-
effectivehealthcare.ahrq.gov/sites/default/files/mccullough.pdf
January 01, 2011 - must be made
Evidence-‐based and values-‐based judgments about clinical benefits and
risks and … their balancing
Slide
9: General Candor-‐Based Considerations
• Clinical judgments about medical … judgment
• Such clinical management carries disease-‐related risks
(from ineffectively managed … of evidence is not
automatically
ruled out in beneficence-‐based clinical judgment as medically … (p. 32-‐
33)
Slide
12: Clinical Challenges (2)
• Acknowledge the patient’s right to make own judgments
-
effectivehealthcare.ahrq.gov/sites/default/files/ijzerman_ahrq-webinar-mcda.pdf
January 01, 2011 - Primary endpoints chosen in clinical trials may not be the most
relevant endpoints for patients … Conjoint analysis methods
Helps to improve judgment
Decomposed
Hierarchical
Low cognitive … Possible to use in N=1 or as
consensus building tool
(group-decision)
Imitates consumers’ judgment … Preference data is to be used in conjunction with clinical data. … They can not replace the original clinical evidence.
18
-
effectivehealthcare.ahrq.gov/sites/default/files/epc-disclosure-policy-form.pdf
March 01, 2023 - defines conflict of interest (COI) as “a set of circumstances that creates a risk that
professional judgment … While both financial and non-financial interests may influence the judgment of an
individual synthesizing … Do you have a primary clinical specialty or
subspecialty?
9. … While both financial and non-financial interests may influence the judgment of an individual synthesizing … Do you have a primary clinical specialty or
subspecialty?
9.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/assessing-applicability.ppt
January 01, 2009 - and report judgments about major limitations to the applicability of individual studies. … Make Judgments About the
Applicability of Individual Studies
Make Judgments About the Applicability … Finally, given the information on the PICOS domains, the judgment that this is an efficacy trial is made … Judgments about applicability of the evidence should consider the entire body of studies. … Judgments about applicability of the evidence should consider the entire body of studies.
-
effectivehealthcare.ahrq.gov/sites/default/files/assessing-applicability.ppt
January 01, 2009 - Make and Report Judgments About Major Limitations to the Applicability of Individual Studies
Make judgments … and report judgments about major limitations to the applicability of individual studies. … Finally, given the information on the PICOS domains, the judgment that this is an efficacy trial is made … Judgments about applicability of the evidence should consider the entire body of studies. … Judgments about applicability of the evidence should consider the entire body of studies.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guidance-grading-strength_methods.pdf
July 01, 2009 - Nonoverlapping confidence
intervals, significant unexplained clinical or statistical heterogeneity, … reviewer’s individual judgments about
domains as background documentation. … level of confidence the authors place in
the estimate of effect for the benefit or harm (i.e., their judgment … degree to which the overall strength of evidence is altered by additional domains
that are used is a judgment … Clinical epidemiology: how to do clinical
practice research.
-
effectivehealthcare.ahrq.gov/sites/default/files/assessing-applicability-quiz.ppt
October 08, 2025 - The adverse events seen in the intervention groups would likely be lower than in the clinical setting … The benefits seen in the intervention groups would likely be lower than in the clinical setting. … In step 2, judgments about whether a trial is an effectiveness or efficacy trial are made, and components … In step 2, judgments about whether a trial is an effectiveness or efficacy trial are made, and components … In step 2, judgments about whether a trial is an effectiveness or efficacy trial are made, and components
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/assessing-applicability-quiz.ppt
October 08, 2025 - The adverse events seen in the intervention groups would likely be lower than in the clinical setting … The benefits seen in the intervention groups would likely be lower than in the clinical setting. … In step 2, judgments about whether a trial is an effectiveness or efficacy trial are made, and components … In step 2, judgments about whether a trial is an effectiveness or efficacy trial are made, and components … In step 2, judgments about whether a trial is an effectiveness or efficacy trial are made, and components
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/assessing-the-risk-of-bias-in-systematic-reviews-of-health-care-interventions-01_0.pdf
May 01, 2005 - This report is not intended to
be a substitute for the application of clinical judgment. … We presented standards to promote transparency of judgments. … A risk-of-bias assessment offers a qualitative judgment of likelihood
of bias.
2. “Inaccuracy.” … Resolve differences in judgment and record
final rating for each outcome
4. … All three of these are subjective judgments.
-
effectivehealthcare.ahrq.gov/sites/default/files/product/pdf/assessing-the-risk-of-bias-in-systematic-reviews-of-health-care-interventions-01.pdf
May 01, 2005 - This report is not intended to
be a substitute for the application of clinical judgment. … We presented standards to promote transparency of judgments. … A risk-of-bias assessment offers a qualitative judgment of likelihood
of bias.
2. “Inaccuracy.” … Resolve differences in judgment and record
final rating for each outcome
4. … All three of these are subjective judgments.
