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121. Serum-Free Light Chain Analysis for the Diagnosis, Management, and Prognosis of Plasma Cell Dyscrasias | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/plasma-cell-dyscrasias-sflc-assay/research-protocol
     December 01, 2019 - the spectrum and is characterized by the neoplastic proliferation of a clone of plasma cells in the bone … marrow plasma cells ≤10% Absence of end-organ damage (bone lesions, anemia, hypercalcemia, or renal … of end-organ damage (bone lesions, anemia, hypercalcemia, or renal failure) 20% of multiple … Bone marrow biopsy. Skeletal lesions. … marrow biopsies, and bone scans.

122. Vitamin-D-Calcium-Protocol-130611 (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/vitamin-d-calcium_research-protocol.pdf
     September 13, 2013 - lack of strong evidence for an association of vitamin D and calcium status with conditions other than bone …  For bone health outcomes, only RCTs of greater than 1 year in duration will be included. … content; BMD = bone mineral density; CVD = cardiovascular disease; UV = ultraviolet light … health clinical outcomes (rickets, fracture, falls, or muscle strength) • Bone health intermediate … outcomes (bone mineral density or content) • Dose-response relationship between intake levels and

123. Vitamin D | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/health-topics/vitamin-d
     March 01, 2023 - Calcium is one of the main building blocks of bone. … A lack of vitamin D can lead to bone diseases such as osteoporosis or rickets . … 14, 2010 Comparative Effectiveness of Treatments to Prevent Fractures in Men and Women with Low Bone

124. Vitamin D and Calcium: A Systematic Review of Health Outcomes | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/vitamin-d-calcium/research-protocol
     December 01, 2019 - lack of strong evidence for an association of vitamin D and calcium status with conditions other than bone … and calcium intake on surrogate or intermediate outcomes, such as hypertension, blood pressure, and bone … Abbreviations: 1,25(OH)2D = 1,25-dihydroxyvitamin D; 25(OH)D = 25-hydroxyvitamin D;BMC = bone mineral … content; BMD = bone mineral density; CVD = cardiovascular disease; UV = ultraviolet light Figure 2 … (bone mineral density or content) Dose-response relationship between intake levels and indicators

125. AHRQ Slide Template 2009 (ppt file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/topic-refinement.ppt
     March 01, 2010 - includes insulin-like growth factors, protein turnover markers, nutritional status, growth measures, bone … variables, insulin-like growth factor variables, hospitalization, bone fracture, health-related quality … The final health outcomes include mortality, hospitalization, bone fracture, and health-related quality … mineralization are associated with improvements in health outcomes of quality of life, bone fracture … mineralization are associated with improvements in health outcomes of quality of life, bone fracture

126. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/stem-cell-children_research-protocol.pdf
     November 01, 2010 - transplantation (HSCT) refers to a procedure in which hematopoietic stem cells are infused to restore bone … nonmalignant diseases, donor hematopoietic stem cells are used to “replace” the patient’s abnormal bone … brain tumors, and those derived from the peripheral nervous system (neuroblastoma), soft tissues or bone … conditions may also be treated with HSCT, and in the pediatric population include hemoglobinopathies, bone … lymphoblastic leukemia; allo: allogeneic; AML: acute myelogenous leukemia; auto: autologous; BMF: bone

127. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/plasma-cell-dyscrasias-sflc-assay_research-protocol.pdf
     May 02, 2011 - Monoclonal gammopathy of undetermined significance (MGUS)  Serum monoclonal protein ≤ 3g/dL  Bone … marrow plasma cells ≤10%  Absence of end-organ damage (bone lesions, anemia, hypercalcemia, or renal …  Asymptomatic  1% per year progress to multiple myeloma or related PCD Multiple myeloma  Bone … marrow immunostaining  Serum monoclonal protein ≥3 g/dL and/or bone marrow plasma cells ≥10%  … marrow biopsies, and bone scans

128. Cystic-Fibrosis-Hgh Surveillance (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/cystic-fibrosis-hgh_surveillance.pdf
     August 01, 2012 - Up-to-date Up-to-date Bone mineralization: Bone age: 2 November 2011 No new evidence July 2012 … [mh] OR "bone fracture*" OR "broken bone*" OR neoplasms[mh] OR neoplas* OR malignan* OR cancer OR cancers … [mh] OR "bone fracture*" OR "broken bone*" OR neoplasms[mh] OR neoplas* OR malignan* OR cancer OR cancers … However, bone mineral content does significantly improve with rhGH therapy in trials, and bone mineral … Bone Consequences and Protein Turnover/Exercise Tolerance/Bone Mineralization: No studies evaluated

129. Effectiveness of Recombinant Human Growth Hormone in the Treatment of Cystic Fibrosis — Research Protocol Document | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/cystic-fibrosis-hgh/research-protocol
     December 01, 2019 - change in FEV1); growth (height, weight, lean body mass, protein turnover); exercise tolerance; and bone … mineralization are associated with improvements in health outcomes of quality of life, bone fracture … mineralization, bone fracture or development of osteoporosis/osteopenia, mortality, glucose measures … Fractures, Bone/ 36. bone fracture$.mp. 37. broken bones.mp. 38. … Fractures, Bone/ 11. bone fracture$.mp. 12. broken bones.mp. 13.

