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1861. Rheumatoid-Arthritis-Medicine Executive (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/rheumatoid-arthritis-medicine_executive.pdf
      April 01, 2012 - The diagnosis is based primarily on the clinical history and physical examination with support from … Clinical experience Effective Health Care Program 2 supports the use of MTX as the oral DMARD of … MTX In patients with early RA, no clinically significant differences in clinical response between … For MTX, the odds for major clinical improvement dropped slightly as the age of clinical trial patients … Ideally, studies need to mimic clinical decisionmaking, where if a patient is not doing well after

1862. C-Diff-Infections-Surveillance-140925 (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/c-diff-infections-surveillance-140925.pdf
      January 01, 2014 - Infectious Diseases, Journal of Gastroenterology, Journal of Hospital Infection, Journal of Clinical … Infectious Diseases, Journal of Gastroenterology, Journal of Hospital Infection, Journal of Clinical … For Key Question 1, included studies needed to have used clinical stool specimen, compared at least … EIA-negative patients did not differ in clinical presentation from EIA-positive patients. … endpoint: clinical cure of CDI at the end of 10 days of treatment.

1863. Effective Health Care (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND_0075_03-10-2009.pdf
      January 01, 2009 - Algorithmic challenges exist with this disease, and clinical consultation suggests there is a high degree … of variation in clinical practice for the treatment and management of Crohn’s disease. … Clinical practice guidelines based on systematic reviews of the literature are limited, and no guidelines

1864. Topic 0505 Genetic Testing for Developmental Diseases NSD FINAL_SJ (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND-0594-131115.pdf
      March 13, 2013 - disabilities (DD/ID) or autism spectrum disorder (ASD) in children and is interested to know the clinical …  Diagnosis of children with DD/ID or ASD can often be made based upon the clinical history and physical … Most of the evidence looks at diagnostic yield, not clinical outcomes.

1865. A Framework for Conceptualizing Evidence Needs of Health Systems (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/white-paper-framework-for-conceptualizing-evidence-needs_0.pdf
      December 01, 2017 - This report is not intended to be a substitute for the application of clinical judgment. … Anyone who makes decisions concerning the provision of clinical care should consider this report in … A wide range of clinical and administrative decisionmakers requested evidence reviews, and the topics … For example, Raymond Baxter of Kaiser Permanente described an effort to gather input from clinical … Balancing health care evidence and art to meet clinical needs: policymakers' perspectives.

1866. Disposition of Comments Report for CER 132 Combination Therapy Versus Intensification of Statin Monotherapy: An Update (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/high-cholestorol-medicines-update_disposition-comments.pdf
      September 01, 2014 - We all are taught not to over-interpret subgroups in clinical trials. … To actually have AHRQ propose that subgroup analyses be used to drive clinical recommendations bumps … trials, combination regimens have not consistently been shown to improve clinical outcomes. … Thus, concerns that “that combination regimens may worsen clinical outcomes” are not supported by … This is missing Unfortunately, the available evidence does not address clinical outcomes.

1867. #06 Developmental Delays ADHD, and Autism (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/06_devdelays_potential_high_impact_2012-12-10.pdf
      January 01, 2012 - Those reports are sent to various experts with clinical, health systems, health administration, and/or … practice, clinical research, health care delivery, health business, health technology assessment, … Experts are identified in the system by the perspective they bring (e.g., clinical, research, health … The ASD clinical pathway is complicated, however, by the subjective nature of diagnosis, which relies … Significant clinical opposition to its use exists because of its potential risks to children and a

1868. DuBenske_Presentation_REVISED_FINAL (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/web-based_dubenske_presenter.pdf
      January 01, 2009 - DuBenske,  PhD   Assistant  Clinical  Professor,  Psychologist   University  of  Wisconsin …  Care  Program  Web  site   (http://www.effectivehealthcare.ahrq.gov/index.cfm)     • Clinical …  Team   o Central  role  connecting  patient  to  clinical  care  system   o IHCS …  IHCS  demonstrating  potential  for  benefits  to  patients,   caregivers  and  clinical

1869. ADHD-Update-protocol-160818 (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/adhd-update_research-protocol.pdf
      August 18, 2016 - NEBA is used to provide clinical support but does not replace the clinical evaluation.14 Adverse … trial[pt] OR “clinical trial”[tiab] OR “clinical trials”[tiab] OR "evaluation studies"[pt] OR "evaluation … trial[pt] OR “clinical trial”[tiab] OR “clinical trials”[tiab] OR "evaluation studies"[pt] OR "evaluation … trial[pt] OR “clinical trial”[tiab] OR “clinical trials”[tiab] OR "evaluation studies"[pt] OR "evaluation … Encyclopedia of Clinical Neuropsychology: Springer New York; 2011:678-680. 23.

1870. PULMONARY with "Discussions" in Exec Summary (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pulmonary-horizon-scan-high-impact-1312.pdf
      December 01, 2013 - Pharmacy clinical policy bulletins. Aetna non-Medicare prescription drug plan. … (External, Clinical). Horizon Scanning Structured Comment Form. … (PRI, Clinical). Horizon Scanning Structured Comment Form. … (External, Clinical). Horizon Scanning Structured Comment Form. … (External, Clinical). Horizon Scanning Structured Comment Form.

