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461. AHRQ Slide Template 2009 (ppt file)
     effectivehealthcare.ahrq.gov/sites/default/files/reporting.ppt
     September 01, 2009 - Cancer 2004;101:1720-32; Briel M, et al. Am J Med 2004;117:596-606. … Cancer 2004;101:1720-32. … Br J Cancer. 2004;91:1050-62. … Br J Cancer 2004;91:1050-62. … Comparative Effectiveness of Therapies for Clinically Localized Prostate Cancer.

462. Disposition of Comments_Comparative Effectiveness Review No. 265_Radiation Therapy for Metastatic Bone Disease: Effectiveness and Harms (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-265-radiation-bone-disease-disposition-comments.pdf
     August 29, 2023 - is within my area of expertise a spine surgeon who evaluates and treats patients with metastatic cancer … This is within my area of expertise a spine surgeon who evaluates and treats patients with metastatic cancer … This is within my area of expertise a spine surgeon who evaluates and treats patients with metastatic cancer … Detailed data abstraction includes information on OS, attrition (including death), tumor/other factors … Detailed data abstraction includes information on OS, attrition (including death), tumor/other factors

463. Systematic Review of Breastfeeding Programs and Policies, Breastfeeding Uptake, and Maternal Health Outcomes in Developed Countries (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/breastfeeding_research-protocol.pdf
     January 01, 2020 - ; ovarian cancer; osteoporosis; type 2 diabetes; hypertension; cardiovascular outcomes (e.g., … , ovarian cancer, osteoporosis, type 2 diabetes, hypertension, cardiovascular outcomes (e.g., stroke … Association between breastfeeding and endometrial cancer risk: Evidence from a systematic review and … Association between breastfeeding and breast cancer risk: evidence from a meta-analysis. … mortality rates and overall Table 2. ovarian cancer, mortality.

464. Layout 1 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/high-cholestorol-medications_executive.pdf
     September 01, 2009 - 28 million Americans have some form of cardiovascular disease (CVD), which causes more deaths than cancer … Harms were SAE, cancer, treatment adherence, withdrawal due to adverse events, participants with at least … Cancer Evidence pertained to all available trial populations and not only those in need of intensive … Cancer was too rare in a single small statin- niacin trial to permit any conclusion. … , the power to detect small differences in the rates of conditions, such as cancer which may have a long

465. Layout 1 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/juvenile-arthritis-dmards_executive.pdf
     September 01, 2011 - Administration (FDA) recently placed a box warning on the entire class of biologic DMARDs targeting tumor … including etanercept, infliximab, and adalimumab, due to concerns about potential increased risk of malignancy … event reporting databases provide indirect evidence that suggests a possible relationship between cancer … and exposure to tumor necrosis factor blockers. … The incidence of malignancies during a short course of DMARD treatment also appears to be very low.

466. Quality-Gap-Palliative-Hospice Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/quality-gap-palliative-hospice_executive.pdf
     October 01, 2012 - Four of these studies were based in ambulatory settings, and six were in cancer populations. … All were RCTs in cancer patients. … Palliative care needs of cancer patients in U.S. nursing homes. … A framework for assessing quality indicators for cancer care at the end of life. … Improving Supportive and Palliative Care for Adults With Cancer. Research Evidence Manual.

467. App-D-Opioid-Chronic-Pain-Surveillance-Report-3 (xls file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/app-d-opioid-chronic-pain-surveillance-report-3.xlsx
     September 30, 2015 - Pain > 3 months, currently prescribed opioids Exclusion: cancer and end-of-life treatment A. … Inclusion: Adults aged 18 to 64 years with post-surgical, non-cancer back pain; addiction to prescription … months of continuous opioid prescriptions of at least 50 morphine milligram equivalents Exclusion: cancer … Exclusion: Received past year treatment for opioid use disorder, cancer, dementia, or end-of-life care … Duration: 12 months Inclusion: Veterans aged ≥18 years with chronic non-cancer pain receiving chronic

