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121. Pharmacological Management of Crohn's Disease: Future Research Needs | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/crohns-disease-future/research
     December 01, 2019 - Skip to main content An official website of the Department of Health & Human Services Careers Contact Us Español FAQs Effective Health Care Program Powered by the Evidence-based Practice Centers …

122. Methods-Balancing-Harms-Benefits Research-2012 (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/methods-balancing-harms-benefits_research-2012.pdf
     January 01, 2012 - To consider the patient’s perspective, investigators should choose outcomes important to patients ( … e.g., mortality or function) as primary outcomes, but in many cases researchers choose an intermediate … Systematic reviews should clearly explain whether or not they choose to use a quantitative approach … If systematic reviewers decide to conduct a quantitative benefit harm assessment, they may choose among … Feasibility is obviously one of the factors that will drive the decision on which approach to choose

123. Slide 1 (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/johnson_-ahrq-mcda-presentation.pdf
     August 27, 2012 - E ff e c ts S e ri o u s S id e -E ff e c t R is k s Which treatment would you choose

124. Diagnosis and treatment of low back pain:Key questions:In patients with low back pain, what are the benefits and harms of identifying risk factors for chronicity and targeting treatment based on assessed… | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/get-involved/nominated-topics/diagnosis-and-treatment-of-low-back-painbr-key-questionsbr-olliin-patients-with-low-back-pain-what-are-the-benefits-and-harms-of-identifying-risk-factors-for-chronicity-and-targeting-treatment-based-on-assessed-riskliliin-pa
     November 01, 2017 - Nominator Information Other Information About You: (optional) Please choose a description that

125. What are the best practice Behavioral Health programs for type 1 diabetes, type 2 diabetes and gestational diabetes. Does educational counseling help paitients improve control and adherence to treatment? | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/get-involved/nominated-topics/what-are-the-best-practice-behavioral-health-programs-for-type-1-diabetes-type-2-diabetes-and-gestational-diabetes-does-educational-counseling-help-paitients-improve-control-and-adherence-to-treatment
     November 01, 2017 - Nominator Information Other Information About You: (optional) Please choose a description that

126. For patients with Crohn's disease, what treatments or therapies, alone or in conjunction with one another, provide the highest rate of disease management with the lowest risk of long term complications, particularly in young women? | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/get-involved/nominated-topics/for-patients-with-crohns-disease-what-treatments-or-therapies-alone-or-in-conjunction-with-one-another-provide-the-highest-rate-of-disease-management-with-the-lowest-risk-of-long-term-complications-particularly-in-young-wome
     November 01, 2017 - Nominator Information Other Information About You: (optional) Please choose a description that

127. Mindfulness meditation encompasses a range of meditation techniques that have been increasingly used to treat behavioral disorders, especially those associated with stress. Some of these were previously described in AHRQ Publication No.… | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/get-involved/nominated-topics/mindfulness-meditation-encompasses-a-range-of-meditation-techniques-that-have-been-increasingly-used-to-treat-behavioral-disorders-especially-those-associated-with-stress-some-of-these-were-previously-described-in-ahrq-publi
     November 01, 2017 - served populations Nominator Information Other Information About You: (optional) Please choose

128. 1. What are the benefits and harms of rhythm control compared to rate control (including newer agents) ? What are the benefits and harms of strict vs more lenient rate control? 2. What are the benefits and harms of different… | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/get-involved/nominated-topics/1-what-are-the-benefits-and-harms-of-rhythm-control-compared-to-rate-control-including-newer-agents-what-are-the-benefits-and-harms-of-strict-vs-more-lenient-rate-control-2-what-are-the-benefits-and-harms-of-different-antico
     November 01, 2017 - Nominator Information Other Information About You: (optional) Please choose a description that

129. How can patients who have chronic diseases better prepare for critical illness and the end of life? Will a decision aid, using individualized estimates of outcomes, help shared decision making about advance care planning? | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/get-involved/nominated-topics/how-can-patients-who-have-chronic-diseases-better-prepare-for-critical-illness-and-the-end-of-life-will-a-decision-aid-using-individualized-estimates-of-outcomes-help-shared-decision-making-about-advance-care-planning
     November 01, 2017 - Nominator Information Other Information About You: (optional) Please choose a description that

130. What is the comparative effectiveness of conventional CT, MDCT (including “virtual CT bronchoscopy”), PET/PET-CT, and MRI for the diagnosis or pretreatment staging of small cell and non-small cell lung cancer? | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/get-involved/nominated-topics/what-is-the-comparative-effectiveness-of-conventional-ct-mdct-including-virtual-ct-bronchoscopy-petpet-ct-and-mri-for-the-diagnosis-or-pretreatment-staging-of-small-cell-and-non-small-cell-lung-cancer
     November 01, 2017 - Nominator Information Other Information About You: (optional) Please choose a description that

