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181. Chronic Kidney Disease Stages 1-3: Screening, Monitoring, and Treatment (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/kidney-disease-medicine_disposition-comments.pdf
     August 01, 2012 - Diabetic nephropathy is a rapidly growing problem and its attendant association with cardiovascular … Such non-diabetic populations may include older patients and those with hypertension, cardiovascular … Cardiovascular disease (CVD) is also an important risk condition that is encompassed by the detection … The risk of cardiovascular events is higher in Hispanic versus non-Hispanic white adults with CKD. … The draft CER focuses on endpoints for end-stage renal disease (ESRD), cardiovascular disease (CVD)

182. Future Research Needs for Treatment of Obstructive Sleep Apnea (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/sleep-apnea-treatment-future_research.pdf
     February 01, 2012 - The clinical outcomes of interest are mortality, cardiovascular disease, and diabetes, including surrogate … The clinical outcomes of interest are mortality, cardiovascular disease, and diabetes, including surrogate … While a study of mortality would require large sample sizes and long periods of followup, cardiovascular … It is known that the outcomes of interest, that is, mortality, cardiovascular disease and diabetes, … Outcomes of interest include adherence, quality of life, cost, and cardiovascular outcomes.

183. Draft Comparative Effectiveness Review Appendicies (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/renal-artery-stenosis_appendixes.pdf
     April 01, 2005 - Robert Safian, MD, FSCAIPeripheral Vascular Disease Committee Society for Cardiovascular Angiography … • Limited data on cardiovascular outcomes. … • Very limited data on cardiovascular outcomes. … Other variables related to cardiovascular disease were also found to predict death. 1 study found … • N/A Overall Summary • The 2 applicable RCTs found no difference in kidney cardiovascular,

184. Defining an Optimal Format for Presenting Research Needs (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-future-presentation-format_research.pdf
     January 01, 2019 - first expert is primarily a trialist who has designed and conducted several high impact trials in cardiovascular … : a meta-analysis of randomized trials 2009 JAMA 16418466 Aspirin for the primary prevention of cardiovascular … disease but with cardiovascular risk factors: meta-analysis of randomised controlled trials 2009 … Intern Med 17517853 Effect of rosiglitazone on the risk of myocardial infarction and death from cardiovascular … PMID Title Year Journal 18480116 Effects of different regimens to lower blood pressure on major cardiovascular

185. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/sleep-apnea_research-protocol.pdf
     March 15, 2010 - OSA has been associated with a variety of adverse clinical outcomes, such as mortality secondary to cardiovascular … gender, body mass index (BMI), existing non-insulin dependent diabetes mellitus (NIDDM), existing cardiovascular … Cardiovascular events (Congestive heart failure symptoms, stroke, arrhythmia events, coronary artery … Long-term cardiovascular outcomes in men with obstructive sleep apnoea-hypopnoea with or without treatment … Sleep-disordered breathing and cardiovascular disease: cross-sectional results of the Sleep Heart Health

186. Since their introduction in 20xx, DES have been shown in clinical trials to decrease TLR (… (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/coronary-stents-outcomes_research.pdf
     January 01, 2010 - Additional support was obtained from the National Cardiovascular Data Registry, American College of … the elderly: results from 262,700 Medicare patients in the American College of Cardiology-National Cardiovascular … Methods: Outcomes were evaluated in 262,700 patients from 650 National Cardiovascular Data Registry … This was accomplished through linkage of the American College of Cardiology National Cardiovascular … Importantly, the project was financed by the Agency for Healthcare Research and Quality, Cardiovascular

187. Methods-Guidance-Applicability Methods (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guidance-applicability_methods.pdf
     January 01, 2011 - For example, evidence of the benefits of aspirin for prevention of cardiovascular events from patients … Outcomes Composite outcomes that mix outcomes of different significance Cardiovascular trials frequently … Problems with use of composite end points in cardiovascular trials: systematic review of randomised … Lipid modification: cardiovascular risk assessment and the modification of blood lipids for the primary … and secondary prevention of cardiovascular disease.

188. Methods Guide Atkins (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/methods_guide_atkins.pdf
     January 01, 2011 - For example, evidence of the benefits of aspirin for prevention of cardiovascular events from patients … Outcomes Composite outcomes that mix outcomes of different significance Cardiovascular trials frequently … Problems with use of composite end points in cardiovascular trials: systematic review of randomised … Lipid modification: cardiovascular risk assessment and the modification of blood lipids for the primary … and secondary prevention of cardiovascular disease.

189. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/atrial-fibrillation-ablation_disposition-comments.pdf
     October 01, 2010 - Journal Cardiovascular Electrophysiology 2008; 19:762-768. 2. … Journal Cardiovascular Electrophysiology, 2007; 18:583-588. … Journal Cardiovascular Electrophysiology 2008; 19:627. … Journal Cardiovascular Electrophysiology 2008; 19:807. … Journal Cardiovascular Electrophysiology 2008; 19:621.

