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1301. Disposition of Comments Report for Interventions To Modify Health Care Provider Adherence to Asthma Guidelines (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/asthma-provider-adherence_disposition-comments.pdf
      May 19, 2013 - We have reworded the document to better explain the criteria used for demonstrating a relationship … We have expanded the Discussion section accordingly to better reflect the complex summary of studies … I liked some of the conclusions, future directions and clinical implications better in the evidence

1302. Evidence-based Practice Center Systematic Review Protocol (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/breast-biopsy_disposition-comments.pdf
      March 11, 2010 - 8 Section Comment Response Introduction The process that breast biopsy works within needs to be better … described so the reader understands the pros and cons better. … Methods The underestimation rates need to be better defined.

1303. High-Cholestorol-Medicines-Update Executive (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/high-cholestorol-medicines-update_executive.pdf
      February 01, 2014 - and populations with greater burden of cardiovascular disease to determine which strategy provides better … studies looked at intermediate outcomes, few studies addressed the question of which approach produces better … Combination of statin with ezetimibe or bile acid sequestrant lowered LDL-c better than intensification … Additional studies evaluating long-term clinical benefits and harms are needed to better inform clinical

1304. Disposition of Comments Report for Antiplatelet and Anticoagulant Treatments for Unstable Angina/Non-ST Elevation Myocardial Infarction (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/angina-heart-attack-treatments_disposition-comments.pdf
      January 01, 2014 - I-17-22 gives a better summary of this. The wording has been changed in the Abstract. … Using terms such as “favors” implies one is better than another. … If the authors tried to do less, focusing on fewer points with better data, it would be stronger. … It could perhaps better take into account biological rationale and statistical consistency. … It might better be displayed as a table.

1305. PCA3 Testing in the Diagnosis and Management of Prostate Cancer: Future Research Needs (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/prostate-cancer-antigen-3-gene_research.pdf
      April 01, 2013 - The Stakeholders agreed with the findings of the CER and recognized that work needed to be done to better … be possible for individual investigators or groups of investigators to re-analyze existing data to better … The Stakeholders agreed with the findings of the CER and recognized that work needed to be done to better … A better understanding of this issue is needed if PCA3 is to be properly evaluated in the context of … Biopsy is not perfect; consider using prostatectomy outcomes to better understand what kinds of tumors

1306. Disposition of Comments Report for Treatment for Hepatitis C Virus Infection in Adults (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/hepatitis-c_disposition-comments.pdf
      November 27, 2012 - comparative effectiveness of the 2 new DAA—of the 2 available regimens, which triple therapy may be better … the time there are enough data to address this question; we will probably have newer and perhaps better … Executive Summary (ES-12) Row 1: "…slightly better short-term scores…" Please state whether the difference … Although early (4-week) virological response predicts SVR, SVR is a better predictor of long-term remission … page 105 described a2b as better than a2a for genotype 2,3 This section does not compare dual therapy

1307. Disposition of Comments for CER 183 Tonsillectomy for OSDB (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/tonsillectomy-disposition-170415.pdf
      January 17, 2017 - (precision, directness, consistency, risk of bias, etc) really enough to concluded cobalation is better … either of these here and they should be mentioned, given the frequency that proponents invoke them as better … #3 Results Harms of tonsillectomy (ES-10)- there are 2 important clinical questions that could be better … Better to list the individual studies in relation to the particular key questions. … example, under KQ1 I would like to read something about whether the AHI versus symptom relief is a better

1308. Disposition of Comments for Pharmacokinetic/Pharmacodynamic Measures for Guiding Antibiotic Treatment for Hospital-Acquired Pneumonia (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/pneumonia-antibiotic-treatment_disposition-comments.pdf
      November 24, 2014 - a broader range of infections (e.g., treatment of severe sepsis/septic shock) might have yielded better … #1 PK/PD data for dosing or monitoring are summarized in Table B, which demonstrated significantly better … valid signal in these smaller studies, is there any reason to think that larger sample sizes and better … Suggestions included a better study model for future studies of PK/PD therapy in ventilated patients … In that way, similar key questions might be better answered in the future.

1309. Long-Term Care for Older Adults Disposition of Comments Report (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/long-term-care-adults_disposition-comments.pdf
      November 07, 2012 - whether or not the family or informal caregiver's needs were assessed and addressed so that they were better … HCBS) is still framed as "which is better" since the populations are very different and, by and large … social isolation, sensory and cognitive losses), it seems important to determine which settings are better … The discussion of the need to address deaths and transfers should be revised to better explain what … assign individuals to nursing homes or home care, might we be able to use data already in existence to better

1310. chronic-fatigue-protocol (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/chronic-fatigue_research-protocol.pdf
      May 01, 2014 - most recent international consensus report advocates moving away from the term CFS in favor of ME to better … with gold standard of measurement have challenged researchers and clinicians in their attempts to better

1311. Disposition of Comments Report for Comparative Effectiveness Review #68 (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/nppv-respiratory-failure_disposition-comments.pdf
      July 01, 2012 - To better address this issue of potential variability by diagnostic groups, we have modified our presentation … We think the Conclusions are now better supported by the Results. … To better address this issue of potential variability by diagnostic groups, we have modified our presentation … amend this sentence to emphasize the importance of further studies in many conditions/situations to better

1312. Disposition of Comments Report for Interventions for Adult Offenders With Serious Mental Illness (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/mental-illness-adults-prisons_disposition-comments.pdf
      August 21, 2013 - I think the better way is to identify key outcomes that you want to know how to impact and then identify … Even better would be forest plots that graphically represent this data. … For example, both studies reported that treatment A was better than treatment B. … Surely we can do better. It is time to put our money where our research is.

