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effectivehealthcare.ahrq.gov/sites/default/files/related_files/kidney-stones-protocol.pdf
September 24, 2024 - Objectives of the Review
This systematic review will assess the effectiveness, comparative effectiveness … • Study Designs: RCTs; NRSI with concurrent comparator group and primary study
aim/outcome to assess … In some cases, we may report an outcome-specific ROB rating within a study if
we assess the outcome … Two reviewers will independently assess the
ROB for each study; disagreements on domain-level … We will assess statistical heterogeneity for any quantitative synthesis with the I2 statistic
and will
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/worker-health_research-protocol.pdf
May 26, 2015 - Assessment of Methodological Risk of Bias of Individual Studies: To assess … These include questions
to assess selection bias, confounding, performance bias, detection bias, and … Two independent reviewers will assess risk of bias for each study. … Two reviewers will assess each domain for
each key outcome, and differences will be resolved by consensus … Source: Berkman et al.23
Assessing Applicability: We will assess the applicability of individual studies
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effectivehealthcare.ahrq.gov/sites/default/files/study-design-considerations-chapter-2.pptx
January 01, 2013 - exposure and the exposure from the outcome
Allows estimation of actual incidence (risk or rate)
Can assess … Appropriate for studying acute effects of transient exposures
Advantages:
Self-controlled
Ability to assess … Advantages
The lack of need to select controls, the ability to assess short-term reversible effects, … Important Considerations
The first step is to identify all cases with the outcome and assess the prevalence … employ a new-user design (or provide a rationale for assessing confounders at the index date), and assess
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/women-hiv_research-protocol.pdf
March 01, 2016 - Assess the performance of diagnostics for co-occurring disease; and assess the effects of
treating … Assess co-occurring diseases and risk factors as
predictor of all-cause mortality and HIV progression … The third interest area includes studies
that assess the performance of tests for diagnosing co-occurring … Alternatively, assess modifiers of initial or continued engagement with a resource (as
defined by the … For the second interest area eligible are studies that assess the association between different
levels
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/undescended-testicle_executive.pdf
December 01, 2012 - For KQ1a and KQ1b, we accepted single-arm studies
because the purpose of those questions was to assess … Neither study included
a clinically relevant outcome, so we did not assess the
strength of the evidence … Therefore, no data
are available to assess whether one approach is superior
for fertility outcomes … Although no study was adequately powered to assess this
possibility, most studies that provide the data … In addition, most
studies provided adequate followup data to assess later
atrophy.
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guidance-grading-strength_methods.pdf
July 01, 2009 - Table 1 defines these and indicates how to assess and apply them. … For strength-of-evidence grading, this domain requires reviewers to assess the
aggregate quality of … Second, EPCs should assess each of the major domains for rating the overall strength of
evidence. … In
addition, EPCs should assess the resulting inter-rater reliability for each domain. … In the future, CERs may increasingly assess diagnostic tests or
strategies.
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/gestational-diabetes-screening-diagnosis_research-protocol.pdf
December 16, 2011 - Next, two reviewers will independently assess the full text of each report using a standard form
that … Assessment of Methodological Quality of Individual Studies
Two reviewers will independently assess … We will assess the methodological quality of studies relevant to KQ1 using the QUADAS
checklist.
22 … For each outcome, we will assess four major domains: risk of bias
(rated as low, moderate, or high) … Assessing Applicability
We will assess the applicability of the body of evidence following the PICOTS
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effectivehealthcare.ahrq.gov/sites/default/files/product/pdf/strategies-integrating-behavioral-health-protocol.pdf
August 04, 2022 - What are the gaps in measurement and what are the implications for our current ability to
measure and assess … is
unlikely to be large randomized controlled trials (RCTs) with patient-level randomization that
assess … As such, we will assess risk of bias for Questions 2 and 5a. … However, we will assess and consider the quality of studies identified for the remaining
questions. … Predefined criteria will be used to assess the risk of bias for each individual
included study, using
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/osteoporosis-vibration-therapy_research-protocol.pdf
January 01, 2020 - One reviewer will collect the data and
assess the evidence against the inclusion and exclusion criteria … comparison group
O — Outcomes
Bone mass density as outcome of interest (yes or no)
Measures used to assess … mass density measurement
Bone mineral content as outcome of interest (yes or no)
Measures used to assess … bone mineral content
Fracture as outcome of interest (yes or no)
Measures used to assess fracture … Quality of life as outcome of interest (yes or no)
Measures used to assess quality of life
Harms reported
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/predictors-trauma-care_research-protocol.pdf
May 31, 2017 - In field triage, emergency
medical services (EMS) personnel assess and monitor circulation and respiration … The
first step is to assess variables such as level of consciousness, circulation, and respiration. … Scope and Key Questions
The scope of this review is limited to measures that assess the physiologic … The study may be missing information,
making it difficult to assess limitations and potential problems … We will
assess whether quantitative synthesis (i.e., meta-analysis) is possible based on the
quantity
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/fibromyalgia_research-protocol.pdf
April 03, 2014 - For randomized clinical trials (RCTs), we will assess the risk of bias using a modified
Cochrane Risk … Additional items will be developed to assess potential risk-of-bias not addressed by
the Cochrane tool … We will include additional items to assess the credibility of subgroup analysis of individual
RCTs based … We developed an instrument to assess risk of bias for observational studies using the RTI
Observational … We will assess the heterogeneity among clinical, methodological and PICOTS elements to
determine the
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/traumatic-brain-injury-rehabilitation_executive.pdf
June 01, 2012 - Several
measures are available to assess severity. … Other intermediate measures are used to assess
the progress of individuals in rehabilitation settings … Two
investigators used the appropriate form to independently
assess the risk of bias of eligible studies … Results from the RCT were primarily used to assess
SOE because the cohort study provided unadjusted … Only one eligible study used an MCID to assess
effectiveness.
