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  1. effectivehealthcare.ahrq.gov/sites/default/files/pdf/urinary-incontinence-update_research-protocol.pdf
    June 06, 2017 - What are the harms from nonpharmacological treatments when compared with no active treatment? … What is the comparative effectiveness of nonpharmacological treatments when compared with each other … What are the comparative harms from nonpharmacological treatments when compared with each other? … What are the harms from pharmacological treatments when compared with no active treatment? 2c. … What is the comparative effectiveness of pharmacological treatments when compared with each other?
  2. effectivehealthcare.ahrq.gov/sites/default/files/related_files/evidence-summary-cer-195-uterine-fibroids-final.pdf
    December 01, 2017 - However, 16 small RCTs compared a treatment to no intervention, typically trials that compared a medication … Tamoxifen use in premenopausal women did not influence length or severity of bleeding compared with … Women receiving tamoxifen had less pain after four months of treatment compared with placebo. … Most studies compared similar procedures, two compared different procedures, and nine compared procedures … Two studies compared UAE to myomectomy; 3 studies compared UAE to hysterectomy; and four studies compared
  3. effectivehealthcare.ahrq.gov/sites/default/files/related_files/arthritis-psoriatric_executive.pdf
    April 01, 2012 - Compared with placebo in one fair study, MTX resulted in greater improvement in physician assessment … Compared with placebo in one good systematic review study, sulfasalazine reduced disease activity. … Compared to anti-TNF monotherapy (adalimumab, etanercept, or infliximab), MTX plus anti-TNF produced … INSUFFICIENT Compared with placebo, adalimumab, etanercept, golimumab, and infliximab led to greater … However, compared with placebo, we noted the following: adalimumab and etanercept had more injection
  4. effectivehealthcare.ahrq.gov/sites/default/files/related_files/hepatitis-c_executive.pdf
    November 01, 2012 - 4A protease inhibitors, with a potential advantage of shorter duration of therapy (24 to 28 weeks) compared … with pegylated interferon alfa-2b plus ribavirin, RR estimates for triple, compared with dual, therapy … In addition, the trials may have overestimated efficacy compared with what would be seen in typical … Second, no trials directly compared regimens with boceprevir with regimens with telaprevir. … Trials directly comparing triple therapy with telaprevir compared with triple therapy with boceprevir
  5. effectivehealthcare.ahrq.gov/sites/default/files/related_files/epilepsy-medicine_disposition-comments.pdf
    March 01, 2012 - We have made the following change: The newer antiepileptic medications compared versus each older agent … However, when we looked at the newer drugs actually compared, there are only but a few newer drugs … PHB produced greater clinical worsening on the MMSE compared to LTG (p<.05). … AHRQ Report Reference: AHRQ Report Page 73: “Phenobarbital had inferior effects on mood as compared … Recommended Correction: Lamotrigine produced a superior effect on mood, i.e. depression compared to
  6. effectivehealthcare.ahrq.gov/sites/default/files/related_files/liver-cancer-therapy_executive.pdf
    May 01, 2013 - Ablative therapies compared with other ablative therapies – 2. … Radiotherapies compared with other radiotherapies – 4. … at 3 years for RFA compared with PEI/PAI, with a low risk of bias. … Three RCTs compared the ablative treatments RFA and PEI/PAI. … Two systematic reviews compared RFA with PEI;30,31 three compared TACE-percutaneous ablation (PA),
  7. effectivehealthcare.ahrq.gov/sites/default/files/pdf/diabetes-behavior-programs_clinician-2016.pdf
    January 01, 2016 - effectiveness and harms of behavioral programs in the community health setting for patients with T1DM when compared … to greater reductions in hemoglobin A1c (HbA1c) levels at a 6-month postintervention followup when compared … reductions in HbA1c levels were observed in patients who participated in a behavioral program, when compared … with T1DM; there was a 21-percent higher risk of attrition for individuals receiving usual care when compared … aspects of the disease (particularly in adolescents) to a greater extent. �� Only one T1DM study compared
  8. effectivehealthcare.ahrq.gov/sites/default/files/hip-fracture-pain_surveillance.pdf
    July 08, 2015 - One trial (n = 38) compared acupressure versus Up-to-date No new research was found ! … These were compared with placebo/standard care, or a different method of nerve blocks. … Another trial (n=30) compared intrathecal isotonic clonidine vs. … One trial (n = 38) compared acupressure versus sham control delivered preoperatively. … These were compared with placebo/standard care, or a different method of nerve blocks.
  9. effectivehealthcare.ahrq.gov/sites/default/files/related_files/hepatitis-c_disposition-comments.pdf
    November 27, 2012 - For example, on Page 17, the last paragraph discusses nine trials that compared dual therapies (citation … AHRQ found the Phase III trial that compared the telaprevir dosing that was ultimately approved by … Specifically compared are interferon alpha 2a and interferon alpha 2b as part of combination therapy … Results (p.48) The sentence “A trial of extended early virologic responders…randomized to 4 compared … with 28 more weeks of dual therapy” should read “…randomized to 24 compared with 28 weeks of dual
  10. Layout 1 (pdf file)

    effectivehealthcare.ahrq.gov/sites/default/files/related_files/renal-artery-stenosis_executive.pdf
    October 01, 2006 - effects of aggressive medical therapy (i.e., antihypertensive, antiplatelet, and antilipid treatment) compared … Description of reviewed studies No study directly compared angioplasty with stent placement to aggressive … Two randomized controlled trials directly compared angioplasty without stent placement to medical treatment … Among the remaining studies that compared revascularization to medical treatment and the noncomparative … • Studies that compared stent placement to no stent placement found no difference in outcomes.
