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1481. Liver-Cancer-Therapy Research-Protocol (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/liver-cancer-therapy_research-protocol.pdf
      November 28, 2012 - Patients with class A cirrhosis and concomitant HCC have the best prognosis and would be candidates … specific guidance on the comparative effectiveness of the therapies (i.e., which therapy offers the best … based on high-quality comparative effectiveness reviews that rigorously and systematically address the best … major) differences occurred with followup; measurement instruments are acceptable (although not the best

1482. DST_Draft_Protocol_Nov_4_2013_clean (2) (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/cancer-decision-support-tools_research-protocol.pdf
      November 12, 2013 - In other words, no universally “optimal” choice exists; the “optimal” choice is the one that best corresponds … Nevertheless, knowing the overall average effect is not enough to promote the use of these tools to their best … o Health care consumers facing screening or treatment decisions where there is no “clearly best” option … Further, almost by definition, DSTs are designed for decisions without a clear “best” option. … as the rank probabilities for each treatment strategy (e.g. probability that a type of DST is the “best

1483. Renal-Cancer Research-Protocol (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/renal-cancer_research-protocol.pdf
      April 20, 2015 - models have modest concordance indices for malignancy in the range of 0.55 to 0.65.[3, 16- 18] The best … comparable oncologic outcomes to partial nephrectomy, although it is not clear which patients are best … This was largely based on expert opinion and best-available studies that were observational and retrospective … Determining the best approach to management of clinically-localized renal masses is a complex task. … T1a tumors, specifically, have the best prognosis and define a category of tumors in which nephron-sparing

1484. Evidence-based Practice Center Systematic Review Protocol (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/vte-prophyalaxis_research-protocol.pdf
      March 01, 2011 - 60 percent of bariatric surgeons preferred LMWH for prophylaxis, but many were uncertain about the best … the proposed CER are likely to be useful to clinicians and patients in making decisions about the best … We will model rare adverse events (<1%) using the Peto odds ratio, which has the best confidence interval … Question At the completion of our review, we will grade the quantity, quality, and consistency of the best … A Framework for "Best Evidence" Approaches in Systematic Reviews.

1485. Decision Support Tools for Screening and Treatment Decisions in Early Cancer | Effective Health Care (EHC) Program
      effectivehealthcare.ahrq.gov/products/cancer-decision-support-tools/research-protocol
      November 12, 2013 - In other words, no universally "optimal" choice exists; the "optimal" choice is the one that best corresponds … Nevertheless, knowing the overall average effect is not enough to promote the use of these tools to their best … Health care consumers facing screening or treatment decisions where there is no “clearly best” option … Further, almost by definition, DSTs are designed for decisions without a clear “best” option. … as the rank probabilities for each treatment strategy (e.g. probability that a type of DST is the “best

1486. Disposition of Comments for Use of Natriuretic Peptide Measurement in the Management of Heart Failure (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/heart-failure-natriuretic-peptide_disposition-comments.pdf
      November 20, 2013 - There appear some significant gaps for reasons stated above We have addressed these gaps to the best … November 20, 2013 9 Commentator & Affiliation Section Comment Response Rev 4 AE General The best … Unfortunately the clinical practice guidelines do not always follow the best available evidence in … Comment Response Rev 8 General/disc Most of the studies included will have had the aim of ‘finding the best … these models (because the authors may not be interested in the value of one predictor, but in the best

1487. Research White Paper: A Framework To Facilitate the Use of Systematic Reviews and Meta-analyses in the Design of Primary Research Studies (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/primary-research-design_research.pdf
      January 01, 2012 - The value of information: best informing research design and prioritization using current methods. … Assessing Validity of Systematic Reviews Comprehensive Literature Search What is Best? … What is Best? Where is This Information? … What is Best? Where is This Information? … What is Best? Where is This Information?

1488. Autism-Adolescents Executive (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/autism-adolescents_executive.pdf
      August 01, 2012 - Our goal was to identify and review the best evidence for assessing the efficacy and effectiveness … Similarly, allied health studies are needed to understand best approaches to fostering independent living … The Aberrant Behavior Checklist is the best outcome measure for behavioral symptoms in ASD in terms … Conclusions Given the number of individuals affected by ASD, there is a dramatic lack of evidence on best … effectiveness in managing irritability and aggression in this age group remains largely unknown and can at best

1489. Disposition of Comments for Comparative Effectiveness of Therapies for Clinically Localized Prostate Cancer: An Update of a 2008 Systematic Review (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/prostate-cancer-therapies-update_disposition-comments.pdf
      December 16, 2014 - Reviewer 3 Methods It seems that a huge number of studies were excluded in order to arrive at the best … While I agree that it is important to perform an analysis of only the best, I think there would be some … Page 18 – It seems that a huge number of studies were excluded in order to arrive at the best evidence … While I agree that it is important to perform an analysis of only the best, I think there would be some … The best that can be done is for investigators to continue performing long-term followup studies that

