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461. 04-E029-1 Summary (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/prostate-cancer-surveillance_executive.pdf
     December 01, 2011 - Key Question 1—Patient Population and Natural History Changes in the Last 30 Years Better understanding … analyses on races other than blacks and whites; this may require adding new registries to SEER that better … In addition, future studies that could uncover better bio- and imaging markers of indolent versus aggressive … disease, and thus could better stage patients as having either low or high risk disease, are necessary … to better inform which patients are most likely to benefit from observational versus active treatment

462. Cancer-Ovarian-Contraceptives Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cancer-ovarian-contraceptives_executive.pdf
     June 01, 2013 - KQ 7: Based on the systematic review and decision model, what research gaps need to be filled to better … Better data on the relative quality-of-life effects of regular OC use, and the outcomes we reviewed … here, would allow for better assessment of the overall tradeoffs between harms and benefits at both … Given the feasibility issues of a randomized trial, this may be one of the only ways to better address … net harms and benefits of progestin- only pills, particularly for vascular events, is potentially better

463. Research White Paper Biorepositories Addendum Registries For Evaluating Patient Outcomes Third Edition (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/wysiwyg/biorepositories-registries-guide-3rd-ed-addendum-white-paper.pdf
     February 01, 2018 - through analysis of biospecimens, and this knowledge is being used to conduct further research to better … Resources for better understanding the true costs of biobanking have recently become 6 Biorepositories … These include active public education on biobanking so that the public better understands the critical … NCI has developed patient brochures to better communicate with potential research participants65 and … video communications to better explain the context for biospecimen donation.66 Harmonization of biospecimen

464. Evidence Summary-Comparative-Effectiveness-Review-213-Lower-Limb-Prostheses (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-213-lower-limb-protheses-evidence-summary.pdf
     September 01, 2018 - and study eligibility criteria were designed to assist Centers for Medicare & Medicaid Services to better … Physical, SF-12 Bodily Pain, SF-36 Physical Functioning (where a modified 15-item version performed better … 36) Specifically: SF-12 total score and SF-36 PF (Physical Functioning subscale, PF 15 performed better … , at least in part, additional studies are needed to confirm their psychometric properties and to better … Further high-quality research is needed to better assess the psychometric properties of instruments

465. A Bayesian Missing Data Framework for Multiple Continuous Outcome Mixed Treatment Comparisons (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/indirect-comparisons_research-2013.pdf
     January 01, 2013 - Our missing data approaches had better power and Type I error than previous Bayesian methods in our … This makes it easier to assign prior distributions on random effects and delivers better statistical … For the pain outcome, strength and proprioception exercises perform significantly better than no active … Although our methods do not deliver strikingly better features over the existing LAREhom model in this … model; lower pD indicates smaller effective model size; lower indicates better model fit.

466. Options for Developing a Web-Based Forum on Patient Registries (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/registries-forums_research_0.pdf
     May 01, 2014 - be determined by the extent to which it was relevant to their work and helped them to do their work better … be determined by the extent to which it was relevant to their work and helped them to do their work better … be determined by the extent to which it was relevant to their work and helped them to do their work better … record [EHR] industry) If a Web-based CoP is to meet the goal of helping its members do their work better … of a Web-based CoP would depend on its ability to remain relevant and enable them to do their work better

467. Chronic Kidney Disease Stages 1-3: Screening, Monitoring, and Treatment (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/kidney-disease-medicine_disposition-comments.pdf
     August 01, 2012 - It may be better explicitly stated, however as there are 3 areas of focus, namely screening, monitoring … estimating formulas are not good at differentiating CKD stages at GFRs above 60 though CKD-EPI is better … Additionally evidence suggests that early referral to nephrologist is associated with better outcomes … the reviewer, in the revised report the future research section has been expanded in an effort to better … In the revised report, we have made additional effort to better specify patient subgroups in whom

468. Urinary-Incontinence-Treatment Surveillance (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/urinary-incontinence-treatment_surveillance.pdf
     October 29, 2012 - Duloxetine was no better than placebo in women with depression, diabetes, and chronic lung diseases … In contrast, trospium was better than placebo at resolving UI only in subjects with fewer than five … Efficacy of Nonpharmacological Treatments Nonpharmacological treatments were better than no active … Duloxetine was no better than placebo in women with depression, diabetes, and chronic lung diseases … In contrast, trospium was better than placebo at resolving UI only in subjects with fewer than five

469. Mental-Illness-Adults-Prisons Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/mental-illness-adults-prisons_executive.pdf
     August 01, 2013 - To receive a grade of low or better, at least two studies must have reported consistent results for … In both of these trials, the non–clozapine-treated subjects did better than the clozapine-treated subjects … More research is needed to better assess the efficacy of these treatments. … More research is needed to better assess the impact of provider type on treatment outcomes.