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/breastfeeding-health-outcomes-research-executive-summ.pdf
March 01, 2025 - We used existing
systematic reviews and a thorough process to select and assess the credibility of these … Evid Rep Technol
Assess (Full Rep). 2007 Apr(153):1-186.
2. Odom EC, Li R, Scanlon KS, et al.
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-215-depression-older-adults-executive-summary.pdf
March 01, 2019 - Adverse Effects of Pharmacologic Treatments of Major Depression in Older Adults
Purpose of Review
To assess … The objective
of this review is to assess comparative adverse
effects of pharmacologic antidepressants … None of the trials were powered to evaluate harms
as they were all designed to assess efficacy. … We found no evidence to assess harms for
several therapies of interest including fluvoxamine,
11 … with
therapies used to treat MDD in older patients,
particularly well controlled studies powered to
assess
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/suicidal-thoughts-young-people-amendement-may-2025.pdf
January 01, 2025 - Purpose of the Review
This systematic review will assess the effectiveness, comparative effectiveness … If evidence is available, we will also
assess how differences in effectiveness and harms are influenced … the risk of bias of the included RCTs using the Cochrane Collaboration’s Risk
of Bias 2 tool28 to assess … will follow the procedures outlined in the EPC Methods Guide for Comparative
Effectiveness Reviews to assess … We will assess scalability of
interventions by summarizing dropout rates and any other relevant information
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/suicidal-thoughts-young-people-draft-protocol.pdf
March 14, 2024 - Purpose of the Review
This systematic review will assess the effectiveness, comparative effectiveness … If evidence is available, we will also
assess how differences in effectiveness and harms are influenced … the risk of bias of the included RCTs using the Cochrane Collaboration’s Risk
of Bias 2 tool28 to assess … will follow the procedures outlined in the EPC Methods Guide for Comparative
Effectiveness Reviews to assess … We will assess scalability of
interventions by summarizing dropout rates and any other relevant information
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND_0161_09-01-2009.pdf
January 01, 2009 - Several randomized controlled trials are available that assess the
effectiveness of Buteyko and other
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effectivehealthcare.ahrq.gov/sites/default/files/ch_2-user-guide-to-ocer_130129.pdf
January 01, 2011 - Cohort studies allow investigators to
assess multiple outcomes from given treatments. … Study Design Considerations
Clinical researchers may also be tempted to assess
the treatments during … It is straightforward to assess multiple
exposures, although this will quickly become
very complicated … Advantages
The lack of need to select controls, the ability to
assess short-term reversible effects … The
use of self-controlled analytical techniques to
assess the temporal association between use of
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effectivehealthcare.ahrq.gov/sites/default/files/estimation-and-reporting_chapter-3.pptx
January 01, 2013 - hypothesized direction of effect within subgroups and the significance levels that will be used to assess … adherence to sound study design principles by evaluating balance on covariates within subgroups to assess … hypothesized direction of effect within subgroups and the significance levels that will be used to assess … methods to adjust for multiple testing, if applicable
Describe how confounding will be addressed - Assess
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effectivehealthcare.ahrq.gov/sites/default/files/suppl-1-user-guide-to-ocer_130129.pdf
January 01, 2011 - Investigators should assess the characteristics of the patient sample relative to the study objective … percent of patients use a beta blocker after
acute myocardial infarction, a CER objective
may be to assess … To make a case that a research design has the
ability to identify a parameter sufficient to assess … If the CER objective is to assess average
treatment effectiveness for the subset of patients
whose … the
authors argued that their IV estimates identified
the treatment effect parameter required to assess