1490. DEcIDE 33: Summary Variables in Observational Resesarch: Propensity Scores and Disease Risk Scores (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/observational-research-scores_research.pdf
      May 01, 2012 - The aim is to describe best practices for creating and applying these two types of scores. … .......................................................................................... 19 How Best … Instead, the aim is to describe best practices for creating and applying these scores. … expectation is that the patient will have a better outcome if they receive the treatment (or the “best … very large number of medications and comorbidities to be accounted for can pose challenges of how best

1491. Trauma-Interventions-Maltreatment-Child Executive (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/trauma-interventions-maltreatment-child_executive.pdf
      April 01, 2013 - The goal of this review is twofold: to provide stakeholders with a synthesis of the best evidence in … To maintain a focus on the best available evidence, studies with a high risk of bias are not included … were included yet found to have lesser scientific support may be second-line options or represent best … As newly developed interventions, the extent to which each represented a “best” alternative treatment … A multisite collaborative would provide a powerful nexus for shared strategies and best practices that

1492. Payer Perspectives on Improving Usability of Effective Health Care Products: Bridging the Gap Between Information Needs and Evidence Translation | Effective Health Care (EHC) Program
      effectivehealthcare.ahrq.gov/products/payer-usability/white-paper
      February 03, 2014 - every evidence need of every stakeholder group, one conclusion is that it should focus on what it does best—producing

1493. Topic Suggestion Description | Effective Health Care Program
      effectivehealthcare.ahrq.gov/get-involved/nominated-topics/1-what-is-the-etiology-of-acute-and-chronic-urinary-retention-in-adults-2-how-do-we-define-urinary-retention-base-case-including-those-with-known-neurologic-problems-aka-what-is-considered-abnormal-pvr-3-what-is-the-natural-h
      April 22, 2011 - Nominator Information Other Information About You: (optional) Please choose a description that best

1494. Omega−3 Fatty Acids and Cardiovascular Disease: An Updated Systematic Review (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/fatty-acids-cardiovascular-disease_executive.pdf
      August 01, 2016 - The best fit curve was found with a knot at 0.3 g/d. … The best fit curve was found with a knot at 0.5 g/d. … The best fit curve was found with a knot at 0.3 g/d. … The best fit curve was found with a knot at 0.4 g/d. … The best fit curve was found with a knot at 0.9 g/d.

1495. Slide 1 (ppt file)
      effectivehealthcare.ahrq.gov/sites/default/files/module_i1.ppt
      October 31, 2011 - Applicable evidence Real-world context Information to address existing stakeholder concerns What are the best … makers who can use the results of a particular piece of research into its formulation and conduct is the best

1496. Methods Future Research Needs Number 8: Framework for Considering Study Designs (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/study-design-framework_research.pdf
      March 01, 2012 - Scope of This Paper This paper is one of a series of papers that provides recommendations and best … and adaptive designs. 7 Advantages of study design for producing a valid result: An RCT is the best … In such situations, purposive sampling may be the best way to assure balancing of covariates between … If sample size is large, this design may be the best method to assess subgroup effect or incidence … This design may be the best way to study some interventions where randomization may not be acceptable

1497. Disposition of Comments for CER 167 Renal Masses (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/renal-cancer_disposition-comments.pdf
      February 24, 2016 - ii.The data on the strength of biopsy are best considered by 3 distinct categorical variables for those … The data are not strong enough to determine at what eGFR CKD status NSS is best suited. … This guideline was largely based on expert opinions and the best studies available at the time, which … This guideline was based on expert opinions and a meta-analysis of the best studies available at the … The best that can be said, from studies in patients with localized renal cortical tumors suspicious

1498. Summary Variables in Observational Research: Propensity Scores and Disease Risk Scores | Effective Health Care (EHC) Program
      effectivehealthcare.ahrq.gov/products/observational-research-scores/research
      May 15, 2012 - The aim is to describe best practices for creating and applying these two types of scores. … Instead, the aim is to describe best practices for creating and applying these scores. … process that may involve a "treatment/no treatment" decision and possibly a decision to identify the "best … the expectation is that the patient will have a better outcome if they receive the treatment (or the "best … Some Unanswered Questions Propensity Scores How Best To Use the Propensity Score Once a propensity

1499. Disposition of Comments for Treatments for Fibromyalgia in Adult Subgroups (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/fibromyalgia_disposition-comments.pdf
      January 26, 2015 - Some of the best mechanistic studies in the pain field have been conducted in FM. … Study selection criteria were decided a priori with a literature scan and expert input to best evaluate … We did not add this reference on how best to measure outcomes changes in chronic pain since that is … Peer Reviewer 1 General At best, this paper reveals that the authors took a great deal of time and effort … Discussion, pg. 42: For clinicians, short-term studies provide very little information about how best

1500. Pressure-Ulcer-Treatment Executive (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/pressure-ulcer-treatment_executive.pdf
      May 01, 2013 - effectiveness and harms in treatment categories for which significant uncertainty exists about the best … In some studies this included use of comparators that may not be considered best practices, such as … In practice, the relevant question is often not “Which therapy works best?” … but rather “Which combination of therapies works best?” … However, we found some evidence to inform decisions and expectations about which ulcers will fare best