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441. Prostate-Cancer-Risk-Assessment-Genes Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/prostate-cancer-risk-assessment-genes_executive.pdf
     July 01, 2012 - incremental gain in AUC observed when the predictive model including the SNP data was compared against the best … of the biases identified would be sufficient to alter the interpretation of the findings from (at best

442. Methods Guide for Medical Test Reviews Chapter 6 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guidance-tests-applicability_methods.pdf
     July 01, 2012 - In these situations, reviewers must weigh how best to capture data relating the two versions of the … Despite best efforts, some contextual factors relevant to applicability may only be uncovered after

443. AHRQ Slide Template 2009 (ppt file)
     effectivehealthcare.ahrq.gov/sites/default/files/selecting-evidence.ppt
     January 01, 2010 - OSs may provide the best or only data for assessing harms in minority or vulnerable populations who are … OSs may provide the best or only data for assessing harms in minority or vulnerable populations who are

444. Quality-Gap-Palliative-Hospice Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/quality-gap-palliative-hospice_executive.pdf
     October 01, 2012 - Grading We assessed the strength of the best available evidence, including the risk of bias in relevant … following patient populations over longer periods of time, will be needed to better understand how best

445. Disposition of Comments_Technical Brief No. 45: Long COVID Models of Care (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/long-covid-disposition-comments.pdf
     January 01, 2022 - Findings As above - Long COVID definition would be best presented based on clinical use. … Comments All models of care should include training in and implementation of trauma-informed care best … General: All models of care should include training in and implementation of trauma-informed care best … the demographic makeup of the patients the existing centers serve would be helpful to determine how best … The website provided by the commenter is on HIV best practices.

446. Comparative Effectiveness Review No. 262_Pharmacotherapy for Adults With Alcohol Use Disorder in Outpatient Settings: Systematic Review (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-262-pharmacotherapy-alcohol-summary.pdf
     November 01, 2023 - Understanding best approaches to using pharmacotherapy for treatment in primary care is an area worthy

447. Disposition of Comments for CER 182 Glasgow Coma Scale (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/field-triage-glascow-disposition-170415.pdf
     January 12, 2017 - factor in a trauma triage decision, and therefore any attempt to tease out its impact is difficult at best … The fact that the best available data shows little difference implies that the mGCS portion of the … As a result, I believe that the herculean task that was performed is probably the best look that we … Probably best to use the current term.

448. Disposition of Comments Report for Interventions To Improve Patient Adherence to Hepatitis C Treatment: Comparative Effectiveness (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/hepatitis-c-treatment-adherence_disposition-comments.pdf
     December 20, 2012 - TEP #5 Executive Summary Page 9, line 21: Genotypes (1-4) may not be the sole “best” predictor of viral … We have revised this sentence to read that genotyping is among the best ways to predict response. … that still needs to be done in this field and the continuing lack of conclusive evidence regarding best … If so, can those best practices be expounded upon?

449. Research White Paper Patient- or Participant-Generated Registries Addendum Registries for Evaluating Patient Outcomes Third Edition (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/wysiwyg/patient-participant-generated-registries-guide-3rd-ed-addendum-white-paper.pdf
     February 01, 2018 - data over 50 years ago, has documented the disease course, helped establish treatment guidelines and best … research and when ethical review is required. 11 Patient- or Participant-Generated Registries Best … The increasing implementation of best practices and evaluation criteria begins to address prior questions … case studies that highlight successful uses of PGRs and through dissemination activities related to best

450. Disposition of Comments for Comparative Effectiveness Review No. 240: Treatments for Acute Pain: A Systematic Review (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/cer-240-acute-pain-revised-comments.pdf
     December 29, 2020 - If opioids are working best, then, that should be the treatment. … would need to take a lower dose, but again that decision is between me and my doctor who knows me best … I can not agree with your assessment of what things are best for the acute care patient. … The state of the art is in optimizing “multimodal” therapy in which the best combination of analgesic … The state of the art is in optimizing “multimodal” therapy in which the best combination of analgesic

451. Carman-notes-151021 copy-Teresa (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/carman-presentation.pdf
     May 29, 2025 - leadership  with, PCORI has taken   leadership  with  and  yet, we’re still learning what the best

452. Ankyloglossia-protocol-140630 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/ankyloglossia_research-protocol.pdf
     June 30, 2014 - The significance of this anomaly and the best method of management have been controversial for more … Perhaps the best available evidence to date is provided by a recent systematic review that found frenotomy … the need to extract data as reported and consider possibilities for stratification to determine how best

453. Research Protocol: Diabetes Medications for Adults With Type 2 Diabetes: An Update Focused on Monotherapy and Add-On Therapy to Metformin (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/diabetes-update-2015_research-protocol.pdf
     January 01, 2015 - pharmacologic treatment for most patients with type 2 diabetes.4 However, the evidence base regarding the best … Outcomes: At the completion of our review, we will grade the quantity, quality and consistency of the best … We will assess the quality and consistency of the best available evidence, including assessment of limitations

454. Presentation of Future Research Needs (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/presentations-future_research.pdf
     April 01, 2012 - 3 Scope of This Paper This paper is one of a series of papers that provide recommendations and best … Aims This project explores how recommendations for FRNs beyond the work done in CE reviews can be best … screening, the question about the adverse consequences of screening (or the long-term effects) may be best

455. Disposition of Comments for Treatment Strategies for Patients With Peripheral Artery Disease (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/peripheral-artery-disease-treatment_disposition-comments.pdf
     May 29, 2013 - The numerous and serious limitations of the studies/review are clearly described (best in Executive … The key questions are appropriate and covers the landscape of PAD treatments and tries to make the best … was already known/suspected, i.e., the evidence base for many treatments of PAD is small and the best

456. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/juvenile-arthritis-dmards_disposition-comments.pdf
     September 01, 2011 - As a clinician, I want to know how best to treat an individual patient with a defined subtype of JIA … This study established the placebo rate for children with IV treatments, it documented the best dose … The best studies to date have been those performed by industry as part of their FDA approval process

457. Dementia-Nursing-Home-Characteristics Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/dementia-nursing-home-characteristics_executive.pdf
     October 01, 2012 - comprehensive evidence-based guidance exists that identifies which characteristics or settings are best … Gaps Assuming the overriding question for stakeholders is whether an individual with dementia is best … We are not convinced that “one-off” studies are the best possible use of research resources.

458. Comparative Effectiveness Research Review Disposition of Comments Report (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/breast-abnormalities-tests-update_disposition-comments.pdf
     February 13, 2012 - The findings of our report should be only one factor that is considered when deciding upon the best … It is unlikely, and rightfully so, to be used by breast imagers to determine best practice. … The findings of our report should be only one factor that is considered when deciding upon the best

459. 13-MDM347013 30..38 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/outcomes-testing-evaluation_research.pdf
     January 01, 2009 - Randomized trials and other comprehensive evaluations of tests and test strategies can best be designed … The best way to evaluate the effects of testing on patient outcome is a randomized controlled trial,

460. 13-MDM347013 30..38 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/whitepaper4-bossuyt02262010-2.pdf
     January 01, 2009 - Randomized trials and other comprehensive evaluations of tests and test strategies can best be designed … The best way to evaluate the effects of testing on patient outcome is a randomized controlled trial,