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121. high-cholesterol-medicines-update-protocol-130516 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/high-cholestorol-medicines-update_research-protocol.pdf
     December 31, 2013 - Background and Objectives for the Systematic Review Epidemiology and Practice Guidelines Cardiovascular … Multiple trials have evaluated the effects of cholesterol reduction on cardiovascular events and mortality … Ten-­‐year mortality  from cardiovascular disease  in relation to cholesterol level among men with … and without  preexisting cardiovascular disease. … Statins for the primary prevention of cardiovascular   disease.

122. Identification and Treatment of Post-Acute Coronary Syndrome (ACS) Depression: A Systematic Review (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/acs-depression-research-protocol-amended.pdf
     February 15, 2017 - significantly increased risk of death.15 Despite the high prevalence of depression, the association with cardiovascular … about exercise, which has been demonstrated to have beneficial effects for emotional health23 and cardiovascular … Depression and cardiovascular disease: a clinical review. … disease Duloxetine Yes Hypertension Levomilnacipran4 Yes Cerebrovascular disease, Cardiovascular … Tricyclic antidepressants should be used with caution in patients with a history of cardiovascular disease

123. Layout 1 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/sleep-apnea_executive.pdf
     July 01, 2011 - Adverse clinical outcomes associated with OSA include: cardiovascular disease, hypertension, non-insulin-dependent … In addition, mortality due to cardiovascular disease, diabetes, motor vehicle accidents, and other causes … The two studies of cardiovascular mortality did not have consistent findings, and the two studies of … did for cardiovascular mortality). … • There were 2 quality A studies that evaluated cardiovascular mortality.

124. Technical Brief Summary - Impact of Community Health Worker Certification on Workforce and Service Delivery for Asthma and Other Selected Chronic Diseases (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/technical-brief-34-health-worker-certification-summary.pdf
     March 01, 2020 - asthma management control.2-4 This applies for maternal-child health and chronic conditions such as cardiovascular … literature evaluated an aspect of CHW certification and addressed outcomes related to type 2 diabetes and cardiovascular

125. Sleep-Apnea Surveillance (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/sleep-apnea_surveillance.pdf
     April 01, 2012 - The two studies of cardiovascular mortality did not have consistent findings, and the two studies of … One study of nonfatal cardiovascular disease found a significant association with baseline AHI (as … they did for cardiovascular mortality). … One study of nonfatal cardiovascular disease found a significant association with baseline AHI (as … they did for cardiovascular mortality).

126. Systematic Review on Opioid Treatments for Chronic Pain: Surveillance Report 2 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/opioid-chronic-pain-surveillance-report-2.pdf
     April 01, 2022 - It is an observational study of patients with rheumatoid arthritis that evaluated the risk of cardiovascular … Opioids vs. no opioids, long-term harms (all-cause mortality and cardiovascular events) New evidence … ) or 3 (cardiovascular events) observational studies 1 retrospective cohort study3 (n=1,320) of … Placebo): Long-Term Followup; Harms (Mortality and Cardiovascular Events) The original report included … events (myocardial infarction in 2 studies and cardiovascular mortality in 1 study) versus no opioid

127. Zikmund (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/zikmund.pdf
     May 29, 2025 - • Gets result: o Your 10-­‐year risk of cardiovascular disease  is: 14.52% Slide  3: Robert’ … Slide  4: Question Is Robert  “informed” about his cardiovascular risk?

128. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/weight-gain-prevention_research-protocol.pdf
     January 01, 2020 - with mental illness.16 Higher grades of obesity are associated with excess mortality, primarily from cardiovascular … dietary fat absorption inhibitor, orlistat, has been shown to help maintain weight loss and improve cardiovascular … of obesity-related clinical outcomes including sleep apnea, degenerative joint disease, diabetes, cardiovascular … Obesity-related clinical outcomes • Mortality • Cancer • Cardiovascular disease • Sub-fertility … Multiple risk factors for cardiovascular disease and diabetes mellitus.

129. Vitamin-D-Calcium-Protocol-130611 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/vitamin-d-calcium_research-protocol.pdf
     September 13, 2013 - combined vitamin D plus calcium intake (but not calcium intake alone) on clinical outcomes, including cardiovascular … o For clinical outcomes of cardiovascular disease (CVD), only studies of adults will be included (≥18 …  Cardiac events or symptoms  Cerebrovascular events  Peripheral vascular events or symptoms  Cardiovascular … death  Study-specific combinations of cardiovascular events o Cancer (incident or mortality) … death; and study-specific combinations of cardiovascular events • CVD intermediate outcomes (diagnosis

130. Appendix A. Long COVID Models of Care – Grey literature sources (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/long-covid-appendix-a.pdf
     December 01, 2022 - Webinar resource list; only relevant resources listed 2022 ACC Expert Consensus Decision Pathway on Cardiovascular … ; CDC = Centers for Disease Control and Prevention; COVID-19 = acute coronavirus disease 2019; CV = cardiovascular

131. Disposition of Comments Report for CER 132 Combination Therapy Versus Intensification of Statin Monotherapy: An Update (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/high-cholestorol-medicines-update_disposition-comments.pdf
     September 01, 2014 - In the ACCORD trial, the addition of fenofibrate to simvastatin did not reduce the rates of cardiovascular … lead to superior lipid outcomes, but fails to reduce atherosclerosis or lead to decreased rates of cardiovascular … , the independent, unblinded Data Safety Monitoring Committee for the >18,000 patient IMPROVE-IT cardiovascular … LDL-c is an important factor in the development of atherosclerotic cardiovascular disease and higher … LDL-c is an important factor in the development of atherosclerotic cardiovascular disease and higher

