-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/antiplatelet-treatment_research-protocol.pdf
November 22, 2011 - systematic reviews that included quantitative analyses (meta-analyses, published in 2010–
2011) have assessed … Four additional meta-analyses have assessed the predictive utility of phenotypic tests for platelet … Furthermore, existing reviews have not assessed comparative test performance for
predicting outcomes … cardiovascular outcomes and an 18 percent increase in mortality.
19
However, no
systematic review has assessed … each outcome of interest between more precise
(larger) and less precise (smaller) studies will be assessed
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/cancer-anemia-update_research-protocol.pdf
June 16, 2010 - Further, analyses of efficacy and safety are
suggested, either assessed per the approved prescribing … undergoing a predefined anticancer
therapy, with predefined criteria when and
how tumor response will be assessed … Assessment of Applicability:
Applicability of findings in this review will be assessed within the EPICOT … Selected studies will be assessed for relevance against target populations, interventions
of interest … For QoL studies it will in addition be assessed whether patients were blinded
towards their Hb levels
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-204-obesity-disposition-comments.pdf
December 01, 2017 - of the studies considered were pre-
registered (or registered at all) in a trial registry should be
assessed … This should be
assessed for the studies considered. … The extent to
which this occurs should be assessed and described. … Was there any consideration of the ability of
study designs to ensure that those in the
population assessed … We clarified that these reviews assessed
effectiveness, but we described them here
because they used
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guidance-harms_methods.pdf
November 01, 2008 - Even when harms are
appropriately assessed and reported, the applicability of efficacy trials to general … In more than one-half of the comparisons
assessed, estimates of relative or absolute risk varied more … that the
prevalence or incidence was zero.
4
It is also important to assess how adverse events are assessed … of summary scores to assess risk of bias.
64
At a minimum, key methodological aspects should be assessed … case-control studies)
Studies do not exceed a defined threshold for risk of bias (e.g., studies assessed
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/bundled-payments-quality-effects_executive.pdf
August 01, 2012 - We assessed the methodological quality of individual
studies and reviews as good (low risk of bias), … from the GRADE (Grading
of Recommendations Assessment, Development and
Education) Working Group and assessed … residual confounding, although the expected
direction of the effect of residual confounding could not be
assessed … important contextual factors were described
in reviewed studies, but their impact was not directly
assessed … All reviewed studies assessed the impact of bundled
payment relative to either fee-for-service or cost-based
-
effectivehealthcare.ahrq.gov/sites/default/files/methodsguide_chou_assessing_harms_when_comparing.pdf
November 01, 2008 - Even when harms are
appropriately assessed and reported, the applicability of efficacy trials to general … In more than one-half of the comparisons
assessed, estimates of relative or absolute risk varied more … that the
prevalence or incidence was zero.
4
It is also important to assess how adverse events are assessed … of summary scores to assess risk of bias.
64
At a minimum, key methodological aspects should be assessed … case-control studies)
Studies do not exceed a defined threshold for risk of bias (e.g., studies assessed
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/chronic-cough_research-protocol.pdf
October 22, 2012 - For all
studies, the overall study quality will be assessed as follows:
• Good (low risk of bias). … Grading the Evidence for Each Key Question
We will grade the strength of evidence for each outcome assessed … The strength of evidence will be assessed by using the approach described in the
Methods Guide.15,18 … Assessment and Management of Chronic Cough
We will grade the strength of evidence for each outcome assessed … The strength of evidence will be assessed by using the approach desc...
