-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/urinary-incontinence-update_research-protocol.pdf
June 06, 2017 - What are the harms from nonpharmacological treatments when compared with no
active treatment? … What is the comparative effectiveness of nonpharmacological treatments when
compared with each other … What are the comparative harms from nonpharmacological treatments when
compared with each other? … What are the harms from pharmacological treatments when compared with no
active treatment?
2c. … What is the comparative effectiveness of pharmacological treatments when
compared with each other?
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/evidence-summary-cer-195-uterine-fibroids-final.pdf
December 01, 2017 - However,
16 small RCTs compared a treatment to no intervention,
typically trials that compared a medication … Tamoxifen use
in premenopausal women did not influence length or
severity of bleeding compared with … Women receiving
tamoxifen had less pain after four months of treatment
compared with placebo. … Most studies compared similar procedures,
two compared different procedures, and nine compared
procedures … Two studies compared UAE to myomectomy;
3 studies compared UAE to hysterectomy; and four studies
compared
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/arthritis-psoriatric_executive.pdf
April 01, 2012 - Compared with placebo in one fair study, MTX resulted
in greater improvement in physician assessment … Compared with placebo in one good systematic review
study, sulfasalazine reduced disease activity. … Compared to anti-TNF monotherapy (adalimumab,
etanercept, or infliximab), MTX plus anti-TNF produced … INSUFFICIENT
Compared with placebo, adalimumab, etanercept,
golimumab, and infliximab led to greater … However, compared
with placebo, we noted the following:
adalimumab and etanercept had more injection
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/hepatitis-c_executive.pdf
November 01, 2012 - 4A protease inhibitors, with a potential advantage of
shorter duration of therapy (24 to 28 weeks) compared … with
pegylated interferon alfa-2b plus ribavirin, RR estimates
for triple, compared with dual, therapy … In
addition, the trials may have overestimated efficacy
compared with what would be seen in typical … Second, no trials directly
compared regimens with boceprevir with regimens with
telaprevir. … Trials directly comparing triple therapy with telaprevir
compared with triple therapy with boceprevir
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/epilepsy-medicine_disposition-comments.pdf
March 01, 2012 - We have made the following change: The newer
antiepileptic medications compared versus each
older agent … However, when we looked at the
newer drugs actually compared, there are only
but a few newer drugs … PHB produced greater clinical worsening on
the MMSE compared to LTG (p<.05). … AHRQ Report Reference: AHRQ Report Page 73: “Phenobarbital
had inferior effects on mood as compared … Recommended Correction: Lamotrigine produced a superior
effect on mood, i.e. depression compared to
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/liver-cancer-therapy_executive.pdf
May 01, 2013 - Ablative therapies compared with other ablative
therapies
– 2. … Radiotherapies compared with other radiotherapies
– 4. … at 3 years for RFA compared with PEI/PAI, with a
low risk of bias. … Three RCTs compared the ablative
treatments RFA and PEI/PAI. … Two systematic reviews compared
RFA with PEI;30,31 three compared TACE-percutaneous
ablation (PA),
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/diabetes-behavior-programs_clinician-2016.pdf
January 01, 2016 - effectiveness and harms of
behavioral programs in the community health setting for
patients with T1DM when compared … to greater
reductions in hemoglobin A1c (HbA1c) levels at a 6-month
postintervention followup when compared … reductions in HbA1c levels were observed in
patients who participated in a behavioral program,
when compared … with T1DM; there was a 21-percent higher risk
of attrition for individuals receiving usual care when
compared … aspects of the disease
(particularly in adolescents) to a greater extent.
�� Only one T1DM study compared
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effectivehealthcare.ahrq.gov/sites/default/files/hip-fracture-pain_surveillance.pdf
July 08, 2015 - One trial (n = 38) compared acupressure versus
Up-to-date No new research was found
! … These were compared with placebo/standard
care, or a different method of nerve blocks. … Another trial (n=30) compared
intrathecal isotonic clonidine vs. … One trial (n =
38) compared acupressure versus
sham control delivered
preoperatively. … These were compared
with placebo/standard care, or a
different method of nerve blocks.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/hepatitis-c_disposition-comments.pdf
November 27, 2012 - For example, on Page 17, the last paragraph
discusses nine trials that compared dual therapies
(citation … AHRQ found the Phase III trial that
compared the telaprevir dosing that was ultimately
approved by … Specifically compared are interferon alpha 2a and
interferon alpha 2b as part of combination therapy … Results (p.48) The sentence “A trial of extended early virologic
responders…randomized to 4 compared … with 28 more
weeks of dual therapy” should read “…randomized to
24 compared with 28 weeks of dual
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/renal-artery-stenosis_executive.pdf
October 01, 2006 - effects of aggressive medical therapy (i.e.,
antihypertensive, antiplatelet, and antilipid
treatment) compared … Description of reviewed studies
No study directly compared angioplasty with stent
placement to aggressive … Two
randomized controlled trials directly compared
angioplasty without stent placement to medical
treatment … Among the
remaining studies that compared revascularization to
medical treatment and the noncomparative … • Studies that compared stent placement to no stent placement found
no difference in outcomes.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/back-pain-treatment_clinician.pdf
November 01, 2016 - Pharmacological therapies are associated with increased risk
of adverse events when compared with placebo … Subacute Low Back Pain: Summary of Key Findings and Strength of
Evidence for Interventions
Intervention Compared … Radicular Low Back Pain: Summary of Key Findings and Strength of Evidence for Interventions
Intervention Compared … stimulation.
