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www.ahrq.gov/sites/default/files/wysiwyg/hai/tools/mrsa/059-nursing-protocol-nasal-mupirocin.docx
October 01, 2024 - A recent study showed a mupirocin & chlorhexidine gluconate (CHG) decolonization strategy to be more … at reducing Staphylococcus aureus isolates in the intensive care unit (ICU) compared to iodophor & CHG
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www.ahrq.gov/sites/default/files/wysiwyg/hai/tools/mrsa-2/092-evidence-decolonization-one-pager.docx
April 01, 2025 - carriers at hospital admission
· Results: For patients colonized with S. aureus at hospital admission, CHG … was a 79 percent decrease in risk of developing a deep SSI due to S. aureus, both MSSA and MRSA, when CHG … who were positive received an intervention bundle that included 5 days of intranasal mupirocin and CHG
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www.ahrq.gov/sites/default/files/wysiwyg/hai/tools/mrsa/075-dec-patient-wall-poster-bathing-reminder.docx
October 01, 2024 - Have you had your CHG bath today?
AHRQ Pub.
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www.ahrq.gov/sites/default/files/wysiwyg/hai/tools/mrsa/001-clabsi-prevention-webinar-slides.pptx
October 01, 2024 - Competency of healthcare personnel involved in insertion
Proper hand hygiene
Chlorhexidine gluconate (CHG … CHG skin preparations are preferred. … During dressing changes, cleanse the site with a CHG-based skin antiseptic. … | 26
AHRQ Safety Program for MRSA Prevention | ICU & Non-ICU
Prevention of CLABSI
26
Daily CHG … Treatment or Bathing44-49
Patients with central lines should be bathed daily with CHG to help remove
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www.ahrq.gov/sites/default/files/wysiwyg/hai/tools/mrsa-2/134-translating-research-into-practice.pptx
April 01, 2025 - :
Preoperative: One-time dose, two swabs of 5% per nostril3,4
Skin Decolonization
Preferred: Pre-op CHG … bathing x5 days5
Alternative: CHG bathing night before/morning of surgery
| 4
AHRQ Safety Program
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www.ahrq.gov/sites/default/files/wysiwyg/hai/tools/mrsa-2/131-ss-swiss-cheese.pptx
April 01, 2025 - Pre-op Clinic: Exam, labs, and CHG bathing and mupirocin information given for decolonization prep prior … Post-op course: CHG and nasal decolonization protocols followed.
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www.ahrq.gov/sites/default/files/wysiwyg/hai/tools/mrsa-2/020-ss-periop-infection-prevention.pptx
April 01, 2025 - Alcohol (ethanol, isopropanol)5
Highly bactericidal and effective
No persistent activity
Chlorhexidine (CHG … Povidone-iodine (PI)6
Residual activity on skin
Skin preparation with a combination of alcohol with CHG … AHRQ Safety Program for MRSA Prevention| Surgical Services
Perioperative Infection Prevention
9
CHG-Alcohol … PI-Alcohol for Skin Antisepsis
Several studies favor CHG-alcohol over PI-alcohol.1
Single-center randomized … Skin prep antisepsis with alcohol-based antiseptic combined with either CHG or povidone-iodine is recommended
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www.ahrq.gov/sites/default/files/wysiwyg/hai/tools/mrsa-surgery/020-perioperative-infection-prevention-strategies-slides.pptx
April 01, 2025 - Alcohol (ethanol, isopropanol)5
Highly bactericidal and effective
No persistent activity
Chlorhexidine (CHG … Povidone-iodine (PI)6
Residual activity on skin
Skin preparation with a combination of alcohol with CHG … AHRQ Safety Program for MRSA Prevention| Surgical Services
Perioperative Infection Prevention
9
CHG-Alcohol … PI-Alcohol for Skin Antisepsis
Several studies favor CHG-alcohol over PI-alcohol.1
Single-center randomized … Skin prep antisepsis with alcohol-based antiseptic combined with either CHG or povidone-iodine is recommended
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www.ahrq.gov/sites/default/files/wysiwyg/hai/tools/clabsi-cauti-icu/clabsi-event-reporting_revised.docx
April 01, 2022 - ☐ YES ☐ NO
44 Did the patient received a daily chlorhexidine (CHG) bath? … What type of CHG bathing was used? … ☐ Impregnated CHG cloth ☐ CHG poured on a sponge/non-cotton cloth
☐ CHG poured into bath water
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www.ahrq.gov/sites/default/files/wysiwyg/hai/tools/mrsa/133-clabsi-prevention-central-line-insertion.docx
October 01, 2024 - after inserting, replacing, accessing, repairing, or dressing an intravascular catheter
Chlorhexidine (CHG … before insertion of central line.
