-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/colorectal-cancer-staging_research-protocol.pdf
May 20, 2013 - Recurrent Colorectal Cancer
Recurrent colorectal cancer arises in some patients after they have undergone … What is the impact of alternative imaging techniques on clinical outcomes?
d. … What is the impact of alternative imaging techniques on clinical outcomes?
d. … Outcomes
o Test performance outcomes
Test performance (e.g., sensitivity, specificity, understaging … Analytical framework of colorectal cancer staging review
Patients
with
colorectal
cancer
(
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/colorectal-cancer-staging_executive.pdf
September 01, 2014 - T2-weighted MRI)
Outcomes:
• Test performance outcomes
– Test performance (sensitivity, specificity … in therapeutic management
• Clinical outcomes
– Overall mortality
– Colorectal cancer–specific … Clinical outcomes. … Very few studies
reported on any outcomes other than staging accuracy. … Screening for Colorectal
Cancer.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/colorectal-surgery-preparation_executive.pdf
April 01, 2014 - (Not all studies
contributed data for all outcomes.) … Some studies did not report
information on some outcomes. … Readmission rates
and cost following colorectal surgery. … Bowel preparation
or not for elective colorectal surgery. … Oral
Mechanical Bowel Preparation for Colorectal Surgery.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/colorectal-surgery-preparation_research-protocol.pdf
March 26, 2013 - • Intermediate outcomes
o Clinical outcomes
a. … ; normal for continuous outcomes) and link function
(e.g., logit for binomial outcomes; identity for … Mechanical bowel preparation for elective
colorectal surgery. … Bowel preparation or not for elective
colorectal surgery. … -130326
colorectal-surgery-preparation-protocol-130326.2
colorectal-surgery-preparation-protocol-130326.3
-
effectivehealthcare.ahrq.gov/products/colorectal-cancer-hepatic-therapy
January 19, 2010 - Health Outcomes of Biologic Agents for Metastatic Colorectal Cancer
Timeline
January … Topic Initiated
January 19, 2010
Abstract
Archived
Health Outcomes … of Biologic Agents for Metastatic Colorectal Cancer
-
effectivehealthcare.ahrq.gov/products/colorectal-cancer-hepatic-therapy/abstract
January 19, 2010 - Health Outcomes of Biologic Agents for Metastatic Colorectal Cancer
Abstract Archived January 19, … support the efficacy of the biologic therapies cetuximab and bevacizumab for the treatment of metastatic colorectal … Medicare program, the National Cancer Center Network (NCCN), the National Cancer Institute’s Cancer Care Outcomes … The study will examine both survival outcomes and the incidence of serious treatment complications such
-
effectivehealthcare.ahrq.gov/products/colorectal-surgery-preparation/research
April 30, 2014 - Systematic Review Sep. 17, 2014 Disposition of Comments Report Oral Mechanical Bowel Preparation for Colorectal … mechanical bowel preparation (OMBP) is often prescribed preoperatively for patients undergoing elective colorectal … , infectious outcomes, anastomotic leakage; health system and resource utilization outcomes such as readmissions … Limitations
The evidence regarding OMBP for colorectal surgery is limited in the following ways: (1 … Oral Mechanical Bowel Preparation for Colorectal Surgery: Systematic Review and Meta-Analysis.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/colorectal-cancer-screening_executive.pdf
February 01, 2012 - Negative Screening
Colorectal Cancer
Colorectal Cancer Treatment
Management/Surveillance
Decreased … details
relating to study design, population characteristics, test and
comparators, and all relevant outcomes … The strength of
evidence for primary outcomes was graded using the
standard process of the Evidence-based … Clinical utility—A test’s ability to improve clinical
outcomes and the test’s usefulness and value it … Molecular tests for
colorectal cancer screening. Clin Colorectal Cancer.
2011 Mar 1;10(1):8-23.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/colorectal-cancer-liver-metastases-therapies_executive.pdf
December 01, 2012 - How these
factors may alter health outcomes remains unclear. … Outcomes
Little controversy exists regarding the most appropriate
direct health outcomes to measure … • Outcomes: Outcomes of interest to patients and their
physicians include survival, quality of life … /ablation for colorectal liver metastases. … Surgical management
and outcomes of colorectal cancer liver metastases.
-
effectivehealthcare.ahrq.gov/products/colorectal-cancer-staging/research
September 10, 2014 - pooled the data using binomial-bivariate random-effects regression models (for diagnostic accuracy outcomes … ) or using random-effects meta-analysis (for under- and overstaging and under- and overtreatment outcomes … Nine studies reported on preoperative colorectal M (metastasis) staging. … The evidence was insufficient for drawing conclusions regarding other interim restaging outcomes for … rectal or colorectal cancer following initial treatment.
