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421. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/medication-adherence-interventions_research-protocol.pdf
     August 18, 2011 - Moreover, the previous review did not assess the impact of system-level interventions on adherence. … 4 Thus, in our review, we would like to assess these interventions and those at the patient and provider … To assess the quality (internal validity) of studies, we will use predefined criteria based on those … To determine whether quantitative analyses are appropriate, we will assess the heterogeneity of the … Two reviewers will assess each domain for each key outcome, and differences will be resolved by consensus

422. Childhood Obesity Prevention Programs: A Comparative Effectiveness Review and Meta-Analysis | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/obesity-child/research-protocol
     December 01, 2019 - obesity: Changes in adiposity due to the intervention in related studies will be our key outcomes to assess … Various measures have been used in the field to assess adiposity and childhood obesity. … The study may have been missing information, making it difficult to assess limitations and potential … We conduct sensitivity analyses by omitting one study at a time to assess the influence of any single … We will assess the strength of the study designs according to those which best control confounding, selection

423. Untitled (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/aggression_research-protocol.pdf
     October 05, 2015 - We understand that a practical need exists to assess the accuracy of available risk assessment tools … We will review systematic reviews (SRs) that address any parts of our KQs and dually assess them for … If we conduct quantitative syntheses (i.e., meta-analysis), we will assess statistical heterogeneity … We will follow EPC guidance to assess publication bias.62 Depending on the evidence available to us, … Two trained reviewers will assess each domain for each key outcome; differences will be resolved by

424. Management and Outcomes of Binge Eating Disorder (BED) | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/binge-eating/research-protocol
     December 01, 2019 - Assessment of Methodological Risk of Bias of Individual Studies To assess the risk of bias (internal … Two independent reviewers will assess the risk of bias for each study. … To determine whether quantitative analyses are appropriate, we will assess the clinical and methodological … If we conduct quantitative syntheses (i.e., meta-analysis), we will assess statistical heterogeneity … Two reviewers will assess each domain for each key outcome, and differences will be resolved by consensus

425. Effects of Dietary Sodium and Potassium Intake on Chronic Disease (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/sodium-potassium_research-protocol.pdf
     April 18, 2017 - studies of sodium reduction and potassium and the suitability and robustness of the RCT design to assess … chloride [salt] or sodium-to-potassium ratio) with validated measures or use biomarker values to assess … Assessment of Methodological Risk of Bias of Individual Studies We will assess the methodological risk … One reviewer will assess the methodological risk of bias for all included studies and at least one other … Grading the Strength of Evidence (SOE) for Major Comparisons and Outcomes We will assess the strength

426. Cerebral-Palsy-Feeding Executive (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/cerebral-palsy-feeding_executive.pdf
     March 01, 2013 - We used the included systematic review on behavioral interventions16 to assess strength of evidence … A study may be missing information, making it difficult to assess limitations and potential problems … No studies were designed or powered to directly assess modifiers of the effectiveness of behavioral … Health Technol Assess 2003;7(27):iii-x, 1-173. PMID: 14499048. 35. … External validation of a measurement tool to assess systematic reviews (AMSTAR).

427. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/treatment-resistant-depression_research-protocol.pdf
     December 09, 2009 - Assessment of Methodological Quality of Individual Studies To assess the quality (internal validity) … To assess the quality of observational studies, we will use criteria outlined by Deeks and colleagues … : December 9, 2009 9 For each of these comparisons, we will first stratify by whether the data assess … Health Technol Assess 2003;7: iii-x, 1-173. 4.

428. Frameworks for Determining Research Gaps During Systematic Reviews (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/methods-future-research-steps-framework_research.pdf
     June 01, 2011 - Int J Technol Assess Health Care 2001;17(3):433-441. 6. … Evid Rep Technol Assess (Full Rep) 2008;(172):1-362. 7. … Evid Rep Technol Assess (Full Rep) 2008;(167):1-195. 8. … Evid Rep Technol Assess (Full Rep) 2007;(160):1-105. 9. … Assess the impact of developing Research Needs documents.

429. Otitis Media With Effusion: Comparative Effectiveness of Treatments | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/ear-infection/research-protocol
     December 01, 2019 - Assessment of Methodological Quality of Individual Studies To assess the risk of bias of studies, we … To determine whether quantitative analyses are appropriate, we will assess the clinical heterogeneity … Two reviewers will assess each domain and the overall grade for each key outcome listed in the PICOTS … Assessing Applicability We will assess the applicability both of individual studies and of the body … To assess the applicability of a body of evidence, we will consider the consistency of results across

430. Maternal and Fetal Effects of Mental Health Treatments in Pregnant and Breastfeeding Women: A Systematic Review of Pharmacological Interventions | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/mental-health-pregnancy/protocol
     January 01, 2020 - To assess the risk of bias (i.e., internal validity), we will use the ROBINS-1 41 tool for observational … For both RCTs and observational studies, risk of bias assessment will include questions to assess selection … To determine whether quantitative analyses are appropriate, we will assess the clinical and methodological … Two reviewers will assess each domain for each key outcome, and differences will be resolved by consensus … Health Technol Assess. 2016 Mar;20(23):1-176. doi: 10.3310/hta20230. PMID: 27029490.

