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361. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/heart-failure-natriuretic-peptide_research-protocol.pdf
     December 20, 2011 - Subgroup analyses for age, gender and co-morbidities will be undertaken to assess clinical diversity … Grading the Evidence for Each Key Question We will assess the overall strength of the evidence (SOE … For KQ1 and KQ2, we will assess SOE using the method for medical tests 29 and for KQ6 we will use … We will assess applicability in accordance with the Methods Guide for Medical Test Reviews. 29 … Evid Rep Technol Assess 2006;(142):1-147. 5. de Lemos JA, McGuire DK, Khera A, et al.

362. Cer-242-Radiation-Therapy-Brain-Metastases-Evidence-Summary (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/cer-242-radiation-therapy-brain-metastases-evidence-summary.pdf
     June 01, 2021 - Studies varied by intervention, comparator, measures used to assess effects, and reported detail. … Studies varied by intervention, comparator, measures used to assess effects, and reported detail.

363. EHC Protocol: Making Healthcare Safer IV: Deprescribing to Reduce Medication Harms in Older Adults (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/deprescribing-protocol.pdf
     July 01, 2023 - When assessing non-randomized studies, we will 7 use specific items in the ROBINS-I tool that assess … Evid Rep Technol Assess (Full Rep). 2013 Mar(211):1-945. PMID: 24423049. 21.

364. EHC Protocol: Addressing Social Isolation To Improve Health of Older Adults: A Rapid Evidence Review (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/high-risk-drugs-protocol.pdf
     July 27, 2023 - We will not independently assess original studies included in any such systematic review. … When assessing non-randomized studies, we will use specific items in the ROBINS-I tool that assess … We will not independently assess original studies included in any such systematic review.

365. hemorrhage-postpartum-protocol-140611 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/hemorrhage-postpartum_research-protocol.pdf
     June 11, 2014 - We will, however, re-assess non-English studies as we update our MEDLINE search. … deem to be of low risk of bias and able to affect conclusions • For KQ 5, studies must explicitly assess … Assessment of Methodological Risk of Bias of Individual Studies We will assess the quality of studies … We will use the McMaster Quality Assessment Scale of Harms (McHarm) tool to assess harms studies.52 … Two senior investigators will independently assess each included study.

366. Pharmacologic Management of Acute Pain by EMS in the Prehospital Setting Protocol Amendment (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/acute-pain-ems-protocol-amendment.pdf
     January 28, 2019 - Impetus for the Review This systematic review will assess the comparative effectiveness and harms … may contact authors of candidate articles for clarification of reported study details in order to assess … non-randomized studies, we will use the Newcastle Ottawa Scale.18 Two reviewers will independently assess … When quantitative pooling of studies is possible, we will assess for the presence of statistical heterogeneity … To assess for the presence of publication bias, visual inspection of funnel plots will be considered

367. Making Healthcare Safer IV: Programs for Responding to Harms Experienced by Patients during Clinical Care (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/clinical-care-protocol.pdf
     January 01, 2024 - For this rapid review, we plan to focus on studies that assess the effectiveness of interventional … .27 When assessing non-randomized studies, we will use specific items in the ROBINS-I tool that assess … Analysis of Subgroups or Subsets We will assess whether the effectiveness of programs differs according

368. Protocol for Quantitative Assessment of Benefit and Harm analysis of Aspirin for primary prevention (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-balancing-harms-benefits_research.pdf
     February 01, 2014 - all Four Outcomes, and Relative Weights of Outcomes ix Background Systematic reviews often assess … We were unable to assess the strength of evidence around the benefit and harm comparison metric, or … We were unable to assess competing risk. We presented results using excess events. … There are no estimates of uncertainty (such as 95% CI), but we could assess the probability of the … In the absence of a gold standard method for elicitation of preferences, such research should assess

369. Assessment Tools for Palliative Care | Effective Health Care (EHC) Program
     effectivehealthcare.ahrq.gov/products/palliative-care-tools/technical-brief-2017

370. Assessment Tools for Palliative Care | Effective Health Care (EHC) Program
     effectivehealthcare.ahrq.gov/products/palliative-care-tools/research-protocol

