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effectivehealthcare.ahrq.gov/get-involved/nominated-topics/peripheral-artery-disease-pad-defined-as-peripheral-artery-disease-of-the-lower-extremities-1-does-aspirin-reduce-the-risk-of-adverse-cardiovascular-events-mi-stroke-cardiovascular-death-in-patients-with-pad-is-there-a-differ
January 20, 2011 - Peripheral Artery Disease (PAD)
defined as peripheral artery disease of the lower extremities
Does aspirin … Is clopidogrel more effective than aspirin in reducing adverse cardiovascular events in PAD? … would like to see compared:
For questions 1 and 2, comparisons between no antiplatelet therapy and aspirin
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effectivehealthcare.ahrq.gov/sites/default/files/ch_3-user-guide-to-ocer_130129.pdf
September 21, 2012 - Let z stand for treatment at two levels {1, 2};
for example, being given aspirin (z =1) or not
(z … In the aspirin-treated subjects, there was a
reduction in mortality (804 deaths among 8,587
people, … 9.4%) relative to subjects not treated
with aspirin (1,016 deaths among 8,600 people,
11.8%, p<0.05 … Rather than inferring that
aspirin should not be used in the treatment of
39
Chapter 3. … When the ATE is clearly positive (both aspirin
and streptokinase reduce mortality in patients
with
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effectivehealthcare.ahrq.gov/products/stent-clopidogrel-practice/research
March 31, 2009 - whether patients were regular aspirin users. … There also was significant variation across the groups in self-reported regular aspirin use. … Most patients in all 4 groups were receiving aspirin at 6, 12 and 24 months; however, there appeared … Aspirin Subgroup Results
To assess whether aspirin use confounded the clopidogrel results, we analyzed … the subset of patients who reported aspirin use at 6 months ( Figures 4A and 4B ).
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/stent-clopidogrel-practice_research.pdf
March 01, 2009 - whether patients were regular aspirin users. … Tables of baseline and angiographic characteristics,
and follow-up aspirin and clopidogrel use were … There also was significant variation across the
groups in self-reported regular aspirin use. … Aspirin Subgroup Results
To assess whether aspirin use confounded the clopidogrel results, we analyzed … the
subset of patients who reported aspirin use at 6 months (Figures 4A and 4B).
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effectivehealthcare.ahrq.gov/products/methods-balancing-harms-benefits
November 19, 2012 - February 13, 2014
Research Report
Evaluation of the Benefits and Harms of Aspirin
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/peripheral-artery-disease-treatment_research-protocol.pdf
January 31, 2013 - (aspirin vs. clopidogrel, monotherapy vs. … A number of trials have addressed the questions of aspirin dose and choice of antiplatelet
strategy, … among patients with PAD, finding that a 75-mg to 150-mg dose
of aspirin was at least as effective as … higher doses.18 However, a recent meta-analysis of all trials
in which aspirin was used for primary … • Should the decision to treat patients with PAD with aspirin and other antiplatelet agents
be based
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/stroke-atrial-fibrillation_executive.pdf
August 01, 2013 - than aspirin alone
for preventing any stroke. … bleeding than aspirin alone (high strength of
evidence) … Results
were also similar in a substudy of the AVERROES
(Apixaban Versus Acetylsalicylic acid [ASA] … Fibrillation
31
ATRIA Anticoagulation and Risk Factors in
Atrial Fibrillation
AVERROES Apixaban Versus Acetylsalicylic … acid (ASA) to Prevent Stroke in
Atrial Fibrillation Patients Who
Have Failed or Are Unsuitable for
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effectivehealthcare.ahrq.gov/sites/default/files/s23.pdf
October 01, 2007 - Aggrenox (Combination of Dipyridamole and
Aspirin) for Secondary Stroke Prevention
Evidence on the stroke … consistently presented in the
article to judge about benefits and harms of Aggrenox when
compared with aspirin … A careful
examination of the article might show that Aggrenox, com-
pared with aspirin alone, is associated … data also shows approximately 4 additional severe
or fatal bleeding episodes with Aggrenox than with aspirin … European stroke prevention study,
part 2: dipyridamole and acetylsalicylic acid in the secondary prevention
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effectivehealthcare.ahrq.gov/products/osteoarthritis-pain/research-protocol
August 05, 2010 - All non-aspirin NSAIDs work equally well for pain reduction
NSAIDs increase the risk of GI bleeding … from other NSAIDs, because it irreversibly inhibits platelet aggregation; salicylic acid derivatives (aspirin … the comparative efficacy and safety of non-opioid oral medications (selective and non-selective non-aspirin … NSAIDs, aspirin, salsalate, and acetaminophen), over-the-counter supplements (chondroitin and glucosamine … Pain: 650-1000 mg up to 4 g/day
Pediatric patients (Peds): 10-15 mg/kg/dose up to 5 doses/day
aspirin
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/osteoarthritis-pain_research-protocol.pdf
August 05, 2010 - • All non-aspirin NSAIDs work equally well for pain reduction
• NSAIDs increase the risk of GI bleeding … from other NSAIDs, because it irreversibly inhibits platelet
aggregation; salicylic acid derivatives (aspirin … the comparative efficacy and safety of non-opioid oral medications
(selective and non-selective non-aspirin … NSAIDs, aspirin, salsalate, and
acetaminophen), over-the-counter supplements (chondroitin and glucosamine … g/day
Pediatric patients (Peds): 10−15
mg/kg/dose up to 5 doses/day
Drug (any trade name): aspirin
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/stroke-atrial-fibrillation_disposition-comments.pdf
August 23, 2013 - Aspirin is a well-
established risk factor for hemorrhage but it would
be unavailable in population … Aspirin is a key exposure that was not
included in the ATRIA bleeding risk score because it
was not … In addition,
apixaban in particular showed safety and efficacy
when compared to aspirin in patients … Aspirin is not recommended for stroke prophylaxis in
AFib. … Prior meta-analyses done through 2007 do
focus on warfarin and aspirin.
