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21. Potential Harms Resulting from Patient-Clinician Real-Time Clinical Encounters using Video-based Telehealth: A Rapid Evidence Review (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/patient-safety-practices-rapid-protocol.pdf
    September 09, 2022 - Potential Harms Resulting from Patient-Clinician Real-Time Clinical Encounters using Video-based Telehealth … Rapid Review Protocol Project Title: Potential Harms Resulting from Patient-Clinician Real-Time Clinical … What is the frequency and severity of harms associated with use of telehealth in real-time clinical … practices and health care systems in the United States No clinical site in the United States … We will ask at least one clinical content expert and one methodological expert to review the draft

22. Environmental, Clinical and Economic Outcomes of Hospital Resources to Prevent Hospital-Acquired Infections (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/prevent-hai-protocol.pdf
    April 16, 2024 - Environmental, Clinical and Economic Outcomes of Hospital Resources to Prevent Hospital-Acquired Infections … Evidence-based Practice Center Technical Brief Protocol Project Title: Environmental, Clinical … prevention, device utilization, and environmental impact, and studies rarely focus simultaneously on clinical … They may include clinical experts, patients, manufacturers, researchers, payers, or other perspectives … Because of their unique clinical or content expertise, individuals are invited to serve as Key Informants

23. Disposition of Comments Report for The Clinical Utility of Fractional Exhaled Nitric Oxide (FeNO) in Asthma Management (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-197-fractional-exhaled-nitric-oxide-disposition-comments.pdf
    December 20, 2017 - The Clinical Utility of Fractional Exhaled Nitric Oxide (FeNO) in Asthma Management. … We do not make clinical recommendations in a SR. … NHLBI will use the report to develop clinical practice guidelines. … The intended users are clinical practice guideline developers. … (clinical scenarios) in which FeNO would be helpful.

24. Therapies for Clinically Localized Prostate Cancer (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/prostate-cancer-therapies-update_clinician.pdf
    January 01, 2016 - The National Comprehensive Cancer Network (NCCN) Clinical Guideline for the Treatment of Prostate Cancer … , published in 2015, defined clinically localized prostate cancer as clinical stages T1–T3a, which … This summary is provided to assist in informed clinical decisionmaking. … However, reviews of evidence should not be construed to represent clinical recommendations or guidelines … Eisenberg Center for Clinical Decisions and Communications Science at Baylor College of Medicine, Houston

25. Evidence Summary - Comparative Effectiveness Review No. 249: Malnutrition in Hospitalized Adults: A Systematic Review (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/cer-249-malnutrition-hospitalized-adults-evidence-summary.pdf
    October 01, 2021 - Systematic Review Evidence Summary Main Points • Association Between Malnutrition and Clinical … outcomes, (2) evaluating the effectiveness of measurement tools of malnutrition on clinical outcomes … Clinical outcomes of interest included mortality, length of stay, 30-day readmission, quality of life … To assess clinical utility of measurement tools we sought to identify prospectively controlled studies … We identified 11 RCTs indicating that some interventions improve clinical outcomes among malnourished

26. Evidence Summary - Comparative Effectiveness Review No. 249: Malnutrition in Hospitalized Adults: A Systematic Review (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-249-malnutrition-hospitalized-adults-evidence-summary_0.pdf
    October 01, 2021 - Systematic Review Evidence Summary Main Points • Association Between Malnutrition and Clinical … outcomes, (2) evaluating the effectiveness of measurement tools of malnutrition on clinical outcomes … Clinical outcomes of interest included mortality, length of stay, 30-day readmission, quality of life … To assess clinical utility of measurement tools we sought to identify prospectively controlled studies … We identified 11 RCTs indicating that some interventions improve clinical outcomes among malnourished

27. Therapies for Clinically Localized Prostate Cancer: Evidence Summary (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/prostate-cancer-therapies-summary.pdf
    September 01, 2020 - • Varying thresholds to define effect size estimates may alter certainty of evidence and clinical … • While clinical and policy decision making often incorporate patient and tumor characteristics, … Our findings have clinical, policy, and research implications. … cautionary note before incorporating newer treatment modalities (including refinements of RP or EBR) into clinical

28. McCullough (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/mccullough.pdf
    January 01, 2011 - Slide  1: An Ethical Framework for Supporting  Shared Decision Making  When Clinical … management of the patient’s condition, diagnosis, or injury, and the clinical benefits and risks of … judgment • Such clinical management carries disease-­‐related risks  (from ineffectively managed … of clinical management • Refusal by the patient of clinical management with very low or low levels … of evidence is not automatically  ruled out in beneficence-­‐based clinical judgment as medically

29. Module III: Points of Engagement in the EHC Program (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/module-iii-points-of-engagement-in-the-ehc-program.pdf
    October 08, 2025 - During this phase, the role of stakeholders is primarily to provide clinical and methodological guidance … on research protocols, methodological and clinical appropriateness of study selection criteria. … Provide clinical and methodological input: § Topic Identification & Nomination § Topic Prioritization … Provide clinical and methodological input: § Topic Identification & Nomination § Topic Prioritization … Provide clinical and methodological input: § Topic Identification & Nomination § Topic Prioritization

30. Making Healthcare Safer IV_Rapid Review: Use of Structured Handoff Protocols for Intrahospital Within-Unit Transitions (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/structured-handoff-rapid-research.pdf
    January 01, 2025 - /clinical-handover/implementation-toolkit-clinical-handover-improvement https://www.safetyandquality.gov.au … /our-work/communicating-safety/clinical-handover/implementation-toolkit-clinical-handover-improvement … Clinical Leadership & Infection Control. June 29, 2016. … Does not measure clinical safety outcomes 45. Mathias JM. … A scoping review of clinical handover mnemonic devices.

