventions (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guidance-bias-individual-studies_methods.pdf
     March 01, 2012 - The biased presentation or “spin” on results, although of concern to the lay reader, if limited to the … overall or differential nonresponse, dropout, loss to follow-up, or exclusion of participants) was a concern … AMWA ethics FAQs, publication practices of particular concern to medical communicators. 2009. … One concern was the growing number of tools being used and inconsistent approaches to risk of bias assessment

205. Disposition of Comments Report for Pharmacologic and Mechanical Prophylaxis of Venous Thromboembolism Among Special Populations (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/vte-prophyalaxis_disposition-comments.pdf
     May 29, 2013 - We share some of the reviewers concern regarding the description of filter related thrombosis. … reviewed are precisely those for which there is little available information and yet VTE is a common concern … We share the reviewers concern about the lack of high quality evidence for several of the KQs Source

206. Critical Analysis of the Evidence for Patient Safety Practices in Nursing Home Settings (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/nursing-home-safety_research-protocol.pdf
     July 22, 2015 - Furthermore, the concern about inaccuracies in self-reported data remains as most outcomes are collected … What are the patient safety issues of particular concern in the nursing home setting and how are they

207. S44 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/s44.pdf
     October 01, 2007 - Unequal Timing A common concern about policy trials is that a new policy should apply immediately to

208. CER 217 Disposition of Comments: Management of Infertility (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-217-management-of-infertility-comments.pdf
     May 14, 2019 - TEP Reviewer #2 Introduction I think that if there is concern that there is bias, then the grade should … Peer Reviewer #5 Results Should add the age concern with reference 94—(I see this mentioned on page … Jessica Goldstein (Public Reviewer #1) Results A large concern is that maternal age was barely mentioned … other studies and systematic reviews, suggests no significant difference, although there is some concern

209. Comparative Effectiveness of Medications in Patients with Epilepsy (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/epilepsy-medicine_disposition-comments.pdf
     March 01, 2012 - This seems to be supported by some epilepsy position statements where their biggest concern is that … Peer Reviewer #3 Discussion It is inappropriate to state that this is only a concern for AED selection … We did not say it was only a concern for this group but this group should be especially concerned. … Robert Labiner, M.D., Vice President National Association of Epilepsy Centers General Our greater concern

210. Disposition of Comments for CER 160 Binge Eating Disorder (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/binge-eating-disposition-160504.pdf
     December 09, 2015 - Most significant concern is the description of BED versus LOC eating. … We have added to the Discussion the concern that specialized care for BED may be harder to obtain in

211. EHC Research Protocol: Documentation Burden (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/documentation-burden-protocol.pdf
     July 26, 2023 - EHC Research Protocol: Documentation Burden Evidence-based Practice Center Technical Brief Protocol Project Title: Documentation Burden I. Background and Objectives Physician job satisfaction and burnout are urgent challenges currently facing the U.S. healthcare system, especially given the effects of t…

212. American Medical Association (AMA) App Challenge and AMA Idealab (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/eaagleston.pdf
     May 29, 2025 - That was also definitely a concern of ours. It was two-part.

213. Cesarean-Birth-2010 Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cesarean-birth-2010_executive.pdf
     January 01, 2010 - in use of cesarean from 1991 to 2007.1 The pattern of increasing use of cesarean has been of concern … most commonly performed major surgery in the United States.1 The Joint Commission has expressed concern … This is a concern, as cesarean rates among low-risk women continue to rise, and the individual and

214. RESPONSE TO REQUEST FOR WORK ASSIGNMENT (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/copd-anticholinergic-medicines_research.pdf
     December 01, 2009 - RESPONSE TO REQUEST FOR WORK ASSIGNMENT The DEcIDE (Developing Evidence to Inform Decisions about Effectiveness) network is part of AHRQ's Effective Health Care Program. It is a collaborative network of research centers that support the rapid development of new scientific information and analyti…

215. Disposition of Comments for Efficacy and Safety of Screening for Postpartum Depression (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/depression-postpartum-screening_disposition-comments.pdf
     May 01, 2013 - The methodologic issues of concern are exhaustively identified and discussed across the available studies … We agree that the low rate of followup is a major concern and limits the effectiveness of screening … Peer Reviewer 7 General One other concern that I had and was not sure where to express - the report

216. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/diabetes-update-2015_disposition-comments.pdf
     January 01, 2015 - Comment Response TEP Reviewer #1 General The report is encyclopedic in its wealth of knowledge, but my concern … My concern is that the discussion, while factually accurate, does not in that section note that the … The Chinese study is of greater concern, but its applicability to other races/ethnicity is uncertain … This issue (lack of bias) could receive more emphasis in the conclusion since it is so often a concern … We definitely appreciate the concern that outcomes assessment should be standardized for all of the

217. Disposition of Comments for Diagnostic Accuracy of Screening and Treatment of Post-Acute Coronary Syndrome Depression (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-200-comments-post-acs.pdf
     November 14, 2017 - Peer Reviewer #2 General Comments Another general concern is that there was a focus on understanding … We understand the reviewer’s concern that the eligibility criteria were too restrictive, but they

218. Methods Guide for Medical Test Reviews Chapter 2 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guidance-tests-topics_methods.pdf
     July 01, 2012 - Methods Guide for Medical Test Reviews Chapter 2 2-1 Chapter 2 Developing the Topic and Structuring Systematic Reviews of Medical Tests: Utility of PICOTS, Analytic Frameworks, Decision Trees, and Other Frameworks David Samson, M.S., Blue Cross and Blue Shield Association Karen M. Schoelles M.D., S.…

219. DRN: Report 1 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/distributed-network-safety_research.pdf
     July 01, 2009 - Need to establish comfort with performance of querying mechanisms (e.g., menu-driven queries)  Big concern … To address this concern, numerous examples of other types of data (e.g., survey data, registry data … The primary concern or barrier regarding DRN implementation is designing a network that will be acceptable

220. Disposition of Comments for CER 195 Management of Uterine Fibroids (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-195-disposition-comments-uterine-fibroids.pdf
     December 14, 2017 - UFS-QoL, we revised the text about the HRQoL to say: "The HRQoL scale includes subscales to assess: 1) concern … We understand the concern that retrieval of the whole mass and all specimen may be less robust for … We assume the concern about incorrect reporting relates to the omission of the two Donnez publications … Other than increasing concern for risk with age, we did not identify consistently reported factors that … Other than increasing concern for risk with age, we did not identify consistently reported factors that