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  1. effectivehealthcare.ahrq.gov/sites/default/files/product/pdf/methods-guide-inclusion-nonrandomized-studies.pdf
    September 01, 2022 - Tools to assess the risk of bias in NRSIs are different from those used to assess risk of bias in RCTs … The inclusion of NRSIs in SRs in this context could help (1) assess how the overall evidence applies … Assess risk of bias using an appropriate tool for NRSIs. 12. … Health Technol Assess. 2003;7(27):iii-x, 1-173. doi: 10.3310/hta7270. PMID: 14499048. 16. … Int J Technol Assess Health Care. 2003;19(4):613-23. doi: 10.1017/s0266462303000576.
  2. effectivehealthcare.ahrq.gov/sites/default/files/pdf/chronic-kidney-disease-anemia-2011_research-protocol.pdf
    January 01, 2011 - Although overarching studies that assess the overall impact of tests on the clinical management process … Assessment of Risk of Bias of Individual Studies We will assess the methodological quality, or risk … When possible, we will perform sensitivity analyses to assess the impact of each quality item on the … of studies as standards of evaluation (e.g., 4 of 5 agree, therefore consistent) but instead will assess … We will assess the precision (precise or imprecise) of the evidence based on the degree of certainty
  3. effectivehealthcare.ahrq.gov/sites/default/files/pdf/alcohol-misuse_research-protocol.pdf
    April 28, 2010 - Assessment of Methodological Quality of Individual Studies To assess the quality (internal validity … In order to determine whether quantitative analyses are appropriate, we will assess the clinical and … Two reviewers will assess each domain for each key outcome, and differences will be resolved by consensus … Assessing Applicability We will assess applicability of the evidence following guidance from the … Health Technol Assess 2003;7(27):iii-x, 1-173. PMID: 14499048. 40.
  4. effectivehealthcare.ahrq.gov/sites/default/files/related_files/coronary-artery-stenting_disposition-comments.pdf
    February 26, 2013 - In addition, they would emphasize that randomized studies are needed to assess the role of IVUS for … The report already details the need for additional studies to assess the role of IVUS for stent optimization … to FFR definitively demonstrate that there is a strong level of evidence that FFR can be used to assess … placement of stents provide critical information regarding the severity of stenosis of a lesion and assess … developed a table that summarizes the Working Group’s assessment of the level of evidence for OCT to assess
  5. effectivehealthcare.ahrq.gov/sites/default/files/pdf/tinnitus_research-protocol.pdf
    February 22, 2012 - The VAS can be used to assess loudness, pitch, and disturbance of the tinnitus.11 Tinnitus questionnaires … , audiologist, neurologist, mental health professional; administration of scales/questionnaires to assess … Assessment of Methodological Quality of Individual Studies To assess individual study quality, … Grading the Evidence for Each Key Question We will assess the overall strength of evidence for … Health Technol Assess 2007 Oct;11(42):1-294. PMID: 17927921. 49. Searchfield G.
  6. effectivehealthcare.ahrq.gov/sites/default/files/pdf/venous-ulcers-treatment_research-protocol.pdf
    September 13, 2012 - Within the context of this review, we will assess the availability of evidence for these intervention … The study may have been missing information, making it difficult to assess limitations and potential … We will assess the risk of bias of individual studies according to study design characteristics, such … We will assess the strength of the best available evidence by assessing the limitations to individual … Assessing Applicability We will assess the applicability of studies in terms of the degree to which
  7. effectivehealthcare.ahrq.gov/sites/default/files/pdf/ace-inhibitor-arb-update_research-protocol.pdf
    May 07, 2010 - months follow-up, or write “NS” if length of follow-up not specified) - Info (if full-text needed to assess … To assess quality, we will employ the strategy to: (1) classify the study design, (2) apply predefined … To assess applicability, we will use the PICOTS format to identify specific issues that may limit the
  8. effectivehealthcare.ahrq.gov/sites/default/files/related_files/liver-cancer-therapy_executive.pdf
    May 01, 2013 - Therefore, the evidence is insufficient to assess the effect of these subgroups for any outcomes of … The evidence is insufficient to assess the effects of lesion size on other outcomes of interest in … A very large sample size with uniform data collection of these variables would be required to assess … RCTs should prespecify subgroup analyses to assess the effects of characteristics such as lesion size … Health Technol Assess. 2003;7(41):1-90. PMID: 14670218. 21.
  9. Gout Executive-2016 (pdf file)

    effectivehealthcare.ahrq.gov/sites/default/files/related_files/gout_executive-2016.pdf
    January 01, 2016 - Scope and Key Questions Scope of the Review The purpose of this review is to assess the evidence on … We used AMSTAR (A Measurement Tool to Assess Systematic Reviews) to assess the quality of existing … Finally, studies are needed that assess the incremental value of ultrasound and DECT imaging over the … Research is needed to assess the incremental value of synovial fluid MSU crystal analysis and imaging … Development of AMSTAR: a measurement tool to assess the methodological quality of systematic reviews
  10. effectivehealthcare.ahrq.gov/sites/default/files/pdf/stroke-atrial-fibrillation_research-protocol.pdf
    January 30, 2012 - Additionally, the use of imaging to assess thromboembolic risk has not been formally reviewed to date … Data needed to assess quality and applicability, as described in the Methods Guide,25 will also be abstracted … Assessment of Methodological Quality of Individual Studies We will assess methodological quality, … The study may have been missing information, making it difficult to assess limitations and potential … Assessing Applicability We will assess applicability across our key questions using the method described
  11. Layout 1 (pdf file)

