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1541. Rheumatoid-Arthritis-Medicine Executive (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/rheumatoid-arthritis-medicine_executive.pdf
      April 01, 2012 - The diagnosis is based primarily on the clinical history and physical examination with support from … Clinical experience Effective Health Care Program 2 supports the use of MTX as the oral DMARD of … MTX In patients with early RA, no clinically significant differences in clinical response between … For MTX, the odds for major clinical improvement dropped slightly as the age of clinical trial patients … Ideally, studies need to mimic clinical decisionmaking, where if a patient is not doing well after

1542. PULMONARY with "Discussions" in Exec Summary (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pulmonary-horizon-scan-high-impact-1312.pdf
      December 01, 2013 - Pharmacy clinical policy bulletins. Aetna non-Medicare prescription drug plan. … (External, Clinical). Horizon Scanning Structured Comment Form. … (PRI, Clinical). Horizon Scanning Structured Comment Form. … (External, Clinical). Horizon Scanning Structured Comment Form. … (External, Clinical). Horizon Scanning Structured Comment Form.

1543. Rapid-Reviews-End-User White-Paper (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/rapid-reviews-end-user_white-paper.pdf
      April 01, 2016 - This report is not intended to be a substitute for the application of clinical judgment. … [guideline developer] Clinical significance Reviews should include considerations of clinical … Journal of clinical epidemiology. 2008;61(6):531-6. 4. … Journal of clinical epidemiology. 2000;53(9):964-72. 22. Selph SS, Ginsburg AD, Chou R. … Rapid versus full systematic reviews: validity in clinical practice?

1544. TND-0543_05-24-2013 (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND-0543_05-24-2013.pdf
      January 01, 2013 - Existing clinical guidelines recommend against routine antibiotic use for ACI in otherwise healthy adults … The conclusions in the most recent clinical trials note that a decrease in antibiotic use was associated … this topic can be used to inform provider and patient education strategies, practice guidelines, and clinical

1545. Breast Abnormalities Update Surveillance Assessment_CER 47_Low (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/breast-abnormalities-tests-update_surveillance.pdf
      September 01, 2012 - Studies that reported they had blinded readers to clinical information had a lower sensitivity than … Subgroup analyses found that studies that had blinded image readers to clinical information had a … Are there demographic (e.g., age) and clinical risk factors (e.g., morphologic characteristics of the … Results of a multicenter patient registry to determine the clinical impact of breast-specific gamma … Studies that reported they had blinded readers to clinical information had a lower sensitivity than

1546. Prostate-Cancer-Therapies-Update Research-Protocol (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/prostate-cancer-therapies-update_research-protocol.pdf
      April 01, 2013 - A study-design filter will be applied to retrieve systematic reviews and ongoing clinical trials. … Available at www.auanet.org/content/clinical-practice- guidelines/clinical-guidelines/main- reports/ … Basic & Clinical Biostatistics. New York: The McGraw-Hill Companies; 2004. 23. … Meta-analysis in clinical trials. Control Clin Trials. 1986 Sep;7(3):177-88. … Because of their unique clinical or content expertise, individuals are invited to serve as Technical

1547. antibiotics-respiratory-infection-protocol-140922 (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/antibiotics-respiratory-infection_research-protocol.pdf
      September 22, 2014 - Existing clinical guidelines indicate that acute bronchitis and other acute RTIs that can be caused … Clinical strategies include delayed prescribing of antibiotics or use of point-of-care diagnostic tests … A 2008 guideline by the United Kingdom’s National Institute for Health and Clinical Excellence (NICE … National Institute for Health and Clinical Excellence. … Clinical strategies, such as a clinical prediction rule, that are implemented at the system-level

1548. TND-0775-150722 (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND-0775-150722.pdf
      May 12, 2015 - Summary: comparative effectiveness of treatments for schizophrenia would inform development of clinical … practice guidelines aimed at optimizing clinical interventions and patient outcomes for individuals … potentially-relevant randomized controlled trials (RCTs) and more than 1,300 ongoing and completed clinical … RCTs (the majority focused on antipsychotic-related weight gain) and nearly 80 ongoing and completed clinical … systematic reviews, more than 500 potentially-relevant RCTs, and more than 300 ongoing and completed clinical

1549. Behavioral Programs for Type 2 Diabetes Mellitus: Current State of the Evidence (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/diabetes-behavior-programs_clinician.pdf
      November 01, 2016 - This summary is provided to assist in informed clinical decisionmaking. … However, reviews of evidence should not be construed to represent clinical recommendations or guidelines … Management of T1DM and T2DM involves clinical care and enabling patients to adopt self-management behaviors … diabetes-behavioral-programs https://www.effectivehealthcare.ahrq.gov/diabetes-behavioral-programs Overview of Clinical … Eisenberg Center for Clinical Decisions and Communications Science at Baylor College of Medicine, Houston

1550. Venous-Ulcers-Treatment-Future Research (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/venous-ulcers-treatment-future_research.pdf
      January 01, 2014 - Ongoing Clinical Trials Searches To identify ongoing clinical trials that may have addressed the future … Ongoing Clinical Trial Searches To identify ongoing clinical trials that may have addressed our future … Wound pain can be an indication of clinical 19 infection. … A-1 Gaps in Clinical Treatments Please rank the following broad types of clinical treatments … Impact –potential to change research practices, reporting practices, clinical practices and/or clinical

