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21. Pharmacologic Therapies for the Management of Crohn’s Disease: Comparative Effectiveness | Effective Health Care (EHC) Program
    effectivehealthcare.ahrq.gov/products/crohns-disease/research
    February 25, 2014 - Growth was an additional safety concern for children.

22. Topic Suggestion Description | Effective Health Care Program
    effectivehealthcare.ahrq.gov/get-involved/nominated-topics/for-women-in-the-postpartum-period-what-is-the-effectiveness-and-safety-of-screening-and-treatment-for-depression-please-use-the-uspstf-framework-which-considers-not-only-screening-but-followup-treatment-and-management-the-tr
    October 01, 2011 - Screening without having treatment and followup services available is a concern among Medicaid programs … The ACA is likely to ameliorate this concern as more mothers remain eligible and covered longer after

23. Pharma-Nonpharma-Ptsd-2022-Update-App-G1 (xls file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/pharma-nonpharma-ptsd-2022-update-app-g1.xlsx
    January 01, 2022 - G-1. RoB 2 Assessment Table G-1. Risk of Bias 2 assessment of new included studies RoB Domain Bias Due to Randomization (Cochrane) or Selection Bias (AHRQ); Randomization Bias Due to Randomization (Cochrane) or Selection Bias (AHRQ); Allocation Bias Due to Randomization (Cochrane) or Selection Bias (AHRQ); Similarit…

24. Evidence-based Practice Center Systematic Review Protocol - Management of Infantile Epilepsies (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-252-infantile-epilepsies-disposition-comments.pdf
    October 25, 2022 - There is concern, based on experimental animal studies, about some medications causing apoptosis which … We completely understand your concern about our exclusion of any studies published in 1998 or earlier … We completely understand your concern about our exclusion of any studies published in 1998 or earlier … We completely understand your concern about our exclusion of any studies published in 1998 or earlier … More importantly, we understand the concern that for infants undergoing surgery, the range of outcomes

25. For adult female patients, what is the comparative effective of non-surgical and surgical treatment of chronic pelvic pain? | Effective Health Care (EHC) Program
    effectivehealthcare.ahrq.gov/get-involved/nominated-topics/for-adult-female-patients-what-is-the-comparative-effective-of-non-surgical-and-surgical-treatment-of-chronic-pelvic-pain
    July 21, 2009 - Also concern involves persistence of chronic pain post-surgery and poassible predictors of poor outcomes

26. Disposition of Comments Technical Brief 30 Assessment Tools for Palliative Care (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/palliative-care-tools-disposition.pdf
    May 04, 2017 - How many Informants were 'researchers'---a small n would create concern regarding the limitation of … We appreciate your concern. … It is a substantial concern to this report. … Those items were dropped because it was low frequency of it being a concern. … life; this concern was not otherwise a priority for the physician.”

27. Disposition of Comments Technical Brief 30 Assessment Tools for Palliative Care (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/palliative-care-tools-disposition.pdf
    May 04, 2017 - How many Informants were 'researchers'---a small n would create concern regarding the limitation of … We appreciate your concern. … It is a substantial concern to this report. … Those items were dropped because it was low frequency of it being a concern. … life; this concern was not otherwise a priority for the physician.”

28. Ptsd-3-Appendix-H-Table-H-1 (xls file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/ptsd-3-appendix-h-table-h-1.xlsx
    January 01, 2021 - H-1. RoB 2 Assessment Table H-1. Risk of Bias 2 Assessment of New Included Studies RoB Domain Bias due to randomization (Cochrane) or Selection bias (AHRQ); Randomization Bias due to randomization (Cochrane) or Selection bias (AHRQ); Allocation Bias due to randomization (Cochrane) or Selection bias (AHRQ); Similarit…

29. A Qualitative Study to Understand Barriers to Conducting Cluster Randomized Trials | Effective Health Care Program
    effectivehealthcare.ahrq.gov/products/cluster-randomized-trials/research
    December 02, 2009 - A Qualitative Study to Understand Barriers to Conducting Cluster Randomized Trials Research Report December 2, 2009 Findings from this study were published in the following journal articles. 1. Mazor KM, Sabin JE, Boudreau D, Goodman MJ, Gurwitz JH, Herrinton LJ, Raebel MA, Roblin D, Smith DH, Meterk…

