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effectivehealthcare.ahrq.gov/sites/default/files/pulmonary-horizon-scan-high-impact-1306.pdf
June 01, 2013 - Azithromycin (Zithromax®, Pfizer,
Inc., New York, NY), is a macrolide antibiotic with broad-spectrum … Additionally, investigators noted concern about antibiotic-resistant bacteria in
patients treated with … Some experts
stated risk of hearing loss, cardiac arrhythmias, and antibiotic resistance are factors … that would make
some physicians reluctant to prescribe the antibiotic. … Antibiotic prevention of acute exacerbations of
COPD. N Engl J Med. 2012 Jul 26;367(4):340-7.
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effectivehealthcare.ahrq.gov/sites/default/files/facilitation-webcast-slides.pptx
June 13, 2013 - (next slide)
6
The overuse of antibiotics: focus group
Question: How can doctors better communicate … ; and the educational approach or information that will gain patients’ cooperation in not overusing antibiotics … (next slide)
7
The overuse of antibiotics: deliberative session
Question: should there be more specific … limits on how doctors use antibiotics? … Should there be more specific limits on how doctors use antibiotics?
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effectivehealthcare.ahrq.gov/sites/default/files/pulmonary-horizon-scan-high-impact-1406.pdf
June 01, 2014 - Macrolide antibiotics also purportedly have
anti-inflammatory properties, which could play a role in … in the azalide subclass
of macrolide antibiotics.3 Azithromycin binds to the 50S ribosomal subunit … Some experts expressed concern about antibiotic
resistance and whether other macrolide antibiotics … Prophylactic use of
azithromycin or other macrolide antibiotics seem to be a promising treatment to … would make some physicians reluctant to prescribe the
antibiotic, some experts stated.
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effectivehealthcare.ahrq.gov/products/procalcitonin-future
January 10, 2013 - Future Research Needs on Procalcitonin-Guided Antibiotic Therapy
Timeline
January 09 … 2013
Systematic Review
Archived
Future Research Needs on Procalcitonin-Guided Antibiotic
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effectivehealthcare.ahrq.gov/products/tympanostomy-tubes/research-2017
May 05, 2017 - If bothersome drainage from TT occurs, evidence supports treating with ear drops rather than oral antibiotics … Should otorrhea develop, the evidence supports topical treatment rather than oral antibiotics or watchful
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/rapid-response-cardio-dental.pdf
July 01, 2023 - undergo transcatheter aortic valve
implantation (TAVI).20 It describes consensus on use of prophylactic antibiotics … 8
strong evidence supporting the necessity of dental care (other than routine prophylactic antibiotics … Rapid Response was not scoped to evaluate primary research studies on the efficacy
of prophylactic antibiotics … Historically, prophylactic antibiotics were used for the majority of patients perceived
to be at risk … Therefore, there is currently no scientific basis for the use of
prophylactic antibiotics before routine
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effectivehealthcare.ahrq.gov/get-involved/nominated-topics/what-are-the-indications-for-inserting-tympanostomy-tubes-how-many-otitis-media-w-effusion-or-acute-otitis-media-episodes-in-what-time-frameshould-clinicians-obtain-a-hearing-test-prior-to-inserting-tympanostomy-tubesshould-c
August 11, 2014 - clinicians obtain a hearing test prior to inserting tympanostomy tubesShould clinicians prescribe topical antibiotic … eardrops andor antibiotics for children with uncomplicated acute tympanostomy tube otorrheaDo children … reporting insufficient evidence6 small shortterm benefits89 or moderate benefits of similar magnitude to antibiotic … of infected secretions obtain middle ear fluid for culture and provide a direct route for delivering antibiotic … with tympanostomy tubes continue to experience AOM episodes they can usuallybe managed with topical antibiotic
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effectivehealthcare.ahrq.gov/products/procalcitonin/
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effectivehealthcare.ahrq.gov/products/ear-infection/research-protocol
March 20, 2012 - Antibiotics currently are not commonly used in the United States to treat OME and are not recommended … for the treatment of OME. 6,10,20 An upcoming Cochrane Collaboration review on the use of antibiotics … Oral steroids alone or in combination with antibiotics had a positive effect on 2-week disease outcomes … Antibiotics for otitis media with effusion in children (protocol). … Which antibiotic for acute otitis media? Drug Ther Bull. 1974 Jul 5; 12(14):53-4. PMID: 4142433.