132. Evaluation of the Benefits and Harms of Aspirin for Primary Prevention of Cardiovascular Events: A Comparison of Quantitative Approaches | Effective Health Care (EHC) Program
     effectivehealthcare.ahrq.gov/products/methods-balancing-harms-benefits/research

133. Systematic Review of Breastfeeding Programs and Policies, Breastfeeding Uptake, and Maternal Health Outcomes in Developed Countries (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/breastfeeding_research-protocol.pdf
     January 01, 2020 - addressed in the 2007 AHRQ review, including hypertension, rates of myocardial infarction and other cardiovascular … other reported harms) o KQ 2: Postpartum depression, breast cancer, ovarian cancer, osteoporosis, cardiovascular … Duration of lactation and risk factors for maternal cardiovascular disease. … Lactation and maternal measures of subclinical cardiovascular disease. … Criteria diabetes, hypertension, cardiovascular outcomes (e.g., stroke, myocardial infarction)

134. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/angina-heart-attack-treatments_research-protocol.pdf
     December 11, 2012 - hospitalization for UA/NSTEMI and continued for long-term management has been shown to reduce future cardiovascular … or oral antiplatelet agents in patients undergoing percutaneous coronary intervention for improving cardiovascular … Cardiovascular disease-related death 3. Nonfatal MI 4. Revascularization 5. Stroke 6. … Definition of Terms ACS acute coronary syndrome CV cardiovascular GP glycoprotein KQ key question … diseases"[MeSH Terms] OR ("cardiovascular"[tw] AND "diseases"[tw]) OR "heart diseases"[MeSH Terms]

135. Rapid Evidence Product_Nonemergent Percutaneous Coronary Intervention Versus Optimal Medical Treatment for Stable Ischemic Heart Disease: A Rapid Response Literature Review (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/rapid-evidence-heart-disease.pdf
     October 01, 2022 - Our primary outcomes of interest were major objective cardiovascular outcomes, including mortality, … Evolocumab and Clinical Outcomes in Patients with Cardiovascular Disease. N Engl J Med. … Alirocumab and Cardiovascular Outcomes after Acute Coronary Syndrome. N Engl J Med. … Bempedoic Acid and Cardiovascular Outcomes in Statin-Intolerant Patients. N Engl J Med. … Rivaroxaban with or without Aspirin in Stable Cardiovascular Disease. N Engl J Med.

136. Contrast-Induced Nephropathy (CIN): Current State of the Evidence on Contrast Media and Prevention of CIN (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/nephropathy-contrast-induced_clinician.pdf
     August 01, 2016 - administration) 18d 4194 ⬌ – 0.80 (0.64 to 1.01) ��� Need for renal replacement therapy e 5 1740 ⬌ – NR ��� Cardiovascular … events are included except CIN (e.g., hypersensitivity reactions, need for renal replacement therapy, cardiovascular … evidence to determine whether they prevent CIN, the SOE is often insufficient for other outcomes (e.g., cardiovascular

137. Ch-7-User-Guide-To-Ocer 130129 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/ch-7-user-guide-to-ocer_130129.pdf
     March 29, 2012 - , thus confounding the relation between antihypertensive treatment and the clinical outcomes of cardiovascular … Any attempt to compare the causal effects of CCBs and diuretics on cardiovascular events would require … taking patients’ underlying risk for cardiovascular events into account through some form of covariate … For example, if we are interested in comparing cardiovascular events between subjects who are completely … Associations of kidney function with cardiovascular medication use after myocardial infarction.

138. Atrial-Fibrillation Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/atrial-fibrillation_executive.pdf
     June 01, 2013 - ); myocardial infarction; cardiovascular hospitalizations; heart failure symptoms; control of AF symptoms … mortality, cardiovascular hospitalizations, heart failure symptoms, control of AF symptoms, quality … Quality of life SOE = Insufficient (2 studies,135 patients) Note: CV = cardiovascular; KQ = Key Question … mortality, or other cardiovascular-related outcomes either in general patients with AF or in patients … Prevalence of atrial fibrillation in elderly subjects (the Cardiovascular Health Study).

139. Executive Summary: Breastfeeding and Health Outcomes for Infants and Children (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/breastfeeding-health-outcomes-research-executive-summ.pdf
     March 01, 2025 - newer primary evidence (generally the last search date of the most recent ESR) Abbreviations: CVD = cardiovascular … Abbreviations: CVD = cardiovascular disease; GI = gastrointestinal; SBP = systolic blood pressure; SOE

140. Measuring-Blood-Pressure Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/measuring-blood-pressure_executive.pdf
     January 01, 2012 - Untreated or ineffectively treated hypertension leads to increased cardiovascular morbidity and mortality … the development of numerous diseases.4 Hypertension has been identified as a major risk factor for cardiovascular … Note: AE = adverse event; BP = blood pressure; CVD = cardiovascular disease; KQ = Key Question; LVH = … Most studies included individuals with uncomplicated hypertension, without recent acute cardiovascular … Trends and cardiovascular mortality effects of state-level blood pressure and uncontrolled hypertension