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  1. effectivehealthcare.ahrq.gov/sites/default/files/pdf/dementia-agitation-aggression_research-protocol.pdf
    November 13, 2014 - We will use data provided by the systematic review to assess strength of evidence for results without … Two investigators will independently assess risk of bias for all included studies. … We will assess harms as dichotomous variables to acknowledge the inherent difficulties of assessing … There are various ways to assess harms; each has problems. … We will assess strength of evidence for key final health outcomes measured with validated scales.
  2. effectivehealthcare.ahrq.gov/sites/default/files/pdf/prostate-cancer-surveillance_research-protocol.pdf
    May 19, 2011 - Men with clinically localized prostate cancer (T1–T2), without (or unable to assess) either regional … Based on the final inclusion and exclusion criteria, we will assess the titles and/or abstracts of … We will assess the directness (direct or indirect) of the evidence. … We will assess the precision (precise or imprecise) of the evidence based on the degree of certainty … Development of AMSTAR: a measurement tool to assess the methodological quality of systematic reviews
  3. effectivehealthcare.ahrq.gov/sites/default/files/related_files/asd-medical-executive-170505.pdf
    May 01, 2017 - Purpose of Review To assess effectiveness and safety of medical interventions for children with autism … We categorized studies as “other” if we could not assess strength of evidence for interventions and … We considered SOE to be insufficient to assess effects. N-acetylcysteine. … Data were inadequate to assess effects on other outcomes (insufficient strength of evidence). … Few studies reported data to assess time to effect of interventions.
  4. effectivehealthcare.ahrq.gov/sites/default/files/sensitivity-analysis-chapter-11.pptx
    January 01, 2013 - Include several different comparison groups to assess robustness of the results. … Change the exposure, outcome, and covariate definitions to assess how well confounding is addressed in … Another option that can be used, when the data permit it, is an instrumental variable analysis to assess … Sample Graphical Presentation (2 of 2) Plot to assess the strength of unmeasured confounding necessary … Assess expected impact of unmeasured confounders on key measures of association.
  5. effectivehealthcare.ahrq.gov/sites/default/files/related_files/gastric-cancers-protocol-amended.pdf
    February 07, 2025 - We will only assess risk of bias for outcomes which will be included in the strength of evidence (SOE … Additionally, we plan to assess the credibility of potentially relevant effect modification using the … Below, we discuss the primary domains and how we will assess them: Study limitations. … Int J Technol Assess Health Care. Summer 2006;22(3):288-94. doi:10.1017/s0266462306051166. … Development of the Instrument to assess the Credibility of Effect Modification Analyses (ICEMAN) in
  6. effectivehealthcare.ahrq.gov/sites/default/files/pdf/decision-models-guidance_methods.pdf
    October 01, 2016 - Health Technol Assess. 2004 Sep;8(36):iii-158. PMID: 15361314. 71. … EUR- ASSESS Project Subgroup report on Methodology. … Health Technol Assess. 2004 Dec;8(49):iii-192. PMID: 15544708. 154. … Health Technol Assess. 2009 Jan;13(8):iii, ix-50. PMID: 19203465. 158. … Health Technol Assess. 2003;7:iii, ix-x, 1-51. PMID: 14609481. 324.
  7. effectivehealthcare.ahrq.gov/sites/default/files/pdf/ptsd-adult-treatment_research-protocol.pdf
    December 20, 2011 - In order to determine whether quantitative analyses are appropriate, we will assess the clinical … Davidson Trauma Scale (DTS)29, 30 • 17-item, self-rating scale used to assess DSM-IV PTSD criteria … Impact of Events Scale (IES)31 • 15-item self-reported measure used to assess the frequency with … • It does not assess all of the 17 DSM symptoms of PTSD and includes items that are not directly … • Assess the severity of PTSD symptoms (consist of the same 17 items as the PSS- I).
  8. M (pdf file)

    effectivehealthcare.ahrq.gov/sites/default/files/systematicreviewsreplacedenovo.pdf
    September 01, 2009 - , we recommend: • At least two independent reviewers should assess SRs for quality … • Determining specific criteria to assess the quality of individual patient data meta-analyses. … Health Technol Assess 2003;7:1-76. 21. Moher D, Pham B, Klassen TP, et al. … Assess for relevance SRs relevant? … Assess for quality STEP 4. Determine use for SR STEP 5.
  9. M (pdf file)

    effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guidance-de-novo-processes_methods.pdf
    September 01, 2009 - , we recommend: • At least two independent reviewers should assess SRs for quality … • Determining specific criteria to assess the quality of individual patient data meta-analyses. … Health Technol Assess 2003;7:1-76. 21. Moher D, Pham B, Klassen TP, et al. … Assess for relevance SRs relevant? … Assess for quality STEP 4. Determine use for SR STEP 5.
  10. effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-249-malnutrition-disposition-comments_0_0.pdf
    October 13, 2021 - In addition, subgroup analysis was performed to assess if treatment effects varied by age, definition … To assess which measure is more effective, one could envision a multi-arm clinical trial that compares … This enables us to track outcomes by nutritional status, but also to assess change. … How else can we assess the impact of treatment or care without measures of change? … However, MCIDs may not be available or developed for all measurement tools or metrics used to assess
  11. Layout 1 (pdf file)