30. Data Points #3: Economic burden of diabetic foot ulcers and amputations | Effective Health Care (EHC) Program
    effectivehealthcare.ahrq.gov/products/diabetes-foot-ulcer-amputation-economics/research
    March 08, 2011 - Concern for cost-effectiveness has also spurred interest in trying to better understand the potential

31. Reliability Testing of the AHRQ EPC Approach to Grading the Strength of Evidence in Comparative Effectiveness Reviews | Effective Health Care (EHC) Program
    effectivehealthcare.ahrq.gov/products/reliability-testing-grading-evidence/research
    May 22, 2012 - Of particular concern is how to deal with (a) outcomes that are evaluated through a combination of RCTs

32. Siminoff_ECCS2012 (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/siminoff_eccs2012.pdf
    January 01, 2012 - .”  The most common concern of patients with diabetes is “loss of a limb.” • Etic o Objective analysis …    “Blood in  the stool  is an indication  of several  serious diseases.”  The most common concern

33. Data Points #17: Trends in bariatric surgery in Medicare beneficiaries | Effective Health Care (EHC) Program
    effectivehealthcare.ahrq.gov/products/bariatric-surgery-trends/research
    November 30, 2012 - Morbidity and mortality rates following bariatric surgery continue to be a major concern.

34. Disposition of Comments for Progestogens for Prevention of Preterm Birth (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/progestogens-preterm-birth-disposition-121205.pdf
    September 07, 2012 - We share the same concern as the reviewer that when it comes time to aggregate results <37 weeks becomes … There is now an RCT that has reported a significant increase in fetal death, strengthening the concern … Use of castor oil as a placebo is a theoretical concern due to its use as an induction agent. … Thank you for raising this concern. … The omission of the safety signal is a major concern.

35. Ced -Appendix-2 (xls file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/ced%20-appendix-2.xlsx
    October 12, 2022 - Concern that increasing the number of requirements will increase burden on sponsors. … diagnostic industry representatives"; ability to comment during public comment period is not suffcient Concern

36. Teen Development | Effective Health Care (EHC) Program
    effectivehealthcare.ahrq.gov/health-topics/teen-development
    Home » Health Topics » Teen Development Definition As a teenager, you go through many physical, mental, emotional, and social changes. The biggest change is puberty, the process of becoming sexually mature. It usually happens between ages 10 and 14 for girls and ages 12 and 16 for boys. As your body change…

37. Disposition of Comments: CER 230 Therapies for Clinically Localized Prostate Cancer (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/cer-230-prostate-cancer-comments.pdf
    September 17, 2020 - The following are the main themes of concern: (1) limited evidence of comparative effectiveness; (2)

38. Topic 0410 Imaging to Diagnose and Statge SCLC and NSCLC NSD SJ clean (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND-0491-140827.pdf
    February 19, 2014 - The associated costs and adverse clinical outcomes are of particular concern due to the size of the

39. Developing Evidence-Based Research Priorities for Off-Label Drug Use | Effective Health Care (EHC) Program
    effectivehealthcare.ahrq.gov/products/off-label-use-research-priorities/research
    June 29, 2009 - The cost, market entry, and drug promotion factors were combined to indicate a heightened concern about … assessment has extended past studies by examining drug characteristics that can impact the level of concern … Off-label use of the atypical antipsychotics has long been a source of concern. … A related concern is that there is a pressing need for investment in a rigorous and complete national … For example, Black Box warnings may not always reflect an equal magnitude of concern about drug safety

40. Rti-Item-Bank Research (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/rti-item-bank_research.pdf
    August 01, 2013 - Vandenbroucke notes that confounding by contraindication is not always a concern for observational … Differential loss to follow-up, for instance, is a concern for cohort studies but not for case-series … As above, blinding of outcome assessors may be of variable concern across different observational … Reporting Bias Reporting bias is a concern across all research regardless of design: authors are more … While no empirical evidence exists that reporting bias is a greater concern for observational studies