· Povidone-iodine preparations should only be considered if use of CHG
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www.ahrq.gov/sites/default/files/wysiwyg/hai/tools/mrsa/040-mrsa-surveillance-notes.docx
October 01, 2024 - involving 98 patients colonized with MRSA, patients were bathed daily with chlorhexidine gluconate (CHG … In addition to CHG, they were randomized to receive either 5 days of mupirocin or 5 days of placebo, … For more information on the study and the importance of mupirocin, in addition to CHG, for decolonization … their body sites cleared of MRSA after finishing a 5-day decolonization process with both mupirocin and CHG
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www.ahrq.gov/sites/default/files/wysiwyg/hai/tools/mrsa-surgery/105-what-are-the-4-es-notes.docx
April 01, 2025 - followup with patients when they arrive for surgery as to whether they completed pre-op chlorhexidine (CHG … A review of the par levels of CHG wipes reveals that levels were consistently low over the last 6 months … It improves access to decolonizing agents, including CHG cloths and nasal decolonization agents, in the … Additionally, CHG is available in different preparations, including liquid CHG or CHG cloths.
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www.ahrq.gov/sites/default/files/wysiwyg/hai/tools/mrsa-2/022-ss-mrsa-surveillance.pptx
April 01, 2025 - proportions of patients were successfully decolonized if they underwent the 5 days of mupirocin and CHG … with 0 to 1 days of pre-operative decolonization, the majority were decolonized
While mupirocin and CHG … Perioperative Roadmap Tool Use
Use in pre-op
Patient compliance with pre-op instructions for decolonization and CHG
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www.ahrq.gov/hai/universal-icu-decolonization/universal-icu-apc.html
September 01, 2013 - Cost saved from bloodstream infections averted
(AA * (1-0.44)) * $18,000
Product cost
[($CHG
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www.ahrq.gov/sites/default/files/wysiwyg/hai/tools/mrsa-surgery/139-sample-completed-staff-safety-assessment.docx
April 01, 2025 - For example, “In Pre-op, we often forget to ask the patient if they have completed their CHG bathing
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www.ahrq.gov/sites/default/files/wysiwyg/hai/tools/mrsa-2/139-sample-completed-staff-safety-assessment.docx
April 01, 2025 - For example, “In Pre-op, we often forget to ask the patient if they have completed their CHG bathing
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www.ahrq.gov/es/hai/universal-icu-decolonization/universal-icu-apc.html
September 01, 2013 - Cost saved from bloodstream infections averted
(AA * (1-0.44)) * $18,000
Product cost
[($CHG
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www.ahrq.gov/sites/default/files/wysiwyg/professionals/quality-patient-safety/patient-safety-resources/resources/advances-in-patient-safety-2/vol2/Advances-Adams-Pizarro_109.pdf
January 08, 2008 - 14)
OR collaborative
(N = 12)
Culture
dimension Baseline
% (±SD)
Followup
% (±SD)
Rel chg … %
Baseline
% (±SD)
Followup
% (±SD)
Rel chg
%
Baseline
% (±SD)
Followup
% (±SD)
Rel chg … %
Baseline
% (±SD)
Followup
% (±SD)
Rel chg
%
Safety grade
(A/B vs. … 14)
OR collaborative
(N = 12)
Culture
dimension
Baseline
% (±SD)
Followup
% (±SD)
Rel chg … %
Baseline
% (±SD)
Followup
% (±SD)
Rel chg
%
Baseline
% (±SD)
Followup
% (±SD)
Rel chg
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www.ahrq.gov/sites/default/files/wysiwyg/hai/tools/mrsa-2/053-sample-script-iodophor.docx
April 01, 2025 - We can use CHG to clean our skin, but it isn't safe to use in the nose.
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www.ahrq.gov/hai/universal-icu-decolonization/index.html
September 01, 2013 - Educational Materials
Universal ICU Decolonization
Universal ICU Decolonization Protocol for CHG