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  1. effectivehealthcare-admin.ahrq.gov/products/care-interventions-pwd/protocol
    August 01, 2020 - The goal is to understand the evidence base for effective care interventions, and to assess the potential … We will assess whether a study is below the threshold of high risk of bias based on selection bias, level … We will assess the clinical and methodological heterogeneity and variation in effect size to determine … appropriateness of pooling data. 15 We will assess statistical heterogeneity with Cochran’s Q test … We will assess strength of evidence for key final health outcomes measured with validated scales.
  2. effectivehealthcare-admin.ahrq.gov/sites/default/files/product/pdf/assessing-the-risk-of-bias-in-systematic-reviews-of-health-care-interventions-01.pdf
    May 01, 2005 - o Assess risk of bias based on study design-specific criteria and conduct rather than quality of reporting … AMSTAR is a reliable and valid measurement tool to assess the methodological quality of systematic … Scales to assess the quality of randomized controlled trials: a systematic review. … A tool to assess the quality of a meta‐analysis. Res Synth Methods. 2013;4(4):351-66. … ROBIS: A new tool to assess risk of bias in systematic reviews was developed.
  3. effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/gout_research-protocol-2014.pdf
    January 01, 2014 - Finally, we will ask the TEP to assess our included studies and to provide references for any studies … For studies that assess the validity of an alternative diagnostic method against that of analysis of … For key questions 1b-d , which assess the validity of diagnostic tests and the potential influence of … Grading the Strength of Evidence (SOE) for Major Comparisons and Outcomes We will assess the overall … Development of AMSTAR: a measurement tool to assess the methodological quality of systematic reviews
  4. effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/ehc-presentation-selection-harms-systematic-reviews.pdf
    February 01, 2018 - �To be useful to decision makers, an evidence synthesis of a medical intervention should assess the balance … Challenges in systematic reviews that assess treatment harms. … Challenges in systematic reviews that assess treatment harms. … Identify Harms that are of Greatest Importance (I) • EPC reviews should assess harms most important … Challenges in systematic reviews that assess treatment harms.
  5. effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/ehc-research-gaps-telehealth.pdf
    April 01, 2023 - 3, 2023 https://effectivehealthcare.ahrq.gov/products/virtual-health-covid/research Purpose To assess … December 26, 2022 https://effectivehealthcare.ahrq.gov/products/rural-telehealth/research Purpose To assess … Future studies should evaluate effectiveness of telehealth interventions and should include studies to assess … 2019 https://effectivehealthcare.ahrq.gov/products/telehealth-acute-chronic/research Purpose To assess
  6. effectivehealthcare-admin.ahrq.gov/products/field-triage-glascow/research-2017
    March 01, 2020 - Structured Abstract Objectives To assess the predictive utility, reliability, and ease of use of … We included only English-language studies and were limited in our ability to assess publication bias.
  7. effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/major-depressive-disorder_research-protocol.pdf
    November 24, 2014 - Assessment of Methodological Risk of Bias of Individual Studies: To assess the risk of bias (internal … Two independent reviewers will assess the risk of bias for each study. … If we conduct quantitative syntheses (i.e., meta-analysis), we will assess statistical heterogeneity … As appropriate, we may update the results of these reviews quantitatively or qualitatively and assess … Assessing Applicability We will assess applicability of the evidence following guidance from the Methods
  8. effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/asthma-immunotherapy-2010_research-protocol.pdf
    January 01, 2010 - Outcomes for Cost The outcomes that we will include to assess economic endpoints are: i. … Two authors will independently assess the included studies for sources of systematic bias according to … We will use the Newcastle-Ottawa Scale52 to assess the methodological quality of observational studies … We will assess the quality and consistency of the best available evidence—including assessment of the … It can be used to diagnose asthma, characterize the severity of asthma, and/or assess the patient's
  9. effectivehealthcare-admin.ahrq.gov/products/aggression/research-protocol
    January 01, 2020 - We understand that a practical need exists to assess the accuracy of available risk assessment tools. … We will review systematic reviews (SRs) that address any parts of our KQs and dually assess them for … As appropriate, we may update the results of these reviews quantitatively or qualitatively and assess … To assess the risk of bias of trials and studies, we will use definitions based on AHRQ guidance 68 … If we conduct quantitative syntheses (i.e., meta-analysis), we will assess statistical heterogeneity
  10. effectivehealthcare-admin.ahrq.gov/products/trauma-interventions-maltreatment-child/research-protocol
    December 01, 2019 - KQ 2 will assess child welfare outcomes, specifically safety, placement stability, and permanency. … Assessing the Risk of Bias of Individual Studies To assess the risk of bias of studies, we will use … Two independent reviewers will assess the risk of bias for each study. … To determine whether quantitative analyses are appropriate, we will assess the clinical heterogeneity … Assessing Applicability We will assess the applicability 34, 36 both of individual studies and of
  11. effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/antiplatelet-treatment_research-protocol.pdf
    November 22, 2011 - Quality B studies may not be randomized or may be missing information, making it difficult to assess … If quantitative analyses are undertaken, we will consider performing subgroup analyses to assess the … We will assess directness of the evidence (“direct” vs. … We will assess the precision of the evidence as precise or imprecise on the basis of the degree of … Health Technol Assess. 2004;8:iii, 1-iii234. (39) Higgins JPT GSe.
