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2061. #14 SUBSTANCE ABUSE (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/substanceabuse_hi_impact.pdf
      January 01, 2012 - Drafts of those reports are sent to various experts with clinical, health systems, health administration … Experts offered different perspectives about potential patient and clinical acceptance. … (External, Clinical). Horizon Scanning Structured Comment Form. … (External, Clinical). Horizon Scanning Structured Comment Form. … (External, Clinical). Horizon Scanning Structured Comment Form.

2062. Rheumatoid-Arthritis-Medicine Executive (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/rheumatoid-arthritis-medicine_executive.pdf
      April 01, 2012 - The diagnosis is based primarily on the clinical history and physical examination with support from … Clinical experience Effective Health Care Program 2 supports the use of MTX as the oral DMARD of … MTX In patients with early RA, no clinically significant differences in clinical response between … For MTX, the odds for major clinical improvement dropped slightly as the age of clinical trial patients … Ideally, studies need to mimic clinical decisionmaking, where if a patient is not doing well after

2063. Antiplatelet-Treatment Executive (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/antiplatelet-treatment_executive.pdf
      September 01, 2013 - Clinical Outcomes Several clinical outcomes of interest were reported: all-cause mortality, cardiac … Clinical Outcomes Six studies (reported in seven publicationsc) provided clinical outcome information … Clinical Outcomes Clinical-outcome comparisons between the randomized treatment groups were reported … for the component clinical events … outcomes in large well-conducted clinical trials.

2064. Frameworks for Determining Research Gaps During Systematic Reviews (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-future-research-steps-framework_research.pdf
      June 01, 2011 - clinical assessment. … Relevant outcomes (O) could include clinical outcomes to assess the benefit of the clinical assessment … practice) by a clinical department. … clinical assessment. … Relevant outcomes (O) could include clinical outcomes to assess the benefit of the clinical assessment

2065. #06 Developmental Delays ADHD, and Autism (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/06_devdelays_potential_high_impact_2012-12-10.pdf
      January 01, 2012 - Those reports are sent to various experts with clinical, health systems, health administration, and/or … practice, clinical research, health care delivery, health business, health technology assessment, … Experts are identified in the system by the perspective they bring (e.g., clinical, research, health … The ASD clinical pathway is complicated, however, by the subjective nature of diagnosis, which relies … Significant clinical opposition to its use exists because of its potential risks to children and a

2066. C-Diff-Infections-Surveillance-140925 (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/c-diff-infections-surveillance-140925.pdf
      January 01, 2014 - Infectious Diseases, Journal of Gastroenterology, Journal of Hospital Infection, Journal of Clinical … Infectious Diseases, Journal of Gastroenterology, Journal of Hospital Infection, Journal of Clinical … For Key Question 1, included studies needed to have used clinical stool specimen, compared at least … EIA-negative patients did not differ in clinical presentation from EIA-positive patients. … endpoint: clinical cure of CDI at the end of 10 days of treatment.

2067. A Framework for Conceptualizing Evidence Needs of Health Systems (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/white-paper-framework-for-conceptualizing-evidence-needs_0.pdf
      December 01, 2017 - This report is not intended to be a substitute for the application of clinical judgment. … Anyone who makes decisions concerning the provision of clinical care should consider this report in … A wide range of clinical and administrative decisionmakers requested evidence reviews, and the topics … For example, Raymond Baxter of Kaiser Permanente described an effort to gather input from clinical … Balancing health care evidence and art to meet clinical needs: policymakers' perspectives.

2068. Disposition of Comments Report for CER 132 Combination Therapy Versus Intensification of Statin Monotherapy: An Update (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/high-cholestorol-medicines-update_disposition-comments.pdf
      September 01, 2014 - We all are taught not to over-interpret subgroups in clinical trials. … To actually have AHRQ propose that subgroup analyses be used to drive clinical recommendations bumps … trials, combination regimens have not consistently been shown to improve clinical outcomes. … Thus, concerns that “that combination regimens may worsen clinical outcomes” are not supported by … This is missing Unfortunately, the available evidence does not address clinical outcomes.

2069. ADHD-Update-protocol-160818 (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/adhd-update_research-protocol.pdf
      August 18, 2016 - NEBA is used to provide clinical support but does not replace the clinical evaluation.14 Adverse … trial[pt] OR “clinical trial”[tiab] OR “clinical trials”[tiab] OR "evaluation studies"[pt] OR "evaluation … trial[pt] OR “clinical trial”[tiab] OR “clinical trials”[tiab] OR "evaluation studies"[pt] OR "evaluation … trial[pt] OR “clinical trial”[tiab] OR “clinical trials”[tiab] OR "evaluation studies"[pt] OR "evaluation … Encyclopedia of Clinical Neuropsychology: Springer New York; 2011:678-680. 23.

2070. PULMONARY with "Discussions" in Exec Summary (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pulmonary-horizon-scan-high-impact-1312.pdf
      December 01, 2013 - Pharmacy clinical policy bulletins. Aetna non-Medicare prescription drug plan. … (External, Clinical). Horizon Scanning Structured Comment Form. … (PRI, Clinical). Horizon Scanning Structured Comment Form. … (External, Clinical). Horizon Scanning Structured Comment Form. … (External, Clinical). Horizon Scanning Structured Comment Form.

