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effectivehealthcare.ahrq.gov/sites/default/files/related_files/disruptive-behavior-disorders-protocol-amendment.pdf
March 22, 2023 - Randomized controlled
trials and NRSIs will be assessed using a priori established criteria consistent … Grading the Strength of Evidence (SOE) for Major Comparisons and Outcomes:
Outcomes to be assessed … , the strength of evidence
for comparison-outcome pairs within each Key Question will be initially assessed … Applicability will be assessed in accordance with the
AHRQ’s Methods Guide, using the PICOTS framework
-
effectivehealthcare.ahrq.gov/sites/default/files/wysiwyg/pdf/epc-pain-management-grand-rounds-slides.pptx
March 01, 2022 - Presentation of a very large number of results
Analytic Framework
11
Note: Restricted to studies that assessed … outcomes ≥1 m after completing treatment or ≥6 m after starting treatment; outcomes assessed at short
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guidance-bias-individual-studies_methods.pdf
March 01, 2012 - Generally speaking, exclude precision and applicability when assessing the risk of
bias because these are assessed … x x x x x
Were interventions/exposures assessed/defined using valid and reliable measures,
implemented … x x x x x
Were outcomes assessed/defined using valid and reliable measures, implemented
consistently … x x x x x
Were confounding variables assessed using valid and reliable measures, implemented
consistently … For example, one commonly
assessed component in RCTs is allocation concealment.51 Reviewers assess whether
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/ptsd-6-protocol.pdf
December 07, 2024 - transparency and ease of future updating, the EPC will
include detailed definitions related to how RoB was assessed … the Strength of Evidence (SOE) for Major Comparisons and Outcomes:
Strength of evidence will not be assessed … 33. 5.2) Is the numerical result being assessed likely to have been selected, on the basis of the
results … 34. 5.3) Is the numerical result being assessed likely to have been selected, on the basis of the
results
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/antiplatelet-treatment_research-protocol.pdf
November 22, 2011 - systematic reviews that included quantitative analyses (meta-analyses, published in 2010–
2011) have assessed … Four additional meta-analyses have assessed the predictive utility of phenotypic tests for platelet … Furthermore, existing reviews have not assessed comparative test performance for
predicting outcomes … cardiovascular outcomes and an 18 percent increase in mortality.
19
However, no
systematic review has assessed … each outcome of interest between more precise
(larger) and less precise (smaller) studies will be assessed
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/plasma-cell-dyscrasias-sflc-assay_executive.pdf
August 01, 2012 - One C-quality retrospective study assessed the need for
bone marrow examination, with the SFLC assay … In the present review, we assessed the comparative
effectiveness of the SFLC assay as an adjunct to … Moreover, without studying a nondiseased
population, true negatives cannot be assessed. … Discordance of the SFLC response and the response as
assessed by traditional testing was reported, although … Without a population with no PCD,
true negatives cannot be assessed.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/chronic-cough_research-protocol.pdf
October 22, 2012 - For all
studies, the overall study quality will be assessed as follows:
• Good (low risk of bias). … Grading the Evidence for Each Key Question
We will grade the strength of evidence for each outcome assessed … The strength of evidence will be assessed by using the approach described in the
Methods Guide.15,18 … Assessment and Management of Chronic Cough
We will grade the strength of evidence for each outcome assessed … The strength of evidence will be assessed by using the approach desc...
VIII.
-
effectivehealthcare.ahrq.gov/sites/default/files/clinical-pathway-methods-report-appendix-k.pdf
February 01, 2018 - Study quality assessment: Guidelines assessed using Penn Medicine’s Center for Evidence-based
Practice … (CEP) Trustworthy Guideline scale, systematic reviews assessed using modified
AMSTAR (Assessing the … Study quality assessed Yes
8. Heterogeneity assessed Yes
9. Publication bias assessed Yes
10.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/cancer-anemia-update_research-protocol.pdf
June 16, 2010 - Further, analyses of efficacy and safety are
suggested, either assessed per the approved prescribing … undergoing a predefined anticancer
therapy, with predefined criteria when and
how tumor response will be assessed … Assessment of Applicability:
Applicability of findings in this review will be assessed within the EPICOT … Selected studies will be assessed for relevance against target populations, interventions
of interest … For QoL studies it will in addition be assessed whether patients were blinded
towards their Hb levels
-
effectivehealthcare.ahrq.gov/sites/default/files/methodsguide_chou_assessing_harms_when_comparing.pdf
November 01, 2008 - Even when harms are
appropriately assessed and reported, the applicability of efficacy trials to general … In more than one-half of the comparisons
assessed, estimates of relative or absolute risk varied more … that the
prevalence or incidence was zero.
4
It is also important to assess how adverse events are assessed … of summary scores to assess risk of bias.
