-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND_0064_11-23-2008.pdf
January 01, 2008 - What are the health risks and benefits of trabeculectomy as compared to
alternatives, including laser … Does treatment response vary for African-Americans as compared to those who are
not African-Americans
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/ace-inhibitor-arb-update_executive.pdf
June 01, 2011 - These studies found the direct renin inhibitor to
have a greater reduction in blood pressure compared … to the
ACEI ramipril (two studies) and no significant difference
compared to the ARB losartan (one … ARB); of treatment success based on use of a single antihypertensive
Insufficient for ARBs compared … (continued) compared with the withdrawal rate associated with ACEIs. … Only nine studies compared ACEIs and ARBs
for periods longer than 1 year.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/juvenile-arthritis-dmards_surveillance.pdf
March 14, 2013 - two
DMARDs; two compared penicillamine to
hydroxychloroquine, and one compared
leflunomide to methotrexate … Thirteen trials
directly compared a DMARD to placebo. … Three RCTs directly compared two
DMARDs; two compared penicillamine to
hydroxychloroquine, and one … compared
leflunomide to methotrexate. … Thirteen trials
directly compared a DMARD to placebo.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/juvenile-arthritis-dmards_surveillance.pdf
March 14, 2013 - two
DMARDs; two compared penicillamine to
hydroxychloroquine, and one compared
leflunomide to methotrexate … Thirteen trials
directly compared a DMARD to placebo. … Three RCTs directly compared two
DMARDs; two compared penicillamine to
hydroxychloroquine, and one … compared
leflunomide to methotrexate. … Thirteen trials
directly compared a DMARD to placebo.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/fatty-acids-cardiovascular-disease_executive.pdf
August 01, 2016 - No study directly compared
formulations. … RCTs
No eligible RCTs compared purified DPA formulations
versus placebo. … One trial compared 2.0 g/d SDA and 1.9 g/d
EPA+DHA+DPA in healthy people. … Few trials compared n-3 FA dose, formulation,
or source. … No trial compared different n-3 to n-6 FA
ratios of supplements or intake.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/pelvic-pain-surveillance-151130.pdf
July 10, 2015 - We compared the conclusions of the included abstracts to the conclusions
of the original systematic … Progestogen-only
contraceptive pill compared with combined oral contraceptive in the treatment of pain … Progestogen-only contraceptive
pill compared with combined oral contraceptive in the treatment of pain … L. and Ferrero, S. 2014
Progestogen-only contraceptive pill compared with combined oral contraceptive … RESULTS: In group POP, 38/62 women (61.2%) were satisfied or very satisfied after treatment, compared
-
effectivehealthcare.ahrq.gov/sites/default/files/diabetes-update-2015_executive.pdf
January 01, 2015 - In this report, several monotherapy and metformin-based
combination medications were compared where … When compared with metformin plus a basal or
premixed insulin, metformin plus a GLP-1 receptor agonist … Comparative effectiveness of sulfonylureas compared with metformin for long-
term all-cause mortality … Efficacy and
tolerability of saxagliptin compared with glimepiride in elderly
patients with type 2 … Intensive blood-
glucose control with sulphonylureas or insulin compared with
conventional treatment
-
effectivehealthcare.ahrq.gov/sites/default/files/cer-241-physical-activity-wheelchair-evidence-summary-updated.pdf
October 01, 2021 - Key Question 2: Benefits and Harms
Compared with no physical activity or usual care, physical activity … Table A summarizes the strength of evidence on effects
of physical activity interventions compared with … usual care and general exercise effect
across interventions compared with usual care. … Effects of physical activity interventions compared with usual carea
Intervention
Category
Intervention
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND_0332_07-29-2010.pdf
January 01, 2010 - 11-16-10
2
(active surveillance vs. active treatment)
lead to improvements in health outcomes compared … Does use of the PCA3 assay lead to improved health outcomes when compared
with or in addition to use … the cost-effectiveness of using PCA3 assays to guide screening and
management for prostate cancer compared
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/adhd-future_research.pdf
May 01, 2012 - standards for diagnosis,
outcomes
Validation of
instrument
compared with
reference
standard … P I C O T S
All ages
Diagnosed
with ADHD
N/A Feasible tools would
be compared with
reference … standards
for diagnosis,
outcomes
Validation of
instrument
compared with
reference
standard … failures
would be compared with other combinations after treatment failures. … Even when the known effect sizes of the compared interventions is large, the sample size
requirements
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/cancer-radiation_technical-brief.pdf
November 01, 2009 - What are the theoretical advantages and disadvantages of these therapies
compared to other radiation … We excluded from the literature scan studies that compared different treatment
plans/algorithms, as … What are the theoretical advantages and disadvantages of these therapies compared to
other radiation … What are the theoretical advantages and disadvantages of
these therapies compared to other radiation … Charged particles have different depth-dose
