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effectivehealthcare.ahrq.gov/health-topics/antibiotics/
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/antibiotics-respiratory-infection_clinician.pdf
March 01, 2016 - A key factor for the increased
rate of antibiotic resistance is high outpatient consumption
of antibiotics … Antibiotics are frequently inappropriately
used for uncomplicated acute RTIs. … ahrq.gov/antibiotics-RTI. … Available at www.effectivehealthcare.ahrq.gov/antibiotics-RTI. … http://www.effectivehealthcare.ahrq.gov/antibiotics-RTI
http://www.effectivehealthcare.ahrq.gov/antibiotics-RTI
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/antibiotics-respiratory-infection_executive.pdf
January 01, 2016 - With antibiotic use, however,
some bacteria can adapt, which can
result in the development of antibiotic … of
new antibiotics, a key factor is high
outpatient consumption of antibiotics.1-3
In response to … Reduced overall prescribing or use of antibiotics for acute RTIs. … antibiotic prescribing, overall prescribing,
or antibiotic resistance (Key Questions 1 and 2), with … Data
were not available on appropriate antibiotic prescribing or
on antibiotic resistance.
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/antibiotics-respiratory-infection_research-protocol.pdf
September 22, 2014 - antibiotics for acute RTI. … antibiotics!for!RTI!
! Improved!clinician!
knowledge!regarding!use!
of!antibiotics!for!RTI!
! … antibiotics!
KQ#1:#
! Improved!appropriate!
prescription!of!antibiotics!
! Improved!appropriate! … antibiotics!
KQ#2:!
! Antibiotic!resistance!
! Medical!complications!)e.g.!
Mortality,!Adverse! … Respiratory tract Infections-
Antibiotic Prescribing: Prescribing of antibiotics for self-limiting respiratory
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effectivehealthcare.ahrq.gov/products/antibiotics-respiratory-infection/clinician
April 06, 2016 - A key factor for the increased rate of antibiotic resistance is high outpatient consumption of antibiotics … Antibiotics are frequently inappropriately used for uncomplicated acute RTIs. … Deciding whether to prescribe antibiotics for acute RTIs is a complex process. … The factors associated with overuse of antibiotics for uncomplicated acute RTIs are numerous and diverse … Clinical Interventions (Delayed Versus Immediate Prescribing)
Delayed prescribing of antibiotics (see
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effectivehealthcare.ahrq.gov/products/antibiotics-respiratory-infection
May 23, 2014 - Improving Antibiotic Prescribing for Uncomplicated Acute Respiratory Tract Infections
Timeline … May 23, 2014
Research Protocol
Archived
Interventions to Improve Appropriate Antibiotic … Infections
January 27, 2016
Systematic Review
Archived
Improving Antibiotic … April 06, 2016
Clinician Summary
Archived
Interventions To Improve Antibiotic
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effectivehealthcare.ahrq.gov/products/antibiotics-respiratory-infection/research-protocol/
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/antibiotics-respiratory-infection_disposition-comments.pdf
January 27, 2016 - and that antibiotics could be
reduced overall. … message about antibiotics to
clinicians (“don’t prescribe antibiotics, but you
should give patients … Changed to “overuse of
antibiotics”
29. … use and antibiotic prescribing. … Peer Reviewer
#17 (TEP
Reviewer)
General Healthcare delivery, access to antibiotics,
antibiotic
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effectivehealthcare.ahrq.gov/products/pneumonia-antibiotic-treatment/research-protocol
July 19, 2013 - Antibiotic PD relates PK parameters to the ability of an antibiotic to kill or inhibit growth of bacterial … Concentration-dependent antibiotic: peak concentration to MIC ratio (C max /MIC)
Time-dependent antibiotic … , clinicians can optimize the PD effects of antibiotics by altering the dosing methods for the antibiotic … Rates of antibiotic-related adverse events? … ] OR "Anti-Bacterial Agents"[mesh])
Limits
Humans
English language
Adults 19+ years or Adults
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/pneumonia-antibiotic-treatment_research-protocol.pdf
July 19, 2013 - Antibiotic PD relates PK parameters to the
ability of an antibiotic to kill or inhibit growth of bacterial … , clinicians can optimize the PD effects of
antibiotics by altering the dosing methods for the antibiotic … Rates of antibiotic-related adverse events? … Rates of antibiotic-related adverse events? … ] OR "Anti-Bacterial Agents"[mesh])
Limits Humans
English language
Adults 19+ years or Adults 18
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/pneumonia-antibiotic-treatment_executive.pdf
November 01, 2014 - Current antibiotic dosing strategies also do not directly
consider the variety of antibiotic-resistance … Given the PK/PD properties of antibiotics, clinicians can
optimize the PD effects of antibiotics by … Among them are improving appropriate use of antibiotics
by promoting antibiotic use only when indicated … antibiotic doses. … concepts such as using extended or prolonged infusions
of time-dependent antibiotics.