1871. Rapid-Reviews-End-User White-Paper (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/rapid-reviews-end-user_white-paper.pdf
      April 01, 2016 - This report is not intended to be a substitute for the application of clinical judgment. … [guideline developer] Clinical significance Reviews should include considerations of clinical … Journal of clinical epidemiology. 2008;61(6):531-6. 4. … Journal of clinical epidemiology. 2000;53(9):964-72. 22. Selph SS, Ginsburg AD, Chou R. … Rapid versus full systematic reviews: validity in clinical practice?

1872. antibiotics-respiratory-infection-protocol-140922 (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/antibiotics-respiratory-infection_research-protocol.pdf
      September 22, 2014 - Existing clinical guidelines indicate that acute bronchitis and other acute RTIs that can be caused … Clinical strategies include delayed prescribing of antibiotics or use of point-of-care diagnostic tests … A 2008 guideline by the United Kingdom’s National Institute for Health and Clinical Excellence (NICE … National Institute for Health and Clinical Excellence. … Clinical strategies, such as a clinical prediction rule, that are implemented at the system-level

1873. Prostate-Cancer-Therapies-Update Research-Protocol (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/prostate-cancer-therapies-update_research-protocol.pdf
      April 01, 2013 - A study-design filter will be applied to retrieve systematic reviews and ongoing clinical trials. … Available at www.auanet.org/content/clinical-practice- guidelines/clinical-guidelines/main- reports/ … Basic & Clinical Biostatistics. New York: The McGraw-Hill Companies; 2004. 23. … Meta-analysis in clinical trials. Control Clin Trials. 1986 Sep;7(3):177-88. … Because of their unique clinical or content expertise, individuals are invited to serve as Technical

1874. Breast Abnormalities Update Surveillance Assessment_CER 47_Low (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/breast-abnormalities-tests-update_surveillance.pdf
      September 01, 2012 - Studies that reported they had blinded readers to clinical information had a lower sensitivity than … Subgroup analyses found that studies that had blinded image readers to clinical information had a … Are there demographic (e.g., age) and clinical risk factors (e.g., morphologic characteristics of the … Results of a multicenter patient registry to determine the clinical impact of breast-specific gamma … Studies that reported they had blinded readers to clinical information had a lower sensitivity than

1875. Disposition of Comments Report for Procalcitonin-Guides Antibiotic Therapy (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer78_procalcitonin_disposition_20121210.pdf
      October 05, 2012 - For example, studies of clinical algorithms to reduce antibiotic prescribing for acute respiratory … In routine US clinical practice, clinicians would not tolerate such interference in their clinical decision-making … U.S. clinicians respond to clinical practice guidelines. … We note uncertainty about the choice of noninferiority margin in clinical trials. … scientific programming and potential development of clinical practice guidelines.

1876. Venous-Ulcers-Treatment-Future Research (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/venous-ulcers-treatment-future_research.pdf
      January 01, 2014 - Ongoing Clinical Trials Searches To identify ongoing clinical trials that may have addressed the future … Ongoing Clinical Trial Searches To identify ongoing clinical trials that may have addressed our future … Wound pain can be an indication of clinical 19 infection. … A-1 Gaps in Clinical Treatments Please rank the following broad types of clinical treatments … Impact –potential to change research practices, reporting practices, clinical practices and/or clinical

1877. Use of Observational Studies in Systematic Reviews of (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guidance-observational-studies_methods.pdf
      June 01, 2010 - hDepartment of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON. … RCTs may be difficult to implement due to entrenched clinical practice or to active consumer pressure … Second, existing reviews on related topics or consultation with clinical experts may also identify … In some clinical circumstances the likelihood of one or 5 more of these biases affecting studies … Evaluating medication effects outside of clinical trials: new-user designs.

1878. Use of Observational Studies in Systematic Reviews of (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/methodsguidenorris_060420101.pdf
      June 01, 2010 - hDepartment of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON. … RCTs may be difficult to implement due to entrenched clinical practice or to active consumer pressure … Second, existing reviews on related topics or consultation with clinical experts may also identify … In some clinical circumstances the likelihood of one or 5 more of these biases affecting studies … Evaluating medication effects outside of clinical trials: new-user designs.

1879. Preventing Complications and Treating Symptoms of Diabetic Peripheral Neuropathy (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/diabetic-neuropathy-disposition-170707.pdf
      March 24, 2017 - Thank you for sharing your clinical experience. … Thank you for sharing your clinical experience. … NO THIS IS NOT MY OR OTHERS CLINICAL EXPERIENCE Thank you for sharing your clinical experience. … Thank you for sharing your clinical experience. … Thank you for sharing your clinical experience.

1880. Preventing Complications and Treating Symptoms of Diabetic Peripheral Neuropathy (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/diabetic-neuropathy-disposition-170707.pdf
      March 24, 2017 - Thank you for sharing your clinical experience. … Thank you for sharing your clinical experience. … NO THIS IS NOT MY OR OTHERS CLINICAL EXPERIENCE Thank you for sharing your clinical experience. … Thank you for sharing your clinical experience. … Thank you for sharing your clinical experience.