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  1. effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND_0064_11-23-2008.pdf
    January 01, 2008 - What are the health risks and benefits of trabeculectomy as compared to alternatives, including laser … Does treatment response vary for African-Americans as compared to those who are not African-Americans
  2. Layout 1 (pdf file)

    effectivehealthcare.ahrq.gov/sites/default/files/related_files/ace-inhibitor-arb-update_executive.pdf
    June 01, 2011 - These studies found the direct renin inhibitor to have a greater reduction in blood pressure compared … to the ACEI ramipril (two studies) and no significant difference compared to the ARB losartan (one … ARB); of treatment success based on use of a single antihypertensive Insufficient for ARBs compared … (continued) compared with the withdrawal rate associated with ACEIs. … Only nine studies compared ACEIs and ARBs for periods longer than 1 year.
  3. effectivehealthcare.ahrq.gov/sites/default/files/related_files/juvenile-arthritis-dmards_surveillance.pdf
    March 14, 2013 - two DMARDs; two compared penicillamine to hydroxychloroquine, and one compared leflunomide to methotrexate … Thirteen trials directly compared a DMARD to placebo. … Three RCTs directly compared two DMARDs; two compared penicillamine to hydroxychloroquine, and one … compared leflunomide to methotrexate. … Thirteen trials directly compared a DMARD to placebo.
  4. effectivehealthcare.ahrq.gov/sites/default/files/pdf/juvenile-arthritis-dmards_surveillance.pdf
    March 14, 2013 - two DMARDs; two compared penicillamine to hydroxychloroquine, and one compared leflunomide to methotrexate … Thirteen trials directly compared a DMARD to placebo. … Three RCTs directly compared two DMARDs; two compared penicillamine to hydroxychloroquine, and one … compared leflunomide to methotrexate. … Thirteen trials directly compared a DMARD to placebo.
  5. effectivehealthcare.ahrq.gov/sites/default/files/related_files/fatty-acids-cardiovascular-disease_executive.pdf
    August 01, 2016 - No study directly compared formulations. … RCTs No eligible RCTs compared purified DPA formulations versus placebo. … One trial compared 2.0 g/d SDA and 1.9 g/d EPA+DHA+DPA in healthy people. … Few trials compared n-3 FA dose, formulation, or source. … No trial compared different n-3 to n-6 FA ratios of supplements or intake.
  6. Untitled (pdf file)