31. White Paper_Supplementing Systematic Review Findings With Healthcare System Data: Pilot Projects From the Agency for Healthcare Research and Quality Evidence-based Practice Center Program (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/pilot-projects-supplementing-white-paper.pdf
    December 01, 2024 - Clinical expertise time accounts for diagnostic code searches only. … However, defining the clinical question with the help of clinical experts early in the review process … Fighting against age discrimination in clinical trials. … Exclusion of pregnant women from industry-sponsored clinical trials. … Should pregnant women be included in phase IV clinical drug trials?

32. Han (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/han.pdf
    December 26, 2012 - Slide 1: Conceptual, methodological, and ethical problems  in communicating   uncertainty  in clinical … Outcomes Research and Evaluation Maine Medical  Center Slide 2: Communicating  uncertainty in clinical … o Meaning and nature of uncertainty in clinical evidence • Methodological: How should we communicate … o Benefits and harms of communicating uncertainty in clinical practice Slide 5: Uncertainty • Main …  evidence: exemplars • Clinical prediction models (CPMs) o “…provide the evidence-­‐based input

33. Migraine Protocol-Appendix 20111103 (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/migraine_protocol-appendix_20111103.pdf
    November 03, 2011 - Trial, Randomized Controlled Trial, English Search Lisuride AND migraine Limits: Humans, Clinical … Trial, Randomized Controlled Trial, English Search Zotepine AND migraine Limits: Humans, Clinical … Trial, Randomized Controlled Trial, English Search Sulpiride AND migraine Limits: Humans, Clinical … Trial, Randomized Controlled Trial, English Search Spiperone AND migraine Limits: Humans, Clinical … Trial, Randomized Controlled Trial, English Search Loxapine AND migraine Limits: Humans, Clinical

34. Evidence-based Practice Center Systematic Review Protocol: Therapies for Clinically Localized Prostate Cancer (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/prostate-cancer-therapies-protocol_amended110619.pdf
    November 02, 2019 - Also, technology has advanced and clinical interest increased around additional focal therapies such … Journal of Clinical Epidemiology. 2011 Nov;64(11):1187- 97. PMID: 21477993. 16. … Journal of Clinical Epidemiology. 2013 Feb;66(2):151-7. … trial, all or clinical trial, phase i or clinical trial, phase ii or clinical trial, phase iii or … clinical trial, phase iv or clinical trial or comparative study or evaluation studies or meta

35. Association Between Outcomes and Dental Services in People at Risk of Post-Transplant Complications: A Rapid Response Review (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/dental-post-transplant-complications-rapid-research.pdf
    May 01, 2025 - This report is not intended to be a substitute for the application of clinical judgment. … Additionally, we consulted our clinical subject matter experts (SMEs) for relevant clinical practice … within the clinical community were missed and to identify publications that lacked clinical applicability … clinical practice guidelines. … The clinical SMEs reviewed the final report to ensure accurate clinical contextualization of any findings

36. Medical Care for Adults with Down Syndrome (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/care-adults-down-syndrome-protocol.pdf
    July 09, 2024 - Fourteen recommendations across nine clinical areas were proposed, with a single strong recommendation … This review will include the nine clinical areas previously examined and expand to additional clinical … Care Guidelines for Adults with Down Syndrome b Clinical area will be included in the update search … Medical Care of Adults With Down Syndrome: A Clinical Guideline. … /linda- crnic-institute/research/immune-skin-clinical-trial ○ Down Syndrome Regression Disorder Clinical

37. EHC Protocol: Addressing Social Isolation To Improve Health of Older Adults: A Rapid Evidence Review (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/mhs4-computerized-cds-protocol.pdf
    May 08, 2023 - Practice Center Rapid Review Protocol Project Title: Making Healthcare Safer IV: Computerized Clinical … What is the rationale for using computerized clinical decision support to prevent or mitigate the harms … What are the effectiveness and unintended effects of using computerized clinical decision support on … Computerized clinical decision support (CDS) as a PSP was identified as high priority for inclusion … decision support on the key clinical outcomes of medication errors and adverse drug events.

38. Quantitative Synthesis: Chapter 1. Decision To Combine Trials (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/ehc-presentation-quantitative-synthesis-chapter-1.pdf
    July 01, 2019 - • Clinical Heterogeneity and Methodological Heterogeneity describe the variations in the population … Meta-analysis of clinical trial safety data in a drug development program: Answers to frequently asked … Consensus-based recommendations for investigating clinical heterogeneity in systematic reviews. … and methodological heterogeneity • Step A: Exploring clinical and methodological heterogeneity of … Consensus-based recommendations for investigating clinical heterogeneity in systematic reviews.

39. genetic-testing-developmental-disabilities-protocol-140930 (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/genetic-testing-developmental-disabilities_research-protocol.pdf
    September 30, 2014 - the clinical condition of interest. … Clinical validity is usually described in terms of clinical sensitivity, clinical specificity, positive … The framework delineates the relationship between analytic validity, clinical validity and clinical … What are the ongoing clinical trials for the clinical utility of the tests? f. … Diagnostic accuracy: is also known as clinical validity (see definition of clinical validity).

40. Technical Brief Disposition of Comments Report for Gene Expression Profiling for Predicting Outcomes in Stage II Colon Cancer (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/colon-cancer-gene-profiling_disposition-comments.pdf
    December 14, 2012 - clinical utility … Clinical Utility: ColoPrint has been compared to clinical risk stratification. … under the Clinical Validity topic. … in clinical care impacts net health outcome (clinical utility) compared to other approaches. … Public Agendia Summary P. 24 (as stated above) Clinical Utility: ColoPrint has been compared to clinical