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281. Medical Therapies for Locally Advanced Gastric Adenocarcinoma (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/gastric-cancers-protocol.pdf
     January 01, 2024 - review (SR) is to summarize the pertinent evidence so that patients and clinicians can select the best … We will use a best evidence approach to address the key questions.16 RCTs at low risk of bias or with … A Framework for "Best Evidence" Approaches in Systematic Reviews.

282. Liver-Cancer-Therapy Research-Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/liver-cancer-therapy_research-protocol.pdf
     November 28, 2012 - Patients with class A cirrhosis and concomitant HCC have the best prognosis and would be candidates … specific guidance on the comparative effectiveness of the therapies (i.e., which therapy offers the best … based on high-quality comparative effectiveness reviews that rigorously and systematically address the best … major) differences occurred with followup; measurement instruments are acceptable (although not the best

283. Disposition of Comments for CER 151 Management of Postpartum Hemorrhage (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/hemorrhage-postpartum_disposition-comments.pdf
     April 28, 2015 - This carefully prepared report illustrates that currently there is not clear evidence for best practices … or the appropriate intervention trajectory to obtain the best result with the least amount of harm … this exhaustive review, the Authors conclude that there is limited high-quality evidence regarding best … The MFM Units Network) would be the best hope for sorting out the multitude of questions regarding timing

284. Training Modules for the User’s Guide for Developing a Protocol for Observational Comparative Effectiveness Research | Effective Health Care (EHC) Program
     effectivehealthcare.ahrq.gov/products/observational-cer-protocol/slides-2013

285. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/vte-prophyalaxis_research-protocol.pdf
     March 01, 2011 - 60 percent of bariatric surgeons preferred LMWH for prophylaxis, but many were uncertain about the best … the proposed CER are likely to be useful to clinicians and patients in making decisions about the best … We will model rare adverse events (<1%) using the Peto odds ratio, which has the best confidence interval … Question At the completion of our review, we will grade the quantity, quality, and consistency of the best … A Framework for "Best Evidence" Approaches in Systematic Reviews.

286. Research White Paper: A Framework To Facilitate the Use of Systematic Reviews and Meta-analyses in the Design of Primary Research Studies (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/primary-research-design_research.pdf
     January 01, 2012 - The value of information: best informing research design and prioritization using current methods. … Assessing Validity of Systematic Reviews Comprehensive Literature Search What is Best? … What is Best? Where is This Information? … What is Best? Where is This Information? … What is Best? Where is This Information?

287. Renal-Cancer Research-Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/renal-cancer_research-protocol.pdf
     April 20, 2015 - models have modest concordance indices for malignancy in the range of 0.55 to 0.65.[3, 16- 18] The best … comparable oncologic outcomes to partial nephrectomy, although it is not clear which patients are best … This was largely based on expert opinion and best-available studies that were observational and retrospective … Determining the best approach to management of clinically-localized renal masses is a complex task. … T1a tumors, specifically, have the best prognosis and define a category of tumors in which nephron-sparing

288. Disposition of Comments for Use of Natriuretic Peptide Measurement in the Management of Heart Failure (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/heart-failure-natriuretic-peptide_disposition-comments.pdf
     November 20, 2013 - There appear some significant gaps for reasons stated above We have addressed these gaps to the best … November 20, 2013 9 Commentator & Affiliation Section Comment Response Rev 4 AE General The best … Unfortunately the clinical practice guidelines do not always follow the best available evidence in … Comment Response Rev 8 General/disc Most of the studies included will have had the aim of ‘finding the best … these models (because the authors may not be interested in the value of one predictor, but in the best

289. DST_Draft_Protocol_Nov_4_2013_clean (2) (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/cancer-decision-support-tools_research-protocol.pdf
     November 12, 2013 - In other words, no universally “optimal” choice exists; the “optimal” choice is the one that best corresponds … Nevertheless, knowing the overall average effect is not enough to promote the use of these tools to their best … o Health care consumers facing screening or treatment decisions where there is no “clearly best” option … Further, almost by definition, DSTs are designed for decisions without a clear “best” option. … as the rank probabilities for each treatment strategy (e.g. probability that a type of DST is the “best

290. Autism-Adolescents Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/autism-adolescents_executive.pdf
     August 01, 2012 - Our goal was to identify and review the best evidence for assessing the efficacy and effectiveness … Similarly, allied health studies are needed to understand best approaches to fostering independent living … The Aberrant Behavior Checklist is the best outcome measure for behavioral symptoms in ASD in terms … Conclusions Given the number of individuals affected by ASD, there is a dramatic lack of evidence on best … effectiveness in managing irritability and aggression in this age group remains largely unknown and can at best

