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  1. effectivehealthcare.ahrq.gov/sites/default/files/related_files/cancer-pancreas_disposition-comments.pdf
    September 23, 2014 - We did revise the report to be clearer about the clinical implications. … This is out of clinical context. One cannot operate on EUS-FNA alone. … We did revise the report to be clearer about the clinical implications. … the appropriate scans to be used for specific clinical indications. … Our goal was to uncover evidence to support clinical actions such as the ones you listed.
  2. effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND_0193_08-12-2009.pdf
    January 01, 2009 - Even in carefully controlled clinical trials, it is difficult to ensure that every patient takes all … of their medications as prescribed, and adherence rates are much lower in ordinary clinical practice … including a review from the Cochrane group and guidelines issued by the National Institute for Health and ClinicalClinical Guidelines and Evidence Review for Medicines Adherence: involving patients in decisions about … NICE and Cochrane did not identify any interventions that appear practical to implement into current clinical
  3. effectivehealthcare.ahrq.gov/sites/default/files/related_files/renal-update_disposition-comments.pdf
    August 16, 2016 - Thank you TEP Reviewer #1 General The review is a useful guide to clinical management of ARAS … problem with a suboptimal database from which to make clinical recommendations. … equipoise” that drives enrollment in clinical trials is completely different than clinical indications … Clearly future clinical trials are needed in this patient population. … Its best to have primary care physicians know the full picture on this vital clinical area.
  4. effectivehealthcare.ahrq.gov/sites/default/files/calcineurin-inhibitor_disposition-comments.pdf
    March 15, 2016 - trial and an NKFsponsored clinical practice guideline that both favor tacrolimus as the first line … The Kidney Disease Improving Global Outcomes KDIGO 2009 clinical practice guideline on the Care of … for clinical practice. … End- users must weigh the benefits and harms in making decisions about clinical care. … The section on clinical/policy decision making was well done.
  5. effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND-0648-140819.pdf
    June 24, 2014 - More specifically, the nominator is interested in the diagnostic accuracy of clinical criteria alone … baseline uric acid levels for determining the effectiveness of treatment on intermediate and final clinical … Staff-Generated PICO Population(s): Adults with or at risk of having gout Intervention(s): Clinical … What is the accuracy of clinical criteria only in the diagnosis of acute gouty from Nominator: arthropathy … However, some studies indicate that diagnosis in primary care is often based primarily on clinical signs
  6. effectivehealthcare.ahrq.gov/sites/default/files/pdf/sleep-apnea-treatment-future_research.pdf
    February 01, 2012 - Outcomes 5O: Almost no data on clinical outcomes. … Outcomes 5O: Almost no data on clinical outcomes. … Clinical outcomes of interest would include incident clinical events, quality of life, and psychological … Incorporates issues around both clinical benefits and potential clinical harms 2f. … Represents important variation in clinical care, or controversy in what constitutes appropriate clinical
  7. effectivehealthcare.ahrq.gov/sites/default/files/related_files/lysosomal-storage-diseases-therapies_disposition-comments.pdf
    January 01, 2014 - A recent clinical trial (Schiffmann et al. … A key clinical study in children under 6 years of age with idursulfase is omitted ‐ A clinical study … A recent clinical trial (Schiffmann et al. … and clinical outcomes for a few LSDs. … Chaperone therapy clinical trials. 7.
  8. effectivehealthcare.ahrq.gov/sites/default/files/related_files/stroke-atrial-fibrillation_executive.pdf
    August 01, 2013 - Clinicians use the prothrombin time and INR as clinical tools to guide anticoagulation therapy. … For a clinical prediction rule, we assumed that a c-statistic <0.6 had no clinical value, 0.6–0.7 had … clinical risk of patients, combining both their risk of stroke and their risk of bleeding? … There is also a need for future studies in special populations and clinical scenarios. … Meta-analysis in clinical trials. Control Clin Trials. 1986;7(3):177-88. PMID: 3802833. 39.
  9. effectivehealthcare.ahrq.gov/sites/default/files/pulmonary-horizon-scan-high-impact-1412.pdf
    October 01, 2015 - The cost of hands-on clinical training for the OCS Lung was $100,000, and clinical field support 24 … (External, Clinical). Horizon Scanning Structured Comment Form. … (External, Clinical). Horizon Scanning Structured Comment Form. … (External, Clinical). Horizon Scanning Structured Comment Form. … (External, Clinical). Horizon Scanning Structured Comment Form.
  10. effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-218-osteoporosis-fracture-prevention-evidence-summary.pdf
    April 01, 2019 - • Long-term oral hormone therapies reduce hip and clinical fractures but increase multiple serious … trial; CF=clinical fracture; CI=confidence intervals; CVF=clinical vertebral fracture; h-IM=highly … Our findings have several clinical implications. … American Association of Clinical Endocrinologists Medical Guidelines for Clinical Practice for the … Safety assessment of raloxifene over eight years in a clinical trial setting.
  11. effectivehealthcare.ahrq.gov/sites/default/files/related_files/heart-failure-natriuretic-peptide_disposition-comments.pdf
    November 20, 2013 - Journal of Clinical Epidemiology 57:925-932. … The clinical context has been described as recommended in current clinical practice guidelines. … context in light of the clinical practice guidelines. … Journal of Clinical Epidemiology 57:925-932. … Journal of Clinical Epidemiology 57:925-932.
  12. effectivehealthcare.ahrq.gov/sites/default/files/related_files/procalcitonin_executive.pdf
    October 01, 2012 - Executive Summary Background Sepsis is a serious condition with high morbidity and mortality for which clinical … units (ICUs) have higher morbidity and mortality rates, the same issues are also relevant to other clinical … Again, the duration of antibiotic therapy is often undefined, and clinical features are of limited … Comparator: Initiation, discontinuation, or intensification of antibiotic therapy guided by clinical … Experience with a clinical guideline for the treatment of ventilator-associated pneumonia.
  13. effectivehealthcare.ahrq.gov/sites/default/files/pdf/prostate-cancer-test_research-protocol.pdf
    October 14, 2011 - and laboratory features into risk scores to help in clinical decisionmaking.5-8 Nomograms are intended …  Long-term health outcomes (clinical utility), including reduced mortality/ morbidity and improved … of life, and the potential clinical and personal harms of PCA3 testing and/or related intervention … Testing complies with requirements of the Clinical Laboratory Improvement Act (Public Law 100-578). … In the indirect chain of evidence, Link B addresses the diagnostic accuracy (clinical validity) of
  14. effectivehealthcare.ahrq.gov/sites/default/files/pdf/meditation_research-protocol.pdf
    October 17, 2012 - Background Meditation is used widely by both clinical populations and the general public to treat … the meditation programs on clinical populations. … outcomes of pain and weight among those with a clinical condition. … Due to the need to limit scope, we have also focused on clinical populations. … settings Clinical settings General and clinical settings Clinical settings Adverse effects of intervention
  15. effectivehealthcare.ahrq.gov/sites/default/files/pdf/arthritis-knee-physical-therapy_research-protocol.pdf
    April 01, 2010 - This search includes regulatory documents and conducted clinical trials. … and WHO Clinical Trials (International). … Osteoarthritis: national clinical guideline for care and management in adults. … Clinical practice. Osteoarthritis of the knee. N Engl J Med 2006;354:841-8. 24. … Meta-analysis in clinical trials. Control Clin Trials 1986;7:177-88. 46. Ebrahim S.
  16. S58 (pdf file)

