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1. Radiation Therapy for Bone Metastases (pdf file)
   effectivehealthcare.ahrq.gov/sites/default/files/product/pdf/rt-bone-metatases-final-protocol-amendment.pdf
   August 10, 2022 - location, whether they are osteolytic, osteoblastic, or mixed), the mechanical stability of the affected bones … Palliation of bone metastases-exploring options beyond radiotherapy. … The role of radiation therapy in bone metastases management. … A Further Analysis of the Dutch Bone Metastasis Study. … KQ1: ("bone metastases"[Title/Abstract] OR "bone neoplasms/radiotherapy"[MeSH Terms]) AND ("external

2. Bone Diseases | Effective Health Care (EHC) Program
   effectivehealthcare.ahrq.gov/health-topics/bone-diseases

3. Osteoporosis-Bone-Fracture Executive (pdf file)
   effectivehealthcare.ahrq.gov/sites/default/files/related_files/osteoporosis-bone-fracture_executive.pdf
   March 01, 2012 - mass and microarchitectural deterioration of bone tissue, with consequent increases in bone fragility … maintenance of bone health. … When serum calcium levels are inadequate, bone tissue is resorbed from the skeleton to maintain serum … strength include bone mineral density and bone quality; some aspects of bone quality that might affect … J Bone Miner Res. 2003;18(6):1125-8. 13.

4. Bone Density | Effective Health Care (EHC) Program
   effectivehealthcare.ahrq.gov/health-topics/bone-density

5. Bone Infections | Effective Health Care (EHC) Program
   effectivehealthcare.ahrq.gov/health-topics/bone-infections

6. Bone Marrow Diseases | Effective Health Care (EHC) Program
   effectivehealthcare.ahrq.gov/health-topics/bone-marrow-diseases

7. Bone Marrow Transplantation | Effective Health Care (EHC) Program
   effectivehealthcare.ahrq.gov/health-topics/bone-marrow-transplantation

8. Bone Cancer | Effective Health Care (EHC) Program
   effectivehealthcare.ahrq.gov/health-topics/bone-cancer

9. Topic Brief: Radiation Therapy for Bone Metastases (pdf file)
   effectivehealthcare.ahrq.gov/system/files/docs/topic-brief-radiation-therapy-bone-metastases.pdf
   August 01, 2022 - Topic Brief: Radiation Therapy for Bone Metastases 1 Topic Brief: Radiation Therapy for Bone … (bone metastasis). … A 2020 population-based study of patients with bone metastases found that the incidence of bone metastases … neoplasms/sc (19257) 2 bone metastas*.ti,ab,kf. (17492) 3 or/1-2 (27965) 4 bone neoplasms/rt or ( … In a 2020 population- based study of patients with bone metastases, the incidence of bone metastasis

10. Osteoporosis-Vibration-Therapy Research-Protocol (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/osteoporosis-vibration-therapy_research-protocol.pdf
    January 01, 2020 - mass and deterioration of bone tissue.1 Osteoporosis is a significant public health problem that … tissue, directly activating mechanosensors in bone cells.33 Animal studies demonstrated that vibration … increases the anabolic (bone building) activity of bone tissue and increases bone http://www.effectivehealthcare.ahrq.gov … Good, good, good... good vibrations: the best option for better bones? … The anabolic activity of bone tissue, suppressed by disuse, is normalized by brief exposure to extremely

11. Cer-265-Radiation-Bone-Disease-Addendum-App (xls file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-265-radiation-bone-disease-addendum-app.xlsx
    May 29, 2025 - controlled trial evaluating external beam radiation therapy for the palliative treatment of metastatic bone … Analyzed at Final Follow-Up, Attrition Intervention, Comparator Prior and Concurrent Treatments Site of Bone … Metastases Characteristics of Bone Metastases Primary Tumor Histology Age, Mean Overall Population Sex … Asian: 4.4% Other: 1.2% Not reported/ unknown: 2.9% NR Comorbidities: NR Duration of pain: NR Non-bone

12. Whole-Body Vibration Therapy for Osteoporosis (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/osteoporosis-vibration-therapy_technical-brief.pdf
    January 01, 2020 - tissue. … density and deterioration of bone tissue.1 The clinical ranges for osteoporosis, osteopenia, and normal … tissue, directly activating mechanosensors in bone cells.40 Animal studies have demonstrated that vibration … increases the anabolic (bone building) activity of bone tissue and increases bone density.26,41-43 … The anabolic activity of bone tissue, suppressed by disuse, is normalized by brief exposure to extremely