468. Moyer_ECCS2012 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/moyer_eccs2012.pdf
     January 01, 2012 - Controversy “Those PSA  [prostate-­‐specific  antigen]  blood  tests  that check for prostate  cancer …  do more harm  than good and healthy men should no longer receive them  as part of routine cancer … o Others • Fellow travelers o American Cancer

469. Santa_ECCS2012 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/santa_eccs2012.pdf
     February 01, 2013 - tests o Electrocardiography o Exercise  test o Pap smear o Bone density o Heart imaging o Colon cancer … treatments o Antibiotics o Heartburn medications o Anti-­‐inflammatory drugs • Disease  approach o Cancer … of selected topics • Longer “stories” about more complex topics: chronic renal failure/dialysis, cancer … 22: Longer Versions  of Consumer Content • Multiple topics across a field • Complex topics • Cancer … (American Society of Clinical Oncology): “Even in cancer, more may not be better.” • Chronic  renal

470. Outcome Measures Framework: Literature Review Findings and Implications (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/wysiwyg/registry-of-patient-registries_research.pdf
     April 15, 2019 - National Cancer Institute. Cancer Data Standards Registry and Repository (caDSR) Synopsis. … National Cancer Institute. Grid-Enabled Measures (GEM). https://www.gem- beta.org/public/Home.aspx? … North American Association of Central Cancer Registries. … A framework for understanding cancer comparative effectiveness research data needs. … J Natl Cancer Inst. 2005 Nov 2;97(21):1568-74. PMID: 16264176. Epub 2005/11/03. eng. 70.

471. Fraenkel (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/fraenkel.pdf
     May 29, 2025 - 4 12” 6 lbs $1300 55 Slide 10: Untitled Pie Chart contacting  the  following  labels:  Cancer … damage • Decreasing the amount of money I spend on medications Slide  23: Deciding About Colorectal Cancer

472. Methods-Balancing-Harms-Benefits Research-2012 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-balancing-harms-benefits_research-2012.pdf
     January 01, 2012 - The National Cancer Institute (NCI), under the leadership of Dr. … registries, and placebo arms of RCTs, they first estimated the expected number of invasive breast cancers … , in situ breast cancers, hip fractures, endometrial cancers, strokes, pulmonary emboli, deep vein … The expected number of prevented invasive and in situ breast cancers was 299 per 10,000 women, with … The International Breast Cancer Study Group. Cancer Treat Rev. 1993; 19 Suppl A:73-84. 58.

473. Crohns-Disease Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/crohns-disease_executive.pdf
     February 01, 2014 - Cervical cancer (insufficient data to estimate incidence) Low The risk of cervical cancer did not differ … reported on cervical cancer. … All cancers (insufficient data to estimate incidence) Low The risk of nonmelanoma skin cancer was higher … All cancers (insufficient data to estimate incidence) Low The risk of nonmelanoma skin cancer was higher … All cancers (insufficient data to estimate incidence) Low The risk of other cancers did not differ

474. Protocol for Quantitative Assessment of Benefit and Harm analysis of Aspirin for primary prevention (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-balancing-harms-benefits_research.pdf
     February 01, 2014 - Relative Weighting of Outcomes (applies only to Gail/National Cancer Institute approach) To assign … Gail/National Cancer Institute Approach Tables 5 and 6 show the absolute numbers of expected events … CI = confidence interval; NCI = National Cancer Institute; NNH = number needed to harm; NNT = number … Weighing the risks and benefits of tamoxifen treatment for preventing breast cancer. … J Natl Cancer Inst. 1999 Nov 3; 91(21):1829-46. 11. Varadhan R, Weiss CO, Segal JB, et al.