VIII.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/plasma-cell-dyscrasias-sflc-assay_executive.pdf
August 01, 2012 - One C-quality retrospective study assessed the need for
bone marrow examination, with the SFLC assay … In the present review, we assessed the comparative
effectiveness of the SFLC assay as an adjunct to … Moreover, without studying a nondiseased
population, true negatives cannot be assessed. … Discordance of the SFLC response and the response as
assessed by traditional testing was reported, although … Without a population with no PCD,
true negatives cannot be assessed.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/antibiotics-respiratory-infection_research-protocol.pdf
September 22, 2014 - Notably, these reviews have not assessed the actual comparative effectiveness of
various strategies. … validity (quality) of systematic reviews, randomized trials, and cohort and case
control studies will be assessed … Reporting bias will be assessed following
EPC guidance (Appendix A), 13 using tests for funnel plot … Selective outcome and analysis reporting bias will be assessed
during individual study quality assessment … Assessing Applicability
Applicability will be assessed by paying special attention to study eligibility
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/single-group-studies_white-paper.pdf
January 01, 2013 - The use of single group studies in comparative effectiveness reviews by type of
interventions assessed … included in the study design, in which all subjects received a single intervention and the
outcomes are assessed … The use of single group studies in comparative effectiveness reviews by type of
interventions assessed … included 14 (67)
Total single group studies included, median (25
th
–75
th
percentile) 21 (8–71)
Assessed … As an example, the change in blood
pressure is assessed in patients with renal artery stenosis before
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/management-adhd-adults-protocol-amendment.pdf
January 08, 2025 - attrition, reporting, and study-specific
sources of bias:
• Selection bias: For selection bias, we assessed … • Detection bias: Detection bias assessed whether outcome assessors were aware of the
intervention … • Study-specific sources of bias: In addition to the types of bias listed above, we assessed
other … Assessing Applicability
Applicability will be assessed in accordance with the AHRQ Methods Guide and … The effects of lisdexamfetamine dimesylate on
driving behaviors in young adults with ADHD assessed with
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/management-adhd-adults-protocol.pdf
June 10, 2024 - attrition, reporting, and study-specific
sources of bias:
• Selection bias: For selection bias, we assessed … • Detection bias: Detection bias assessed whether outcome assessors were aware of the
intervention … • Study-specific sources of bias: In addition to the types of bias listed above, we assessed
other … Assessing Applicability
Applicability will be assessed in accordance with the AHRQ Methods Guide and … The effects of lisdexamfetamine dimesylate on
driving behaviors in young adults with ADHD assessed with
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/mhs-IV-rapid-response-deprescribing.pdf
February 01, 2024 - What studies have assessed the effectiveness and unintended effects of
deprescribing interventions … done for the MHS III report, in English and performed in the United States, and having
each study assessed … What Studies Have Assessed the
Effectiveness and Unintended Effects of Deprescribing
Interventions … We identified 15 systematic reviews14,15,24,27,30-40 and 7 original research articles
that assessed … Four new original research studies assessed barriers and enablers for specific
deprescribing initiatives
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/alcohol-misuse-drug-therapy_policymaker.pdf
August 01, 2016 - Strength of Evidence for the Efficacy and Effectiveness of Medications Used To Treat AUD
(Note: Studies assessed
-
effectivehealthcare.ahrq.gov/sites/default/files/wysiwyg/pdf/epc-pain-management-grand-rounds-slides.pptx
March 01, 2022 - Presentation of a very large number of results
Analytic Framework
11
Note: Restricted to studies that assessed … outcomes ≥1 m after completing treatment or ≥6 m after starting treatment; outcomes assessed at short
-
effectivehealthcare.ahrq.gov/sites/default/files/assessing-quality.ppt
January 01, 2010 - Assessing the Quality of Individual Studies
Assessing the Quality of
Individual Studies
Agency for Healthcare Research and Quality (AHRQ)
Training Modules for Methods Guide on Effectiveness and Comparative Effectiveness Reviews
Assessing the Quality of Individual Studies
Systematic Review Process Overview
*
…
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/migraine-prevention_executive.pdf
June 01, 2013 - We assessed
errors by comparing established ranges for each variable
and data charts from the original … We abstracted the time when the
outcomes were assessed as weeks from randomization and
time of followup … We assessed
heterogeneity in results with chi-square and I-squared
tests. … Grading the Evidence for Each Key Question
We assessed strength of evidence according to risk of bias … of clinically important
improvement in migraine-related disability, and quality
of life.23 We also assessed
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/depression-postpartum-screening_research-protocol.pdf
May 01, 2013 - For all
studies, the overall study quality will be assessed as follows:
• Good (low risk of bias … Grading the Evidence for Each Key Question
We will grade the strength of evidence for each outcome assessed … The
strength of evidence will be assessed by using the approach described in the Methods
Guides.30,31,38 … Any additional screening instruments identified during
the review will be assessed for validity against … The strength of evidence will be assessed by using the approach described in the Methods Guides.30,31,38
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/abnormal-uterine-bleeding_executive.pdf
March 01, 2013 - Quality (Risk of Bias) Assessment
We assessed quality of RCTs using the Cochrane
Collaboration Risk … Two independent reviewers assessed risk
of bias as low, high, or unclear for each domain. … Applicability
We assessed applicability of the results from the literature
to the population of women … Overall, 68 percent of women
taking the COC achieved excellent or good cycle control
as assessed by … treated for 3 to
6 months and at higher rates with longer use.105-107
However, the majority of use assessed
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/depression-pregnancy-postpartum_executive.pdf
July 01, 2014 - Study Selection
Two reviewers independently assessed titles and abstracts
of publications identified … Two reviewers assessed potentially relevant full
text. … Risk-of-Bias Assessment of Individual Studies
We assessed the risk of bias (internal validity) based … Applicability
We assessed applicability by examining the characteristics
of the enrolled populations … Additionally, we
formally assessed the risk of bias in individual studies and
graded the strength of