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41. Assessing Applicability: Interactive Case Study Quiz (ppt file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/assessing-applicability-quiz.ppt
    September 02, 2013 - A study shows that the use of a new medication in male astronauts, 25 to 35 years of age, prevents bone … In addition, bone mineral density is a surrogate end point for the risk of bone fracture, which limits … In addition, bone mineral density is a surrogate end point for the risk of bone fracture, which limits … In addition, bone mineral density is a surrogate end point for the risk of bone fracture, which limits … In addition, bone mineral density is a surrogate end point for the risk of bone fracture, which limits

42. Assessing Applicability: Interactive Case Study Quiz (ppt file)
    effectivehealthcare.ahrq.gov/sites/default/files/assessing-applicability-quiz.ppt
    September 02, 2013 - A study shows that the use of a new medication in male astronauts, 25 to 35 years of age, prevents bone … In addition, bone mineral density is a surrogate end point for the risk of bone fracture, which limits … In addition, bone mineral density is a surrogate end point for the risk of bone fracture, which limits … In addition, bone mineral density is a surrogate end point for the risk of bone fracture, which limits … In addition, bone mineral density is a surrogate end point for the risk of bone fracture, which limits

43. CER 174 Executive Summary: Imaging for the Pretreatment of Small Cell Lung Cancer (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/lung-cancer-staging_executive.pdf
    April 01, 2016 - scintigraphy, bone scan). … of osseous (bone or bone marrow) metastases; this evidence base comprised two studies making direct … or bone marrow). … or bone marrow) MDCT vs. … Bone scintigraphy; 1 study, n=28 MDCT vs. FDG PET/CT; 1 study, n=29 Bone scintigraphy vs.

44. Disposition of Comments Report for Whole-Body Vibration Therapy for Osteoporosis (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/osteoporosis-vibration-therapy_disposition-comments.pdf
    November 15, 2011 - The effective stress on the bone by this method is the combined stress on the bone from low-level vibration … input and the stress on the bone by optimal muscle contraction. … vibration displacements and optimal muscle contraction will prevent damage to the cartilage or brittle bones … J Bone Miner Res 2008; 23: 1318-25, in the discussion of safety issues. … For example, normal bone density is a T-score greater than or equal to -1.0.

45. Comparative Effectiveness of Treatments To Prevent Fractures in Men and Women With Low Bone Density or Osteoporosis | Effective Health Care Program
    effectivehealthcare.ahrq.gov/products/osteoporosis
    December 17, 2007 - Comparative Effectiveness of Treatments To Prevent Fractures in Men and Women With Low Bone Density or … Archived Comparative Effectiveness of Treatments To Prevent Fractures in Men and Women With Low Bone

46. Disposition of Comments Report for Imaging Techniques for Treatment Evaluation for Metastatic Breast Cancer (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/breast-cancer-imaging_disposition-comments.pdf
    October 01, 2014 - We have deleted “physical and chemical” in the bone scan description and now state that “bone scans … are used to identify areas of damage to the bones…” We agree that bone scans do not assess the extent … For exemple, 18F-FNa (assessing bone metastasis) is also FDA approved. … Page 32 line 39-40: Too restrictive, since only bone is mentioned. … Specifically how to follow bone metastasis is unclear, and the exclusion of the bone dominant patients

47. The Performance of Fusion Procedures for Degenerative Disease of the Lumbar Spine (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/lumbar-spinal-fusion-key-question.pdf
    January 01, 2023 - graft extenders and biologic substitutes (demineralized bone matrix, cadaveric allograft, cortical … fibers, bone morphogenic protein, cellular allografts)? … harms (KQ1-4, 6) Interventions: • Surgical treatment with diskectomy and spinal fusion using bone … fibers, bone morphogenic protein, cellular allografts) OUTCOMES (1A) Reduction in back pain and … Poor Bone Quality, Multilevel Surgery, and Narrow and Tall Cages Are Associated with Intraoperative

