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1. Exhibit 3.4. Cardiovascular Procedures
   hcup-us.ahrq.gov/reports/factsandfigures/figures/2005/2005_3_4.jsp
   January 01, 2005 - Cardiovascular Procedures Number of Inpatient Hospital Cardiovascular Procedures, 1993-2005

2. Microsoft Word - hcup_proj_2012-02.docx (pdf file)
   hcup-us.ahrq.gov/reports/projections/2012-02.pdf
   January 01, 2012 - HCUP Projections: Cardiovascular/Cerebrovascular Conditions and Procedures 2001 to 2012. 2012. … • cardiovascular/cerebrovascular system procedures, overall • four specific cardiovascular/cerebrovascular … The cardiovascular/cerebrovascular conditions and procedures reported in this study are identified … Cardiac Projections Return to Contents Cardiovascular/Cerebrovascular Procedures Cardiovascular … procedures • 63 Other non-OR therapeutic cardiovascular procedures HCUP Projections: Cardiovascular

3. Microsoft Word - Table1-FY2006-V3_1.doc (pdf file)
   hcup-us.ahrq.gov/toolssoftware/comorbidity/Table1-FY2006-V3_1.pdf
   December 01, 2006 - MAJOR CV DX Cardiac 554 OTHER VASCULAR PROCEDURES W CC W/O MAJOR CV DX Cardiac 555 PERCUTANEOUS CARDIOVASCULAR … PERCUTANEOUS CARDIOVASC PROC W NON-DRUG-ELUTING STENT W/O MAJ CV DX Cardiac 557 PERCUTANEOUS CARDIOVASCULAR … PROC W DRUG-ELUTING STENT W MAJOR CV DX Cardiac 558 PERCUTANEOUS CARDIOVASCULAR PROC W DRUG-ELUTING

4. Microsoft Word - Cover.doc (pdf file)
   hcup-us.ahrq.gov/db/nation/nis/APS-DRGsV20WeightsManual.pdf
   January 06, 2025 - Procedures with AMI) and 517 (Percutaneous Cardiovascular Procedures without AMI, with Coronary Artery … with AMI 527 Percutaneous Cardiovascular Procedure with Drug-Eluding Stent without AMI The … procedure that would quality them for assignment to DRG 517 (Percutaneous Cardiovascular Procedure … Procedure with Drug-Eluting Stent with AMI 516 Percutaneous Cardiovascular Procedures with AMI … 527 Percutaneous Cardiovascular Procedure with Drug-Eluting Stent without AMI 517 Percutaneous Cardiovascular

5. Coronary Artery Disease, Acute Myocardial Infarction, and Ischemic Stroke Rates Among Inpatient Stays, 2001-2014 (pdf file)
   hcup-us.ahrq.gov/reports/statbriefs/sb241-Coronary-Artery-AMI-Stroke-Hospital-Stays-2001-2014.pdf
   January 01, 2014 - Introduction Atherosclerotic cardiovascular disease (ASCVD) refers to disease of the heart and blood … ASCVD can limit blood flow to the heart (coronary artery disease) and lead to dangerous cardiovascular … Cardiovascular Disease: A Costly Burden for America, Projections Through 2035. 2017. www.heart.org/idc … Adult ASCVD inpatient stays with common cardiovascular procedures, 2001–2014 Abbreviations: ASCVD … The largest variation between the two cardiovascular procedures occurred among ASCVD stays with CABG

6. Trends in Operating Room Procedures in U.S. Hospitals, 2001—2011 - Statistical Brief #171
   hcup-us.ahrq.gov/reports/statbriefs/sb171-Operating-Room-Procedure-Trends.jsp
   March 01, 2014 - Two common cardiovascular procedures decreased from 2001—2011. … OR procedures involving the cardiovascular system decreased from 15.5 percent of all OR procedures in … system 44: Coronary artery bypass graft (CABG) Cardiovascular system 45: Percutaneous … procedures Cardiovascular system Figure 5: Other vascular OR procedures 51: Endarterectomy … , vessel of head and neck Cardiovascular system 55: Peripheral vascular bypass Cardiovascular