distributions compared to photons.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/peripheral-artery-disease-treatment_executive.pdf
May 01, 2013 - Selected medical therapies have been shown to improve
walking distance in patients with PAD, compared … Of these,
four observational studies compared usual care with
endovascular intervention. … One RCT showed higher survival in
autologous vein graft compared with prosthetic graft. … The role of
DAPT compared with aspirin monotherapy is less certain. … A single RCT has compared clopidogrel with
aspirin, and three RCTs have compared clopidogrel plus
aspirin
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/antipsychotics-adults_surveillance.pdf
August 30, 2014 - Schizophrenia
• A total of 41 studies compared outcomes for predefined subgroups. … No notable differences were observed for the subgroups
compared to the overall findings. … : Bipolar Disorder
Mood (mania)
SOE: Low
Seven studies compared haloperidol to
SGAs and found no … No notable differences were
observed for the subgroups compared
to the overall findings. … A significant
difference favored haloperidol
compared with ziprasidone for core
illness symptoms (
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/hepatitis-c-screening_executive.pdf
November 01, 2012 - without cirrhosis is associated with
worse quality of life measures and symptoms (primarily
fatigue) compared … There was no direct evidence on
clinical benefits associated with screening compared
with no screening … No study compared effects of screening with not screening
pregnant women. … The
studies of referral populations reported somewhat higher
rates of treatment (30–40 percent) compared … Although none of the studies assessing diagnostic accuracy
of noninvasive tests compared to liver biopsy
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cad-women-diagnosis_executive.pdf
June 01, 2012 - Effective
Health Care
percent, compared with 80 percent in men,
which complicates diagnosis in women … These limitations are
generally considered to be minor when compared with the
benefits of the procedure … What is the accuracy of one NIT in diagnosing
obstructive and nonobstructive CAD when compared
with … Is there evidence that the use of NITs
(when compared with other NITs or with coronary
angiography) … Summary of accuracy of NITs compared with coronary angiography for diagnosing
CAD in women
Modality
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/high-cholestorol-medicines-update_executive.pdf
February 01, 2014 - We aimed to answer the questions
below by reviewing trials of adults that compared a higher
potency … KQ 3: Compared with higher dose statins and with one
another, do combination regimens differ in benefits … Data Synthesis
We compared lower potency statins in combination
therapy with higher potency statin … Three trials compared low-potency statin in combination
with niacin to mid-potency statin monotherapy … No study reported
on the effectiveness of niacin plus statin compared to
intensification of statin
-
effectivehealthcare.ahrq.gov/sites/default/files/cer30_hip-fracture-pain-executive-summary_20110517.pdf
May 01, 2011 - Three RCTs
compared additional fentanyl (n = 40), morphine
(n = 40), and sufentanil (n = 50) versus … Similarly, three RCTs (n = 132) that compared the
addition of sufentanil found no difference between … One trial (n = 38) compared acupressure versus
sham control delivered preoperatively. … These were
compared with placebo/standard care, or a different
method of nerve blocks. … Eight trials
compared skin traction (n = 498) versus no traction
(n = 594) and found no significant
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/rheumatoid-arthritis-2007_executive.pdf
January 01, 2007 - We did not find any head-to-head
RCTs that compared one biologic DMARD with
another. … No evidence exists on abatacept and rituximab
compared with other biologic DMARDs. … One nonrandomized, open-label trial
directly compared the tolerability of two biologic
DMARDs. … One open-label RCT compared synthetic DMARD use
with and without prednisolone. … Most of the other studies compared
combinations of biologic DMARDs and methotrexate
with monotherapies
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/musculoskeletal-complaints-tests-children_executive.pdf
March 01, 2012 - ANA, RF, and CCP tests in children and
adolescents with undiagnosed MSK pain and/or joint
swelling compared … comorbidities, and recent infections
modify the diagnostic performance of ANA, RF, and CCP
for pSLE compared … comorbidities, and recent infections
modify the diagnostic performance of ANA, RF, and CCP
for JIA compared … In studies using the case-
control design, children with known disease (i.e., JIA or
pSLE) were compared … Prevalence of IgM-,
IgA- and IgG-rheumatoid factors in seronegative polyarticular
disease compared
-
effectivehealthcare.ahrq.gov/sites/default/files/study-design-considerations-chapter-2.pptx
January 01, 2013 - To ensure internal validity, treatment groups compared must have the same underlying risk for outcome … assumption needed for nonexperimental comparative effectiveness research is that the treatment groups compared … Cohort designs are easy to conceptualize and are readily compared to the randomized controlled trial, … Advantages
The oversampling of persons with the outcome increases efficiency when compared with the full … The case-cohort design is intended to increase efficiency, when compared with the nested case-control