431. Comparative Effectiveness of Venous Thromboembolism (VTE) Prophylaxis in Orthopedic Surgery | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/blood-clots-hip-knee-surgery/research-protocol
     December 01, 2019 - select the most appropriate form of prophylaxis, the AAOS encourages practitioners to individually assess … , mobilization status of the patients, use of concurrent standard medical therapies, data needed to assess … The study may be missing information, making it difficult to assess limitations and potential problems … Visual inspection of funnel plots and Egger’s weighted regression statistics will be used to assess for … Subgroup and sensitivity analyses will be conducted to assess the effect of heterogeneity (both clinical

432. Can Physical Activity Improve the Health of Wheelchair Users? A Systematic Review | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/physical-activity-wheelchair/protocol
     October 01, 2019 - and wheelchair mobility programs points out a clear need for more programs, particularly those that assess … National Center for Medical Rehabilitation Research for a Pathways to Prevention (P2P) workshop to assess … Prioritized outcomes for which we will assess the strength of evidence include: cardiovascular mortality … The study may be missing information, making it difficult to assess limitations and potential problems … The I-squared statistic will be used to assess statistical heterogeneity.

433. Oral Mechanical Bowel Preparation for Colorectal Surgery | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/colorectal-surgery-preparation/research-protocol
     December 01, 2019 - Assessment of Methodological Risk of Bias of Individual Studies We will assess the risk of bias for … In quantitative analyses, we will consider performing subgroup analyses to assess the impact of each … We will assess directness of the evidence (“direct” vs. … We will assess the precision of the evidence as precise or imprecise on the basis of the degree of … Health Technol Assess 2003;7(27):iii-x, 1-173. PMID: 144990348. Caldwell DM, Ades AE, Higgins JP.

434. Maternal and Fetal Effects of Mental Health Treatments in Pregnant and Breastfeeding Women: A Systematic Review of Pharmacological Interventions (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/protocol-pharm-pregnant-women_0.pdf
     December 05, 2018 - Child Cohort Study33 and the Danish National Birth Cohort,34 capture sufficiently large samples to assess … To assess the risk of bias (i.e., internal validity), we will use the ROBINS-141 tool for observational … To determine whether quantitative analyses are appropriate, we will assess the clinical and methodological … Two reviewers will assess each domain for each key outcome, and differences will be resolved by consensus … Health Technol Assess. 2016 Mar;20(23):1-176. doi: 10.3310/hta20230. PMID: 27029490. 37.

435. Can Physical Activity Improve the Health of Wheelchair Users? Amended Protocol (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/wheelchair-users-amended-protocol.pdf
     June 21, 2019 - and wheelchair mobility programs points out a clear need for more programs, particularly those that assess … National Center for Medical Rehabilitation Research for a Pathways to Prevention (P2P) workshop to assess … The study may be missing information, making it difficult to assess limitations and potential problems … The I-squared statistic will be used to assess statistical heterogeneity. … We will use this information to assess the situations in which the evidence is most relevant and to

436. Research Protocol: Measuring Healthcare Organization Characteristics in Cancer Care Delivery Research (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/cancer-care-delivery-research-protocol.pdf
     October 06, 2022 - efforts have sought to expand our understanding of the quality of care, measurement frameworks to assess … In addition, many measures used to assess organizational characteristics were investigator- developed … Some of these characteristics are straightforward to assess. … al. review, which found that investigators frequently had to rely on study-specific survey items to assess … Paired reviewers will independently assess the quality of information about the organizational characteristic

437. Living Systematic Review on Plant-Based Treatment for Chronic Pain (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/plant-based-treatments-revised-protocol.pdf
     March 29, 2023 - Purpose of the Review This is a “living systematic review” (LSR), which will assess the effectiveness … Eligible observational studies must assess a mean duration of treatment of one month, and have concurrent … language articles to identify studies that would otherwise meet inclusion criteria in order to help assess … Grading the Strength of Evidence for Major Comparisons and Outcomes We will assess the strength of … We will use this information to assess the situations in which the evidence is most relevant and to

438. Living Systematic Review on Cannabis and Other Plant-Based Treatments for Chronic Pain | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/plant-based-chronic-pain-treatment/protocol
     April 01, 2023 - Purpose of the Review This is a "living systematic review" (LSR), which will assess the effectiveness … Eligible observational studies must assess a mean duration of treatment of one month, and have concurrent … language articles to identify studies that would otherwise meet inclusion criteria in order to help assess … Assessment of Methodological Risk of Bias of Individual Studies Predefined criteria will be used to assess … Grading the Strength of Evidence for Major Comparisons and Outcomes We will assess the strength of

439. Measuring Healthcare Organization Characteristics in Cancer Care Delivery Research | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/organization-cancer-care/protocol
     November 01, 2022 - , efforts have sought to expand our understanding of the quality of care, measurement frameworks to assess … In addition, many measures used to assess organizational characteristics were investigator-developed, … Some of these characteristics are straightforward to assess. … al. review, which found that investigators frequently had to rely on study-specific survey items to assess … Paired reviewers will independently assess the quality of information about the organizational characteristic

440. Chapter 1: Introduction to the Methods Guide for Medical Test Reviews | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/methods-guidance-tests-introduction/methods
     December 01, 2019 - Medical tests may also be used to assess immediate or future response to treatment, including the probability … and physical examination, as well as scored questionnaires intended, for example, for screening or to assess … Medical Test Methods Guide complements AHRQ’s General Methods Guide , 1 which focuses on methods to assess … describe how to determine the key questions, as well as in chapters 5 and 6, which describe how to assess … Here we suggest that systematic reviewers search the literature to assess which factors are likely to