291. Trauma-Interventions-Maltreatment-Child Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/trauma-interventions-maltreatment-child_executive.pdf
     April 01, 2013 - The goal of this review is twofold: to provide stakeholders with a synthesis of the best evidence in … To maintain a focus on the best available evidence, studies with a high risk of bias are not included … were included yet found to have lesser scientific support may be second-line options or represent best … As newly developed interventions, the extent to which each represented a “best” alternative treatment … A multisite collaborative would provide a powerful nexus for shared strategies and best practices that

292. DEcIDE 33: Summary Variables in Observational Resesarch: Propensity Scores and Disease Risk Scores (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/observational-research-scores_research.pdf
     May 01, 2012 - The aim is to describe best practices for creating and applying these two types of scores. … .......................................................................................... 19 How Best … Instead, the aim is to describe best practices for creating and applying these scores. … expectation is that the patient will have a better outcome if they receive the treatment (or the “best … very large number of medications and comorbidities to be accounted for can pose challenges of how best

293. Disposition of Comments for Comparative Effectiveness of Therapies for Clinically Localized Prostate Cancer: An Update of a 2008 Systematic Review (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/prostate-cancer-therapies-update_disposition-comments.pdf
     December 16, 2014 - Reviewer 3 Methods It seems that a huge number of studies were excluded in order to arrive at the best … While I agree that it is important to perform an analysis of only the best, I think there would be some … Page 18 – It seems that a huge number of studies were excluded in order to arrive at the best evidence … While I agree that it is important to perform an analysis of only the best, I think there would be some … The best that can be done is for investigators to continue performing long-term followup studies that

294. Disposition of Comments_Comparative Effectiveness Review No. 256: Effectiveness of Telehealth for Women's Preventive Services (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-256-telehealth-women-disposition-comments.pdf
     June 16, 2022 - “Studies were reviewed and highlighted using a hierarchy-of-evidence approach, where the best evidence … Uncertainty remains regarding the most effective approaches for delivering these services and how to best … new evidence - The challenge to practicing clinicians right now is that we are struggling with how best … methods: “Studies were reviewed and highlighted using a hierarchy-of-evidence approach, where the best

295. Evidence Summary_Comparative Effectiveness Review No. 255: Transitions of Care From Pediatric to Adult Services for Children With Special Healthcare Needs (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-255-transitions-care-pediatric-to-adult-services-evidence-summary.pdf
     May 01, 2022 - CSHCN, their caregivers, providers, and other stakeholders may initially draw from evidence and best

296. Executive Summary: Comparative Effectiveness Review No. 256_Effectiveness of Telehealth for Women's Preventive Services (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-256-telehealth-women-preventive-services-executive-summary.pdf
     June 01, 2022 - regarding the effectiveness of telehealth for delivering specific preventive services for women and how to best

297. Evidence Summary: CER 237_Integrating Palliative Care in Ambulatory Care of Noncancer Serious Chronic Illness (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/cer-237-evidence-summary-palliative-care-ambulatory.pdf
     February 01, 2021 - patients, and caregivers is “How can people with serious life-threatening chronic illness or conditions best

298. Evidence Summary: Management of Colonic Diverticulitis (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-233-diverticulitis-evidence-summary.pdf
     October 01, 2020 - To enable better guidance about best options for patient management, there is a clear need for high-quality

299. Disposition of Comments_Systematic Review: Breastfeeding and Health Outcomes for Infants and Children (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/breastfeeding-health-outcomes-disposition-comments.pdf
     March 31, 2025 - Organizations such as Fed is Best are likely to seize on any doubtful-sounding wording in health outcomes … associated with this clustered randomized approach to maternal care practices provide perhaps the best … and Elien Rouw, Academy of Breastfeeding Medicine Introduction Introduction General It would be best … unethical to randomize a non-breastfeeding group, a measure of association will continue to be our best … led by Black, Indigenous, and people of color (BIPOC) and other marginalized communities, are often best

300. Omega−3 Fatty Acids and Cardiovascular Disease: An Updated Systematic Review (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/fatty-acids-cardiovascular-disease_executive.pdf
     August 01, 2016 - The best fit curve was found with a knot at 0.3 g/d. … The best fit curve was found with a knot at 0.5 g/d. … The best fit curve was found with a knot at 0.3 g/d. … The best fit curve was found with a knot at 0.4 g/d. … The best fit curve was found with a knot at 0.9 g/d.