48. Breast-Cancer-Imaging Technical-Brief (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/breast-cancer-imaging_technical-brief.pdf
    October 01, 2014 - Approximately 5 percent were diagnosed with distant metastases, most commonly to the bones, lungs, liver … Bone Scan (Scintigraphy) Bone scans are used to identify areas of damage to the bones throughout the … The most commonly used radiotracer for bone scans is technetium-99m.26 Safety issues pertaining to bone … metastatic breast cancer, since healing bones may appear as “flares” on bone scans, and treatment that … choice unless a bone lesion is found, since treating bone lesions has large effect on the patient’s

49. Comparative Effectiveness of Treatments To Prevent Fractures in Men and Women With Low Bone Density or Osteoporosis | Effective Health Care (EHC) Program
    effectivehealthcare.ahrq.gov/products/osteoporosis/research
    December 17, 2007 - Systematic Review Comparative Effectiveness of Treatments To Prevent Fractures in Men and Women With Low Bone … reduction and the harms from adverse events (AE) among and within the various classes of treatment for low bone

50. CER 218 Disposition of Comments: Long-Term Drug Therapy and Drug Holidays for Osteoporosis Fracture Prevention (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/cer-218-osteoporosis-disposition-comments.pdf
    April 23, 2019 - Effect of denosumab on bone density and turnover in postmenopausal w omen w ith low bone mass after … Bone 2008;43:222-229. … Effect of denosumab on bone density and turnover in postmenopausal w omen w ith low bone mass after … J Bone Miner Res 2018;33:190-198. 5Tsourdi E, Zillikens MC. … Effect of denosumab on bone density and turnover in postmenopausal women with low bone mass after long

51. CER 218 Disposition of Comments: Long-Term Drug Therapy and Drug Holidays for Osteoporosis Fracture Prevention (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-218-osteoporosis-disposition-comments.pdf
    April 23, 2019 - Effect of denosumab on bone density and turnover in postmenopausal w omen w ith low bone mass after … Bone 2008;43:222-229. … Effect of denosumab on bone density and turnover in postmenopausal w omen w ith low bone mass after … J Bone Miner Res 2018;33:190-198. 5Tsourdi E, Zillikens MC. … Effect of denosumab on bone density and turnover in postmenopausal women with low bone mass after long

52. Hip-Fracture-Pain Consumer (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/hip-fracture-pain_consumer.pdf
    May 01, 2011 - A broken hip is a break in the thigh bone (called the “femur”) near the hip joint. … The femur is one of the strongest bones in your body, but it may weaken with age. … Even a minor injury may cause the bone to break. … People who have a bone-weakening condition called “osteoporosis” are more likely to break a hip.

53. Effective Health Care (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND_0277_03-10-2008.pdf
    January 01, 2008 - Document Completion Date: 6-2-09 1 Results of Topic Selection Process & Next Steps  Bone … )  A more specific term for ‘bone marrow transplantation’ is ‘hematopoietic stem cell transplantation … with HSCT, a comprehensive review that focuses on both benefits and harms across a set of diseases Bone

54. Serum-Free Light Chain Analysis for the Diagnosis, Management, and Prognosis of Plasma Cell Dyscrasias | Effective Health Care (EHC) Program
    effectivehealthcare.ahrq.gov/products/plasma-cell-dyscrasias-sflc-assay/research-protocol
    May 02, 2011 - the spectrum and is characterized by the neoplastic proliferation of a clone of plasma cells in the bone … marrow with resulting end-organ damage, including skeletal destruction (lytic bone lesions), hypercalcemia … marrow plasma cells ≤10% Absence of end-organ damage (bone lesions, anemia, hypercalcemia, or renal … Bone marrow biopsy. Skeletal lesions. … marrow biopsies, and bone scans.