2071. Rapid-Reviews-End-User White-Paper (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/rapid-reviews-end-user_white-paper.pdf
      April 01, 2016 - This report is not intended to be a substitute for the application of clinical judgment. … [guideline developer] Clinical significance Reviews should include considerations of clinical … Journal of clinical epidemiology. 2008;61(6):531-6. 4. … Journal of clinical epidemiology. 2000;53(9):964-72. 22. Selph SS, Ginsburg AD, Chou R. … Rapid versus full systematic reviews: validity in clinical practice?

2072. antibiotics-respiratory-infection-protocol-140922 (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/antibiotics-respiratory-infection_research-protocol.pdf
      September 22, 2014 - Existing clinical guidelines indicate that acute bronchitis and other acute RTIs that can be caused … Clinical strategies include delayed prescribing of antibiotics or use of point-of-care diagnostic tests … A 2008 guideline by the United Kingdom’s National Institute for Health and Clinical Excellence (NICE … National Institute for Health and Clinical Excellence. … Clinical strategies, such as a clinical prediction rule, that are implemented at the system-level

2073. Prostate-Cancer-Therapies-Update Research-Protocol (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/prostate-cancer-therapies-update_research-protocol.pdf
      April 01, 2013 - A study-design filter will be applied to retrieve systematic reviews and ongoing clinical trials. … Available at www.auanet.org/content/clinical-practice- guidelines/clinical-guidelines/main- reports/ … Basic & Clinical Biostatistics. New York: The McGraw-Hill Companies; 2004. 23. … Meta-analysis in clinical trials. Control Clin Trials. 1986 Sep;7(3):177-88. … Because of their unique clinical or content expertise, individuals are invited to serve as Technical

2074. Breast Abnormalities Update Surveillance Assessment_CER 47_Low (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/breast-abnormalities-tests-update_surveillance.pdf
      September 01, 2012 - Studies that reported they had blinded readers to clinical information had a lower sensitivity than … Subgroup analyses found that studies that had blinded image readers to clinical information had a … Are there demographic (e.g., age) and clinical risk factors (e.g., morphologic characteristics of the … Results of a multicenter patient registry to determine the clinical impact of breast-specific gamma … Studies that reported they had blinded readers to clinical information had a lower sensitivity than

2075. Disposition of Comments Report for Procalcitonin-Guides Antibiotic Therapy (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer78_procalcitonin_disposition_20121210.pdf
      October 05, 2012 - For example, studies of clinical algorithms to reduce antibiotic prescribing for acute respiratory … In routine US clinical practice, clinicians would not tolerate such interference in their clinical decision-making … U.S. clinicians respond to clinical practice guidelines. … We note uncertainty about the choice of noninferiority margin in clinical trials. … scientific programming and potential development of clinical practice guidelines.

2076. Venous-Ulcers-Treatment-Future Research (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/venous-ulcers-treatment-future_research.pdf
      January 01, 2014 - Ongoing Clinical Trials Searches To identify ongoing clinical trials that may have addressed the future … Ongoing Clinical Trial Searches To identify ongoing clinical trials that may have addressed our future … Wound pain can be an indication of clinical 19 infection. … A-1 Gaps in Clinical Treatments Please rank the following broad types of clinical treatments … Impact –potential to change research practices, reporting practices, clinical practices and/or clinical

2077. Use of Observational Studies in Systematic Reviews of (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guidance-observational-studies_methods.pdf
      June 01, 2010 - hDepartment of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON. … RCTs may be difficult to implement due to entrenched clinical practice or to active consumer pressure … Second, existing reviews on related topics or consultation with clinical experts may also identify … In some clinical circumstances the likelihood of one or 5 more of these biases affecting studies … Evaluating medication effects outside of clinical trials: new-user designs.

2078. Use of Observational Studies in Systematic Reviews of (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/methodsguidenorris_060420101.pdf
      June 01, 2010 - hDepartment of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON. … RCTs may be difficult to implement due to entrenched clinical practice or to active consumer pressure … Second, existing reviews on related topics or consultation with clinical experts may also identify … In some clinical circumstances the likelihood of one or 5 more of these biases affecting studies … Evaluating medication effects outside of clinical trials: new-user designs.

2079. Slide 1 (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/introductory-slides-ahrq-cf-webinar.pdf
      August 27, 2012 - research  Decision modeling, with or without cost information  Retrospective analysis of existing clinical … Prospective non-experimental studies, including registries  Experimental studies, including randomized clinical … Chair of the Steering Committee for the COPD Outcomes-based Network for Clinical Effectiveness and

2080. Effective Health Care (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND_0108_05-24-2009.pdf
      January 01, 2009 - more specific topic of the efficacy of IV Benadryl, Toradol, and Reglan in an emergency department or clinical …  There appears to be significant clinical uncertainty surrounding acute migraine treatment in … Several consensus statements, clinical guidelines, and evidence reviews caution against the use of opioids