64
At a minimum, key methodological aspects should be assessed … case-control studies)
Studies do not exceed a defined threshold for risk of bias (e.g., studies assessed
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guidance-harms_methods.pdf
November 01, 2008 - Even when harms are
appropriately assessed and reported, the applicability of efficacy trials to general … In more than one-half of the comparisons
assessed, estimates of relative or absolute risk varied more … that the
prevalence or incidence was zero.
4
It is also important to assess how adverse events are assessed … of summary scores to assess risk of bias.
64
At a minimum, key methodological aspects should be assessed … case-control studies)
Studies do not exceed a defined threshold for risk of bias (e.g., studies assessed
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-204-obesity-disposition-comments.pdf
December 01, 2017 - of the studies considered were pre-
registered (or registered at all) in a trial registry should be
assessed … This should be
assessed for the studies considered. … The extent to
which this occurs should be assessed and described. … Was there any consideration of the ability of
study designs to ensure that those in the
population assessed … We clarified that these reviews assessed
effectiveness, but we described them here
because they used
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/antibiotics-respiratory-infection_research-protocol.pdf
September 22, 2014 - Notably, these reviews have not assessed the actual comparative effectiveness of
various strategies. … validity (quality) of systematic reviews, randomized trials, and cohort and case
control studies will be assessed … Reporting bias will be assessed following
EPC guidance (Appendix A), 13 using tests for funnel plot … Selective outcome and analysis reporting bias will be assessed
during individual study quality assessment … Assessing Applicability
Applicability will be assessed by paying special attention to study eligibility
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/single-group-studies_white-paper.pdf
January 01, 2013 - The use of single group studies in comparative effectiveness reviews by type of
interventions assessed … included in the study design, in which all subjects received a single intervention and the
outcomes are assessed … The use of single group studies in comparative effectiveness reviews by type of
interventions assessed … included 14 (67)
Total single group studies included, median (25
th
–75
th
percentile) 21 (8–71)
Assessed … As an example, the change in blood
pressure is assessed in patients with renal artery stenosis before
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/bundled-payments-quality-effects_executive.pdf
August 01, 2012 - We assessed the methodological quality of individual
studies and reviews as good (low risk of bias), … from the GRADE (Grading
of Recommendations Assessment, Development and
Education) Working Group and assessed … residual confounding, although the expected
direction of the effect of residual confounding could not be
assessed … important contextual factors were described
in reviewed studies, but their impact was not directly
assessed … All reviewed studies assessed the impact of bundled
payment relative to either fee-for-service or cost-based
-
effectivehealthcare.ahrq.gov/sites/default/files/selecting-evidence.ppt
January 01, 2010 - Finally, those OSs found to have the potential to answer key questions should be assessed carefully to … Reviewers must consider whether or not the risk of bias can be fully assessed. … Other observational studies should be evaluated for relevance and then assessed for risk of bias before
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/selecting-evidence.ppt
January 01, 2010 - Finally, those OSs found to have the potential to answer key questions should be assessed carefully to … Reviewers must consider whether or not the risk of bias can be fully assessed. … Other observational studies should be evaluated for relevance and then assessed for risk of bias before
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/management-adhd-adults-protocol.pdf
June 10, 2024 - attrition, reporting, and study-specific
sources of bias:
• Selection bias: For selection bias, we assessed … • Detection bias: Detection bias assessed whether outcome assessors were aware of the
intervention … • Study-specific sources of bias: In addition to the types of bias listed above, we assessed
other … Assessing Applicability
Applicability will be assessed in accordance with the AHRQ Methods Guide and … The effects of lisdexamfetamine dimesylate on
driving behaviors in young adults with ADHD assessed with
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/management-adhd-adults-protocol-amendment.pdf
January 08, 2025 - attrition, reporting, and study-specific
sources of bias:
• Selection bias: For selection bias, we assessed … • Detection bias: Detection bias assessed whether outcome assessors were aware of the
intervention … • Study-specific sources of bias: In addition to the types of bias listed above, we assessed
other … Assessing Applicability
Applicability will be assessed in accordance with the AHRQ Methods Guide and … The effects of lisdexamfetamine dimesylate on
driving behaviors in young adults with ADHD assessed with
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/mhs-IV-rapid-response-deprescribing.pdf
February 01, 2024 - What studies have assessed the effectiveness and unintended effects of
deprescribing interventions … done for the MHS III report, in English and performed in the United States, and having
each study assessed … What Studies Have Assessed the
Effectiveness and Unintended Effects of Deprescribing
Interventions … We identified 15 systematic reviews14,15,24,27,30-40 and 7 original research articles
that assessed … Four new original research studies assessed barriers and enablers for specific
deprescribing initiatives