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181. Facts and Figures Exhibit 2.2
     hcup-us.ahrq.gov/reports/factsandfigures/2007/exhibit2_2.jsp
     January 01, 2007 - degenerative joint disease) 105 323 1.6 3.5 206 Disorders of intervertebral discs and bones

182. Nrd 2013 Maskedstats Severity (pdf file)
     hcup-us.ahrq.gov/db/nation/nrd/stats/NRD_2013_MaskedStats_Severity.PDF
     January 01, 2013 - Liver transplant &/or intestinal transplant 2,829 0.02% 2: Heart &/or lung transplant 1,821 0.01% 3: Bone … infections 3,852 0.03% 82: Eye disorders except major infections 10,543 0.07% 89: Major cranial/facial bone … larynx & trachea procedures 1,903 0.01% 91: Other major head & neck procedures 3,538 0.02% 92: Facial bone … procedures except major cranial/facial bone procedures 10,004 0.07% 93: Sinus & mastoid procedures

183. Nrd 2012 Maskedstats Severity V2 (pdf file)
     hcup-us.ahrq.gov/db/nation/nrd/stats/NRD_2012_MaskedStats_Severity_V2.PDF
     January 01, 2012 - Liver transplant &/or intestinal transplant 2,641 0.02% 2: Heart &/or lung transplant 1,600 0.01% 3: Bone … infections 3,545 0.03% 82: Eye disorders except major infections 10,065 0.07% 89: Major cranial/facial bone … larynx & trachea procedures 1,746 0.01% 91: Other major head & neck procedures 3,410 0.03% 92: Facial bone … procedures except major cranial/facial bone procedures 9,839 0.07% 93: Sinus & mastoid procedures 2,248

184. Nrd 2011 Maskedstats V2 Severity (pdf file)
     hcup-us.ahrq.gov/db/nation/nrd/stats/NRD_2011_MaskedStats_V2_Severity.PDF
     January 01, 2011 - Liver transplant &/or intestinal transplant 2,819 0.02% 2: Heart &/or lung transplant 1,647 0.01% 3: Bone … infections 3,894 0.03% 82: Eye disorders except major infections 10,510 0.08% 89: Major cranial/facial bone … larynx & trachea procedures 1,787 0.01% 91: Other major head & neck procedures 3,512 0.03% 92: Facial bone … procedures except major cranial/facial bone procedures 10,040 0.07% 93: Sinus & mastoid procedures

185. Nrd 2010 Maskedstats Severity V2 (pdf file)
     hcup-us.ahrq.gov/db/nation/nrd/stats/NRD_2010_MaskedStats_Severity_V2.PDF
     January 01, 2010 - Liver transplant &/or intestinal transplant 2,720 0.02% 2: Heart &/or lung transplant 1,570 0.01% 3: Bone … infections 3,768 0.03% 82: Eye disorders except major infections 10,194 0.07% 89: Major cranial/facial bone … larynx & trachea procedures 1,705 0.01% 91: Other major head & neck procedures 3,253 0.02% 92: Facial bone … procedures except major cranial/facial bone procedures 10,300 0.07% 93: Sinus & mastoid procedures

186. Hospital Inpatient Statistics, 1996
     hcup-us.ahrq.gov/reports/natstats/his95/table1a.htm
     January 01, 1996 - $7,848 $14,250 $22,842 8.4 7.9 76.2 67.9 2.11.3 Cancer of bone … $9,520 $17,900 7.0 10.8 48.3 63.1 2.12.5 Secondary malignancy of bone

187. Hospital Inpatient Statistics, 1996
     hcup-us.ahrq.gov/reports/natstats/his96/table1a.htm
     January 01, 1996 - $7,848 $14,250 $22,842 8.4 7.9 76.2 67.9 2.11.3 Cancer of bone … $9,520 $17,900 7.0 10.8 48.3 63.1 2.12.5 Secondary malignancy of bone

188. Statistics From the HCUP-3 Nationwide Inpatient Sample for 1993: Principal Diagnoses
     hcup-us.ahrq.gov/reports/natstats/93dcchp.htm
     March 10, 2016 - 3,105 0.01 9.44 18,121 respiratory and intrathoracic 21 Cancer of bone … Other connective 105,775 0.30 4.20 7,470 tissue disease 212 Other bone

189. HCUP-3 Nationwide Inpatient Sample for 1994: Principal Diagnoses
     hcup-us.ahrq.gov/reports/natstats/94dcchpr.htm
     November 01, 1998 - 3,000 0.01 9.17 18,660 respiratory and intrathoracic 21 Cancer of bone … Other connective 105,812 0.31 4.00 8,159 tissue disease 212 Other bone