  12. effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/dietary-protein-intake-protocol-amendment.pdf
    November 28, 2023 - Isoleucine, Leucine, Lysine, Methionine, Phenylalanine, Threonine, Tryptophan, ● Studies that only assess … Information from these sources will be used to assess publication and reporting bias and inform future … We will first describe the results in evidence tables, and then assess the clinical and methodological … We will identify heterogeneity (inconsistency) through visual inspection of the forest plots to assess … Thus, including all metabolic studies that assess protein or amino acid requirements, regardless
  13. effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/prostate-cancer-risk-assessment-genes_executive.pdf
    July 01, 2012 - disease36,39,40 and may be useful in predicting the risk for disease.41 The aim of this review is to assess … (KQ3) These questions represent the links in the chain between using an SNP-based panel to assess a … We could not assess consistency of results for panels assessed in single studies only. … We were unable to assess the extent of publication bias in this review. … A critical appraisal of the scientific basis of commercial genomic profiles used to assess health risks
  14. effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/community-health-worker-protocol.pdf
    March 26, 2019 - Thus, the overarching goal of this project is to assess the current state of evidence of the processes … For eligible systematic reviews and guidelines, we will assess their quality and extract select key … We will use ROBIS to assess the quality of systematic reviews and the AGREE-II instrument to assess … ROBIS: A new tool to assess risk of bias in systematic reviews was developed.
  15. effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/celiac-disease_research-protocol.pdf
    June 12, 2014 - We will also assess the quality of existing reviews we include as evidence using the AMSTAR13 instrument … described below, clearly report the analytic methods used, assess the applicability to the populations … The rating system was originally designed to assess the body of evidence on health care interventions … Evid Rep Technol Assess (Summ). 2004 Jun(104):1-6. PMID: 15346868. 9. … Development of AMSTAR: a measurement tool to assess the methodological quality of systematic reviews
  16. effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/dietary-protein-intake-executive-summary.pdf
    November 01, 2024 - We identified a critical need for the development of a single standardized and validated method to assess … This field critically needs a single standardized and validated method to assess protein and amino acid
  17. effectivehealthcare-admin.ahrq.gov/products/insomnia/clinician
    March 01, 2021 - Outcome measures include: Sleep outcome measures : These assess specific sleep parameters (sleep-onset … Global outcome measures : These assess improvements in both sleep and accompanying daytime dysfunction … For additional details on the methodology used to assess strength of evidence, please refer to: Owens … Evidence was insufficient to assess the efficacy or comparative effectiveness of CAM interventions.
  18. effectivehealthcare-admin.ahrq.gov/products/sodium-potassium/research-protocol
    January 01, 2019 - Assessment of Methodological Risk of Bias of Individual Studies We will assess the methodological risk … We will implement the Cochrane Risk of Bias tool to assess risk of bias of RCTs and use questions relevant … for prospective studies from the Newcastle-Ottawa tool to assess risk of bias among observational studies … One reviewer will assess the methodological risk of bias for all included studies and at least one other … Grading the Strength of Evidence (SOE) for Major Comparisons and Outcomes We will assess the strength
  19. effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/ped-mindfulness-protocol-amended.pdf
    September 25, 2024 - Purpose of the Review This systematic review will assess the effectiveness and potential harms of MBIs … We will assess the risk of bias for each included study using the Cochrane Risk of Bias 2 (ROB2) tool … Although we will assess selective outcome reporting, we will not incorporate it in the overall risk … To assess effectiveness, we will tackle two interrelated tasks: evaluate the overall effectiveness of … Assessing Applicability: We will assess applicability according to the approach described in the AHRQ
  20. effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/ped-mindfulness-protocol-amendment.pdf
    February 05, 2025 - Purpose of the Review This systematic review will assess the effectiveness and potential harms of MBIs … We will assess the risk of bias for each included study using the Cochrane Risk of Bias 2 (ROB2) tool … Although we will assess selective outcome reporting, we will not incorporate it in the overall risk … To assess effectiveness, we will tackle two interrelated tasks: evaluate the overall effectiveness of … Assessing Applicability: We will assess applicability according to the approach described in the AHRQ

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