475. Evidence Report on the (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/crohns-disease_research-protocol.pdf
     September 01, 2010 - extra-intestinal problems such as inflammatory arthritis, rashes, mouth ulcers, and increased risk of colon cancer … • For KQ3, harms of interest include mortality, lymphomas and other cancers, infections, infusion … in children Post-surgery *Adverse effects of treatment (KQ3) • Mortality • Lymphoma and other cancers … necrosis factor”[tiab] OR “tumor necrosis factor-alpha”[tiab] OR TNF[tiab] OR TNF- alpha[tiab]) AND … □ For Key Question 3, harms of medication, we will include mortality, lymphomas and other cancers

476. Improving the Management of Menopausal Symptoms in Perimenopausal and Early Postmenopausal Women: A Systematic Review (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/menopausal-symptoms-protocol-final.pdf
     October 15, 2024 - prevent chronic disease in postmenopausal women (age 50–79 years) and examined incident invasive breast cancer … estrogen plus progestin was associated with an increased risk of conditions such as heart disease, breast cancer … stroke were higher during treatment, there was no elevated risk and possibly a reduced risk of breast cancer … typically recommended when contraindications to HT are present—for example, history of hormone-sensitive cancers … • Endometrial cancer • Colorectal cancer • Ovarian cancer • Osteopenia and osteoporosis • Alzheimer

477. Improving the Management of Menopausal Symptoms in Perimenopausal and Early Postmenopausal Women: A Systematic Review (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/menopausal-symptoms-protocol.pdf
     October 15, 2024 - prevent chronic disease in postmenopausal women (age 50–79 years) and examined incident invasive breast cancer … estrogen plus progestin was associated with an increased risk of conditions such as heart disease, breast cancer … stroke were higher during treatment, there was no elevated risk and possibly a reduced risk of breast cancer … typically recommended when contraindications to HT are present—for example, history of hormone-sensitive cancers … • Endometrial cancer • Colorectal cancer • Ovarian cancer • Osteopenia and osteoporosis • Alzheimer

478. Research Protocol: Diabetes Medications for Adults With Type 2 Diabetes: An Update Focused on Monotherapy and Add-On Therapy to Metformin (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/diabetes-update-2015_research-protocol.pdf
     January 01, 2015 - 1) regarding liver injury, lactic acidosis, pancreatitis, hypoglycemia, congestive heart failure, cancer … 1) regarding liver injury, lactic acidosis, pancreatitis, hypoglycemia, congestive heart failure, cancer … Risk of bladder cancer among patients with diabetes treated with a 15 mg pioglitazone dose in Korea: … Association between longer therapy with thiazolidinediones and risk of bladder cancer: a cohort study … J Natl Cancer Inst. 2012 Sep 19;104(18):1411-21. 17. U.S. Food and Drug Administration.

479. Disposition of Comments Report for Imaging Techniques for the Diagnosis and Staging of Hepatocellular Carcinoma (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/liver-cancer_disposition-comments.pdf
     October 23, 2014 - Early HCC (1-2cm) can be difficult to find by pathology correlation even if the location of the tumor … The doubling rate, phenotype of HCC is variable from well differentiated tumors that are incapsulated … to poor differentiated tumors that are infiltrative. … is however, very good information on the influence for diagnosis of lesion size and also degree of tumor … Network (NCCN) has clinical practice guidelines on hepatobiliary cancers.5 The guidelines outline considerations

480. Defining an Optimal Format for Presenting Research Needs (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-future-presentation-format_research.pdf
     January 01, 2019 - 16705109 Anti-TNF antibody therapy in rheumatoid arthritis and the risk of serious infections and malignancies … and meta- analysis 2009 Lancet 18177773 Adjuvant chemotherapy in oestrogen-receptor-poor breast cancer … in the treatment of chronic venous leg ulcers 2006 Pharmacoeconomics 16751321 Implications of cancer … in Bayesian value of information analysis: a case of the complex health economic model for breast cancer … patients: application of statistical decision theory to the treatment of advanced ovarian cancer