190. Section2 1 (pdf file)
     hcup-us.ahrq.gov/reports/factsandfigures/2007/pdfs/section2_1.pdf
     January 01, 2007 - disease Chronic obstructive pulmonary disease and bronchiectasis Disorders of intervertebral discs and bones

191. Maskedstats Nrd 2022 Core Weighted (pdf file)
     hcup-us.ahrq.gov/db/nation/nrd/stats/MaskedStats_NRD_2022_Core_Weighted.PDF
     January 01, 2022 - MARROW TRANSPLANT 6,559 0.02% 16: AUTOLOGOUS BONE MARROW TRANSPLANT WITH CC/MCC 8,808 0.03% 17: AUTOLOGOUS … BONE MARROW TRANSPLANT WITHOUT CC/MCC 179 0.00% 18: CHIMERIC ANTIGEN RECEPTOR (CAR) T-CELL AND OTHER … MARROW TRANSPLANT 2,342 0.01% 016: AUTOLOGOUS BONE MARROW TRANSPLANT WITH CC/MCC 2,760 0.01% 017: … AUTOLOGOUS BONE MARROW TRANSPLANT WITHOUT CC/MCC 68 0.00% please refer to the section on Description … DISEASES AND ARTHROPATHIES WITH MCC 5,858 0.02% 554: BONE DISEASES AND ARTHROPATHIES WITHOUT MCC 25,676

192. Maskedstats Nis 2015Q1Q3 Severity (pdf file)
     hcup-us.ahrq.gov/db/nation/nis/tools/stats/MaskedStats_NIS_2015Q1Q3_Severity.PDF
     November 08, 2017 - Liver transplant &/or intestinal transplant 1,015 0.02% 2: Heart &/or lung transplant 712 0.01% 3: Bone … infections 1,038 0.02% 82: Eye disorders except major infections 3,325 0.06% 89: Major cranial/facial bone … larynx & trachea procedures 705 0.01% 91: Other major head & neck procedures 1,216 0.02% 92: Facial bone … procedures except major cranial/facial bone procedures 3,297 0.06% 93: Sinus & mastoid procedures 670

193. Nis 2014 Maskedstats Severity (pdf file)
     hcup-us.ahrq.gov/db/nation/nis/tools/stats/NIS_2014_MaskedStats_Severity.PDF
     January 01, 2014 - Liver transplant &/or intestinal transplant 1,311 0.02% 2: Heart &/or lung transplant 921 0.01% 3: Bone … infections 1,348 0.02% 82: Eye disorders except major infections 4,462 0.06% 89: Major cranial/facial bone … larynx & trachea procedures 1,017 0.01% 91: Other major head & neck procedures 1,561 0.02% 92: Facial bone … procedures except major cranial/facial bone procedures 4,302 0.06% 93: Sinus & mastoid procedures 958

194. Nis 2013 Maskedstats Severity (pdf file)
     hcup-us.ahrq.gov/db/nation/nis/tools/stats/NIS_2013_MaskedStats_Severity.PDF
     January 01, 2013 - Liver transplant &/or intestinal transplant 1,239 0.02% 2: Heart &/or lung transplant 897 0.01% 3: Bone … infections 1,893 0.03% 82: Eye disorders except major infections 5,112 0.07% 89: Major cranial/facial bone … larynx & trachea procedures 978 0.01% 91: Other major head & neck procedures 1,551 0.02% 92: Facial bone … procedures except major cranial/facial bone procedures 4,559 0.06% 93: Sinus & mastoid procedures 1,004

195. Nis 2011 Maskedstats Severity (pdf file)
     hcup-us.ahrq.gov/db/nation/nis/tools/stats/NIS_2011_MaskedStats_Severity.PDF
     January 01, 2011 - Liver transplant &/or intestinal transplant 1,120 0.01% 2: Heart &/or lung transplant 988 0.01% 3: Bone … infections 2,177 0.03% 82: Eye disorders except major infections 5,664 0.07% 89: Major cranial/facial bone … larynx & trachea procedures 988 0.01% 91: Other major head & neck procedures 1,701 0.02% 92: Facial bone … procedures except major cranial/facial bone procedures 4,881 0.06% 93: Sinus & mastoid procedures 1,253

196. Kid 2012 Maskedstats Severity (pdf file)
     hcup-us.ahrq.gov/db/nation/kid/tools/stats/KID_2012_MaskedStats_Severity.PDF
     January 01, 2012 - Liver transplant &/or intestinal transplant 397 0.01% 2: Heart &/or lung transplant 329 0.01% 3: Bone … infections 2,025 0.06% 82: Eye disorders except major infections 4,353 0.14% 89: Major cranial/facial bone … larynx & trachea procedures 800 0.03% 91: Other major head & neck procedures 179 0.01% 92: Facial bone … procedures except major cranial/facial bone procedures 5,544 0.17% 93: Sinus & mastoid procedures 1,008