-
effectivehealthcare.ahrq.gov/products/transparency-tympanostomy/research-protocol
September 03, 2016 - the effectiveness of tympanostomy tubes, compared to watchful waiting with episodic or prophylactic antibiotic … , comorbidities, and sociodemographic risk factors, history of complications of acute otitis media, antibiotic … drops versus systemic antibiotics or watchful waiting on duration of otorrhea, quality of life, or need … Avoidance of high-risk activities
Ear plugs, headbands, other canal occlusion methods
Ototopical antibiotic … prophylaxis
KQ 5: Ototopical preparations
Antibiotics (common examples listed)
Ciprofloxacin 0.2%
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/ear-infection_executive.pdf
May 01, 2013 - controls + antibiotics
MA of 3 RCTs (N=243) No difference in persisting OME at 1-2 months (antibiotics … Antibiotics
for otitis media with effusion in children. … Phosphorylcholine-coated
antibiotic tympanostomy tubes: are post-tube placement
complications reduced … A cost-benefit analysis of
the post-operative use of antibiotic ear drops following grommet
insertion … The use of antibiotic/steroid ear drops to
reduce post-operative otorrhoea and blockage of ventilation
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/venous-ulcers-treatment_executive.pdf
January 01, 2014 - Antibiotics
Clinicians commonly use antibiotics to treat venous ulcers. … and comparisons
Adverse Effects of Treatment (KQs 1, 2, & 3 )
Chronic
Venous
Ulcers
Antibiotic-specific … Hypersensitivity
Antibiotic resistance
Systemic absorption
Drug toxicity
Clostridium difficile … For KQ 2, there are harms for both patient and society from
antibiotic overuse, with few data to guide … research include cellular human skin equivalents, collagen
dressings, dressings that enhance debridement, antibiotic
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/c-diff-infections_disposition-comments.pdf
March 01, 2012 - Peer Reviewer
#8
Introduction The statements regarding antibiotics and the pathophysiology of
CDAD … the
clindamycin and quinolone resistance or is there actual evidence of
resistance to the treating antibiotics … risks is not discussed, neither is the lack of a
coherent explanation as to why all classes of antibiotics … Subjects received the
probiotic along with a standard antibiotic. … one of his
symptoms, being a stubborn, private individual who hated most
medical care, especially antibiotics
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effectivehealthcare.ahrq.gov/health-topics/sepsis-0
April 26, 2011 - Research Protocol
Archived
April 26, 2011
Future Research Needs on Procalcitonin-Guided Antibiotic
-
effectivehealthcare.ahrq.gov/get-involved/nominated-topics/sepsis-biomarkers-and-their-utility
June 17, 2009 - Sepsis biomarkers and their utility
Future Research Needs on Procalcitonin-Guided Antibiotic Therapy … Procalcitonin-Guided Antibiotic Therapy
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/transparency-tympanostomy_research-protocol.pdf
September 02, 2016 - the effectiveness of tympanostomy tubes, compared to watchful
waiting with episodic or prophylactic antibiotic … comorbidities, and sociodemographic risk factors,
history of complications of acute otitis media, antibiotic … drops versus systemic antibiotics or watchful
waiting on duration of otorrhea, quality of life, or … Avoidance of high-risk activities
o Ear plugs, headbands, other canal occlusion methods
o Ototopical antibiotic … prophylaxis
• KQ 5: Ototopical preparations
o Antibiotics (common examples listed)
§ Ciprofloxacin
-
effectivehealthcare.ahrq.gov/sites/default/files/c-difficile-update_disposition-comments.pdf
March 29, 2016 - and non-
antibiotic ) and prevention. … and non antibiotic
are drug company sponsored. … Rifaximin is an antibiotic, and should be
included with antibiotics. … Treatment CDI – Antibiotics-
4. … Therapy is divided into
both antibiotic and non-antibiotic strategies, both
of which are of significant
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/c-diff-infections-surveillance-140925.pdf
January 01, 2014 - 60
days of discharge
observed risk of CDI
associated with total
dose, duration, and
number of antibiotics … , and days of antibiotic exposure. … received 2, 3
or 4, or 5 or more antibiotics were 2.5 (95% CI: 1.6-4.0),
3.3 (95% CI: 2.2-5.2), and … controlled,
multicentre trial
years and older and
exposed to one or
more oral or
parenteral
antibiotics … prescribed antibiotics
or on antibiotic
therapy for <48
hours were eligible
eligible patients, 275
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effectivehealthcare.ahrq.gov/sites/default/files/c-diff-infections-nomination-140925.pdf
February 19, 2014 - § Antibiotic use
§ Gloves
§ Disposable thermometer
§ Handwashing/alcohol gel
§ Disinfection … component strategies
Key Question 3: What are the comparative effectiveness and harms of different
antibiotic … For a first recurrence, the
effectiveness of antibiotic therapy is around 60% and further declines with … What are the comparative effectiveness and harms of different antibiotic treatments?
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/febrile-infants-diagnosis-management_executive.pdf
March 01, 2012 - risk
Hospitalize
Empiric antibiotics
Not defined Hospitalize
Empiric antibiotics
Hospitalize … We identified 10 studies reporting on immediate antibiotic
(or antiviral) therapy administered to infants … Febrile infants classified as being at high risk for SBI were
administered immediate antibiotic therapy … 18.9 percent had infiltration of an intravenous
line.12 In another study,32 immediate intravenous antibiotic … percent of these infants were transferred to an
outpatient day treatment center to complete their antibiotic