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101. Ced-Appendix-3 (xls file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/ced-appendix-3.xlsx
     June 24, 2022 - outcome(s) that is measured objectively rather than subject to clinical judgment Grace 5.1 Design … or participant-reported) be consistently reduced to a useful clinical phenotype? … trials, or from patients having the medicine in clinical practice. … trials, or from patients having the medicine in clinical practice. … clinical trial to supplement trial data or to address specific identified uncertainties.

102. Monitoring-Programs-Rapid-Research-Appendix-C (xls file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/monitoring-programs-rapid-research-appendix-c.xlsx
     October 08, 2025 - system 2) Evaluation - Identify alternative options: Evaluation of therapeutic alternatives from a clinical … technology by developing messaging and decision support tools in the EHR, educate staff to ensure clinical … team awareness, and integrate active clinical workflows 5) Sustainability - Ensure quality patient care … consolidation, and interpretation because of multiple data sources in different formats 4) Lack of clinical … The leadership vision was to transform clinical, operational, and financial performance of the health

103. Integrating Health System Data With Systematic Reviews_Methods Research Report (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-research-report-integrating-health-system-data.pdf
     April 01, 2020 - This report is not intended to be a substitute for the application of clinical judgment. … Anyone who makes decisions concerning the provision of clinical care should consider this report in … and harms/safety of a given clinical service, but rather, for example, understanding gaps in uptake … or use of a clinical service and questions and considerations of how best to implement a given clinical … Health technology assessment in Australia: a role for clinical registries?

104. PROPOSALS FOR A PHASED EVALUATION OF (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/medical-tests-proposals_research.pdf
     January 01, 2009 - It derives its name from the four components: analytic validity; clinical validity; clinical utility … Clinical efficacy of diagnostic imaging: love it or leave it. … Three dimensions of clinical efficacy assessment applied to magnetic resonance imaging. … A framework for clinical evaluation of diagnostic technologies. … How many observers are needed in clinical studies of medical imaging?

105. PROPOSALS FOR A PHASED EVALUATION OF (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/whitepaper3-lijmer02262010-2.pdf
     January 01, 2009 - It derives its name from the four components: analytic validity; clinical validity; clinical utility … Clinical efficacy of diagnostic imaging: love it or leave it. … Three dimensions of clinical efficacy assessment applied to magnetic resonance imaging. … A framework for clinical evaluation of diagnostic technologies. … How many observers are needed in clinical studies of medical imaging?

106. Back-Pain-Imaging Clinician (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/back-pain-imaging_clinician.pdf
     April 01, 2016 - Early Imaging for Back Pain and Clinical Outcomes in Older Adults: A Brief Summary of Findings and … Key Points for Clinician-Patient Discussions KEY CLINICAL ISSUE What were the clinical outcomes and … ous systematic review suggested that there is an under-representation of the older population in clinical … This increase in cost was in the absence of a clinical benefit. … construed to represent clinical recommendations or guidelines. 1.

107. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/stroke-atrial-fibrillation_research-protocol.pdf
     January 30, 2012 - consequent deterioration of mechanical function.1 AF is the most common cardiac arrhythmia seen in clinical … document could help improve the utility of their use in clinical practice. … or provide clinicians with adequate evidence to incorporate into their clinical practice. … decisionmaking (diagnostic thinking, therapeutic efficacy, and patient outcome efficacy) of clinical … or imaging tools listed for assessing thromboembolic risk o KQ 2: Other clinical tools listed for

108. Psychosocial and Pharmacologic Interventions for Disruptive Behavior in Children and Adolescents (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/disruptive-behavior-disorders-protocol.pdf
     January 31, 2023 - The American Academy of Pediatrics (AAP) intends to use the systematic evidence review to inform clinical … We added autism spectrum disorder and comorbid internalizing disorders to clinical characteristics in … Clinical setting, including medical or psychosocial care that is delivered to individuals by clinical … threshold for having disruptive behavior or a conduct problem using a validated clinical instrument … Technical Experts Technical Experts constitute a multi-disciplinary group of clinical, content, and

109. Association Between Outcomes and Dental Services in People With Substance Use Disorder: A Rapid Response Review (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/outcomes-dental-services-rapid-research.pdf
     May 01, 2025 - This report is not intended to be a substitute for the application of clinical judgment. … We also consulted our clinical subject matter experts (SMEs) for relevant clinical practice guidelines … within the clinical community were missed and to identify publications that lacked clinical applicability … clinical practice guidelines. … The clinical SMEs reviewed the final report to ensure accurate clinical contextualization of any findings

110. Disposition of Comments Report for Intravascular Diagnostic Procedures and Imaging Techniques Versus Angiography Alone in Coronary Artery Stenting (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/coronary-artery-stenting_disposition-comments.pdf
     February 26, 2013 - We do not make clinical practice recommendations, and this review should not be mistaken for a Clinical … This is a clinical phenomenon which happens in the United States and Europe. … FFR, and clinical guidelines and appropriate use criteria that are based on clinical literature. … In reviewing the clinical data for FFR and the guidelines and AUC based on the respective clinical data … .9 The clinical publications noted in Exhibit III demonstrate that OCT provides similar clinical decision-making

111. Research White Paper: Outcome Measure Harmonization and Data Infrastructure for Patient-Centered Outcomes Research in Depression (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/wysiwyg/white-paper-outcome-measure-harmonization-depression.pdf
     November 01, 2020 - This report is not intended to be a substitute for the application of clinical judgment. … Anyone who makes decisions concerning the provision of clinical care should consider this report in … Clinical Response Improvement in Depressive Symptoms— Response Patient age 18 or older with a … Further work is needed to explore the utility of the FIBSER in routine clinical care. … Harmonized Outcome Measures for Use in Depression Patient Registries and Clinical Practice.