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/peripheral-artery-disease-treatment_disposition-comments.pdf
May 29, 2013 - asymptomatic
PAD patients (92% IC, 8% asymptomatic), dual
antiplatelet therapy (clopidogrel with aspirin … I agree with the findings for lack of
benefit of aspirin in asymptomatic PAD. … In
symptomatic PAD (IC) the weight of evidence is also
not in support of aspirin and therefore it is … More research is needed, both with
aspirin and with novel antiplatelet agents. … in older studies versus aspirin,
beta blockade, and statin in more recent studies), and
appropriate
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effectivehealthcare.ahrq.gov/sites/default/files/cer-234-headaches-pregnancy-summary.pdf
November 01, 2020 - intravenous magnesium use during pregnancy may be
associated with fetal/child adverse effects, but low-dose aspirin … periventricular leukomalacia, intraventricular hemorrhage, and necrotizing
enterocolitis (low SoE), but low-dose aspirin … +)
~ (+) -
NSAIDs Any Nonuse Various - ~ (++) -
Indomethacin Nonuse Various - - ↑ (+)
Low-dose aspirin
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-234-headaches-pregnancy-summary.pdf
November 01, 2020 - intravenous magnesium use during pregnancy may be
associated with fetal/child adverse effects, but low-dose aspirin … periventricular leukomalacia, intraventricular hemorrhage, and necrotizing
enterocolitis (low SoE), but low-dose aspirin … +)
~ (+) -
NSAIDs Any Nonuse Various - ~ (++) -
Indomethacin Nonuse Various - - ↑ (+)
Low-dose aspirin
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/antiplatelet-treatment_executive.pdf
September 01, 2013 - , TRITON-TIMI 38 compared aspirin plus
clopidogrel versus aspirin plus prasugrel, and the PLATO
trial … compared aspirin plus clopidogrel versus aspirin plus
ticagrelor. … aspirin plus
clopidogrel vs. aspirin plus ticagrelor. … aspirin plus clopidogrel
vs. aspirin plus ticagrelor. … Clopidogrel plus aspirin
versus aspirin alone for preventing cardiovascular disease.
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effectivehealthcare.ahrq.gov/products/dietary-supplements/research
April 30, 2012 - One pragmatic trial in women showed no benefit from coadministering vitamin E with aspirin on a composite
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effectivehealthcare.ahrq.gov/products/headaches-pregnancy/protocol
November 12, 2019 - Nonsteroidal antiinflammatory drugs (NSAIDs) (e.g., ibuprofen, naproxen, aspirin, celecoxib, ketorolac … Other over-the-counter analgesics (e.g., combination aspirin, acetaminophen, and caffeine; combination … Nonsteroidal AND (antiinflammatory OR anti-inflammatory)) OR NSAID OR Excedrin OR ibuprofen OR naproxen OR aspirin … Nonsteroidal AND (antiinflammatory OR anti-inflammatory)) OR NSAID OR Excedrin OR ibuprofen OR naproxen OR aspirin … butorphanol
#26; 'nonsteroidal anti-inflammatory' OR nsaid OR excedrin OR ibuprofen OR naproxen OR aspirin
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/headaches-pregnancy.pdf
March 23, 2019 - acetaminophen)
8
o Nonsteroidal antiinflammatory drugs (NSAIDs) (e.g., ibuprofen,
naproxen, aspirin … , ketoprofen,
diclofenac, mefenamic acid)
o Other over-the-counter analgesics (e.g., combination aspirin … Nonsteroidal AND (antiinflammatory OR anti-
inflammatory)) OR NSAID OR Excedrin OR ibuprofen OR naproxen OR aspirin … Nonsteroidal AND (antiinflammatory OR anti-
inflammatory)) OR NSAID OR Excedrin OR ibuprofen OR naproxen OR aspirin … butorphanol
#26; 'nonsteroidal anti-inflammatory' OR nsaid OR excedrin OR ibuprofen OR naproxen OR
aspirin
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/breast-biopsy-update_consumer.pdf
May 01, 2016 - Some medicines, including aspirin, increase the risk of bleeding and
bruising. … Preparing for a biopsy
� How many days before my biopsy should I stop taking aspirin?
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/angina-heart-attack-treatments_disposition-comments.pdf
January 01, 2014 - favor high dose
aspirin. … TEP Member 4 Executive
Summary
ES-3 Table A, should the aspirin doses be defined. … As suggested the sentence on possible confounding
has been added to the PPI + aspirin section. … The low vs high dose aspirin data have many problems. All
the data provided are observational. … We have added data from the recent PLATO study
publication on aspirin dose.