1551. #06 Developmental Delays ADHD, and Autism (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/06_devdelays_potential_high_impact_2012-12-10.pdf
      January 01, 2012 - Those reports are sent to various experts with clinical, health systems, health administration, and/or … practice, clinical research, health care delivery, health business, health technology assessment, … Experts are identified in the system by the perspective they bring (e.g., clinical, research, health … The ASD clinical pathway is complicated, however, by the subjective nature of diagnosis, which relies … Significant clinical opposition to its use exists because of its potential risks to children and a

1552. Disposition of Comments Report for Procalcitonin-Guides Antibiotic Therapy (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer78_procalcitonin_disposition_20121210.pdf
      October 05, 2012 - For example, studies of clinical algorithms to reduce antibiotic prescribing for acute respiratory … In routine US clinical practice, clinicians would not tolerate such interference in their clinical decision-making … U.S. clinicians respond to clinical practice guidelines. … We note uncertainty about the choice of noninferiority margin in clinical trials. … scientific programming and potential development of clinical practice guidelines.

1553. Use of Observational Studies in Systematic Reviews of (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/methodsguidenorris_060420101.pdf
      June 01, 2010 - hDepartment of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON. … RCTs may be difficult to implement due to entrenched clinical practice or to active consumer pressure … Second, existing reviews on related topics or consultation with clinical experts may also identify … In some clinical circumstances the likelihood of one or 5 more of these biases affecting studies … Evaluating medication effects outside of clinical trials: new-user designs.

1554. Use of Observational Studies in Systematic Reviews of (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guidance-observational-studies_methods.pdf
      June 01, 2010 - hDepartment of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON. … RCTs may be difficult to implement due to entrenched clinical practice or to active consumer pressure … Second, existing reviews on related topics or consultation with clinical experts may also identify … In some clinical circumstances the likelihood of one or 5 more of these biases affecting studies … Evaluating medication effects outside of clinical trials: new-user designs.

1555. Preventing Complications and Treating Symptoms of Diabetic Peripheral Neuropathy (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/diabetic-neuropathy-disposition-170707.pdf
      March 24, 2017 - Thank you for sharing your clinical experience. … Thank you for sharing your clinical experience. … NO THIS IS NOT MY OR OTHERS CLINICAL EXPERIENCE Thank you for sharing your clinical experience. … Thank you for sharing your clinical experience. … Thank you for sharing your clinical experience.

1556. Preventing Complications and Treating Symptoms of Diabetic Peripheral Neuropathy (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/diabetic-neuropathy-disposition-170707.pdf
      March 24, 2017 - Thank you for sharing your clinical experience. … Thank you for sharing your clinical experience. … NO THIS IS NOT MY OR OTHERS CLINICAL EXPERIENCE Thank you for sharing your clinical experience. … Thank you for sharing your clinical experience. … Thank you for sharing your clinical experience.

1557. #06 Developmental Delays ADHD, and Autism (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/developmental-delays-horizon-scan-high-impact-1406.pdf
      June 01, 2014 - Those reports are sent to various experts with clinical, health systems, health administration, and/or … practice, clinical research, health care delivery, health business, health technology assessment, … Experts are identified in the system by the perspective they bring (e.g., clinical, research, health … However, three clinical trials are registered, each with an intended enrollment of more than 140 total … (External, Clinical). Horizon Scanning Structured Comment Form.

1558. Protocol Amendment - Safety of Vaccines 030413 (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/vaccines-safety-protocol-130325.pdf
      September 18, 2012 - so that the FDA can monitor the safety of clinical trial subjects and ensure that the study design … What AEs are collected in clinical studies (phases I–IV) and in observational studies containing a … What AEs are collected in clinical studies (phases I–IV) and in observational studies containing a … Department of Health and Human Services: Grade 1: Mild; asymptomatic or mild symptoms; clinical … Relatively few clinical trials are designed with applicability in mind; furthermore, they sometimes

1559. Prognostic Tests (ppt file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/medical-test-reviews-prognostic.ppt
      June 01, 2012 - , clinical practices, and prognostic groups? … Clinical outcomes: Would use of the prognostic test improve patient outcomes? … Did the sample represent patients who would be tested in clinical practice? … Meta-analysis in clinical trials. Control Clin Trials 1986 Sep;7(3):177-88. … Clinical outcomes Clinical utility Prospective clinical validation Proof of concept None of the above

1560. Prognostic Tests (ppt file)
      effectivehealthcare.ahrq.gov/sites/default/files/medical-test-reviews-prognostic.ppt
      June 01, 2012 - , clinical practices, and prognostic groups? … Clinical outcomes: Would use of the prognostic test improve patient outcomes? … Did the sample represent patients who would be tested in clinical practice? … Meta-analysis in clinical trials. Control Clin Trials 1986 Sep;7(3):177-88. … Clinical outcomes Clinical utility Prospective clinical validation Proof of concept None of the above