190. Methods Guide for Comparative Effectiveness Reviews - Expanded Guidance on Selected Quantitative Synthesis Topics (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/quantitative-synthesis-expanded-methods_methods.pdf
     March 01, 2013 - Number needed to treat with statins to prevent one cardiovascular event in 5 years. .... 11 Table 2. … For example, “cardiovascular event (yes/no)” could be defined as a composite of MI, stroke, and death … from cardiovascular disease. … Number needed to treat with statins to prevent one cardiovascular event in 5 years Trials Number … Problems with use of composite end points in cardiovascular trials: systematic review of randomised

191. Obesity (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/obesity-horizon-scan-high-impact-1406.pdf
     June 01, 2014 - They cited the importance of an ongoing cardiovascular outcomes trial to determine the true potential … [Qsymia] patients had improved cardiovascular and metabolic risk factors and a decrease in the need … As one expert representing a research perspective noted, “Serious potential adverse events (cardiovascular … Obesity and diabetes are major risk factors for cardiovascular diseases and cancer, hence, an effective … However, the concerns about 20 cardiovascular issues and breast cancer, as well as the likelihood

192. Standardized Library of Atrial Fibrillation Outcome Measures (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/wysiwyg/white-paper-library-afib.pdf
     November 15, 2018 - REFERENCE Survival All-cause mortality All-cause mortality Workgroup recommendation Survival Cardiovascular … death Cardiovascular death indicates cause of death was sudden cardiac death, MI, unstable angina … , stroke, bleeding, atrial fibrillation, repeat AF-ablations, periprocedural complication, other cardiovascular … Hicks KA, Tcheng JE, Bozkurt B, et al. 2014 ACC/AHA Key Data Elements and Definitions for Cardiovascular

193. Effective Health Care (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND_0095_04-10-2009.pdf
     January 01, 2009 - )  Cardiovascular disease is the leading cause of mortality for women in the US.

194. Noninvasive Testing for Coronary Artery Disease (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/coronary-artery-disease-testing_research-protocol.pdf
     January 15, 2015 - Quality of life • Change in angina (e.g., worsening) • MI • Heart failure • Stroke • Death • Cardiovascular … Forecasting the future of cardiovascular disease in the United States: a policy statement from the American … Nurses Association, Society for Cardiovascular Angiography and Interventions, and Society of Thoracic … of the American College of Cardiology Foundation Appropriate Use Criteria Task Force, Society for Cardiovascular … Cardiovascular imaging. 2014 Jun;7(6):593-604. PMID: 24925328. 15.

195. Microsoft Word - ehcrr#2toCSI.doc (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/atypical-antipsychotics-seniors-death_research.pdf
     August 01, 2007 - nitroglycerin use, percutaneous coronary interventions, or coronary artery bypass graft surgery), other cardiovascular … likely than new users of the atypical agents to have cerebrovascular disease, diabetes, AMI, other cardiovascular … Simultaneous assessment of short-term gastrointestinal benefits and cardiovascular risks of selective … infarction 551 2.3% 354 2.7% 1.2 0.05 Other ischemic heart disease 665 2.7% 493 3.8% 1.4 <.0001 Other cardiovascular … disease, congestive heart failure, diabetes, myocardial infarction, other ischemic heart disease, other cardiovascular

196. Effective Health Care (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND_0255_06-25-2010.pdf
     January 01, 2010 - Outcome(s): • Cardiovascular events (mortality or myocardial infarction) • In-Stent Restenosis

197. Renal Artery Stenosis Management Strategies: An Updated Comparative Effectiveness Review (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/renal-update_executive.pdf
     August 01, 2016 - The assessed outcomes included all-cause and cardiovascular mortality, cardiovascular events (including … In general, patients with histories of cardiovascular disease were at increased risk of adverse clinical … Two studies found no difference in composite cardiovascular and renal outcomes by age. … Only the CORAL (Cardiovascular Outcomes in Renal Atherosclerotic Lesions) trial explicitly incorporated … Only one trial of PTRAS versus medical therapy had a primary clinical outcome (CORAL: composite cardiovascular

198. Horizon Scanning Protocol and Operations Manual September 2015 Revision (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/ahrq-healthcare-horizon-scan-protocol-operations-manual-151001.pdf
     September 01, 2015 - Cardiovascular disease 4. Dementia (including Alzheimer’s Disease) 5. … journal from the American Heart Association that publishes original medical research related to cardiovascular … Protection (ESH) 1, 11 Annual meeting presenting hypertension and cardiovascular research X … Interventions (EuroPCR) 1, 11 Annual meeting presenting cardiovascular research X X X X X X X … Therapeutics (TCT) 1, 11 Annual meeting presenting research on cardiovascular therapies X X

199. Horizon Scanning Protocol and Operations Manual September 2015 Revision (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/ahrq-healthcare-horizon-scan-protocol-operations-manual-151001.pdf
     September 01, 2015 - Cardiovascular disease 4. Dementia (including Alzheimer’s Disease) 5. … journal from the American Heart Association that publishes original medical research related to cardiovascular … Protection (ESH) 1, 11 Annual meeting presenting hypertension and cardiovascular research X … Interventions (EuroPCR) 1, 11 Annual meeting presenting cardiovascular research X X X X X X X … Therapeutics (TCT) 1, 11 Annual meeting presenting research on cardiovascular therapies X X

200. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/cancer-ovarian-contraceptives_research-protocol.pdf
     March 13, 2012 - incidence, cervical cancer incidence, venous thromboembolic disease, neurological conditions, stroke, or cardiovascular … outcomes: diagnosis of breast cancer, cervical cancer, venous thromboembolic event (VTE), stroke, cardiovascular … lack of randomized trial data; recent experience with hormone replacement therapy for prevention of cardiovascular … The balance of other benefits and harms (particularly cardiovascular and thrombotic risks) may differ … cervical cancer incidence, venous thromboembolic disease, neurological conditions, stroke, or cardiovascular