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21. Radiation Therapy for Bone Metastases | Effective Health Care (EHC) Program
    effectivehealthcare.ahrq.gov/products/radiation-therapy-bone-metastases/protocol

22. | Effective Health Care (EHC) Program
    effectivehealthcare.ahrq.gov/health-topics/pagets-disease-of-bone

23. Executive Summary_The Effect of Protein Intake on Health: A Systematic Review (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/effect-protein-intake-executive-summary.pdf
    November 01, 2024 - showed mixed results on bone health measures such as turnover markers, and lumbar spine bone mineral … density, content, and bone area. … and benefit on outcomes such as bone turnover markers, bone mineral density of the lumbar spine, total … Effect of pH on bone resorption by rat osteoclasts in vitro. … Protein consumption and bone fractures in women.

24. Disposition of Comments_Comparative Effectiveness Review No. 265_Radiation Therapy for Metastatic Bone Disease: Effectiveness and Harms (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-265-radiation-bone-disease-disposition-comments.pdf
    August 29, 2023 - Disposition of Comments_Comparative Effectiveness Review No. 265_Radiation Therapy for Metastatic Bone … Effectiveness Review Disposition of Comments Report Title: Radiation Therapy for Metastatic Bone … Radiation Therapy for Metastatic Bone Disease: Effectiveness and Harms. … mets or lower extremity or pelvis bone mets)? … https://effectivehealthcare.ahrq.gov/products/radiation-therapy-bone-metastases/research

25. Executive Summary: Radiation Therapy for Metastatic Bone Disease: Effectiveness and Harms (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-265-radiation-bone-disease-summary.pdf
    August 01, 2023 - Executive Summary: Radiation Therapy for Metastatic Bone Disease: Effectiveness and Harms Comparative … Effectiveness Review Number 265 Radiation Therapy for Metastatic Bone Disease: Effectiveness … and Harms Executive Summary Main Points Background and Purpose Bone metastases are … The intended audiences for this • In patients having initial palliative radiation for metastatic bone … Radiation Therapy for Metastatic Bone Disease: Effectiveness and Harms.

26. Assessing Applicability: Interactive Case Study Quiz (ppt file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/assessing-applicability-quiz.ppt
    May 29, 2025 - A study shows that the use of a new medication in male astronauts, 25 to 35 years of age, prevents bone … In addition, bone mineral density is a surrogate end point for the risk of bone fracture, which limits … In addition, bone mineral density is a surrogate end point for the risk of bone fracture, which limits … In addition, bone mineral density is a surrogate end point for the risk of bone fracture, which limits … In addition, bone mineral density is a surrogate end point for the risk of bone fracture, which limits

27. Assessing Applicability: Interactive Case Study Quiz (ppt file)
    effectivehealthcare.ahrq.gov/sites/default/files/assessing-applicability-quiz.ppt
    May 29, 2025 - A study shows that the use of a new medication in male astronauts, 25 to 35 years of age, prevents bone … In addition, bone mineral density is a surrogate end point for the risk of bone fracture, which limits … In addition, bone mineral density is a surrogate end point for the risk of bone fracture, which limits … In addition, bone mineral density is a surrogate end point for the risk of bone fracture, which limits … In addition, bone mineral density is a surrogate end point for the risk of bone fracture, which limits

28. Evidence-based Practice Center Systematic Review Protocol (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/osteoporosis-bone-fracture_research-protocol.pdf
    May 14, 2010 - mass and microarchitectural deterioration of bone tissue, with consequent increases in bone fragility … Osteoporosis is diagnosed by assessing bone mineral density (BMD). … Low bone mass or density is defined as a T-score between -2.5 and - 1. … America’s bone health: The state of osteoporosis and low bone mass in our nation. … J Bone Miner Res. 2007 Mar;22(3):465-75. 4. National Osteoporosis Foundation.

29. Topic 0414 Imaging techniques and metastatic breast cancer tx NSD FINAL (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND-0495_05-24-2013.pdf
    January 01, 2013 - Intervention(s): Imaging techniques to assess response to treatment including, but not limited to: bone … cancer, involves the spread of cancer from the breast to other organs of the body, such as the lungs, bones …  Multiple imaging modalities such as bone scintigraphy, CT, MRI, x-ray, ultrasound, PET/CT and FDG

30. CER 218 Evidence Summary: Long-Term Drug Therapy and Drug Holidays for Osteoporosis Fracture Prevention: A Systematic Review (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-218-osteoporosis-fracture-prevention-evidence-summary.pdf
    April 01, 2019 - mass and microarchitectural deterioration of bone, leading to bone fragility and increased risk of … The recent prevalence of osteoporosis and low bone mass in the United States based on bone mineral … Effect of denosumab on bone density and turnover in postmenopausal women with low bone mass after long … Bone HG, Hosking D, Devogelaer JP, et al. … Zoledronic acid for the prevention of bone loss in postmenopausal women with low bone mass: a randomized