1313. Disposition of Comments Report for Decision Aids for Cancer Screening and Treatment (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/cancer-decision-support-tools_disposition-comments.pdf
      December 23, 2014 - #4 Introduction P 7 Abstract review methods second sentence – remove “already developed” perhaps better … Selection of outcomes: the explanation of why hard outcomes are not used is not very clear and may be better … plots of the three meta-analyzed outcomes, stratified by the three populations, if possible, to have a better … Any need for future work to see which aids work better?

1314. Febrile-Infants-Diagnosis-Management Executive (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/febrile-infants-diagnosis-management_executive.pdf
      March 01, 2012 - In recent decades, increasing awareness of these trade-offs has led to efforts to discriminate better … (26.3 percent to 28.0 percent).28 The overall diagnostic accuracy of PCT for predicting SBI was better … clinical criteria alone (not well appearing infants, age < 30 days, gender, fever > 40°C) reported better … In the absence of better data on harms and the costs of diagnostics and therapeutics or improved positive … study evaluating the Rochester criteria in neonates the testing in the neonatal age group showed better

1315. Treatments for Basal Cell and Squamous Cell Carcinoma of the Skin - Executive Summary (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/evidence-summary-cer-199-skin-cancer.pdf
      December 01, 2017 - • There is moderate confidence that PDT for BCC is associated with better cosmetic outcomes than surgery … Table B shows that the percentage of lesions with good or better cosmetic outcomes ranged between 74.3 … Radiation (D) had the smallest percentage of good or better cosmetic outcome. … recurrence, surgical treatments and radiation therapy appear to be (statistically significantly) better … Fourth, better monitoring of population trends in BCCs and SCCs can help focus research on the most

1316. PEPTIC ULCER #11 (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/peptic-ulcer-horizon-scan-high-impact-1312.pdf
      December 01, 2013 - Scanning System is to conduct horizon scanning of emerging health care technologies and innovations to better … interest in natural orifice transluminal endoscopic surgery (known as NOTES) if it can demonstrate better … , POEM could renew interest in NOTES procedures and instrumentation if ongoing trials demonstrate better … increase the size and density of intestinal villi in the intestinal epithelial layer, resulting in better … of teduglutide, prescribed by a gastroenterologist, could help patients with poor access to care better

1317. Diabetes Mellitus (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/07_diabetes_potential_high_impact_june_2012.pdf
      January 01, 2012 - Scanning System is to conduct horizon scanning of emerging health care technologies and innovations to better … showing use of these systems will “prevent or reduce the length and severity of hypoglycemia events better … hypoglycemic agents with different mechanisms of action may have additive therapeutic effects and result in better … of GLP-1 agonists on the market, one expert said that this therapy could reduce HbA1c levels and better … expensive for patients, third party payers, and healthcare facilities if the patient would be able better

1318. Crosscutting-Horizon-Scan-High-Impact-1312 (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/crosscutting-horizon-scan-high-impact-1312.pdf
      December 01, 2013 - Scanning System is to conduct horizon scanning of emerging health care technologies and innovations to better … aid patient adherence to medication regimens for chronic diseases and be used in clinical trials to better … financial impact if more data show it can actually can cut costs by reducing complications through better … only have the younger patients that are less complicated, need less medical services/tests, and have better … environment established by senior-specific EDs would facilitate improved communication and allow for better

1319. Physical Therapy for Knee Pain Secondary to Osteoarthritis Disposition of Comment Report (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/arthritis-knee-physical-therapy_disposition-comments.pdf
      November 06, 2012 - Later criteria (strength of quadracep measured in nm/x are better determiners. … balance, walking) and participation in activities of daily living would allow better prediction of patient … If this approach is included with the category of the distribution method, then a better description … represented minimal clinically important changes while a reduction of 33 percent represented “much better … patient- oriented outcomes that should be used in clinical trials and the latter can be addressed by better

1320. Renal-Function Executive (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/renal-function_executive.pdf
      August 01, 2014 - type of troponin assay, do the operating characteristics of a certain type of troponin test perform better … effectiveness of interventions or management strategies for ACS (e.g., Is an aggressive strategy better … ) against another type of troponin assay, does a certain type of troponin test estimate prognosis better … using the profile likelihood estimate for calculating between-study variance.30 This method provides better … Therefore, we are unable to draw any specific conclusion about which biomarker is better in the CKD