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effectivehealthcare-admin.ahrq.gov/products/procalcitonin-future/research
December 01, 2019 - Home
Evidence Reports
Future Research Needs on Procalcitonin-Guided Antibiotic … Early initiation of appropriate antibiotics and goal-directed therapies reduce mortality. … Conversely, overuse and misuse of antibiotics, including continuing antibiotics longer than necessary … for cure can result in adverse events and add to the increasing problem of antibiotic resistance. … Project Timeline
Future Research Needs on Procalcitonin-Guided Antibiotic Therapy
Jan 9, 2013
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effectivehealthcare-admin.ahrq.gov/system/files/docs/acute-diverticulitis-topic-nomination.pdf
August 13, 2018 - Do the effectiveness/harms vary by route of administration of antibiotic, type of antibiotic,
duration … of course of antibiotic? … ,
clear liquid diet
only, antibiotics by
other route of
administration,
type of antibiotic,
duration … exp Anti-Bacterial Agents/ or ((oral* or parenteral*) adj3 (antibiotic* or
antibacterial* or anti-bacterial … cond=diverticulitis&term=&cntry=&state=&city=&dist=
KQ 1 (Antibiotics)
• Antibiotics vs. resection
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effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/TND-0768-141211.pdf
October 23, 2014 - least 3
episodes per year for 3 years)
Intervention(s): Tonsillectomy
Comparator(s): Prophylactic antibiotic … PICO
Population(s): Children, ages 1 to 18, who undergo tonsillectomy
Intervention(s): Perioperative antibiotic … Should clinicians administer or prescribe perioperative antibiotics to children
undergoing tonsillectomy … effectiveness of tonsillectomy in SDB and
the comparative effectiveness of prescribing perioperative antibiotics … some reduction in morbidities associated with tonsillectomy through the use of
perioperative topical antibiotics
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effectivehealthcare-admin.ahrq.gov/products/pneumonia-antibiotic-treatment/research
December 01, 2019 - pharmacokinetic/pharmacodynamic (PK/PD) measures or strategies to dose and monitor intravenous (IV) antibiotics … One trial (rated high risk of bias) used PK/PD measures to study the impact of different antibiotic dosing … Evidence is also insufficient to draw conclusions about the effect of continuous infusions of beta-lactam antibiotics … Clinical response, duration of mechanical ventilation, superinfection, rates of antibiotic-related adverse … https://effectivehealthcare.ahrq.gov/products/pneumonia-antibiotic-treatment/research
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effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/copd-research-protocol.pdf
April 11, 2018 - ,
where safely possible, to reduce potential harms including development of antibiotic
resistance, … Antibiotic therapy in exacerbations of chronic
obstructive pulmonary disease. … Antibiotic treatment in exacerbations of chronic
obstructive pulmonary disease: Recent trial
results … 2 Receptor Agonists/ or exp
Cholinergic Antagonists/ or exp Phosphodiesterase 4 Inhibitors/ or exp Antibiotic … Prophylaxis/ or exp Anti-Bacterial Agents/ or exp antibiotic agent/ or exp
Benzodiazepines/ or exp
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effectivehealthcare-admin.ahrq.gov/products/copd/protocol
January 01, 2019 - One uncertainty relates to the need for antibiotics in mild and moderately severe AECOPD, especially … of severe AECOPD, the need for antibiotics in less severe forms of COPD is unclear. 33 Uncertainty … , where safely possible, to reduce potential harms including development of antibiotic resistance, and … Antibiotic therapy in exacerbations of chronic obstructive pulmonary disease. … Antibiotic treatment in exacerbations of chronic obstructive pulmonary disease: Recent trial results.