55. Comparative Effectiveness of Hematopoietic Stem-cell Transplantation in the Pediatric Population | Effective Health Care (EHC) Program
    effectivehealthcare.ahrq.gov/products/stem-cell-children/research-protocol
    August 05, 2010 - transplantation (HSCT) refers to a procedure in which hematopoietic stem cells are infused to restore bone … nonmalignant diseases, donor hematopoietic stem cells are used to “replace” the patient’s abnormal bone … brain tumors, and those derived from the peripheral nervous system (neuroblastoma), soft tissues or bone … conditions may also be treated with HSCT, and in the pediatric population include hemoglobinopathies, bone … marrow" 16:46:12 227780 #45 Search "Bone Marrow Transplantation"[Mesh] OR ("Hematopoietic Stem

56. Imaging for Pretreatment Staging of Small Cell Lung Cancer | Effective Health Care (EHC) Program
    effectivehealthcare.ahrq.gov/products/lung-cancer-staging/research-protocol
    December 08, 2014 - , bone marrow, and brain. 7 The first system, the Veterans Administration Lung Study Group (VALSG) … Bone Scintigraphy Bone scintigraphy uses a gamma camera to create two-dimensional images of the distribution … Scintigraphy of radiotracers that localize to the bones is useful in cancer staging because areas of … scintigraphy indirectly reveals sites of metabolic bone turnover in reaction to bone marrow metastatic … scan” OR “bone scintigraphy” OR (bone AND scan*) 5 Imaging 'endosonography' OR 'eus' OR (endoscop

57. Disposition of Comments Report for Vitamin D and Calcium: A Systematic Review of Health Outcomes (Update) (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/vitamin-d-calcium_disposition-comments.pdf
    September 15, 2014 - This failure to follow the bone protocol was probably the reason the bone data was never published … performance measures) and “bone density/bone mineral content” for both vitamin D alone and combined … These bone-related sections are separated by sections on non-bone related outcomes (mortality, and … I think the totality of evidence for “bone health” would be easier to gauge if bone density/bone mineral … content section was placed after the material on the clinical bone outcomes.

58. Protocol: Imaging for Pretreatment Staging of Small Cell Lung Cancer (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/lung-cancer-staging_research-protocol.pdf
    December 08, 2014 - , bone marrow, and brain.7 Some debate exists about which system should be used. … Bone Scintigraphy Bone scintigraphy uses a gamma camera to create two-dimensional images of the distribution … Scintigraphy of radiotracers that localize to the bones is useful in cancer staging because areas of … scintigraphy indirectly reveals sites of metabolic bone turnover in reaction to bone marrow metastatic … scan” OR “bone scintigraphy” OR (bone AND scan*) 5 'endosonography' OR 'eus' OR (endoscop* AND (ultrasound

59. Vitamin D and Calcium: A Systematic Review of Health Outcomes | Effective Health Care (EHC) Program
    effectivehealthcare.ahrq.gov/products/vitamin-d-calcium/research-protocol
    June 10, 2013 - released in 1997, based the recommended levels of vitamin D and calcium on the role of these nutrients in bone … lack of strong evidence for an association of vitamin D and calcium status with conditions other than bone … Abbreviations: 1,25(OH)2D = 1,25-dihydroxyvitamin D; 25(OH)D = 25-hydroxyvitamin D;BMC = bone mineral … content; BMD = bone mineral density; CVD = cardiovascular disease; UV = ultraviolet light Figure 2 … (bone mineral density or content) Dose-response relationship between intake levels and indicators

60. Vitamin-D-Calcium-Protocol-130611 (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/vitamin-d-calcium_research-protocol.pdf
    September 13, 2013 - lack of strong evidence for an association of vitamin D and calcium status with conditions other than bone …  For bone health outcomes, only RCTs of greater than 1 year in duration will be included. … content; BMD = bone mineral density; CVD = cardiovascular disease; UV = ultraviolet light … health clinical outcomes (rickets, fracture, falls, or muscle strength) • Bone health intermediate … outcomes (bone mineral density or content) • Dose-response relationship between intake levels and