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121. Topic Brief: Cervical Degenerative Disease (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/nt_docs/cervical-degenerative-topic-brief.pdf
     March 01, 2023 - Clinical Neurology & Neurosurgery. 2017 Nov;162:108-14. … at 2 levels: results from a prospective randomized controlled clinical trial. … Clinical neurosurgery. 2016;63(164). doi: https://doi.org/10.1227/01.neu.0000489728.54111.6e. … Clinical spine surgery.33(9):339-44. doi: https://doi.org/10.1097/BSD.0000000000001087. 47. … Incorporates issues around both clinical benefits and potential clinical harms Yes. 2d.

122. FRN 29: Future Research Needs on Procalcitonin-Guided Antibiotic Therapy (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/procalcitonin-future_research.pdf
     August 01, 2014 - May inform and help focus future clinical trials and data collection. … May inform and help focus future clinical trials and data collection. … Journal of Clinical Epidemiology 2010;63:491-501. PMID: 19540721. 11. … *Comparison between procalcitonin measurement plus clinical criteria versus clinical criteria alone to … Use of plasma procalcitonin levels as an adjunct to clinical microbiology.

123. EHC Protocol: Addressing Social Isolation To Improve Health of Older Adults: A Rapid Evidence Review (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/mhs-IV-sepsis.pdf
     July 01, 2023 - experts in patient safety with representatives of governmental agencies, healthcare stakeholders, clinical … symptoms are nonspecific (e.g., fever, nausea, vomiting, muscle pain), particularly early in its clinical … process outcomes: • Time to diagnosis or treatment • Adherence to clinical guidelines • SEP-I … validity of risk assessment and predictive systems if accompanied by evaluation of clinical utility … We will ask at least one clinical content expert and one methodological expert to review the draft

124. #05 DEPRESSION (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/depression-horizon-scan-high-impact-1412.pdf
     December 01, 2014 - Clinical trials: Multiple ongoing clinical trials are investigating off-label ketamine for treatment-resistant … of robust clinical trials. … Clinical trials: In completed and ongoing clinical trials, researchers use Child Depression Rating … (External, Clinical). Horizon Scanning Structured Comment Form. … (External, Clinical). Horizon Scanning Structured Comment Form.

125. PEPTIC ULCER #11 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/peptic-ulcer-horizon-scan-high-impact-1512.pdf
     December 01, 2015 - The clinical expert stated, “The disruption would be a good one. … (External, Clinical). Horizon Scanning Structured Comment Form. … (External, Clinical). Horizon Scanning Structured Comment Form. … (External, Clinical). Horizon Scanning Structured Comment Form. … (External, Clinical). Horizon Scanning Structured Comment Form.

126. Evidence Summary: Pharmacologic and Nonpharmacologic Therapies in Adult Patients With Exacerbation of COPD (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-221-copd-evidence-summary_0.pdf
     October 01, 2019 - Key Messages • Antibiotic therapy increases the clinical cure rate and reduces the clinical failure … • Oral and intravenous corticosteroids improve dyspnea and reduce the clinical failure rate. … cure and clinical failure. … Clinical outcomes and cost analysis of exacerbations in chronic obstructive pulmonary disease. … Clinical Investigation. 2015 01 Feb;5(2):189-204. doi: http:// dx.doi.org/10.4155/cli.14.113.

127. Methods Guide for Medical Test Reviews Chapter 11 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guidance-tests-genetic_methods.pdf
     July 01, 2012 - CLIA does not require clinical validation and many LDTs have had no clinical validation or clinical … What is the specific clinical disorder to be studied? 2. … What are the clinical findings defining this disorder? 3. … * ACCE = Analytic validity, Clinical validity, Clinical utility, and Ethical, legal and social implications … Genetic and clinical factors relating to warfarin dosing.

128. Partial Breast Irradiation for Breast Cancer: Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/product/pdf/pbi-protocol.pdf
     August 09, 2021 - Yet, significant variation in patient selection, treatment technique, and reported clinical outcomes … series" or "case studies" or "clinical study" or "clinical trial" or (("phase 0" or "phase 1" or "phase … series" or "case studies" or "clinical study" or "clinical trial" or (("phase 0" or "phase 1" or "phase … series” or “case studies” or “clinical study” or “clinical trial” or ((“phase 0” or “phase 1” or “phase … series" or "case studies" or "clinical study" or "clinical trial" or (("phase 0" or "phase 1" or "phase

129. DEMENTIA INCLUDING ALZHEIMER'S #04 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/dementia-horizon-scan-high-impact-1406.pdf
     February 01, 2015 - Those reports are sent to various experts with clinical, health systems, health administration, and/or … practice, clinical research, health care delivery, health business, health technology assessment, … The largest clinical trial to date is scheduled to conclude in 2015. … larger clinical trials; this concern may be addressed by ongoing trials … (External, Clinical). Horizon Scanning Structured Comment Form.

130. Effective Health Care (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND_0012_03-21-2008.pdf
     January 01, 2008 - Does screening for sub-clinical thyroid dysfunction reduce morbidity or mortality? 1b. … Does screening high-risk groups for sub-clinical thyroid dysfunction reduce morbidity or mortality? … Does treatment make a difference in morbidity or mortality when sub-clinical hypothyroidism or hyperthyroidism … What are the harms of treatment of sub-clinical hypothyroidism and sub-clinical hyperthyroidism? … Four related clinical trials were identified on clinicaltrials.gov.