    effectivehealthcare.ahrq.gov/sites/default/files/related_files/pelvic-pain-surveillance-151130.pdf
    July 10, 2015 - We compared the conclusions of the included abstracts to the conclusions of the original systematic … Progestogen-only contraceptive pill compared with combined oral contraceptive in the treatment of pain … Progestogen-only contraceptive pill compared with combined oral contraceptive in the treatment of pain … L. and Ferrero, S. 2014 Progestogen-only contraceptive pill compared with combined oral contraceptive … RESULTS: In group POP, 38/62 women (61.2%) were satisfied or very satisfied after treatment, compared
  7. effectivehealthcare.ahrq.gov/sites/default/files/diabetes-update-2015_executive.pdf
    January 01, 2015 - In this report, several monotherapy and metformin-based combination medications were compared where … When compared with metformin plus a basal or premixed insulin, metformin plus a GLP-1 receptor agonist … Comparative effectiveness of sulfonylureas compared with metformin for long- term all-cause mortality … Efficacy and tolerability of saxagliptin compared with glimepiride in elderly patients with type 2 … Intensive blood- glucose control with sulphonylureas or insulin compared with conventional treatment
  8. effectivehealthcare.ahrq.gov/sites/default/files/cer-241-physical-activity-wheelchair-evidence-summary-updated.pdf
    October 01, 2021 - Key Question 2: Benefits and Harms Compared with no physical activity or usual care, physical activity … Table A summarizes the strength of evidence on effects of physical activity interventions compared with … usual care and general exercise effect across interventions compared with usual care. … Effects of physical activity interventions compared with usual carea Intervention Category Intervention
  9. effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND_0332_07-29-2010.pdf
    January 01, 2010 - 11-16-10 2 (active surveillance vs. active treatment) lead to improvements in health outcomes compared … Does use of the PCA3 assay lead to improved health outcomes when compared with or in addition to use … the cost-effectiveness of using PCA3 assays to guide screening and management for prostate cancer compared
  10. effectivehealthcare.ahrq.gov/sites/default/files/pdf/adhd-future_research.pdf
    May 01, 2012 - standards for diagnosis, outcomes Validation of instrument compared with reference standard … P I C O T S All ages Diagnosed with ADHD N/A Feasible tools would be compared with reference … standards for diagnosis, outcomes Validation of instrument compared with reference standard … failures would be compared with other combinations after treatment failures. … Even when the known effect sizes of the compared interventions is large, the sample size requirements
  11. effectivehealthcare.ahrq.gov/sites/default/files/pdf/cancer-radiation_technical-brief.pdf
    November 01, 2009 - What are the theoretical advantages and disadvantages of these therapies compared to other radiation … We excluded from the literature scan studies that compared different treatment plans/algorithms, as … What are the theoretical advantages and disadvantages of these therapies compared to other radiation … What are the theoretical advantages and disadvantages of these therapies compared to other radiation … Charged particles have different depth-dose distributions compared to photons.
  12. effectivehealthcare.ahrq.gov/sites/default/files/related_files/peripheral-artery-disease-treatment_executive.pdf
    May 01, 2013 - Selected medical therapies have been shown to improve walking distance in patients with PAD, compared … Of these, four observational studies compared usual care with endovascular intervention. … One RCT showed higher survival in autologous vein graft compared with prosthetic graft. … The role of DAPT compared with aspirin monotherapy is less certain. … A single RCT has compared clopidogrel with aspirin, and three RCTs have compared clopidogrel plus aspirin
  13. effectivehealthcare.ahrq.gov/sites/default/files/related_files/antipsychotics-adults_surveillance.pdf
    August 30, 2014 - Schizophrenia • A total of 41 studies compared outcomes for predefined subgroups. … No notable differences were observed for the subgroups compared to the overall findings. … : Bipolar Disorder Mood (mania) SOE: Low Seven studies compared haloperidol to SGAs and found no … No notable differences were observed for the subgroups compared to the overall findings. … A significant difference favored haloperidol compared with ziprasidone for core illness symptoms (
  14. effectivehealthcare.ahrq.gov/sites/default/files/related_files/hepatitis-c-screening_executive.pdf
    November 01, 2012 - without cirrhosis is associated with worse quality of life measures and symptoms (primarily fatigue) compared … There was no direct evidence on clinical benefits associated with screening compared with no screening … No study compared effects of screening with not screening pregnant women. … The studies of referral populations reported somewhat higher rates of treatment (30–40 percent) compared … Although none of the studies assessing diagnostic accuracy of noninvasive tests compared to liver biopsy
  15. effectivehealthcare.ahrq.gov/sites/default/files/related_files/cad-women-diagnosis_executive.pdf
    June 01, 2012 - Effective Health Care percent, compared with 80 percent in men, which complicates diagnosis in women … These limitations are generally considered to be minor when compared with the benefits of the procedure … What is the accuracy of one NIT in diagnosing obstructive and nonobstructive CAD when compared with … Is there evidence that the use of NITs (when compared with other NITs or with coronary angiography) … Summary of accuracy of NITs compared with coronary angiography for diagnosing CAD in women Modality
  16. effectivehealthcare.ahrq.gov/sites/default/files/related_files/high-cholestorol-medicines-update_executive.pdf
    February 01, 2014 - We aimed to answer the questions below by reviewing trials of adults that compared a higher potency … KQ 3: Compared with higher dose statins and with one another, do combination regimens differ in benefits … Data Synthesis We compared lower potency statins in combination therapy with higher potency statin … Three trials compared low-potency statin in combination with niacin to mid-potency statin monotherapy … No study reported on the effectiveness of niacin plus statin compared to intensification of statin
  17. effectivehealthcare.ahrq.gov/sites/default/files/cer30_hip-fracture-pain-executive-summary_20110517.pdf
    May 01, 2011 - Three RCTs compared additional fentanyl (n = 40), morphine (n = 40), and sufentanil (n = 50) versus … Similarly, three RCTs (n = 132) that compared the addition of sufentanil found no difference between … One trial (n = 38) compared acupressure versus sham control delivered preoperatively. … These were compared with placebo/standard care, or a different method of nerve blocks. … Eight trials compared skin traction (n = 498) versus no traction (n = 594) and found no significant
  18. Layout 1 (pdf file)

    effectivehealthcare.ahrq.gov/sites/default/files/related_files/rheumatoid-arthritis-2007_executive.pdf
    January 01, 2007 - We did not find any head-to-head RCTs that compared one biologic DMARD with another. … No evidence exists on abatacept and rituximab compared with other biologic DMARDs. … One nonrandomized, open-label trial directly compared the tolerability of two biologic DMARDs. … One open-label RCT compared synthetic DMARD use with and without prednisolone. … Most of the other studies compared combinations of biologic DMARDs and methotrexate with monotherapies
  19. effectivehealthcare.ahrq.gov/sites/default/files/related_files/musculoskeletal-complaints-tests-children_executive.pdf
    March 01, 2012 - ANA, RF, and CCP tests in children and adolescents with undiagnosed MSK pain and/or joint swelling compared … comorbidities, and recent infections modify the diagnostic performance of ANA, RF, and CCP for pSLE compared … comorbidities, and recent infections modify the diagnostic performance of ANA, RF, and CCP for JIA compared … In studies using the case- control design, children with known disease (i.e., JIA or pSLE) were compared … Prevalence of IgM-, IgA- and IgG-rheumatoid factors in seronegative polyarticular disease compared
  20. effectivehealthcare.ahrq.gov/sites/default/files/study-design-considerations-chapter-2.pptx
    January 01, 2013 - To ensure internal validity, treatment groups compared must have the same underlying risk for outcome … assumption needed for nonexperimental comparative effectiveness research is that the treatment groups compared … Cohort designs are easy to conceptualize and are readily compared to the randomized controlled trial, … Advantages The oversampling of persons with the outcome increases efficiency when compared with the full … The case-cohort design is intended to increase efficiency, when compared with the nested case-control

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