�� Pharmacological therapies were associated with increased risk of
adverse events when compared … Chronic Low Back Pain: Summary of Key Findings and Strength of Evidence for Interventions
Intervention Compared
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/plasma-cell-dyscrasias-sflc-assay-future_research.pdf
September 01, 2012 - • Key Question 2: As compared with traditional tests, how well does the SFLC assay
independently predict … As compared
with traditional
tests, how well
does the SFLC
assay
independently
predict progression … The studies identified in the searches were compared against the nominated FRN topics to assess
if they … Finally, one
study explored whether the use of the SFLC assay compared with traditional testing would … The studies identified in the searches were compared against the nominated FRN topics to assess
if they
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/alcohol-misuse-drug-therapy-surveillance.pdf
September 01, 2017 - We qualitatively compared original SR
conclusions with the new input from the literature and experts … One study (n=243) compared disulfiram vs acamprosate vs naltrexone. 18
Depression decreased and all … One study (n=243) compared disulfiram vs
acamprosate vs naltrexone. … However, nalmefene users had lower incidence of
diarrhea compared to placebo. … "T" allele carriers on
naltrexone had more abstinence compared to "CC"
subjects on naltrexone.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/antipsychotics-adults_executive.pdf
August 01, 2012 - Two studies compared
haloperidol versus olanzapine and found no significant
Table B. … KQ5: Subgroups
A total of 41 studies compared outcomes for predefined
subgroups. … No notable differences were observed for the subgroups
compared with the overall findings. … Applicability
This report included studies that compared an individual
FGA with an individual SGA. … There were no notable differences in
outcomes for these subgroups compared with the overall
results
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/asd-medical-executive-170505.pdf
May 01, 2017 - those receiving DHA, while teachers rated communication
as more improved in the treatment group compared … Most studies
had placebo comparators, while five compared a
pharmaceutical agent to behavioral treatment … The methodologic rigor of studies has increased
substantially compared with those studies reported in … We found positive effects of atomoxetine compared with
placebo on hyperactivity in children with ASD … Few studies (n=10) compared active treatments,
and future research to assess comparative effectiveness
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-193-naloxone-executive-summary.pdf
November 01, 2017 - Key Messages
• Higher concentration intranasal
naloxone may be similarly
effective and safe compared … • No study compared different doses of naloxone
administered via the same route; there was too much … • No study compared benefits and harms of differences in
timing of repeat dosing of naloxone (SOE: … No study compared outcomes among patients with
confirmed or suspected opioid overdose who responded … No study
directly compared different doses of naloxone administered
via the same route.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND_0064_11-23-2008.pdf
January 01, 2008 - What are the health risks and benefits of trabeculectomy as compared to
alternatives, including laser … Does treatment response vary for African-Americans as compared to those who are
not African-Americans
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-234-headaches-pregnancy-summary.pdf
November 01, 2020 - Compared with nonuse (either during or before pregnancy),
triptan use may not be associated with spontaneous … A single primary study found that compared with oral codeine,
combination metoclopramide and diphenhydramine … randomized controlled trials, 8 nonrandomized comparative studies [i.e., observational
studies that compared … with spontaneous abortion, elective or induced abortion, or major or minor congenital
anomalies, compared … Treatment—antiemetics (dopamine receptor antagonists), antihistamines, and
opioids: One RCT found that, compared
-
effectivehealthcare.ahrq.gov/sites/default/files/cer-241-physical-activity-wheelchair-evidence-summary-updated.pdf
October 01, 2021 - Key Question 2: Benefits and Harms
Compared with no physical activity or usual care, physical activity … Table A summarizes the strength of evidence on effects
of physical activity interventions compared with … usual care and general exercise effect
across interventions compared with usual care. … Effects of physical activity interventions compared with usual carea
Intervention
Category
Intervention
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cell-free-dna-executive-summary.pdf
May 01, 2025 - Points
• No completed studies show if blood-based, multicancer screening tests help
people compared … estimates
from 11 studies)
Sensitivity and AUC were lower in
prediagnostic performance designs
compared … help people in ways such as saving lives, reducing advanced
cancers, or improving quality of life compared … United
Kingdom that will evaluate whether screening with the Galleri MCST reduces advanced
cancers compared … Cancer
stage compared with mortality as end points
in randomized clinical trials of cancer
screening