371. Assessment and Management of Chronic Cough | Effective Health Care (EHC) Program
     effectivehealthcare.ahrq.gov/products/chronic-cough/research

372. Assessment and Management of Chronic Cough | Effective Health Care (EHC) Program
     effectivehealthcare.ahrq.gov/products/chronic-cough/research-protocol

373. Transparency of Reporting Requirements: Omega-3 Fatty Acids and Cardiovascular Disease (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/transparency-omega-3_research-protocol.pdf
     September 02, 2016 - For newly found studies, we will record additional data and assess their risk of bias. … For studies identified in the original review, we will also assess the congruence of any additional … If meta-analyses are not conducted, we will assess whether the new studies fall within the range of … Evid Rep Technol Assess (Summ). 2004 Mar(94):1-8. PMID: 15133888. 18. … Evid Rep Technol Assess (Summ). 2004 Mar(93):1-6. PMID: 15133887. 19.

374. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/trauma-child-interventions_research-protocol.pdf
     March 26, 2012 - To assess the risk of bias of studies, we will use criteria described in the AHRQ Methods Guide for … will use questions specified in the RTI Item Bank36 and the Cochrane Risk of Bias tool.37 We will assess … To determine whether quantitative analyses are appropriate, we will assess the clinical heterogeneity … Two reviewers will assess each domain for each key outcome listed in the framework, and conflicts will … To assess the applicability of a body of evidence, we will consider the consistency of results across

375. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/vaccine-safety_research-protocol.pdf
     September 18, 2012 - can monitor the safety of clinical trial subjects and ensure that the study design is appropriate to assess … Assessing Strength of Evidence: Grading the Strength of Evidence for Individual Outcomes We will assess … applicability in mind; furthermore, they sometimes report only a few of the factors needed to fully assess … Evidence tables will clearly distinguish studies designed to assess effectiveness versus those designed … specifically to assess safety.

376. EHC Protocol: Addressing Social Isolation To Improve Health of Older Adults: A Rapid Evidence Review (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/mhs-IV-patient-family-engagement.pdf
     July 01, 2023 - biases.14 When assessing non-randomized studies, we will use specific items in the ROBINS-I tool that assess

377. Untitled (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/thromboembolism-update_research-protocol.pdf
     February 17, 2016 - February 17, 2016 9 Assessment of Methodological Risk of Bias of Individual Studies – We will assess … body of evidence as per the AHRQ methods guide on assessing the strength of evidence.5 We plan to assess … AHRQ approach, for each intervention and comparison of intervention, and for each outcome, we will assess … Assessing Applicability: We will assess the applicability within and across studies with reference to … At a minimum, factors of interest to assess applicability will be the key potential modifiers listed

378. EHC Protocol: Addressing Social Isolation To Improve Health of Older Adults: A Rapid Evidence Review (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/mhs-IV-sepsis.pdf
     July 01, 2023 - .12 When assessing non-randomized studies, we will use specific items in the ROBINS-I tool that assess

379. Blood-based Tests for Multiple Cancer Screening: A Systematic Review (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cell-free-dna-protocol.pdf
     June 05, 2024 - evolve and it will not be practical to evaluate each new generation of a test in a large trial to assess … Objectives of the Review This systematic review will assess the accuracy, effectiveness, and harms … In some cases, we may report an outcome-specific ROB rating within a study if we assess the outcome … Two reviewers will independently assess the ROB for each study; disagreements on domain-level ratings … For KQs 1 and 2, we will assess reporting bias by comparing protocols to final reported methods and

380. Systematic Review Update: Noninvasive Nonpharmacologic Treatment for Chronic Pain (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/nonpharm-treatment-chronic-pain-protocol.pdf
     December 11, 2018 - the Department of Health & Human Services (HHS) to contract with the Institute of Medicine (IOM) to assess … We will assess strength of evidence and draw conclusions based on the totality of evidence available … of Bias of Individual Studies The predefined criteria used for the 2018 report will be used to assess … The study may be missing information, making it difficult to assess limitations and potential problems … We will use this information to assess the situations in which the evidence is most relevant and to