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361. Vitamin D and Calcium: A Systematic Review of Health Outcomes (Update) | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/vitamin-d-calcium/research
     December 01, 2019 - identify the vitamin D assay methods and procedures used for the interventional studies that aimed to assess … group and health status of participants, baseline vitamin D status, dose, duration, and assay used to assess

362. Transparency of Reporting Requirements: Tympanostomy Tubes (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/transparency-tympanostomy_research-protocol.pdf
     September 02, 2016 - For newly found studies, we will record additional data and assess their risk of bias. … For studies identified in the original review, we will also assess the congruence of any additional … At the level of the evidence-base, and for each pertinent exposure-outcome relationship, we will assess … We will assess whether the additional information in the registry records changes the risk of bias assessments … If meta-analyses are not conducted, we will assess whether the new studies fall within the range of

363. Management of Gout | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/gout/research-protocol
     March 01, 2020 - Included studies will be limited to those that fit the PICOTs described above, namely those that assess … Studies will also be included if they assess the effects of comorbidities, other potential modifying … Finally, we will ask the Technical Expert panel (TEP) to assess our included studies and to provide references … history of similar symptoms, results of HLA typing), analytic methods, and characteristics necessary to assess … Grading the Strength of Evidence (SOE) for Major Comparisons and Outcomes We will assess the overall

364. Opioid Treatments for Chronic Pain Research Protocol (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/opioid-treatments-chronic-pain-protocol.pdf
     December 19, 2018 - instrument on factors such as the methods used to conduct searches, select studies, abstract data, assess … The study may be missing information, making it difficult to assess limitations and potential problems … The key questions are designed to assess the comparative effectiveness and harms by patient demographics … We will use this information to assess the situations in which the evidence is most relevant and to … (risk and (predict$ or assess$)).ti,ab,kf. 27. or/17-26 28. 16 and 27 29. limit 28 to yr="2014

365. Opioid Treatments for Chronic Pain | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/opioids-chronic-pain/protocol
     May 01, 2020 - language articles to identify studies that would otherwise meet inclusion criteria, in order to help assess … instrument on factors such as the methods used to conduct searches, select studies, abstract data, assess … The study may be missing information, making it difficult to assess limitations and potential problems … The key questions are designed to assess the comparative effectiveness and harms by patient demographics … (risk and (predict$ or assess$)).ti,ab,kf.

366. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/juvenile-arthritis-dmards_research-protocol.pdf
     March 09, 2010 - In order to assess the benefits or harms of any therapy, it is critical to have a comparison treatment … the measure, it is important to be able to measure clinically meaningful responses to therapy and to assess … • Case control studies are acceptable to assess for adverse events of DMARD treatment (KQ3, KQ4) … Data elements include descriptors to assess applicability, quality elements, intervention/exposure details … To assess individual observational studies, we will adapt a basic set of quality criteria used in previous

367. Autism Spectrum Disorder — An Update | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/autism-update/research-protocol
     December 01, 2019 - Little evidence was available to assess allied health therapies or CAM. … ABA is an umbrella term describing principles and techniques used to assess, treat, and prevent challenging … After reviewing a sample of relevant articles, the team will assess the data-collection forms from the … Assessment of Methodological Risk of Bias of Individual Studies We will assess the overall quality … We will assess the SOE only for those studies rated as good or fair in quality (low or moderate risk

368. Screening and Diagnosis of Gestational Diabetes Mellitus | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/gestational-diabetes-screening-diagnosis/research-protocol
     December 01, 2019 - Next, two reviewers will independently assess the full text of each report using a standard form that … Assessment of Methodological Quality of Individual Studies Two reviewers will independently assess … We will assess the methodological quality of studies relevant to KQ1 using the QUADAS checklist. 22 … In addition, information will be collected for each study on the source of funding. 24 We will assess … For each outcome, we will assess four major domains: risk of bias (rated as low, moderate, or high),

369. Acute Migraine Treatment in Emergency Settings | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/migraine-emergency/research-protocol
     December 01, 2019 - Side effects The second objective of this CER is to assess important immediate and longer term side … The Newcastle-Ottawa Scale will be used to assess cohort studies. 21 This scale includes eight items … that assess sample selection, comparability of cohorts, and assessment of outcomes. … Two reviewers will independently assess the methodological quality of included studies. … Sensitivity analyses will be conducted to assess the robustness of the findings across study quality,

370. Disposition of Comments for Pharmacokinetic/Pharmacodynamic Measures for Guiding Antibiotic Treatment for Hospital-Acquired Pneumonia (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/pneumonia-antibiotic-treatment_disposition-comments.pdf
     November 24, 2014 - As stated in our Methods section, “To assess the risk of bias (i.e., internal validity) of studies, … This approach uses questions to assess selection bias, confounding, performance bias, detection bias … We believe that the description in our methods section, “To assess the risk of bias (i.e., internal … VAT/VAP data would also assess specific outcomes: ventilator days, ICU days, days to becoming afebrile … For example, patients randomized to PK/PD antibiotic therapy vs a control group, could assess results