-
effectivehealthcare.ahrq.gov/products/colorectal-surgery-preparation/research-protocol
March 26, 2013 - Intermediate outcomes
Clinical outcomes Infectious outcomes (classified according to the definitions … ; normal for continuous outcomes) and link function (e.g., logit for binomial outcomes; identity for … Mechanical bowel preparation for elective colorectal surgery. … Colorectal Dis 2009 Jul;11(6):619-24. PMID: 18727727.
Eagye KJ, Nicolau DP. … Bowel preparation or not for elective colorectal surgery.
-
effectivehealthcare.ahrq.gov/products/colorectal-cancer-staging/research-protocol
May 21, 2013 - Recurrent Colorectal Cancer
Recurrent colorectal cancer arises in some patients after they have undergone … What is the impact of alternative imaging techniques on clinical outcomes? … What is the impact of alternative imaging techniques on clinical outcomes? … Outcomes
Test performance outcomes
Test performance (e.g., sensitivity, specificity, understaging, … Clinical outcomes .
-
effectivehealthcare.ahrq.gov/products/colorectal-cancer-screening/research-protocol
May 18, 2011 - CRC screening improves health outcomes by detecting early stage cancer, which has a better prognosis, … Outcomes
KQ 1: Final Health Outcomes
CRC-specific or all-cause mortality
CRC incidence
KQs … 2 & 3: Diagnostic Outcomes
Sensitivity, specificity, positive predictive value, negative predictive … Outcomes
KQ 1: CRC incidence (or advanced neoplasia incidence if CRC incidence is not reported), … Colorectal cancer screening. [Review].
-
effectivehealthcare.ahrq.gov/products/colorectal-cancer-liver-metastases-therapies/research-protocol
January 31, 2012 - Outcomes
KQ 1:
Final outcomes: Survival and quality of life
Intermediate outcomes: Time to progression … and final health outcomes. … outcomes (dotted line). … Abbreviations: CRC = colorectal cancer; KQ = key question
Figure 2. … and final health outcomes.
-
effectivehealthcare.ahrq.gov/products/colorectal-cancer-liver-metastases-therapies/research
December 11, 2012 - Disposition of Comments Report Local Hepatic Therapies for Metastases to the Liver From Unresectable Colorectal … effectiveness and harms of various local hepatic therapies for metastases to the liver from unresectable colorectal … Review methods
We sought studies reporting two outcomes--overall survival and quality of life--and
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/colorectal-surgery-preparation_disposition-comments.pdf
April 30, 2014 - Oral Mechanical
Bowel Preparation for Colorectal Surgery. … Unfortunately this was not one of the predefined
outcomes for our review. … “percent of all elective colorectal surgeries.”
We have rephrased as suggested. … We have added results from these analyses for all
outcomes. … Does it make sense
to group these 3 outcomes as one?
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/colorectal-cancer-staging_disposition-comments.pdf
November 20, 2014 - For this topic, outcomes are somewhat hard to define.
Thank you, we agree. … No studies reporting patient oriented outcomes.
The detail is, at times, overwhelming. … We analyzed the outcomes “correct
treatment,” “undertreatment,” and
“overtreatment.” … in therapeutic management.7 In
addition, the Draft Report addresses clinical outcomes. … This is distinct from the
outcomes, or endpoints, classically applied in.
-
effectivehealthcare.ahrq.gov/health-topics/colonic-diseases
April 02, 2014 - of Pancreatic Adenocarcinoma
Research Protocol
Archived
August 9, 2013
Health Outcomes … of Biologic Agents for Metastatic Colorectal Cancer
Abstract
Archived
January 19, 2010 … Gene Expression Profiling for Predicting Outcomes in Stage II Colon Cancer
Technical Brief … Archived
December 14, 2012
Gene Expression Profiling for Predicting Outcomes in Patients … Modalities
Research Protocol
Archived
March 5, 2012
Chemotherapy in Advanced Colorectal
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/colorectal-cancer-screening_research-protocol.pdf
May 18, 2011 - CRC screening improves health outcomes by detecting early
stage cancer, which has a better prognosis … Outcomes KQ 1: Final Health Outcomes
1) CRC-specific or all-cause mortality
2) CRC incidence … DNA Screening
Colorectal
Cancer
Decreased Colorectal
Cancer or All-Cause
Mortality
Colorectal … Grading the Evidence for Each Key Question
We will grade the strength of evidence for primary outcomes … Colorectal cancer screening. [Review].
-
effectivehealthcare.ahrq.gov/health-topics/digestive-diseases
May 20, 2013 - January 31, 2012
Local Hepatic Therapies for Metastases to the Liver From Unresectable Colorectal … Hepatocellular Carcinoma
Systematic Review
Archived
October 23, 2014
Health Outcomes … of Biologic Agents for Metastatic Colorectal Cancer
Abstract
Archived
January 19, 2010 … Gene Expression Profiling for Predicting Outcomes in Stage II Colon Cancer
Technical Brief … Archived
December 14, 2012
Gene Expression Profiling for Predicting Outcomes in Patients