130. Effective Health Care (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/TND_0320_06-17-2009.pdf
     January 01, 2009 - patients presenting with any of the non-specific complaints associated with these diseases (i.e., bone … savings (e.g., decreased length of stay and number of clinic visits); decreased whole body scans or bone … Are the number of bone marrow biopsies and/or whole body scans decreased in NSMM when FLCs are measured

131. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/cystic-fibrosis-hgh_research-protocol.pdf
     August 22, 2008 - CF, what is the strength of evidence that intermediate outcomes of pulmonary function, growth, and bone … mineralization are associated with improvements in health outcomes of quality of life, bone fracture … mineralization, bone fracture or development of osteoporosis/osteopenia, mortality, glucose measures … Fractures, Bone/ 36. bone fracture$.mp. 37. broken bones.mp. 38. … Published Online: January 22, 2010 15 11. bone fracture$.mp. 12. broken bones.mp.

132. Plasma-Cell-Dyscrasias-Sflc-Assay Executive (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/plasma-cell-dyscrasias-sflc-assay_executive.pdf
     August 01, 2012 - after treatment and provide prognostic information,9,10 potentially reducing the need for frequent bone … AL amyloidosis), does the use of the SFLC assay reduce the need for other diagnostic tests (e.g., bone … One C-quality retrospective study assessed the need for bone marrow examination, with the SFLC assay … The authors concluded it was not possible to eliminate the need for bone marrow testing to evaluate … Bone Marrow Transplantation. 2005 Oct;36(7):597-600. 11. Katzmann JA.

133. Imaging Techniques for Treatment Evaluation for Metastatic Breast Cancer | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/breast-cancer-imaging/technical-brief
     December 01, 2019 - Findings We identified bone scan (scintigraphy), magnetic resonance imaging (MRI), computed tomography … general, uptake of tracers such as FDG in PET/CT scans is associated with tumor response as determined by bone … Systematic Review Systematic Review Aug 29, 2023 Radiation Therapy for Metastatic Bone

134. Dp5 Maps (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/dp5_maps.pdf
     June 22, 2011 - DataPoints5Maps_heartlung[1].pdf DataPoints5Maps_rehab[1].pdf DataPoints5Maps_urethra&bone[1].pdf

135. Rapid Response: Efficacy of Dental Services for Reducing Adverse Events in Those Receiving Chemotherapy for Cancer (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/rapid-response-chemotherapy-dental.pdf
     July 01, 2023 - Some cancer treatments are associated with an increased risk of severe deterioration of the bones of … tissue. … It is standard practice to delay beginning bisphosphonates or other agents that act directly on bones … Bone Marrow Transplant. 1988 Jan;3(1):43-51. PMID: 3048469. 47. … The presenting dental status of solid tumours with bone metastases requiring bone-targeting agents

136. Bruises | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/health-topics/bruises
     You can get skin, muscle and bone bruises. Bone bruises are the most serious.

137. Effectiveness of Recombinant Human Growth Hormone (rhGH) in the Treatment of Patients With Cystic Fibrosis | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/cystic-fibrosis-hgh/research
     December 01, 2019 - 95 percent CI 7.01 to 18.12), lean body mass (LBM) (WMD 1.92 kg, 95 percent CI 1.47 to 2.37 kg)] and bone … strength (bone mineral content (WMD 192 g, 95 percent CI 110 to 273 g)] were significantly improved … IV antibiotic use during therapy, pulmonary exacerbations, health-related quality-of-life (HRQoL), bone … Improvements in bone mineral content are also promising.

138. Disposition of Comments for Treatment To Prevent Fractures in Men and Women With Low Bone Density or Osteoporosis -- Update of a 2007 Report (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/osteoporosis-bone-fracture_disposition-comments.pdf
     March 01, 2012 - Disposition of Comments for Treatment To Prevent Fractures in Men and Women With Low Bone Density or … Comments Report Research Review Title: Treatment to Prevent Fractures in Men and Women with Low Bone … mass and produced bone that was normal (e.g., no qualitative abnormalities). … Bone. 2011 Apr 1;48(4):677-92. Epub 2010 Dec 9. … The use of markers of bone turnover is not part of the scope of the review.

139. Vitamin D and Calcium: A Systematic Review of Health Outcomes (Update) | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/vitamin-d-calcium/research
     December 01, 2019 - with calcium on selected health outcomes included in the earlier review: primarily those related to bone … Available evidence focused mainly on bone health, cardiovascular diseases, or cancer outcomes. … Findings were inconsistent across studies for bone health; breast, colorectal, and prostate cancer; cardiovascular … cardiovascular outcomes, all-cause mortality, several types of cancer, and intermediate outcomes for bone

140. Imaging Techniques for Treatment Evaluation for Metastatic Breast Cancer | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/breast-cancer-imaging/research-protocol
     December 01, 2019 - Approximately 5 percent were diagnosed with distant metastases, most commonly to the bones, lungs, liver … resonance imaging (MRI), computed tomography (CT), positron emission tomography (PET), PET-CT, and bone … PET-CT 12 and abdominal ultrasound are also widely used. 11 For patients with bone-only metastases, … bone scans are the most common imaging modality, with supplemental use of x-ray, CT, MRI and/or PET-CT … Imaging bone metastases in breast cancer: techniques and recommendations for diagnosis.