371. Evaluation of Effectiveness and Safety of Antiepileptic Medications in Patients with Epilepsy | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/epilepsy-medicine/research-protocol
     December 01, 2019 - (Table 5) The rating system does not attempt to assess the comparative validity across different types … The study may be missing information, making it difficult to assess limitations and potential problems … Statistical heterogeneity will be addressed using the I2 statistic to assess the degree of inconsistency … Visual inspection of funnel plots and Egger’s weighted regression statistics will be used to assess the … To assess study design, we will record if the study was a randomized controlled trial or an observational

372. Critical Analysis of the Evidence for Patient Safety Practices in Nursing Home Settings | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/nursing-home-safety/research-protocol
     December 01, 2019 - The most commonly used and cited data set has been the CMS MDS because the MDS is intended to assess … Scope and Format As noted above, methods used to assess patient safety have ranged from database analyses … reviewers who have had a training session to promote consistency/shared understanding of the tool will assess … The ROBIS tool is designed to assess relevance, potential for bias in the study eligibility criteria, … ROBIS: Tool to assess risk of bias in systematic reviews - Guidance on how to use ROBIS. 2015.

373. Chapter 10: Deciding Whether To Complement a Systematic Review of Medical Tests With Decision Modeling | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/methods-guidance-tests-decision-models/methods
     December 01, 2019 - Assess whether modeling may be useful. … Step 3: Assess whether modeling could be useful in the PET and AD evidence report. … Step 4: Assess whether prior modeling studies could be utilized. … Health Technol Assess 2004; 8(31):1-103, iii. Meltzer DO, Hoomans T, Chung JW, Basu A. … Health Technol Assess 2007; 11(52):iii-xi, 1.

374. Modeling to evaluate benefits and harms of new diagnostic tests compared to established diagnostic tests – uses and limitations (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/benefits-harms-modeling_research.pdf
     November 19, 2009 - utility of medical tests.8,9 Herein, we discuss the rationale for and impact of using modeling to assess … Decision analysis is a natural framework to assess such tradeoffs. … Health Technol Assess 2007;11:iii-xi, 1. 13. Gillies CL, Lambert PC, Abrams KR, et al. … Health Technol Assess 2004;8:iii-xi, 1. 28. Philips Z, Bojke L, Sculpher M, et al. … Health Technol Assess 2007;11:iii-xi, 1. 57.

375. Psychosocial and Pharmacologic Interventions for Disruptive Behavior Disorders in Children and Adolescents: Current State of the Evidence | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/disruptive-behavior-disorder/clinician
     June 01, 2021 - The current systematic review aimed to assess psychosocial and pharmacologic treatment approaches for … For additional details on the methodology used to assess strength of evidence, please refer to: Owens … The review did not assess DBD interventions by etiology, although disruptive behaviors may stem from

376. Digestible Carbohydrate Intake and Maternal-Infant Outcomes: A Systematic Review (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/carbohydrate-intake-protocol.pdf
     April 08, 2024 - total digestible carbohydrates or enough data to allow this to be calculated • Studies that only assess … digestible carbohydrate intake via infusions • Studies that only assess exposure to digestible … Assessment of Risk of Bias for Individual Studies We will use predefined criteria to assess the risk … Otherwise, we will qualitatively assess the literature for indications of publication bias. … We will assess statistical heterogeneity of sensitivity and subgroup analyses (e.g., differences by

377. Omega-3 Fatty Acids and Cardiovascular Disease: Current State of the Evidence | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/fatty-acids-cardiovascular-disease/clinician
     January 01, 2020 - For additional details on the methodology used to assess strength of evidence, please refer to: Owens … Evid Rep Technol Assess (Summ). 2004 Mar;(93):1-6. PMID: 15133887. … Evid Rep Technol Assess (Summ). 2004 Mar;(94):1-8. PMID: 15133888.

378. Digestible Carbohydrate Intake and Maternal-Infant Outcomes: A Systematic Review | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/carbohydrate-intake/protocol
     May 01, 2024 - Assessment of Risk of Bias for Individual Studies We will use predefined criteria to assess the risk … Otherwise, we will qualitatively assess the literature for indications of publication bias. … be missing information related to attrition, blinding, or analytic methods, making it difficult to assess … We will assess statistical heterogeneity of sensitivity and subgroup analyses (e.g., differences by study … Review of abstracted information on these factors will be used to assess situations for which the evidence

379. Effective Health Care (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/TND_0161_09-01-2009.pdf
     January 01, 2009 - Several randomized controlled trials are available that assess the effectiveness of Buteyko and other

380. worker-health-protocol-150526 (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/worker-health_research-protocol.pdf
     May 26, 2015 - Assessment of Methodological Risk of Bias of Individual Studies: To assess … These include questions to assess selection bias, confounding, performance bias, detection bias, and … Two independent reviewers will assess risk of bias for each study. … Two reviewers will assess each domain for each key outcome, and differences will be resolved by consensus … Source: Berkman et al.23 Assessing Applicability: We will assess the applicability of individual studies