    effectivehealthcare.ahrq.gov/sites/default/files/s58.pdf
    October 01, 2007 - Whereas participants in randomized clinical trials (RCTs) of drugs sometimes fail to represent the full … Supports study designs that incorporate linkages to other sources of clinical, contextual and outcome … Linkages to external sources of clinical information may be possible in some studies. … Variable construction should be informed by clinical understanding of relevant conditions, treatments … Adapting a clinical comorbidity index for use with ICD-9-CM administrative databases.
  17. PEPTIC ULCER #11 (pdf file)

    effectivehealthcare.ahrq.gov/sites/default/files/peptic-ulcer-horizon-scan-high-impact-1406.pdf
    June 01, 2014 - Those reports are sent to various experts with clinical, health systems, health administration, and/or … practice, clinical research, health care delivery, health business, health technology assessment, … Pharmacy clinical policy bulletins. … (External, Clinical). Horizon Scanning Structured Comment Form. … (External, Clinical). Horizon Scanning Structured Comment Form.
  18. effectivehealthcare.ahrq.gov/sites/default/files/pdf/asthma-provider-adherence_research-protocol.pdf
    March 02, 2012 - Clinical Figure 1. … Reviewer pairs will be formed to include personnel with both clinical or domain, and methodological … Why don't physicians follow clinical practice guidelines? A framework for improvement. … Meta-analysis in clinical trials. Control Clin Trials 1986; 7(3):177-88. 37. … Journal of clinical epidemiology, 2010. 63(5): p. 513-23. V.
  19. effectivehealthcare.ahrq.gov/sites/default/files/pdf/antibiotics-respiratory-infection_clinician.pdf
    March 01, 2016 - Although this summary provides a review of evidence, it should not be construed to represent clinical … and physician perception of patient expectations; clinician specialty, knowledge, and experience; clinical … Interventions include clinical strategies (e.g., use of point-of-care diagnostic tests, delayed antibiotic … Clinical Interventions (Point-of-Care Testing): ��Procalcitonin point-of-care testing in adults reduced … Clinical Interventions (Delayed Versus Immediate Prescribing): ��Delayed prescribing of antibiotics
  20. Layout 1 (pdf file)

    effectivehealthcare.ahrq.gov/sites/default/files/related_files/breast-cancer-medications_executive.pdf
    September 01, 2009 - Recent clinical trials have demonstrated the efficacy of three medications—tamoxifen citrate, raloxifene … Current clinical recommendations, including those from the U.S. … The review also examines issues related to clinical effectiveness, such as patient choice, concordance … What methods, such as clinical risk-assessment models, have been used to identify women who could benefit … trials, it is not clear which women in clinical practice would optimally benefit from risk reduction

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