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effectivehealthcare.ahrq.gov/products/procalcitonin/research
October 05, 2012 - Outcomes were antibiotic use, mortality, morbidity, and adverse drug events of antibiotic therapy. … Procalcitonin guidance reduces antibiotic use when used to discontinue antibiotics in adult ICU patients … Conclusions
Procalcitonin guidance reduces antibiotic use when used to discontinue antibiotics in adult … ICU patients and to initiate or discontinue antibiotics in patients with respiratory tract infections … antibiotic resistance and for adverse events of antibiotic therapy.
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effectivehealthcare.ahrq.gov/sites/default/files/ebc-challenge-2ndplace-paws.pdf
January 26, 2013 - P A W S, Prescription for Antibiotics or Wait and See: Ear Infections: Are Antibiotics the Right Choice … P A W S
Prescription for
Antibiotics or
Wait and See
Ear Infections
Are Antibiotics the Right … Not all ear infections require imme-
diate treatment with antibiotics. … Antibiotics that are taken when they
are not needed can be harmful. … Af-
ter each course of antibiotics, re-
sistant bacteria may develop.
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/c-difficile-update_consumer.pdf
May 01, 2017 - Antibiotics
If your CDI happened after you took an antibiotic, your health care
professional may have … you stop taking the antibiotic. … The antibiotic your doctor recommends may depend
on the availability and cost of the antibiotic, what … Take all antibiotics exactly as instructed. … the antibiotic?
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effectivehealthcare.ahrq.gov/sites/default/files/cer-221-copd-evidence-summary.pdf
October 01, 2019 - Key Messages
• Antibiotic therapy increases the clinical cure rate and
reduces the clinical failure … Systemic Antibiotics Versus Placebo
or Management Without Systemic
Antibiotics
Antibiotics increased … dosages of the
same antibiotic was insufficient for mortality,
clinical cure and clinical failure. … Antibiotic therapy in exacerbations of chronic
obstructive pulmonary disease. … Procalcitonin to guide antibiotic
administration in COPD exacerbations: a meta-
analysis.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-221-copd-evidence-summary_0.pdf
October 01, 2019 - Key Messages
• Antibiotic therapy increases the clinical cure rate and
reduces the clinical failure … Systemic Antibiotics Versus Placebo
or Management Without Systemic
Antibiotics
Antibiotics increased … dosages of the
same antibiotic was insufficient for mortality,
clinical cure and clinical failure. … Antibiotic therapy in exacerbations of chronic
obstructive pulmonary disease. … Procalcitonin to guide antibiotic
administration in COPD exacerbations: a meta-
analysis.
-
effectivehealthcare.ahrq.gov/products/pneumonia-antibiotic-treatment/research
November 24, 2014 - Apr. 16, 2015 Disposition of Comments Report Pharmacokinetic/Pharmacodynamic Measures for Guiding Antibiotic … pharmacokinetic/pharmacodynamic (PK/PD) measures or strategies to dose and monitor intravenous (IV) antibiotics … One trial (rated high risk of bias) used PK/PD measures to study the impact of different antibiotic dosing … Evidence is also insufficient to draw conclusions about the effect of continuous infusions of beta-lactam antibiotics … Clinical response, duration of mechanical ventilation, superinfection, rates of antibiotic-related adverse
-
effectivehealthcare.ahrq.gov/health-topics/antibiotic-resistance/
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effectivehealthcare.ahrq.gov/system/files/docs/acute-diverticulitis-topic-nomination.pdf
August 13, 2018 - Do the effectiveness/harms vary by route of administration of antibiotic, type of antibiotic,
duration … of course of antibiotic? … ,
clear liquid diet
only, antibiotics by
other route of
administration,
type of antibiotic,
duration … exp Anti-Bacterial Agents/ or ((oral* or parenteral*) adj3 (antibiotic* or
antibacterial* or anti-bacterial … cond=diverticulitis&term=&cntry=&state=&city=&dist=
KQ 1 (Antibiotics)
• Antibiotics vs. resection
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effectivehealthcare.ahrq.gov/products/copd/research
October 11, 2019 - Key Messages
Antibiotic therapy increases the clinical cure rate and reduces the clinical failure rate … Antibiotics and corticosteroids are not associated with increase in serious adverse events. … Antibiotic therapy increases the clinical cure rate and reduces the clinical failure rate regardless … There is insufficient evidence to support a particular antibiotic regimen. … Systemic antibiotics and corticosteroids are associated with improved outcomes in mild and moderate to