    effectivehealthcare.ahrq.gov/sites/default/files/related_files/juvenile-arthritis-dmards_executive.pdf
    September 01, 2011 - Developing instruments that accurately assess the effect of JIA on health and well- being is critical … to enable us to assess the overall impact of the disease and to quantify the efficacy of treatments. … Multiple instruments have been developed or adapted to assess severity of disease, disability, and quality … Multidimensional instruments appear to better assess outcomes. … Implementing more general disease-based registries could not only help assess risk but help evaluate
  12. effectivehealthcare.ahrq.gov/sites/default/files/pdf/acs-pci-adjunctive-devices_research-protocol.pdf
    July 01, 2010 - Criteria for Inclusion and Exclusion of Studies in the Review Two independent reviewers will assess … The study may be missing information, making it difficult to assess limitations and potential problems … Visual inspection of funnel plots and Egger’s weighted regression statistics will be used to assess … These analyses will also be conducted to assess the effect of trial inclusion criteria, patient demographics … We will assess whether or not the effect sizes were on the same side of unity; whether the range of
  13. effectivehealthcare.ahrq.gov/sites/default/files/related_files/gastric-cancers-protocol.pdf
    January 01, 2024 - We will only assess risk of bias for outcomes which will be included in the strength of evidence (SOE … Additionally, we plan to assess the credibility of potentially relevant effect modification using the … Below, we discuss the primary domains and how we will assess them: Study limitations. … Int J Technol Assess Health Care. Summer 2006;22(3):288-94. doi:10.1017/s0266462306051166. … Development of the Instrument to assess the Credibility of Effect Modification Analyses (ICEMAN) in
  14. Hi Les, (pdf file)

    effectivehealthcare.ahrq.gov/sites/default/files/pdf/rtc-design-principles_research.pdf
    January 01, 2009 - • Second, to assess the incremental sensitivity and specificity of adding the new test to estimate … When do we need long-term RCTs to assess trade-offs between the benefits and harms of a new test? … RCTs are needed to assess the efficacy of an existing treatment for the extra cases detected by a new … more sensitive test, just as they are needed to assess the efficacy of new treatments. … Health Technol Assess 2006;10(15). 16. Bates SM, Kearon C, Crowther M, et al.
  15. effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guidance-principles_methods.pdf
    August 01, 2009 - and harms for different treatments and tests in a consistent way so that decisionmakers can fairly assess … Effectiveness studies use less stringent eligibility criteria, assess health outcomes, and have longer … We will continue to assess both the ability to implement our recommendations and the validity of the … Challenges in systematic reviews that assess treatment harms [review]. … Int J Technol Assess Health Care 2008;24(03):244–58. 24. Black D. POM + EBM = CPD? [editorial].
  16. effectivehealthcare.ahrq.gov/sites/default/files/related_files/gastric-cancers-protocol-amendment.pdf
    May 02, 2025 - We will only assess risk of bias for outcomes which will be included in the strength of evidence (SOE … Additionally, we plan to assess the credibility of potentially relevant effect modification using the … Below, we discuss the primary domains and how we will assess them: Study limitations. … Int J Technol Assess Health Care. Summer 2006;22(3):288-94. doi:10.1017/s0266462306051166. … Development of the Instrument to assess the Credibility of Effect Modification Analyses (ICEMAN) in
  17. effectivehealthcare.ahrq.gov/sites/default/files/pdf/cystic-fibrosis-hgh_research-protocol.pdf
    August 22, 2008 - the 10th percentile for height and for weight.13 Percentage weight- for-height may also be used to assess … Visual inspection of funnel plots and Egger’s weighted regression statistics will be used to assess … Subgroup analyses will be conducted to assess the effect age, gender, and baseline clinical status on … We will first assess the risk of bias based on the study designs of the available evidence. … Subgroup analyses will be conducted to assess the effect age, gender, and baseline clinic...
  18. effectivehealthcare.ahrq.gov/sites/default/files/related_files/anal-cancer-protocol.pdf
    September 26, 2023 - Purpose of this review This systematic review will assess the effectiveness and harms of treatment … Assessment of Methodological Risk of Bias of Individual Studies We will assess risk of bias of eligible … We will assess the clinical and methodological heterogeneity and variation in effect size to determine … We will identify heterogeneity (inconsistency) through visual inspection of the forest plots to assess … r) adj2 (assess* or burden or grade or grading or invasive* or metastas?
  19. effectivehealthcare.ahrq.gov/sites/default/files/pdf/integrating-evidence_methods.pdf
    February 01, 2015 - It is more important to assess and include prior reviews that are most relevant and of high quality … Appraising the approach used to assess RoB includes determining if the prior review used a generally … It is also important to assess consistency to ensure that the questions with and without new studies … Criteria to assess the relevance, in terms of question elements and currency, and quality of existing … A surveillance system to assess the need for updating systematic reviews.
  20. effectivehealthcare.ahrq.gov/sites/default/files/pdf/ptsd-adult-treatment-update_research-protocol.pdf
    December 31, 2017 - The core of the controversy stems from differences in the rating systems each review applied to assess … If we conduct quantitative syntheses (i.e., meta-analysis), we will assess statistical heterogeneity … Impact of Events Scale (IES)39 • 15-item self-reported measure used to assess the frequency with … Los Angeles Symptom Checklist (LASC)38 • 43-item self-report measure used to assess PTSD symptoms … • Assess the severity of PTSD symptoms (consist of the same 17 items as the PSS- I).

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