197. 2011Nedserratanotification022415 (pdf file)
     hcup-us.ahrq.gov/db/nation/neds/2011NEDSErrataNotification022415.pdf
     February 01, 2015 - 84,142 20: Cancer; other respiratory and intrathoracic -- 778 639 917 788 647 928 21: Cancer of bone … connective tissue disease -- 2,168,153 2,072,366 2,263,940 2,153,405 2,057,316 2,249,493 212: Other bone … Cancer; other respiratory and intrathoracic -- 88.3% 83.0% 93.6% 86.5% 81.0% 91.9% 21: Cancer of bone … Cancer; other respiratory and intrathoracic -- 0.00% 0.00% 0.00% 0.00% 0.00% 0.00% 21: Cancer of bone … Cancer; other respiratory and intrathoracic -- 3.39% 0.51% 6.27% 3.35% 0.50% 6.19% 21: Cancer of bone

198. Kid 2022 Maskedstats Core (pdf file)
     hcup-us.ahrq.gov/db/nation/kid/tools/stats/KID_2022_MaskedStats_Core.PDF
     January 01, 2022 - MARROW TRANSPLANT 906 0.03% 16: AUTOLOGOUS BONE MARROW TRANSPLANT WITH CC/MCC 587 0.02% 17: AUTOLOGOUS … BONE MARROW TRANSPLANT WITHOUT CC/MCC <= 10 *.**% 18: CHIMERIC ANTIGEN RECEPTOR (CAR) T-CELL AND OTHER … TRACHEOSTOMY FOR FACE, MOUTH AND NECK DIAGNOSES OR LARYNGECTOMY WITH CC <= 10 *.**% 014: ALLOGENEIC BONE … BONE MARROW TRANSPLANT WITHOUT CC/MCC <= 10 *.**% 018: CHIMERIC ANTIGEN RECEPTOR (CAR) T-CELL AND OTHER … DISEASES AND ARTHROPATHIES WITH MCC 102 0.00% 554: BONE DISEASES AND ARTHROPATHIES WITHOUT MCC 308

199. Kid 2022 Maskedstats Core Weighted (pdf file)
     hcup-us.ahrq.gov/db/nation/kid/tools/stats/KID_2022_MaskedStats_Core_Weighted.PDF
     January 01, 2022 - .**% 14: ALLOGENEIC BONE MARROW TRANSPLANT 1,240 0.02% 16: AUTOLOGOUS BONE MARROW TRANSPLANT WITH CC … /MCC 802 0.01% 17: AUTOLOGOUS BONE MARROW TRANSPLANT WITHOUT CC/MCC <= 50 *.**% 18: CHIMERIC ANTIGEN … TRACHEOSTOMY FOR FACE, MOUTH AND NECK DIAGNOSES OR LARYNGECTOMY WITH CC <= 50 *.**% 014: ALLOGENEIC BONE … BONE MARROW TRANSPLANT WITHOUT CC/MCC <= 50 *.**% 018: CHIMERIC ANTIGEN RECEPTOR (CAR) T-CELL AND OTHER … DISEASES AND ARTHROPATHIES WITH MCC 139 0.00% 554: BONE DISEASES AND ARTHROPATHIES WITHOUT MCC 416

200. Nis 2004 Summarystats 10Pct Severity A (pdf file)
     hcup-us.ahrq.gov/db/nation/nis/tools/stats/NIS_2004_SummaryStats_10PCT_SEVERITY_A.PDF
     January 01, 2004 - Frequency Percent of Total 1: LIVER TRANSPLANT 142 0.02 2: HEART &/OR LUNG TRANSPLANT 51 0.01 3: BONE … PROCEDURES EXCEPT MAJOR CRANIAL/FACIAL BONE PROCEDURES 608 0.08 93: SINUS & MASTOID PROCEDURES 161 … DISEASES & ARTHROPATHIES W/O CC 445 0.06 2461: BONE DISEASES & ARTHROPATHIES W CC 468 0.06 2462: BONE … MARROW TRANSPLANT W/O CC 30 0.00 4811: BONE MARROW TRANSPLANT W CC 137 0.02 4812: BONE MARROW TRANSPLANT … 316 0.04 MUS17: Fracture or Sprain: Ankle 2369 0.30 MUS18: Fracture, Dislocation, or Sprain: Facial Bones