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  1. effectivehealthcare.ahrq.gov/sites/default/files/related_files/kidney-stones-protocol.pdf
    September 24, 2024 - Objectives of the Review This systematic review will assess the effectiveness, comparative effectiveness … • Study Designs: RCTs; NRSI with concurrent comparator group and primary study aim/outcome to assess … In some cases, we may report an outcome-specific ROB rating within a study if we assess the outcome … Two reviewers will independently assess the ROB for each study; disagreements on domain-level … We will assess statistical heterogeneity for any quantitative synthesis with the I2 statistic and will
  2. effectivehealthcare.ahrq.gov/sites/default/files/pdf/worker-health_research-protocol.pdf
    May 26, 2015 - Assessment of Methodological Risk of Bias of Individual Studies: To assess … These include questions to assess selection bias, confounding, performance bias, detection bias, and … Two independent reviewers will assess risk of bias for each study. … Two reviewers will assess each domain for each key outcome, and differences will be resolved by consensus … Source: Berkman et al.23 Assessing Applicability: We will assess the applicability of individual studies
  3. effectivehealthcare.ahrq.gov/sites/default/files/study-design-considerations-chapter-2.pptx
    January 01, 2013 - exposure and the exposure from the outcome Allows estimation of actual incidence (risk or rate) Can assess … Appropriate for studying acute effects of transient exposures Advantages: Self-controlled Ability to assess … Advantages The lack of need to select controls, the ability to assess short-term reversible effects, … Important Considerations The first step is to identify all cases with the outcome and assess the prevalence … employ a new-user design (or provide a rationale for assessing confounders at the index date), and assess
  4. effectivehealthcare.ahrq.gov/sites/default/files/pdf/women-hiv_research-protocol.pdf
    March 01, 2016 - Assess the performance of diagnostics for co-occurring disease; and assess the effects of treating … Assess co-occurring diseases and risk factors as predictor of all-cause mortality and HIV progression … The third interest area includes studies that assess the performance of tests for diagnosing co-occurring … Alternatively, assess modifiers of initial or continued engagement with a resource (as defined by the … For the second interest area eligible are studies that assess the association between different levels
  5. effectivehealthcare.ahrq.gov/sites/default/files/related_files/undescended-testicle_executive.pdf
    December 01, 2012 - For KQ1a and KQ1b, we accepted single-arm studies because the purpose of those questions was to assess … Neither study included a clinically relevant outcome, so we did not assess the strength of the evidence … Therefore, no data are available to assess whether one approach is superior for fertility outcomes … Although no study was adequately powered to assess this possibility, most studies that provide the data … In addition, most studies provided adequate followup data to assess later atrophy.
  6. effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guidance-grading-strength_methods.pdf
    July 01, 2009 - Table 1 defines these and indicates how to assess and apply them. … For strength-of-evidence grading, this domain requires reviewers to assess the aggregate quality of … Second, EPCs should assess each of the major domains for rating the overall strength of evidence. … In addition, EPCs should assess the resulting inter-rater reliability for each domain. … In the future, CERs may increasingly assess diagnostic tests or strategies.
  7. effectivehealthcare.ahrq.gov/sites/default/files/pdf/gestational-diabetes-screening-diagnosis_research-protocol.pdf
    December 16, 2011 - Next, two reviewers will independently assess the full text of each report using a standard form that … Assessment of Methodological Quality of Individual Studies Two reviewers will independently assess … We will assess the methodological quality of studies relevant to KQ1 using the QUADAS checklist. 22 … For each outcome, we will assess four major domains: risk of bias (rated as low, moderate, or high) … Assessing Applicability We will assess the applicability of the body of evidence following the PICOTS
  8. effectivehealthcare.ahrq.gov/sites/default/files/product/pdf/strategies-integrating-behavioral-health-protocol.pdf
    August 04, 2022 - What are the gaps in measurement and what are the implications for our current ability to measure and assess … is unlikely to be large randomized controlled trials (RCTs) with patient-level randomization that assess … As such, we will assess risk of bias for Questions 2 and 5a. … However, we will assess and consider the quality of studies identified for the remaining questions. … Predefined criteria will be used to assess the risk of bias for each individual included study, using
  9. effectivehealthcare.ahrq.gov/sites/default/files/pdf/osteoporosis-vibration-therapy_research-protocol.pdf
    January 01, 2020 - One reviewer will collect the data and assess the evidence against the inclusion and exclusion criteria … comparison group O — Outcomes Bone mass density as outcome of interest (yes or no) Measures used to assess … mass density measurement Bone mineral content as outcome of interest (yes or no) Measures used to assess … bone mineral content Fracture as outcome of interest (yes or no) Measures used to assess fracture … Quality of life as outcome of interest (yes or no) Measures used to assess quality of life Harms reported
  10. effectivehealthcare.ahrq.gov/sites/default/files/pdf/predictors-trauma-care_research-protocol.pdf
    May 31, 2017 - In field triage, emergency medical services (EMS) personnel assess and monitor circulation and respiration … The first step is to assess variables such as level of consciousness, circulation, and respiration. … Scope and Key Questions The scope of this review is limited to measures that assess the physiologic … The study may be missing information, making it difficult to assess limitations and potential problems … We will assess whether quantitative synthesis (i.e., meta-analysis) is possible based on the quantity
  11. effectivehealthcare.ahrq.gov/sites/default/files/pdf/fibromyalgia_research-protocol.pdf
    April 03, 2014 - For randomized clinical trials (RCTs), we will assess the risk of bias using a modified Cochrane Risk … Additional items will be developed to assess potential risk-of-bias not addressed by the Cochrane tool … We will include additional items to assess the credibility of subgroup analysis of individual RCTs based … We developed an instrument to assess risk of bias for observational studies using the RTI Observational … We will assess the heterogeneity among clinical, methodological and PICOTS elements to determine the
  12. effectivehealthcare.ahrq.gov/sites/default/files/related_files/traumatic-brain-injury-rehabilitation_executive.pdf
    June 01, 2012 - Several measures are available to assess severity. … Other intermediate measures are used to assess the progress of individuals in rehabilitation settings … Two investigators used the appropriate form to independently assess the risk of bias of eligible studies … Results from the RCT were primarily used to assess SOE because the cohort study provided unadjusted … Only one eligible study used an MCID to assess effectiveness.