  11. effectivehealthcare.ahrq.gov/sites/default/files/pdf/back-pain-treatment_clinician.pdf
    November 01, 2016 - Pharmacological therapies are associated with increased risk of adverse events when compared with placebo … Subacute Low Back Pain: Summary of Key Findings and Strength of Evidence for Interventions Intervention Compared … Radicular Low Back Pain: Summary of Key Findings and Strength of Evidence for Interventions Intervention Compared … stimulation. �� Pharmacological therapies were associated with increased risk of adverse events when compared … Chronic Low Back Pain: Summary of Key Findings and Strength of Evidence for Interventions Intervention Compared
  12. effectivehealthcare.ahrq.gov/sites/default/files/pdf/plasma-cell-dyscrasias-sflc-assay-future_research.pdf
    September 01, 2012 - • Key Question 2: As compared with traditional tests, how well does the SFLC assay independently predict … As compared with traditional tests, how well does the SFLC assay independently predict progression … The studies identified in the searches were compared against the nominated FRN topics to assess if they … Finally, one study explored whether the use of the SFLC assay compared with traditional testing would … The studies identified in the searches were compared against the nominated FRN topics to assess if they
  13. effectivehealthcare.ahrq.gov/sites/default/files/related_files/alcohol-misuse-drug-therapy-surveillance.pdf
    September 01, 2017 - We qualitatively compared original SR conclusions with the new input from the literature and experts … One study (n=243) compared disulfiram vs acamprosate vs naltrexone. 18 Depression decreased and all … One study (n=243) compared disulfiram vs acamprosate vs naltrexone. … However, nalmefene users had lower incidence of diarrhea compared to placebo. … "T" allele carriers on naltrexone had more abstinence compared to "CC" subjects on naltrexone.
  14. effectivehealthcare.ahrq.gov/sites/default/files/related_files/antipsychotics-adults_executive.pdf
    August 01, 2012 - Two studies compared haloperidol versus olanzapine and found no significant Table B. … KQ5: Subgroups A total of 41 studies compared outcomes for predefined subgroups. … No notable differences were observed for the subgroups compared with the overall findings. … Applicability This report included studies that compared an individual FGA with an individual SGA. … There were no notable differences in outcomes for these subgroups compared with the overall results
  15. effectivehealthcare.ahrq.gov/sites/default/files/related_files/asd-medical-executive-170505.pdf
    May 01, 2017 - those receiving DHA, while teachers rated communication as more improved in the treatment group compared … Most studies had placebo comparators, while five compared a pharmaceutical agent to behavioral treatment … The methodologic rigor of studies has increased substantially compared with those studies reported in … We found positive effects of atomoxetine compared with placebo on hyperactivity in children with ASD … Few studies (n=10) compared active treatments, and future research to assess comparative effectiveness
  16. effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-193-naloxone-executive-summary.pdf
    November 01, 2017 - Key Messages • Higher concentration intranasal naloxone may be similarly effective and safe compared … • No study compared different doses of naloxone administered via the same route; there was too much … • No study compared benefits and harms of differences in timing of repeat dosing of naloxone (SOE: … No study compared outcomes among patients with confirmed or suspected opioid overdose who responded … No study directly compared different doses of naloxone administered via the same route.
  17. effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND_0064_11-23-2008.pdf
    January 01, 2008 - What are the health risks and benefits of trabeculectomy as compared to alternatives, including laser … Does treatment response vary for African-Americans as compared to those who are not African-Americans
  18. effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-234-headaches-pregnancy-summary.pdf
    November 01, 2020 - Compared with nonuse (either during or before pregnancy), triptan use may not be associated with spontaneous …  A single primary study found that compared with oral codeine, combination metoclopramide and diphenhydramine … randomized controlled trials, 8 nonrandomized comparative studies [i.e., observational studies that compared … with spontaneous abortion, elective or induced abortion, or major or minor congenital anomalies, compared … Treatment—antiemetics (dopamine receptor antagonists), antihistamines, and opioids: One RCT found that, compared
  19. effectivehealthcare.ahrq.gov/sites/default/files/cer-241-physical-activity-wheelchair-evidence-summary-updated.pdf
    October 01, 2021 - Key Question 2: Benefits and Harms Compared with no physical activity or usual care, physical activity … Table A summarizes the strength of evidence on effects of physical activity interventions compared with … usual care and general exercise effect across interventions compared with usual care. … Effects of physical activity interventions compared with usual carea Intervention Category Intervention
  20. effectivehealthcare.ahrq.gov/sites/default/files/related_files/cell-free-dna-executive-summary.pdf
    May 01, 2025 - Points • No completed studies show if blood-based, multicancer screening tests help people compared … estimates from 11 studies) Sensitivity and AUC were lower in prediagnostic performance designs compared … help people in ways such as saving lives, reducing advanced cancers, or improving quality of life compared … United Kingdom that will evaluate whether screening with the Galleri MCST reduces advanced cancers compared … Cancer stage compared with mortality as end points in randomized clinical trials of cancer screening

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