131. Dyspnea DEcIDE (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/dyspnea_research.pdf
     April 01, 2010 - Clinical practice guidelines for palliative care: 2004. … Validation of a vertical visual analogue scale as a measure of clinical dyspnea. … Mahler DA, Guyatt GH, Jones PW Clinical measurement of dyspnea. … Evaluation of clinical methods for rating dyspnea. Chest 1988;93:580-586. 32. … A measure of quality of life for clinical trials in chronic lung disease.

132. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/antiplatelet-treatment_research-protocol.pdf
     November 22, 2011 - These questions broadly follow the ACCE framework, covering Analytic validity, Clinical validity, Clinical … and clinical outcomes in patients who are receiving clopidogrel therapy? … and clinical outcomes in patients who are receiving clopidogrel therapy? … Pharmacogenetics of CYP2C19: functional and clinical implications of a new variant CYP2C19*17. … Clinical utility: Clinical utility refers to whether a test can provide information about diagnosis

133. DEcIDE 34 - Developing a Registry of Patient Registries: Options for the Agency for Healthcare Research and Quality (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/registry-of-patient-registries-development_research_0.pdf
     February 01, 2012 - Trials Registry  WHO International Clinical Trial Registry Platform  Australian Clinical Trials … Registry  Netherlands Trial Registry  UMIN Clinical Trials Registry (Japan) The Australian Clinical … PDQ Cancer Clinical Trials Registry The Physician Data Query (PDQ) Clinical Trials Registry is a service … Clinical Trial Register (ChiCTR)  Clinical Trials Registry - India (CTRI)  German Clinical Trials … Is this clinical trial fully registered?

134. #05 DEPRESSION (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/depression-horizon-scan-high-impact-1506.pdf
     June 01, 2015 - Consulted clinical, health systems, and research experts agreed that more clinical data are needed … (External, Clinical). Horizon Scanning Structured Comment Form. … (External, Clinical). Horizon Scanning Structured Comment Form. … (External, Clinical). Horizon Scanning Structured Comment Form. … (External, Clinical). Horizon Scanning Structured Comment Form.

135. Disposition of Comments for Pharmacokinetic/Pharmacodynamic Measures for Guiding Antibiotic Treatment for Hospital-Acquired Pneumonia (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/pneumonia-antibiotic-treatment_disposition-comments.pdf
     November 24, 2014 - In the study by Lorente and colleagues, clinical success was higher with continuous infusion. … Overall Conclusion: theoretical data is not supported by current clinical data. … Because of the clinical nature of this report, we purposely focused this report for use by clinical … The target population is well defined and the key clinical questions are clearly stated. … The more important outcomes are the clinical outcomes.

136. Executive Summary_Comparative Effectiveness Review No. 259: Partial Breast Irradiation for Breast Cancer (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-259-partial-breast-irradiation-executive-summary.pdf
     January 01, 2023 - However, significant variation in patient selection, treatment technique, and reported clinical outcomes … Limitations The clinical trials included in our aggregate analysis represent a variety of treatment … Many of the included clinical trials did not report subgroup analyses, and often, the subgroups were … and tumor characteristics similar to those represented in clinical trials, for example, postmenopausal … True recurrence vs. new primary ipsilateral breast tumor relapse: an analysis of clinical and pathologic

137. Methods Guide for Medical Test Reviews Chapter 7 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guidance-tests-grading_methods.pdf
     July 01, 2012 - Matchar, M.D., Duke-NUS Medical School Singapore, Duke Center for Clinical Health Policy Research, Durham … as the mechanisms by which the test could improve clinical outcomes or cause harms. … Reviewers should carefully consider which accuracy outcomes are linked to clinical outcomes. … practice and projecting how the test would impact clinical outcomes. … Reviewers should evaluate the surrogate in the context of the clinical outcome.

138. Disposition of Comments_Comparative Effectiveness Review No. 263: Management of Postpartum Hypertensive Disorders of Pregnancy (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/hypertensive-disorders-pregnancy-disposition-comments.pdf
     May 31, 2023 - • Several reviewers commented on clinical applicability. … EPC authors believe these issues are very important for the authors of clinical practice guidelines … As such, the data will not be sufficiently useful to inform clinical practice guidelines. … We agree careful consideration should be given to the ethics and design of clinical trials. … Central blood pressure: current evidence and clinical importance.

139. CER 220 Evidence Summary: Comparative Effectiveness of Analgesics To Reduce Acute Pain in the Prehospital Setting (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-220-analgesics-acute-pain-summary.pdf
     September 01, 2019 - We do not make clinical recommendations. … Nebulized fentanyl vs intravenous morphine for ED patients with acute limb pain: a randomized clinical … A double-blind randomized clinical trial. Am J Emerg Med. 2018 Mar;36(3):376-379. … Intravenous paracetamol vs ibuprofen in renal colic: a randomised, double-blind, controlled clinical … Expedited delivery of pain medication for long- bone fractures using an intranasal fentanyl clinical

140. Layout 1 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cancer-radiation_executive.pdf
     November 01, 2009 - Four reviewers identified studies of any design describing clinical outcomes or adverse events with 10 … Each of four reviewers extracted study, patient, and treatment characteristics; clinical outcomes; and … Technical Briefs are designed to provide an overview of key issues related to clinical intervention or … Current clinical evidence on charged particle radiotherapy Notes: Each circle represents a study, … Some studies reported clinical outcomes that are relevant to the quality of life, such as eye retention