7. Trends in Operating Room Procedures in U.S. Hospitals, 2001–2011 (pdf file)
   hcup-us.ahrq.gov/reports/statbriefs/sb171-Operating-Room-Procedure-Trends.pdf
   September 01, 2013 - ■ Two common cardiovascular procedures decreased from 2001–2011. … OR procedures involving the cardiovascular system decreased from 15.5 percent of all OR procedures in … (PTCA) Cardiovascular system 48: Cardiac pacemaker or cardioverter/defibrillator procedures Cardiovascular … system Figure 5: Other vascular OR procedures 51: Endarterectomy, vessel of head and neck Cardiovascular … system 55: Peripheral vascular bypass Cardiovascular system Figure 6: OR procedures related to

8. Adverse Drug Events in U.S. Hospitals, 2010 Versus 2014 (pdf file)
   hcup-us.ahrq.gov/reports/statbriefs/sb234-Adverse-Drug-Events.pdf
   June 01, 2016 - caused by smooth muscle and respiratory drugs (up 24 percent) and decreased the most for ADEs caused by cardiovascular …  Rate of stays decreased most for cardiovascular drugs; average costs and length of stay increased … for ADEs caused by smooth muscle and respiratory drugs and decreased the most for ADEs caused by cardiovascular … The largest decreases were for cardiovascular drugs (down 46.2 percent), agents affecting blood constituents … drugs Digoxin, antiadrenergics, and other cardiovascular drugs Water, mineral, and uric acid metabolism

9. PRCCSR ChangeLog v20221 v20231 (xls file)
   hcup-us.ahrq.gov/toolssoftware/ccsr/PRCCSR-ChangeLog-v20231-v20241.xlsx
   December 01, 2023 - Bioprosthetic Valve into Inferior Vena Cava, Percutaneous Approach, New Technology Group 9 'CAR029' Cardiovascular … Bioprosthetic Valve into Superior Vena Cava, Percutaneous Approach, New Technology Group 9 'CAR029' Cardiovascular … Device, Bioprosthetic Valve into Right Femoral Vein, Open Approach, New Technology Group 9 'CAR029' Cardiovascular … Device, Bioprosthetic Valve into Left Femoral Vein, Open Approach, New Technology Group 9 'CAR029' Cardiovascular … XXE2X19 Measurement of Cardiac Output, Computer-aided Assessment, New Technology Group 9 'MAM010' Other cardiovascular

10. Statistical Brief #109
    hcup-us.ahrq.gov/reports/statbriefs/sb109.jsp
    April 01, 2011 -     Systemic agents not elsewhere classified‡ 2,900 0.1% 10,800 1.1% 5 6 Cardiovascular … related adverse outcomes within age group. 17 and under; psychotropics, 8.1%; antibiotics, 16.0%; cardiovascular … Cardiovascular drugs were a common cause of drug-related adverse outcomes in children and in those patients … 13.0%; 65 and older; systemic agents; 0%; other antiinfectives, 0%; agents effecting blood, 14.2%; cardiovascular … E933.0 Systemic agents not elsewhere classified‡ 963.8, 963.9, E858.1, E933.8, E933.9 Cardiovascular

11. Adverse Drug Events in U.S. Hospitals, 2010 Versus 2014 #234
    hcup-us.ahrq.gov/reports/statbriefs/sb234-Adverse-Drug-Events.jsp
    January 01, 2018 - Rate of stays decreased most for cardiovascular drugs; average costs and length of stay increased most … Cardiovascular drugs: -46.2% originated during stay, 0.7% present on admission. … Cardiovascular drugs: 34.3% originated during stay, 22.7% present on admission. … Cardiovascular drugs: 29.4% originated during stay, 7.4% present on admission. … drugs Digoxin, antiadrenergics, and other cardiovascular drugs Water, mineral, and uric acid

12. AHRQ-HCUP-Outpatient-Surgery-Infographic-v06f (pdf file)
    hcup-us.ahrq.gov/reports/infographics/AHRQ-HCUP-Outpatient-Surgery-Infographic-v06f.pdf
    March 04, 2015 - AHRQ-HCUP-Outpatient-Surgery-Infographic-v06f Obstetric Surgeries: 97.7% Cardiovascular Surgeries:

13. Exhibit 4.1 Costs for the Most Frequent Diagnoses
    hcup-us.ahrq.gov/reports/factsandfigures/figures/2005/2005_4_1B.jsp
    January 01, 2005 - Diagnoses Amount and Growth in Inflation-adjusted* Hospitalization Costs for Six of the Most Costly Cardiovascular

14. Healthcare Cost and Utilization Project (HCUP) KID Notes
    hcup-us.ahrq.gov/db/vars/prccsr_aaannn/kidnote.jsp
    September 01, 2008 - Each clinical domain is abbreviated using a three-character scheme such as CAR for Cardiovascular Procedures … PRCCSR_CAR003 indicates CCSR category for Coronary artery bypass grafts (CABG) under the clinical domain of Cardiovascular

15. Healthcare Cost and Utilization Project (HCUP) NIS Notes
    hcup-us.ahrq.gov/db/vars/prccsr_aaannn/nisnote.jsp
    September 01, 2008 - Each clinical domain is abbreviated using a three-character scheme such as CAR for Cardiovascular Procedures … PRCCSR_CAR003 indicates CCSR category for Coronary artery bypass grafts (CABG) under the clinical domain of Cardiovascular

16. Healthcare Cost and Utilization Project (HCUP) NEDS Notes
    hcup-us.ahrq.gov/db/vars/prccsr_aaannn/nedsnote.jsp
    May 01, 2015 - Each clinical domain is abbreviated using a three-character scheme such as CAR for Cardiovascular Procedures … PRCCSR_CAR003 indicates CCSR category for Coronary artery bypass grafts (CABG) under the clinical domain of Cardiovascular

17. Healthcare Cost and Utilization Project (HCUP) NRD Notes
    hcup-us.ahrq.gov/db/vars/prccsr_aaannn/nrdnote.jsp
    August 01, 2015 - Each clinical domain is abbreviated using a three-character scheme such as CAR for Cardiovascular Procedures … PRCCSR_CAR003 indicates CCSR category for Coronary artery bypass grafts (CABG) under the clinical domain of Cardiovascular

18. Section4 1 (pdf file)
    hcup-us.ahrq.gov/reports/factsandfigures/2008/pdfs/section4_1.pdf
    January 01, 2008 -  Five of the twenty most expensive conditions were cardiovascular: coronary atherosclerosis, acute …  With the exception of costs of stays for cardiac dysrhythmias, the costs for these cardiovascular

19. Clinical Classifications for Health Policy Research: Hospital Inpatient Statistics, 1995
    hcup-us.ahrq.gov/reports/natstats/his95/table2a.htm
    February 11, 2011 - Operations on the nose, mouth, and pharynx Operations on the respiratory system Operations on the cardiovascular … ___________________________________________________________________________ 7 Operations on the cardiovascular … 0.45 $30,021 $8,948 $16,429 $32,200 8.5 5.1 53.2 60 7.20 Other diagnostic cardiovascular … 0.11 $13,993 $6,795 $10,619 $16,771 5.9 0.9 56.8 62 7.21 Other non-OR therapeutic cardiovascular

20. Statistical Brief #109: Medication-Related Adverse Outcomes in U.S. Hospitals and Emergency Departments, 2008 (pdf file)
    hcup-us.ahrq.gov/reports/statbriefs/sb109.pdf
    April 01, 2011 - , such as anticoagulants; systemic agents, such as antineoplastic and immunosuppressive drugs; and cardiovascular … agents Sedatives and hypnotics Diuretics other than saluretics Other agents primarly affecting the cardiovascular … -r el at ed a dv er se ou tc om es w ith in a ge g ro up Psychotropics Antibiotics Cardiovascular … Cardiovascular drugs were a common cause of drug- related adverse outcomes in children and in those patients … E942.4 Antilipemics 972.2, E942.2 Other and unspecified agents primarily affecting the cardiovascular