-
effectivehealthcare.ahrq.gov/sites/default/files/methods_guide_atkins.pdf
January 01, 2011 - • Judgments about applicability of the evidence should consider the entire body of studies. … Reviewers must instead exercise judgment to select a subset of
the most important study parameters for … Although this step involves judgment, such judgments can be made
more explicit by considering how different … Practical
clinical trials: increasing the value of clinical
research for decision making in clinical … Example evidence table of individual studies with key applicability factors abstracted
and judgment
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guidance-applicability_methods.pdf
January 01, 2011 - • Judgments about applicability of the evidence should consider the entire body of studies. … Reviewers must instead exercise judgment to select a subset of
the most important study parameters for … Although this step involves judgment, such judgments can be made
more explicit by considering how different … Practical
clinical trials: increasing the value of clinical
research for decision making in clinical … Example evidence table of individual studies with key applicability factors abstracted
and judgment
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/white-paper-roadmap-interventions.pdf
November 01, 2020 - This report is not intended to be
a substitute for the application of clinical judgment. … The term clinical importance is
appropriate in systematic reviews about clinical topics. … Strength or certainty of evidence: a global judgment about the certainty in estimates
across five domains … For example, the size
of an effect can affect the judgment about clinical importance. … Judgments about the
clinical importance and size constructs are needed to determine the precision and
-
effectivehealthcare.ahrq.gov/sites/default/files/mcda-ijzerman.pdf
January 01, 2011 - Primary endpoints chosen in clinical trials may not be the most relevant
endpoints for patients … AHP)
Helps to improve judgment
Decomposed
Hierarchical
Low cognitive stress
Less realistic … use in N=1 or as consensus building tool (group-decision)
CA methods
Imitates consumers’ judgment … Preference data is to be used in conjunction with clinical data. … They cannot
replace the original clinical evidence.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guidance-grading-evidence_methods.pdf
November 01, 2013 - This report is not intended to
be a substitute for the application of clinical judgment. … The goal of strength of evidence assessments is to
provide clearly explained, well-reasoned judgments … They expect that
end-users can and will make their own global summary judgments of relative benefits … When
meta-analysis results are unavailable, EPCs will need to rely on the reviewers’ judgment. … Clinical Epidemiology: How to Do Clinical
Practice Research.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/nursing-staff-shortages-rapid-research-appendix-c.xlsx
January 01, 2024 - Do preceptorship and clinical supervision programmes support the retention of nurses? … judgment to assign patient's acuity. … judgment to assign the patient’s acuity. … Author, Year Risk of Bias Judgment: Confounding Risk of Bias Judgment: Selection Risk of Bias Judgment … of Bias Judgment: Missing Data Risk of Bias Judgment: Measurement of Outcomes Risk of Bias Judgment:
-
effectivehealthcare.ahrq.gov/sites/default/files/assessing-quality.ppt
January 01, 2010 - Arrive at a summary judgment of the study’s quality to rate studies good, fair, or poor
Requires resolution … is to use the information from the assessment across multiple sources of bias to arrive at a summary judgment … Arrive at a Comprehensive Judgment of Quality
After assessment of individual criteria, assign ratings … Universal judgments of quality should be accompanied by text explaining the reason for the rating, particularly … evidence
Key Messages (I): Definition of Quality Assessment
In acknowledging the central role of judgment
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/grading.ppt
January 01, 2010 - A growing number of organizations adopt systematic approaches to making judgments about the strength … Inconsistent evidence bases:
Have nonoverlapping confidence intervals
Have significant unexplained clinical … Nonoverlapping confidence intervals, significant unexplained clinical or statistical heterogeneity, or … Use two or more reviewers with the appropriate clinical and methodological expertise. … level of confidence the reviewers place in the estimate of effect for the benefit or harm (i.e., their judgment
-
effectivehealthcare.ahrq.gov/sites/default/files/grading.ppt
January 01, 2013 - A growing number of organizations adopt systematic approaches to making judgments about the strength … Inconsistent evidence bases:
Have nonoverlapping confidence intervals
Have significant unexplained clinical … Nonoverlapping confidence intervals, significant unexplained clinical or statistical heterogeneity, or … This domain is a complicated concept, because judgments about precision may depend on or be contingent … level of confidence the reviewers place in the estimate of effect for the benefit or harm (i.e., their judgment
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/renal-cancer_research-protocol.pdf
April 20, 2015 - Risk of bias judgment
Bias in
selection of
participants
into the study
2.1. … Risk of bias judgment
Bias due to
departures
from intended
interventions
4.1. … Risk of bias judgment
Bias due to
missing data
5.1 Are outcome data reasonably complete? … Risk of bias judgment
Bias in
measurement
of outcomes
6.1 Was the outcome measure objective? … Risk of bias judgment
Overall bias Risk of bias judgment
Table 4.