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21. Exhibit 4.3 Average Length of Stay and Average Charges
    hcup-us.ahrq.gov/reports/factsandfigures/figures/2006/2006_4_3.jsp
    January 01, 2006 - Cancer of rectum and anus 8.7 48,261 Intracranial injury 6.6 48,330 Cancer of colon

22. DXCCSR ChangeLog v20221 v20231 (xls file)
    hcup-us.ahrq.gov/toolssoftware/ccsr/DXCCSR-ChangeLog-v20231-v20241.xlsx
    December 01, 2023 - specified and unspecified gastrointestinal disorders K90821 Short bowel syndrome with colon … specified and unspecified gastrointestinal disorders K90822 Short bowel syndrome without colon … disease FAC021 Personal/family history of disease Z83711 Family history of hyperplastic colon … of disease FAC021 Personal/family history of disease Z83718 Other family history of colon … history of disease FAC021 Personal/family history of disease Z83719 Family history of colon

23. HCUP Statistical Brief #37: Pediatric Hospital Stays for Cancer, 2005 (pdf file)
    hcup-us.ahrq.gov/reports/statbriefs/sb37.pdf
    September 01, 2007 - the most hospital stays in children, hospitalizations for cancers of the uterus, lung, breast, and colon … 11: Cancer of head and neck – 12: Cancer of esophagus – 13: Cancer of stomach – 14: Cancer of colon

24. Statistical Brief #63: Hospital Stays for Lung Cancer, 2006 (pdf file)
    hcup-us.ahrq.gov/reports/statbriefs/sb63.pdf
    November 01, 2008 - United States in 2006, and among all cancers, lung cancer had the highest mortality rate—more than colon … malignancies (9.8 percent), radiotherapy or chemotherapy (1.4 percent), and other cancers (1.1 percent)—colon

25. Statistical Brief #37
    hcup-us.ahrq.gov/reports/statbriefs/sb37.jsp
    September 01, 2007 - the most hospital stays in children, hospitalizations for cancers of the uterus, lung, breast, and colon … Cancer of head and neck – 12: Cancer of esophagus – 13: Cancer of stomach – 14: Cancer of colon

26. Most Common Diagnoses and Procedures in U.S. Community Hospitals, 1996
    hcup-us.ahrq.gov/reports/natstats/commdx/table2h.htm
    February 11, 2011 - Cancer of colon [14] 118,489 100.00 0.34

27. Most Common Diagnoses and Procedures in U.S. Community Hospitals, 1996
    hcup-us.ahrq.gov/reports/natstats/commdx/table1c.htm
    February 11, 2011 - Cancer of colon [14] 93,978 37.08 0.27

28. Statistical Brief #85: Inpatient Stays in Rural Hospitals, 2007 (pdf file)
    hcup-us.ahrq.gov/reports/statbriefs/sb85.pdf
    January 01, 2010 - use of a balloon-tipped catheter to enlarge a narrowed artery) 35 0.7 15 633 1.8 6 Resection of colon … rehabilitation/detoxification 33 0.7 18 313 0.9 16 Colonoscopy and biopsy (procedure to view and biopsy the colon

29. Most Common Diagnoses and Procedures in U.S. Community Hospitals, 1996
    hcup-us.ahrq.gov/reports/natstats/commdx/table2a.htm
    February 11, 2011 - Cancer of colon D80. Other female genital disorders D81. Cancer of prostate D82.

30. 2015-02 (pdf file)
    hcup-us.ahrq.gov/reports/projections/2015-02.pdf
    January 01, 2015 - risk factor for CDI is previous antimicrobial therapy, which may suppress the normal flora of the colon

31. Clostridium Difficile Infection 2011-2012 (pdf file)
    hcup-us.ahrq.gov/reports/projections/CDI_Regional_projections_Final.pdf
    July 10, 2012 - factor for CDI is previous antimicrobial therapy which may have suppressed the normal flora of the colon

32. Ccscategorynames Fulllabels (pdf file)
    hcup-us.ahrq.gov/toolssoftware/ccs/CCSCategoryNames_FullLabels.pdf
    October 07, 2016 - infectious disease 11 Cancer of head and neck 12 Cancer of esophagus 13 Cancer of stomach 14 Cancer of colon … Immunizations and screening for infectious disease [10] 2 Neoplasms 2.1 Colorectal cancer 2.1.1 Cancer of colon … and unspecified benign neoplasm [47] 2.16.2.1 Benign neoplasm of ovary 2.16.2.2 Benign neoplasm of colon

33. HCUPanalysisCdiff2019 (pdf file)
    hcup-us.ahrq.gov/reports/ataglance/HCUPanalysisCdiff.pdf
    April 12, 2021 - factor for C. diff is previous antimicrobial therapy, which may suppress the normal flora of the colon

34. Hcupcdiffhosp2011-2015Rpt081618 (pdf file)
    hcup-us.ahrq.gov/reports/ataglance/HCUPCDiffHosp2011-2015Rpt081618.pdf
    August 18, 2018 - risk factor for CDI is previous antimicrobial therapy, which may suppress the normal flora of the colon

35. HCUP Facts and Figures 2007: Statistics on Hospital-Based Care in the United States
    hcup-us.ahrq.gov/reports/factsandfigures/2007/sources_methods.jsp
    January 01, 2007 - Cancer of head and neck 12 Cancer of esophagus 13 Cancer of stomach 14 Cancer of colon

36. Clinical Classifications Software (CCS) for ICD-9-CM
    hcup-us.ahrq.gov/toolssoftware/ccs/ccs.jsp
    July 01, 2025 - Control charts to identify adverse outcomes in elective colon resection.

37. 50-State Environmental Scan of State Publications Documenting Racial and Ethnic Disparities in Health Status and Health Care
    hcup-us.ahrq.gov/reports/race/50_state_r_e_rpt.jsp
    July 01, 2016 - lfserver/Public/DHS-5573B-ENG 2009 Diabetes, High Blood Pressure, Breast Cancer, Cervical Cancer, Colon … race-ethnicity-report/healthstatus.pdf 2010 Insurance Coverage, Access to Health Care, Prenatal Care, Colon

38. Statistics From the HCUP-3 Nationwide Inpatient Sample for 1993: Principal Diagnoses
    hcup-us.ahrq.gov/reports/natstats/93dcchp.htm
    March 10, 2016 - 29,674 13 Cancer of stomach 25,401 0.07 13.83 28,913 14 Cancer of colon

39. HCUP-3 Nationwide Inpatient Sample for 1994: Principal Diagnoses
    hcup-us.ahrq.gov/reports/natstats/94dcchpr.htm
    November 01, 1998 - 29,808 13 Cancer of stomach 25,976 0.08 12.87 28,822 14 Cancer of colon

40. 2011Nedserratanotification022415 (pdf file)
    hcup-us.ahrq.gov/db/nation/neds/2011NEDSErrataNotification022415.pdf
    February 01, 2015 - 6,908 6,342 7,474 13: Cancer of stomach -- 10,535 9,639 11,430 10,725 9,818 11,631 14: Cancer of colon … 85.4% 81.0% 78.4% 83.5% 13: Cancer of stomach -- 90.9% 89.4% 92.3% 88.1% 86.3% 89.9% 14: Cancer of colon … 1.84% 1.43% 0.81% 2.04% 13: Cancer of stomach -- 0.36% 0.12% 0.60% 0.62% 0.30% 0.94% 14: Cancer of colon … 10.85% 9.06% 7.53% 10.60% 13: Cancer of stomach -- 7.33% 6.21% 8.45% 7.13% 6.04% 8.23% 14: Cancer of colon