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241. Future Research Needs for Angiotensin-Converting Enzyme Inhibitors (ACEIs), Angiotensin II Receptor Antagonists (ARBs), or Direct Renin Inhibitors (DRIs) for Treating Hypertension (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/ace-inhibitor-arb-future_research.pdf
     March 01, 2012 - Anyone who makes decisions concerning the provision of clinical care should consider this report in … If not, then large long-term clinical trial or observational study would be preferable. 2. … benefits and potential clinical harms • Represents important variation in clinical care, or controversy … Hypertension Research - Clinical & Experimental 33 (Nov) 1150-4 ClinicalTrials.gov: The Clinical … Comparative assessment of angiotensin receptor blockers in different clinical settings.

242. Arthritis and Nontraumatic Joint Disease (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/01_-arthritis_potential_high_impact_june_2012.pdf
     January 01, 2012 - (PRI, Clinical). Horizon Scanning Structured Comment Form. … (External, Clinical). Horizon Scanning Structured Comment Form. … (PRI, Clinical). Horizon Scanning Structured Comment Form. … (NICE clinical guideline; no. 79). … (PRI, Clinical). Horizon Scanning Structured Comment Form.

243. PULMONARY with "Discussions" in Exec Summary (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/13_pulmonary_potential_high_impact_2012-12-11.pdf
     January 01, 2012 - Those reports are sent to various experts with clinical, health systems, health administration, and/or … practice, clinical research, health care delivery, health business, health technology assessment, … the experts thought patient and clinical acceptance of ivacaftor would be wide and rapid. … (External, Clinical). Horizon Scanning Structured Comment Form. … (PRI, Clinical). Horizon Scanning Structured Comment Form.

244. Chronic-urinary-retention-protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/chronic-urinary-retention_research-protocol.pdf
     November 19, 2012 - Clinical guideline for male lower urinary tract symptoms. … Journal of Clinical Epidemiology. 2011 Nov;64(11):1187-97. PMID 21477993. 13. … trial/  (476450) 23 clinical trial, phase i.pt. (12809) 24 clinical trial, phase ii.pt. (20505) 25 … clinical trial, phase iii.pt. (7571) 26 clinical trial, phase iv.pt. (759) 27 controlled clinical … trial.pt. (476450) 31 exp Clinical Trials as topic/ (264416) 32 or/17-­‐31  (949526) 33 (clinical

245. Radiation Therapy for Bone Metastases (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/product/pdf/rt-bone-metatases-final-protocol-amendment.pdf
     August 10, 2022 - decision making, clinical practice, cost-conscious utilization, and patient outcomes, information on … Intended audiences for this review are those seeking to update clinical recommendations or guidelines … Clinical oncology (Royal College of Radiologists (Great Britain)). 2020;32(11):685-7. doi: 10.1016/ … Complex clinical decision-making process of re-irradiation. … IOM Clinical Practice Guidelines We Can Trust — But What About the IOM?

246. Obesity (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/obesity-horizon-scan-high-impact-1306.pdf
     July 01, 2013 - However, one clinical expert noted that available clinical data suggest liraglutide is safe and associated … Institute for Clinical Systems Improvement (ICSI). … (PRI, Clinical). Horizon Scanning Structured Comment Form. … (PRI, Clinical). Horizon Scanning Structured Comment Form. … (PRI, Clinical). Horizon Scanning Structured Comment Form.

247. Obesity (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/obesity-horizon-scan-high-impact-1312.pdf
     December 01, 2013 - According to a clinical expert, unless data supporting clinical effectiveness emerge, ReShape Duo is … However, one clinical expert noted that available clinical data suggest liraglutide is safe and associated … Institute for Clinical Systems Improvement (ICSI). … (PRI, Clinical). Horizon Scanning Structured Comment Form. … (PRI, Clinical). Horizon Scanning Structured Comment Form.

248. Asthma-Immunotherapy-2010 Research-Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/asthma-immunotherapy-2010_research-protocol.pdf
     January 01, 2010 - Description of the Condition Allergic rhinitis is a common clinical problem. … Current clinical trials in the United States are being carried out to address these clinical issues … Clinical immunology: principles and practice. St. Louis, MO: Mosby; 1996. … Immunologic and clinical studies. Ann Intern Med 1971;75:663-71. 26. Frew AJ. … Again, both subjective and objective clinical parameters can be measured.

249. S16 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/s16.pdf
     October 01, 2007 - Clinical practice guidelines—When should therapy for low bone density be initiated? … Practical clinical trials, increasing the value of clinical research for decision making in clinical … Can randomized trials inform clinical decisions about individ- ual patients. … NIH Program on Clinical Research Policy and Analysis and Coordination. … Implications of pharmacogenomics for drug development and clinical practice.

250. PEPTIC ULCER #11 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/peptic-ulcer-horizon-scan-high-impact-1312.pdf
     December 01, 2013 - ’s clinical experience. … (External, Clinical). Horizon Scanning Structured Comment Form. … (External, Clinical). Horizon Scanning Structured Comment Form. … Pharmacy clinical policy bulletins. … (PRI, Clinical). Horizon Scanning Structured Comment Form.

251. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/sleep-apnea_research-protocol.pdf
     March 15, 2010 - While in-laboratory polysomnography is considered the gold standard in clinical practice to diagnose … Change in clinical management 4. … Sleep / wakefulness clinical outcomes a. Quality of life i. … Comorbidities clinical outcomes a. Mortality b. … trial.pt. 748992 15 Clinical Trials.mp. or exp Clinical Trials/ 282752 16 (clinic$ adj25 trial$).tw

252. Obesity (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/obesity-horizon-scan-high-impact-1412.pdf
     December 01, 2014 - Clinical trials: A four-part, phase III RCT, SCALE™ (Satiety and Clinical Adiposity- Liraglutide Evidence … (External, Clinical). Horizon Scanning Structured Comment Form. … (External, Clinical). Horizon Scanning Structured Comment Form. … (External, Clinical). Horizon Scanning Structured Comment Form. … Institute for Clinical Systems Improvement (ICSI).

253. 08 Functional Limitations Potential High Impact 2012-12-10 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/08_functional_limitations_potential_high_impact_2012-12-10.pdf
     January 01, 2012 - FDA did not cite any clinical safety or efficacy issues or request any additional clinical studies … (PRI, Clinical). Horizon Scanning Structured Comment Form. … (External, Clinical). Horizon Scanning Structured Comment Form. … (External, Clinical). Horizon Scanning Structured Comment Form. … (PRI, Clinical). Horizon Scanning Structured Comment Form.

254. Disposition of Comments Report for Imaging Techniques for Treatment Evaluation for Metastatic Breast Cancer (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/breast-cancer-imaging_disposition-comments.pdf
     October 01, 2014 - the appropriate scans to be used for specific clinical indications. … The American College of Radiology (ACR) has clinical practice guidelines on breast cancer. … by how it informs specific clinical care, not how it ranks in comparison to other modalities. … The Draft Technical Brief points to lack of studies on “clinical and patient centered outcomes”. … each test used to inform the complex clinical decision process in unique and inimitable ways.

255. PowerPoint Presentation (ppt file)
     effectivehealthcare.ahrq.gov/sites/default/files/medical-test-reviews-strength-evidence.ppt
     June 01, 2012 - Other key question topics—such as analytic validity, clinical validity, and clinical utility—can also … There was little uncertainty about the clinical implications of these results. … There was uncertainty about the clinical implications of these results. … The triage test is not linked directly to the clinical outcome. … They are considered indirect evidence of clinical outcomes.

256. Disposition of Comments Report for Methods for Insulin Delivery and Glucose Monitoring (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/insulin-blood-sugar-2010_disposition-comments.pdf
     January 01, 2010 - We have added the following statement to the "Future Research" section regarding clinical outcomes: … We still believe that the most relevant comparisons are the ones used currently in clinical practice … A significant emphasis is given randomized clinical trials. … This is described more fully in the clinical literature referenced as an attachment. … All the clinical trials identified using rtCGM included concomitant SMBG for calibration.

257. PowerPoint Presentation (ppt file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/medical-test-reviews-strength-evidence.ppt
     June 01, 2012 - Other key question topics—such as analytic validity, clinical validity, and clinical utility—can also … There was little uncertainty about the clinical implications of these results. … There was uncertainty about the clinical implications of these results. … The triage test is not linked directly to the clinical outcome. … They are considered indirect evidence of clinical outcomes.

258. Cad-Women-Diagnosis Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cad-women-diagnosis_executive.pdf
     June 01, 2012 - Based on their clinical and methodological expertise, two researchers were assigned to abstract data … There was limited or insufficient evidence on the influence of clinical and demographic factors on … In routine clinical practice, clinicians order one type of NIT modality based on a patient’s ability … , treatment decisions, and clinical outcomes. … Assessing clinical and demographic factors that influence diagnostic accuracy.

259. Hypertension-Pulmonary-Arterial Research-Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/hypertension-pulmonary-arterial_research-protocol.pdf
     January 30, 2013 - • Does use of echocardiography and biomarkers affect decisionmaking and clinical outcomes? … and (b) echocardiography plus clinical assessment versus echocardiography plus biomarkers and clinical … Med Decis Making 1991;11(2):88-94. bIn conjunction with routine clinical assessment (functional class … assessment (indirect comparison) o Biomarkers vs. clinical assessment (indirect comparison) • … trial[pt] OR "clinical trial"[tw] OR "clinical trials"[tw] OR "evaluation studies"[Publication Type

260. FRN 39 - Nonoperative and Operative Treatments for Rotator Cuff Tears: Future Research Needs (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/rotator-cuff-tears-future_research.pdf
     February 01, 2013 - 0 0 What patient demographics and clinical profiles are important? … care, clinical benefits and harms, and high costs. … Incorporates issues around both clinical benefits and potential clinical harms 2f. … Represents important variation in clinical care, or controversy in what constitutes appropriate clinical … Advanced imaging should not replace a good clinical exam.