31. Long-Term Drug Therapy and Drug Holidays for Osteoporotic Fracture Prevention (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/research-protocol-osteoporosis_2.pdf
    October 05, 2018 - mass and microarchitectural deterioration of bone, leading to bone fragility and increased risk of … imaging measures and biochemical bone turnover markers. … bone mineral density at the femoral neck or lumbar spine, J Bone Miner Res 29(11) (2014) 2520-6 … Density/ (53169) 4 exp Fractures, Bone/ (178905) 5 or/1-4 (249251) 6 Bone Density Conservation … Density/ (22135) 4 exp *Fractures, Bone/ (160114) 5 or/1-4 (227622) 6 *Bone Density Conservation

32. Disposition of Comments Report for Whole-Body Vibration Therapy for Osteoporosis (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/osteoporosis-vibration-therapy_disposition-comments.pdf
    November 15, 2011 - The effective stress on the bone by this method is the combined stress on the bone from low-level vibration … input and the stress on the bone by optimal muscle contraction. … vibration displacements and optimal muscle contraction will prevent damage to the cartilage or brittle bones … J Bone Miner Res 2008; 23: 1318-25, in the discussion of safety issues. … For example, normal bone density is a T-score greater than or equal to -1.0.

33. CER 174 Executive Summary: Imaging for the Pretreatment of Small Cell Lung Cancer (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/lung-cancer-staging_executive.pdf
    April 01, 2016 - scintigraphy, bone scan). … of osseous (bone or bone marrow) metastases; this evidence base comprised two studies making direct … or bone marrow). … or bone marrow) MDCT vs. … Bone scintigraphy; 1 study, n=28 MDCT vs. FDG PET/CT; 1 study, n=29 Bone scintigraphy vs.

34. Disposition of Comments for Treatment To Prevent Fractures in Men and Women With Low Bone Density or Osteoporosis -- Update of a 2007 Report (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/osteoporosis-bone-fracture_disposition-comments.pdf
    March 01, 2012 - Disposition of Comments for Treatment To Prevent Fractures in Men and Women With Low Bone Density or … Comments Report Research Review Title: Treatment to Prevent Fractures in Men and Women with Low Bone … mass and produced bone that was normal (e.g., no qualitative abnormalities). … Bone. 2011 Apr 1;48(4):677-92. Epub 2010 Dec 9. … The use of markers of bone turnover is not part of the scope of the review.

35. Disposition of Comments Report for Imaging Techniques for Treatment Evaluation for Metastatic Breast Cancer (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/breast-cancer-imaging_disposition-comments.pdf
    October 01, 2014 - We have deleted “physical and chemical” in the bone scan description and now state that “bone scans … are used to identify areas of damage to the bones…” We agree that bone scans do not assess the extent … For exemple, 18F-FNa (assessing bone metastasis) is also FDA approved. … Page 32 line 39-40: Too restrictive, since only bone is mentioned. … Specifically how to follow bone metastasis is unclear, and the exclusion of the bone dominant patients

36. Association Between Outcomes and Dental Services in People Receiving Treatments That Cause Medication-Related Osteonecrosis of the Jaw: A Rapid Response Review (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/dental-jaw-rapid-response.pdf
    May 01, 2025 - defined by (1) exposed upper and/or lower jaw bone or bone that can be probed through intraoral or … turnover, increase bone density, and improve overall bone quality; however, they are also associated … tissue.11 As of 2010, approximately 10 million Americans aged 50 and older experience osteoporosis … The Recent Prevalence of Osteoporosis and Low Bone Mass in the United States Based on Bone Mineral … Keeping Your Bones and Teeth Strong For Life.

37. Breast-Cancer-Imaging Technical-Brief (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/breast-cancer-imaging_technical-brief.pdf
    October 01, 2014 - Approximately 5 percent were diagnosed with distant metastases, most commonly to the bones, lungs, liver … Bone Scan (Scintigraphy) Bone scans are used to identify areas of damage to the bones throughout the … The most commonly used radiotracer for bone scans is technetium-99m.26 Safety issues pertaining to bone … metastatic breast cancer, since healing bones may appear as “flares” on bone scans, and treatment that … choice unless a bone lesion is found, since treating bone lesions has large effect on the patient’s

38. CER 218 Disposition of Comments: Long-Term Drug Therapy and Drug Holidays for Osteoporosis Fracture Prevention (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-218-osteoporosis-disposition-comments.pdf
    April 23, 2019 - Effect of denosumab on bone density and turnover in postmenopausal w omen w ith low bone mass after … Bone 2008;43:222-229. … Effect of denosumab on bone density and turnover in postmenopausal w omen w ith low bone mass after … J Bone Miner Res 2018;33:190-198. 5Tsourdi E, Zillikens MC. … Effect of denosumab on bone density and turnover in postmenopausal women with low bone mass after long

39. Hip-Fracture-Pain Consumer (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/hip-fracture-pain_consumer.pdf
    May 01, 2011 - A broken hip is a break in the thigh bone (called the “femur”) near the hip joint. … The femur is one of the strongest bones in your body, but it may weaken with age. … Even a minor injury may cause the bone to break. … People who have a bone-weakening condition called “osteoporosis” are more likely to break a hip.

40. Effective Health Care (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND_0277_03-10-2008.pdf
    January 01, 2008 - Document Completion Date: 6-2-09 1 Results of Topic Selection Process & Next Steps  Bone … )  A more specific term for ‘bone marrow transplantation’ is ‘hematopoietic stem cell transplantation … with HSCT, a comprehensive review that focuses on both benefits and harms across a set of diseases Bone