    effectivehealthcare.ahrq.gov/sites/default/files/related_files/gerd-2005_executive.pdf
    January 01, 2005 - Long-term studies are needed to assess the risks associated with acid suppression on the development … of pneumonia and enteric infections, and to assess the consequences of long-term hypergastrinemia.
  12. effectivehealthcare.ahrq.gov/sites/default/files/hip-fracture-pain_surveillance.pdf
    July 08, 2015 - The search was conducted to assess the currency of conclusions using journals from among the top 10 … 26534) 5 1 and 4 (905) 6 ((pain* or discomfort* or ache* or aching or so re* or suffer*) adj3 (assess
  13. effectivehealthcare.ahrq.gov/sites/default/files/presentation.ppt
    August 01, 2009 - This is often the case in fields where there may be many relevant outcomes or multiple ways to assess
  14. Untitled (pdf file)

    effectivehealthcare.ahrq.gov/sites/default/files/pdf/antipsychotics-children-update_research-protocol.pdf
    December 04, 2015 - Two experienced reviewers will independently assess the methodological quality of all original and … We will re-assess original studies because of changes to guidance in the EPC program made subsequent … We will assess directness of the evidence (direct or indirect) on the basis of the use of surrogate … We will assess precision (precise or imprecise) on the basis of sample size and, if size is adequate … We will assess the applicability of the findings with respect to our PICOTS elements.
  15. effectivehealthcare.ahrq.gov/sites/default/files/medical-test-reviews-genetic.ppt
    June 01, 2012 - Assess the importance of preanalytic, analytic, and postanalytic factors used for evaluating genetic … used as predictive indicators; recognize the utility of organizing frameworks and analytic frameworks; assess … Reviewers should assess the added value of using genetic testing along with known factors when compared … term=19141767 Sample Size Calculations It is important to assess whether sample size calculations … Illustrative Example 1: Cytochrome P450 Testing (2 of 2) This is the analytic framework created to assess
  16. effectivehealthcare.ahrq.gov/sites/default/files/related_files/medical-test-reviews-genetic.ppt
    June 01, 2012 - Assess the importance of preanalytic, analytic, and postanalytic factors used for evaluating genetic … used as predictive indicators; recognize the utility of organizing frameworks and analytic frameworks; assess … Reviewers should assess the added value of using genetic testing along with known factors when compared … term=19141767 Sample Size Calculations It is important to assess whether sample size calculations … Illustrative Example 1: Cytochrome P450 Testing (2 of 2) This is the analytic framework created to assess
  17. effectivehealthcare.ahrq.gov/sites/default/files/pdf/omega-3-maternity_research-protocol.pdf
    May 18, 2015 - likely to be rare, and case-control studies are inadequate to address these issues); and the need to assess … were from dietary supplements, some were indirect (through breast milk), and many studies did not assess … cognitive, neurological, and visual function development, we will run test searches in PsychInfo to assess … Assessment of Methodological Risk of Bias of Individual Studies We will assess the methodological quality … A surveillance system to assess the need for updating systematic reviews. Syst Rev. 2013;2:104.
  18. effectivehealthcare.ahrq.gov/sites/default/files/pdf/arthritis-knee-physical-therapy_research-protocol.pdf
    April 01, 2010 - We will classify interventions and methods to assess the outcomes according to the classifications set … To assess harms of treatments we will follow the recommendations from the Methods Guide for Comparative … comparing the direction and strength of the association.42 Chi square and I square tests will be used to assess … Grading the Evidence for Each Key Question We will assess strength of evidence by following the guidelines … Grading the Evidence for Each Key Question We will assess strength of evidence by following the guidelines
  19. effectivehealthcare.ahrq.gov/sites/default/files/pdf/osteoarthritis-pain_research-protocol.pdf
    August 05, 2010 - inclusion based on the key questions and PICOTS, the following data will be extracted and used to assess … Assessment of Methodological Quality of Individual Studies We will assess the methodological quality … Grading the Evidence for Each Key Question We will assess the overall strength of evidence for a body … AMSTAR is a reliable and valid measurement tool to assess the methodological quality of systematic reviews
  20. effectivehealthcare.ahrq.gov/sites/default/files/pdf/autism-adolescents_research-protocol.pdf
    March 29, 2011 - We will capture and report data on instruments used to assess outcomes and how that may affect interpretation … each question: At this time, we have identified a set of anticipated outcome areas that we will assess … Assessment of Methodological Quality of Individual Studies We will assess study quality by using … Two senior investigators will independently assess each included study with disagreements between assessors … Assessing Applicability We will assess the applicability of findings reported in the included literature

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