13. Cer-265-Radiation-Bone-Disease-App-F (xls file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-265-radiation-bone-disease-app-f.xlsx
    January 01, 2019 - controlled trials evaluating external beam radiation therapy for the palliative treatment of metastatic bone … No Unclear Unclear Unclear Yes Fair Badzio, 2003 Yes Yes Yes No No No Yes Yes Yes Unclear Yes Fair Bone … (Sprave, 2018 above) Unclear Unclear No Unclear No No Yes No Yes No Yes Fair Steenland, 1999 Dutch Bone … (subsequent publication) NA NA Yes Unclear No No Yes No Yes NA Yes Fair van der linden, 2004 Dutch Bone … interventions evaluating external beam radiation therapy for the palliative treatment of metastatic bone

14. The Effect of Protein Intake on Health (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/effect-protein-intake-protocol-amendment.pdf
    November 29, 2023 - growth factor 1(IGF 1), a growth hormone that promotes normal growth in bones and tissues,6 and 2) … bone mineral density, bone mineral content Inclusion criteria: Bone outcomes including but not … ti,ab. 351405 2 "Bone and Bones"/ or Bone Density/ or bone diseases/ or bone diseases, metabolic/ or … bone demineralization, pathologic/ or bone resorption/ or Fractures, Bone/ or (bone disease? … or bone densit* or bone demineralization or bone health or bone mass or bone resorption or fracture*

15. Topic 0414 Imaging techniques and metastatic breast cancer tx NSD FINAL (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND-0495_05-24-2013.pdf
    January 01, 2013 - Intervention(s): Imaging techniques to assess response to treatment including, but not limited to: bone … cancer, involves the spread of cancer from the breast to other organs of the body, such as the lungs, bones …  Multiple imaging modalities such as bone scintigraphy, CT, MRI, x-ray, ultrasound, PET/CT and FDG

16. Palliative radiation therapy for bone metastases: Update of an ASTRO Evidence-Based Guideline (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/topic-nomination-bone-metastases.pdf
    February 01, 2017 - Terms common to all searches included: bone metastasis, bone metastases, radiation, and radiotherapy. … use of SBRT for nonspine metastases, highly conformal therapy can allow for treatment of vertebral bones … J Bone Miner Res. 2010;25:440-446. 32. Fizazi K, Carducci M, Smith M, et al. … A definition of "uncomplicated bone metastases" based on previous bone metastases radiation trials comparing … J Bone Oncol. 2015;4:13-17. 39. Radiation Therapy and Oncology Group.

17. Disposition of Comments_Comparative Effectiveness Review No. 265_Radiation Therapy for Metastatic Bone Disease: Effectiveness and Harms (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-265-radiation-bone-disease-disposition-comments.pdf
    August 29, 2023 - Disposition of Comments_Comparative Effectiveness Review No. 265_Radiation Therapy for Metastatic Bone … Effectiveness Review Disposition of Comments Report Title: Radiation Therapy for Metastatic Bone … Radiation Therapy for Metastatic Bone Disease: Effectiveness and Harms. … mets or lower extremity or pelvis bone mets)? … https://effectivehealthcare.ahrq.gov/products/radiation-therapy-bone-metastases/research

18. Executive Summary_The Effect of Protein Intake on Health: A Systematic Review (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/effect-protein-intake-executive-summary.pdf
    November 01, 2024 - showed mixed results on bone health measures such as turnover markers, and lumbar spine bone mineral … density, content, and bone area. … and benefit on outcomes such as bone turnover markers, bone mineral density of the lumbar spine, total … Effect of pH on bone resorption by rat osteoclasts in vitro. … Protein consumption and bone fractures in women.

19. Executive Summary: Radiation Therapy for Metastatic Bone Disease: Effectiveness and Harms (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-265-radiation-bone-disease-summary.pdf
    August 01, 2023 - Executive Summary: Radiation Therapy for Metastatic Bone Disease: Effectiveness and Harms Comparative … Effectiveness Review Number 265 Radiation Therapy for Metastatic Bone Disease: Effectiveness … and Harms Executive Summary Main Points Background and Purpose Bone metastases are … The intended audiences for this • In patients having initial palliative radiation for metastatic bone … Radiation Therapy for Metastatic Bone Disease: Effectiveness and Harms.

20. Evidence-based Practice Center Systematic Review Protocol (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/osteoporosis-bone-fracture_research-protocol.pdf
    May 14, 2010 - mass and microarchitectural deterioration of bone tissue, with consequent increases in bone fragility … Osteoporosis is diagnosed by assessing bone mineral density (BMD). … Low bone mass or density is defined as a T-score between -2.5 and - 1. … America’s bone health: The state of osteoporosis and low bone mass in our nation. … J Bone Miner Res. 2007 Mar;22(3):465-75. 4. National Osteoporosis Foundation.