131. Does the use of Cytochrome P450 2C19 (CYP2C19) testing to predict response to clopidogrel in people: (1) with acute coronary syndrome, (2) who have suffered other cardiovascular disease-related events (e.g., ischemic stroke, symptomatic… | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/get-involved/nominated-topics/does-the-use-of-cytochrome-p450-2c19-cyp2c19-testing-to-predict-response-to-clopidogrel-in-people-1-with-acute-coronary-syndrome-2-who-have-suffered-other-cardiovascular-disease-related-events-eg-ischemic-stroke-symptomatic-
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132. COPD is common and respiratory failure due to COPD is an increasingly common disorder. Use of non-invasive positive pressure ventilation (NPPV) for patients with respiratory failure due to exacerbatons of COPD. Several trials and… | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/get-involved/nominated-topics/copd-is-common-and-respiratory-failure-due-to-copd-is-an-increasingly-common-disorder-use-of-non-invasive-positive-pressure-ventilation-nppv-for-patients-with-respiratory-failure-due-to-exacerbatons-of-copd-several-trials-an
     November 01, 2017 - Please choose a description that best describes your role or perspective: (you may select more than one

133. 1. Does mass spectrometric analysis and therapeutic monitoring of tacrolimus as compared with immunoassay analysis and therapeutic monitoring produce a) better organ survival rate, b) fewer rejections, c) less nephrotoxicity and/or d) cost… | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/get-involved/nominated-topics/1-does-mass-spectrometric-analysis-and-therapeutic-monitoring-of-tacrolimus-as-compared-with-immunoassay-analysis-and-therapeutic-monitoring-produce-a-better-organ-survival-rate-b-fewer-rejections-c-less-nephrotoxicity-andor
     November 01, 2017 - none Nominator Information Other Information About You: (optional) Please choose a description

134. Description of a question or questions about a health care test or treatment: o In women with leiomyomas who are candidates for surgery, does the use of adjunctive medical treatment result in better outcomes? (Preoperative adjuvants &… | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/get-involved/nominated-topics/description-of-a-question-or-questions-about-a-health-care-test-or-treatment-o-in-women-with-leiomyomas-who-are-candidates-for-surgery-does-the-use-of-adjunctive-medical-treatment-result-in-better-outcomes-preoperative-adjuv
     November 01, 2017 - Other Information About You: (optional) Please choose a description that best describes your role

135. What evidence exists for programs to increase patient adherence to prescription medications? Which programs/approaches are most effective at increasing adherence for which populations and conditions? If little or no evidence exists, can… | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/get-involved/nominated-topics/what-evidence-exists-for-programs-to-increase-patient-adherence-to-prescription-medications-which-programsapproaches-are-most-effective-at-increasing-adherence-for-which-populations-and-conditions-if-little-or-no-evidence-ex
     November 01, 2017 - Nominator Information Other Information About You: (optional) Please choose a description that

136. Comparative effectiveness of conventional computed tomography (CT), multidetector computed tomography (MDCT) (CT colonography), fludeoxyglucose positron emission tomography (FDG-PET) or FDG-PET/CT, magnetic resonance imaging (MRI),… | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/get-involved/nominated-topics/comparative-effectiveness-of-conventional-computed-tomography-ct-multidetector-computed-tomography-mdct-ct-colonography-fludeoxyglucose-positron-emission-tomography-fdg-pet-or-fdg-petct-magnetic-resonance-imaging-mri-ultraso
     November 01, 2017 - Nominator Information Other Information About You: (optional) Please choose a description that

137. Comparative effectiveness of ultrasound (US), conventional computed tomography (CT), multidetector computed tomography (MDCT), magnetic resonance imaging (MRI), fludeoxyglucose positron emission tomography (FDG-PET) or FDG-PET/CT for the… | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/get-involved/nominated-topics/comparative-effectiveness-of-ultrasound-us-conventional-computed-tomography-ct-multidetector-computed-tomography-mdct-magnetic-resonance-imaging-mri-fludeoxyglucose-positron-emission-tomography-fdg-pet-or-fdg-petct-for-the-p
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138. Peripheral Artery Disease (PAD) - defined as peripheral artery disease of the lower extremities 1) Does aspirin reduce the risk of adverse cardiovascular events (MI, stroke, cardiovascular death) in patients with PAD? Is there a… | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/get-involved/nominated-topics/peripheral-artery-disease-pad-defined-as-peripheral-artery-disease-of-the-lower-extremities-1-does-aspirin-reduce-the-risk-of-adverse-cardiovascular-events-mi-stroke-cardiovascular-death-in-patients-with-pad-is-there-a-diffe
     November 01, 2017 - Nominator Information Other Information About You: (optional) Please choose a description that

139. For patients with PKU, there is now a pharmaceutical drug to treat this condition. In the past is was treated by medical foods that eliminated the harmful substance phenylalanine. The cost of the new drug is $70K year. The cost to treat… | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/get-involved/nominated-topics/for-patients-with-pku-there-is-now-a-pharmaceutical-drug-to-treat-this-condition-in-the-past-is-was-treated-by-medical-foods-that-eliminated-the-harmful-substance-phenylalanine-the-cost-of-the-new-drug-is-70k-year-the-cost-t
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140. Assessing-The-Risk-Of-Bias-In-Systematic-Reviews-Of-Health-Care-Interventions (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/assessing-the-risk-of-bias-in-systematic-reviews-of-health-care-interventions-01_0.pdf
     May 01, 2005 - • Recommendations for choosing instruments for assessing risk of bias o Choose risk-of-bias instruments … o Choose instruments that include items assessing specific concerns related to each of the risk of bias … o Systematic reviewers who choose to exclude high risk-of-bias studies from their analysis should explain … If reviewers choose to use or adapt an existing risk of bias tool/instrument, thoughtful consideration … First, if there are systematic reviews on the interventions (or topics) of interest, reviewers may choose