112. Executive Summary_Systematic Review: Psychosocial and Pharmacologic Interventions for Disruptive Behavior in Children and Adolescents (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/disruptive-behavior-disorders-research-executive-summ.pdf
     April 01, 2025 - recently published evidence for psychosocial and pharmacological treatments for DBDs in order to guide clinical … • Evidence for differential benefit and harms of interventions based on patient, clinical, and treatment … was also insufficient evidence to evaluate the extent to which patient or family characteristics, clinical … Implications for Clinical and Policy Decisions Findings from this review indicate that psychosocial … The influence of race and ethnicity on psychiatric diagnoses and clinical characteristics of children

113. Making Healthcare Safer IV Rapid Review: Patient Monitoring Systems To Prevent Failure To Rescue (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/patient-monitoring-systems-rapid-review.pdf
     December 01, 2024 - ’ clinical status through the information gathered by CoNiM. … Continuous monitoring in an inpatient medical-surgical unit: a controlled clinical trial. … Automated Identification of Adults at Risk for In-Hospital Clinical Deterioration. … This report is not intended to be a substitute for the application of clinical judgment. … Integrating a Machine Learning System Into Clinical Workflows: Qualitative Study.

114. Ced -Appendix-2 (xls file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/ced%20-appendix-2.xlsx
     October 08, 2025 - CMS should consider value assessment and tie reimbursement to meaningful patient outcomes in clinical … CED should not substitute CMS analysis of clinical evidence and conclusions for decisions delegated to … Ask that AHRQ decline to support CED mechanisms or clinical studies associated with safe and effective … Benefits and risks across diverse clinical populations in diverse clinical settings, without imposing … Benefits and risks across diverse clinical populations in diverse clinical settings, without imposing

115. Liver-Cancer Research-Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/liver-cancer_research-protocol.pdf
     July 24, 2013 -  Effects on clinical decisionmaking. …  Effects on clinical decisionmaking. …  Effects on clinical decisionmaking. … • Effects on clinical decisionmaking. … • Effects on clinical decisionmaking.

116. Long-Term Drug Therapy and Drug Holidays for Osteoporotic Fracture Prevention (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/research-protocol-osteoporosis_2.pdf
     October 05, 2018 - year.[4] Many types of fractures cause pain, disability and impaired quality of life, and hip and clinical … Petak, American Association of Clinical Endocrinologists Medical Guidelines for Clinical Practice for … trial/ (553719) 72 clinical trial, phase i.pt. (20676) 73 clinical trial, phase ii.pt. (33325 … ) 74 clinical trial, phase iii.pt. (15646) 75 clinical trial, phase iv.pt. (1673) 76 controlled … . (254739) 79 clinical trial.pt. (553719) 80 exp Clinical trials as topic/ (335805) 81

117. Comparative Effectiveness of Coronary Bypass Surgery and Percutaneous Coronary Interventions for Multivessel Disease: A Pooled Analysis of Individual Patient Data from Ten Randomized Trials (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cad-pci-bypass_addendum.pdf
     February 01, 2010 - This report is intended as a reference and not as a substitute for clinical judgment. … This report may be used, in whole or in part, as the basis for development of clinical practice guidelines … of treatments for a given clinical condition. … it remained significant after adjustment for other baseline clinical characteristics. … A hierarchical Bayesian meta-analysis of randomised clinical trials of drug-eluting stents.

118. The series of articles beginning with this issue of the Journal form the most up-to-date version of the Guide for Conducting Comparative Effectiveness Reviews (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guidance-principles_methods.pdf
     August 01, 2009 - • Fully explore the clinical logic underlying the rationale for a service. … CERs have become a foundation for decisionmaking in clinical practice and health policy. … • Fully exploring the clinical logic underlying the rationale for a service. … decisions are made and illuminate disagreements about the clinical logic that underlie clinical controversies … Practical clinical trials: increasing the value of clinical research for decision making in clinical

119. 13-MDM347013 30..38 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/outcomes-testing-evaluation_research.pdf
     January 01, 2009 - different pathways than clinical management. … effect on patients from testing should have a clinical measure as the primary outcome. … Even if the clinical outcome remains pivotal in test evaluations, changes in clinical management and … These changes may amplify or attenuate the intended effect on the primary clinical outcome. … Multiple Analyses in Clinical Trials. New York: Springer; 2003. 50.

120. 13-MDM347013 30..38 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/whitepaper4-bossuyt02262010-2.pdf
     January 01, 2009 - different pathways than clinical management. … effect on patients from testing should have a clinical measure as the primary outcome. … Even if the clinical outcome remains pivotal in test evaluations, changes in clinical management and … These changes may amplify or attenuate the intended effect on the primary clinical outcome. … Multiple Analyses in Clinical Trials. New York: Springer; 2003. 50.