  13. effectivehealthcare.ahrq.gov/sites/default/files/related_files/breastfeeding-health-outcomes-research-executive-summ.pdf
    March 01, 2025 - We used existing systematic reviews and a thorough process to select and assess the credibility of these … Evid Rep Technol Assess (Full Rep). 2007 Apr(153):1-186. 2. Odom EC, Li R, Scanlon KS, et al.
  14. effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-215-depression-older-adults-executive-summary.pdf
    March 01, 2019 - Adverse Effects of Pharmacologic Treatments of Major Depression in Older Adults Purpose of Review To assess … The objective of this review is to assess comparative adverse effects of pharmacologic antidepressants … None of the trials were powered to evaluate harms as they were all designed to assess efficacy. … We found no evidence to assess harms for several therapies of interest including fluvoxamine, 11 … with therapies used to treat MDD in older patients, particularly well controlled studies powered to assess
  15. effectivehealthcare.ahrq.gov/sites/default/files/related_files/suicidal-thoughts-young-people-amendement-may-2025.pdf
    January 01, 2025 - Purpose of the Review This systematic review will assess the effectiveness, comparative effectiveness … If evidence is available, we will also assess how differences in effectiveness and harms are influenced … the risk of bias of the included RCTs using the Cochrane Collaboration’s Risk of Bias 2 tool28 to assess … will follow the procedures outlined in the EPC Methods Guide for Comparative Effectiveness Reviews to assess … We will assess scalability of interventions by summarizing dropout rates and any other relevant information
  16. effectivehealthcare.ahrq.gov/sites/default/files/related_files/suicidal-thoughts-young-people-draft-protocol.pdf
    March 14, 2024 - Purpose of the Review This systematic review will assess the effectiveness, comparative effectiveness … If evidence is available, we will also assess how differences in effectiveness and harms are influenced … the risk of bias of the included RCTs using the Cochrane Collaboration’s Risk of Bias 2 tool28 to assess … will follow the procedures outlined in the EPC Methods Guide for Comparative Effectiveness Reviews to assess … We will assess scalability of interventions by summarizing dropout rates and any other relevant information
  17. effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND_0161_09-01-2009.pdf
    January 01, 2009 - Several randomized controlled trials are available that assess the effectiveness of Buteyko and other
  18. effectivehealthcare.ahrq.gov/sites/default/files/ch_2-user-guide-to-ocer_130129.pdf
    January 01, 2011 - Cohort studies allow investigators to assess multiple outcomes from given treatments. … Study Design Considerations Clinical researchers may also be tempted to assess the treatments during … It is straightforward to assess multiple exposures, although this will quickly become very complicated … Advantages The lack of need to select controls, the ability to assess short-term reversible effects … The use of self-controlled analytical techniques to assess the temporal association between use of
  19. effectivehealthcare.ahrq.gov/sites/default/files/estimation-and-reporting_chapter-3.pptx
    January 01, 2013 - hypothesized direction of effect within subgroups and the significance levels that will be used to assess … adherence to sound study design principles by evaluating balance on covariates within subgroups to assess … hypothesized direction of effect within subgroups and the significance levels that will be used to assess … methods to adjust for multiple testing, if applicable Describe how confounding will be addressed - Assess
  20. effectivehealthcare.ahrq.gov/sites/default/files/suppl-1-user-guide-to-ocer_130129.pdf
    January 01, 2011 - Investigators should assess the characteristics of the patient sample relative to the study objective … percent of patients use a beta blocker after acute myocardial infarction, a CER objective may be to assess … To make a case that a research design has the ability to identify a parameter sufficient to assess … If the CER objective is to assess average treatment effectiveness for the subset of patients whose … the authors argued that their IV estimates identified the treatment effect parameter required to assess

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