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21. Exhibit 4.3 Average Length of Stay and Average Charges
    hcup-us.ahrq.gov/reports/factsandfigures/figures/2006/2006_4_3.jsp
    January 01, 2006 - Cancer of rectum and anus 8.7 48,261 Intracranial injury 6.6 48,330 Cancer of colon

22. DXCCSR ChangeLog v20221 v20231 (xls file)
    hcup-us.ahrq.gov/toolssoftware/ccsr/DXCCSR-ChangeLog-v20231-v20241.xlsx
    December 01, 2023 - specified and unspecified gastrointestinal disorders K90821 Short bowel syndrome with colon … specified and unspecified gastrointestinal disorders K90822 Short bowel syndrome without colon … disease FAC021 Personal/family history of disease Z83711 Family history of hyperplastic colon … of disease FAC021 Personal/family history of disease Z83718 Other family history of colon … history of disease FAC021 Personal/family history of disease Z83719 Family history of colon

23. Statistical Brief #37
    hcup-us.ahrq.gov/reports/statbriefs/sb37.jsp
    September 01, 2007 - the most hospital stays in children, hospitalizations for cancers of the uterus, lung, breast, and colon … Cancer of head and neck – 12: Cancer of esophagus – 13: Cancer of stomach – 14: Cancer of colon

24. Statistical Brief #63: Hospital Stays for Lung Cancer, 2006 (pdf file)
    hcup-us.ahrq.gov/reports/statbriefs/sb63.pdf
    November 01, 2008 - United States in 2006, and among all cancers, lung cancer had the highest mortality rate—more than colon … malignancies (9.8 percent), radiotherapy or chemotherapy (1.4 percent), and other cancers (1.1 percent)—colon

25. HCUP Statistical Brief #37: Pediatric Hospital Stays for Cancer, 2005 (pdf file)
    hcup-us.ahrq.gov/reports/statbriefs/sb37.pdf
    September 01, 2007 - the most hospital stays in children, hospitalizations for cancers of the uterus, lung, breast, and colon … 11: Cancer of head and neck – 12: Cancer of esophagus – 13: Cancer of stomach – 14: Cancer of colon

26. Most Common Diagnoses and Procedures in U.S. Community Hospitals, 1996
    hcup-us.ahrq.gov/reports/natstats/commdx/table2h.htm
    February 11, 2011 - Cancer of colon [14] 118,489 100.00 0.34

27. Most Common Diagnoses and Procedures in U.S. Community Hospitals, 1996
    hcup-us.ahrq.gov/reports/natstats/commdx/table1c.htm
    February 11, 2011 - Cancer of colon [14] 93,978 37.08 0.27

28. Newsletter Spring 2022
    hcup-us.ahrq.gov/news/newsletters/newsltrQ1_2022.jsp
    January 01, 2022 - state of healthcare quality and disparities in the United States and identifies improvements in HIV and colon

29. Clostridium Difficile Infection 2011-2012 (pdf file)
    hcup-us.ahrq.gov/reports/projections/CDI_Regional_projections_Final.pdf
    July 10, 2012 - factor for CDI is previous antimicrobial therapy which may have suppressed the normal flora of the colon

30. 2015-02 (pdf file)
    hcup-us.ahrq.gov/reports/projections/2015-02.pdf
    January 01, 2015 - risk factor for CDI is previous antimicrobial therapy, which may suppress the normal flora of the colon

31. Most Common Diagnoses and Procedures in U.S. Community Hospitals, 1996
    hcup-us.ahrq.gov/reports/natstats/commdx/table2a.htm
    February 11, 2011 - Cancer of colon D80. Other female genital disorders D81. Cancer of prostate D82.

32. Statistical Brief #85: Inpatient Stays in Rural Hospitals, 2007 (pdf file)
    hcup-us.ahrq.gov/reports/statbriefs/sb85.pdf
    January 01, 2010 - use of a balloon-tipped catheter to enlarge a narrowed artery) 35 0.7 15 633 1.8 6 Resection of colon … rehabilitation/detoxification 33 0.7 18 313 0.9 16 Colonoscopy and biopsy (procedure to view and biopsy the colon

33. Ccscategorynames Fulllabels (pdf file)
    hcup-us.ahrq.gov/toolssoftware/ccs/CCSCategoryNames_FullLabels.pdf
    October 07, 2016 - infectious disease 11 Cancer of head and neck 12 Cancer of esophagus 13 Cancer of stomach 14 Cancer of colon … Immunizations and screening for infectious disease [10] 2 Neoplasms 2.1 Colorectal cancer 2.1.1 Cancer of colon … and unspecified benign neoplasm [47] 2.16.2.1 Benign neoplasm of ovary 2.16.2.2 Benign neoplasm of colon

34. HCUPanalysisCdiff2019 (pdf file)
    hcup-us.ahrq.gov/reports/ataglance/HCUPanalysisCdiff.pdf
    April 12, 2021 - factor for C. diff is previous antimicrobial therapy, which may suppress the normal flora of the colon

35. Tofrcodes Proccodesforu Flagsforicd-10-Pcs (pdf file)
    hcup-us.ahrq.gov/toolssoftware/utilflagsicd10/TofRCodes_ProcCodesforU_FlagsforICD-10-PCS.pdf
    December 12, 2016 - Codes: 00F3XZZ: Fragmentation in Epidural Space, External Approach 0DFKXZZ: Fragmentation in Ascending Colon … , External Approach 0DFLXZZ: Fragmentation in Transverse Colon, External Approach 0DFMXZZ: Fragmentation … in Descending Colon, External Approach 0DFNXZZ: Fragmentation in Sigmoid Colon, External Approach 0DFPXZZ

36. Hcupcdiffhosp2011-2015Rpt081618 (pdf file)
    hcup-us.ahrq.gov/reports/HCUPCDiffHosp2011-2015Rpt081618.pdf
    August 18, 2018 - risk factor for CDI is previous antimicrobial therapy, which may suppress the normal flora of the colon

37. Hcupcdiffhosp2011-2015Rpt081618 (pdf file)
    hcup-us.ahrq.gov/reports/ataglance/HCUPCDiffHosp2011-2015Rpt081618.pdf
    August 18, 2018 - risk factor for CDI is previous antimicrobial therapy, which may suppress the normal flora of the colon

38. HCUP Facts and Figures 2007: Statistics on Hospital-Based Care in the United States
    hcup-us.ahrq.gov/reports/factsandfigures/2007/sources_methods.jsp
    January 01, 2007 - Cancer of head and neck 12 Cancer of esophagus 13 Cancer of stomach 14 Cancer of colon

39. Clinical Classifications Software (CCS) for ICD-9-CM
    hcup-us.ahrq.gov/toolssoftware/ccs/ccs.jsp
    March 01, 2017 - Control charts to identify adverse outcomes in elective colon resection.

40. HCUP-3 Nationwide Inpatient Sample for 1994: Principal Diagnoses
    hcup-us.ahrq.gov/reports/natstats/94dcchpr.htm
    November 01, 1998 - 29,808 13 Cancer of stomach 25,976 0.08 12.87 28,822 14 Cancer of colon