470. Interventions To Prevent Age-Related Cognitive Decline, Mild Cognitive Impairment, and Clinical Alzheimer’s-Type Dementia (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/cognitive-decline-disposition-170707pdf.pdf
     March 24, 2017 - The goals and the studies included need to be better aligned, or some additional explanation is needed … Figures/ Tables Peer Reviewer #2 The use of symbols in page 172 and on should be better explained … General Peer Reviewer #1 Page and chapter numbers unclear and need better organization. … We note in the Results Summary tables in each results section if the control group performed better … However, more and better work remains to be done.

471. Interventions To Prevent Age-Related Cognitive Decline, Mild Cognitive Impairment, and Clinical Alzheimer’s-Type Dementia (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cognitive-decline-disposition-170707pdf.pdf
     March 24, 2017 - The goals and the studies included need to be better aligned, or some additional explanation is needed … Figures/ Tables Peer Reviewer #2 The use of symbols in page 172 and on should be better explained … General Peer Reviewer #1 Page and chapter numbers unclear and need better organization. … We note in the Results Summary tables in each results section if the control group performed better … However, more and better work remains to be done.

472. Layout 1 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/c-diff-infections_executive.pdf
     December 01, 2011 - Gene detection tests that focus on toxin B tended to have better sensitivity than immunoassays for toxins … The available evidence is insufficient to say whether any antimicrobial treatment is better than another … or a monoclonal antibody to C. difficile toxins A and B along with standard antibiotics for CDI are better … detect genetic residue related to C. difficile toxin production rather than the toxins per se lead to better … The search for a better treatment for recurrent Clostridium difficile disease: use of high-dose vancomycin

473. Disposition of Comments Report for Interventions To Modify Health Care Provider Adherence to Asthma Guidelines (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/asthma-provider-adherence_disposition-comments.pdf
     May 19, 2013 - We have reworded the document to better explain the criteria used for demonstrating a relationship … We have expanded the Discussion section accordingly to better reflect the complex summary of studies … I liked some of the conclusions, future directions and clinical implications better in the evidence

474. Disposition of Comments Report for Allergen-Specific Immunotherapy for the Treatment of Allergic Rhinoconjunctivitis and/or Asthma (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/asthma-immunotherapy-2010_disposition-comments.pdf
     January 01, 2010 - post-fact in an attempt to “mine the data” to learn as much as possible about a study drug’s effects, to better … We added a statement in the text to avoid confusion. 27 Peer Reviewer #4 Results We would be better … 32 Peer Reviewer #4 Results For this SLIT Tablet (and the above SCIT Table), it would be much better

475. PEPTIC ULCER #11 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/peptic-ulcer-horizon-scan-high-impact-1412.pdf
     December 01, 2014 - Scanning System is to conduct horizon scanning of emerging health care technologies and innovations to better … increases the size and density of intestinal villi in the intestinal epithelial layer, resulting in better … increase the size and density of intestinal villi in the intestinal epithelial layer, resulting in better

476. PEPTIC ULCER #11 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/peptic-ulcer-horizon-scan-high-impact-1406.pdf
     June 01, 2014 - Scanning System is to conduct horizon scanning of emerging health care technologies and innovations to better … increases the size and density of intestinal villi in the intestinal epithelial layer, resulting in better … increase the size and density of intestinal villi in the intestinal epithelial layer, resulting in better

477. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/breast-biopsy_disposition-comments.pdf
     March 11, 2010 - 8 Section Comment Response Introduction The process that breast biopsy works within needs to be better … described so the reader understands the pros and cons better. … Methods The underestimation rates need to be better defined.

478. Cover Page (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/medicine-safety-call-center_research.pdf
     September 01, 2007 - mechanisms, there is a need for a comprehensive adverse event data collection mechanism that can provide better … observe that the discrimination between adverse drug events from other adverse clinical events was better … pharmaceutical care programs aimed at giving the pharmacists a greater role in providing the patients with better

479. Cover Page (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/it-architecture-for-post-marketing-surveillance-arizona-cert.pdf
     September 01, 2007 - mechanisms, there is a need for a comprehensive adverse event data collection mechanism that can provide better … observe that the discrimination between adverse drug events from other adverse clinical events was better … pharmaceutical care programs aimed at giving the pharmacists a greater role in providing the patients with better

480. Assessing Applicability (ppt file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/assessing-applicability.ppt
     January 01, 2009 - clinical trials, it appears that certain therapies, such as hydralazine with isosorbide dinitrate, work better … in African Americans, but ß-blockers, such as metoprolol succinate and bucindolol, work better in whites … effects, or lack of response are found, then this reduces applicability of the study results because better