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effectivehealthcare-admin.ahrq.gov/get-involved/nominated-topics/management-acute-diverticulitis
January 01, 2019 - for the treatment of diverticulitis compared to each other and compared to treatment without antibiotics … Do the effectiveness/harms vary by route of administration of antibiotic, type of antibiotic, duration … of course of antibiotic? … With the increasing use of oral antibiotics with high bioavailability, parenteral antibiotics given as … CT, colonoscopy) for diagnosis or management of diverticulitis, the optimal choice and duration of antibiotic
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effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/TND-0765-150129.pdf
November 03, 2014 - uncertainty regarding indications for
Summary: tympanostomy in children as well as the prescription of antibiotics … drops
and/or systemic antibiotics for children with tympanostomy tube otorrhea (TTO)? … drops or systemic antibiotic administration
Comparator(s): Systemic antibiotic administration or topical … Should clinicians prescribe topical antibiotic eardrops and/or antibiotics for children
with uncomplicated … approximately 16% of children
within four weeks of surgery and 26% of children while tubes are in place.3 Antibiotics
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effectivehealthcare-admin.ahrq.gov/products/diverticulitis/protocol
October 01, 2019 - Initially reserved for the sickest, highest-risk surgical patients, drainage and antibiotic treatment … Do the (comparative) effects and harms vary by route of administration of antibiotics, type of antibiotic … , and duration of course of antibiotics? … versus No antibiotics or versus Alternative antibiotic regimen (for any patient)
Any class, route … (C diff) infection
Antibiotic resistance
Interventional radiology comparisons:
Adverse
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effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/diverticulitis-research-protocol.pdf
January 01, 2019 - Initially reserved for the sickest, highest-risk surgical patients,
drainage and antibiotic treatment … • Do the (comparative) effects and harms vary by route of administration of antibiotics,
type of antibiotic … , and duration of course of antibiotics? … versus No antibiotics or versus Alternative antibiotic regimen (for any
patient)
o Any class, route … to each
other and to placebo (or no antibiotics).
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effectivehealthcare-admin.ahrq.gov/products/copd/research
January 01, 2021 - Key Messages Antibiotic therapy increases the clinical cure rate and reduces the clinical failure rate … Antibiotics and corticosteroids are not associated with increase in serious adverse events. … Antibiotic therapy increases the clinical cure rate and reduces the clinical failure rate regardless … There is insufficient evidence to support a particular antibiotic regimen. … Systemic antibiotics and corticosteroids are associated with improved outcomes in mild and moderate to
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effectivehealthcare-admin.ahrq.gov/sites/default/files/ebc-challenge-1stplace-qrmedica.pdf
January 01, 2013 - AOM is the most common childhood infection for
which antibiotics are prescribed in the United
States. … Antibiotic Options
Amoxicillin
Ampicillin
Cefdinir
Ceftriaxone
Azithromycin … Information on Antibiotic Use
There are a few options to try before an antibiotic; warm compresses, … Amoxicillin is still the safest, most least expensive antibiotic for patients without a penicillin allergy … Some liquid antibiotics, like Amoxicillin, need to be kept in the refrigerator.
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effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/procalcitonin_executive.pdf
October 01, 2012 - Early initiation of appropriate
antibiotics and goal-directed therapies
reduces mortality. … Conversely, overuse
and misuse of antibiotics, including
continuing antibiotics longer than
necessary … In view of the present emphasis on the overuse of
antibiotics, other interventions to reduce antibiotic … ’s total
exposure to all antibiotics and is conventionally reported
as mean days per 1,000 days of … to all
antibiotics per 1,000 days of followup.
2.
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effectivehealthcare-admin.ahrq.gov/get-involved/nominated-topics/for-persons-who-present-with-acute-cough-illness-aci-what-is-the-comparative-effectiveness-of-various-interventions-for-reducing-inappropriate-antimicrobial-use
November 01, 2017 - , adverse drug effects, and antibiotic resistance. … It is also unclear why antibiotics prescribing practices vary in the management of ACI, despite efforts … of antibiotic resistance and adverse effects. … in the effectiveness of antibiotics in pediatric populations and subsets of adult patients with ACI … (e.g., with co-morbidities) who may derive modest benefit from antibiotics.
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effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/colorectal-surgery-preparation_disposition-comments.pdf
April 30, 2014 - for identifying the articles are fine, except that it has
ignored the entire literature on the oral antibiotic … already a strong body of evidence that
supports the use of 1) mechanical bowel preparation, 2) oral
antibiotic … preparation, and 3) appropriate systemic antibiotic all used
together for the optimum prevention of … concrete suggestions regarding future research
that could clarify the relationship between OMBP
and oral antibiotic … recent trials did
not include oral antibiotics.
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effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/procalcitonin-future_research.pdf
August 01, 2014 - Conversely, overuse and misuse of antibiotics, including
continuing antibiotics longer than necessary … Conversely, overuse and misuse of antibiotics, including
continuing antibiotics longer than necessary … to discontinue antibiotics in adult ICU patients and to initiate or discontinue
antibiotics in patients … Consistent use of measures of total antibiotic exposure
(e.g. mean days total exposure to all antibiotics … Vulnerable to antibiotic
resistance and adverse effects
of antibiotics.
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effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/venous-ulcers-treatment_research-protocol.pdf
September 13, 2012 - Antibiotics
Antibiotic use is prevalent in the management of skin ulcers, even in the absence of … The indications for the use of systemic or topical antibiotics are
not defined, but antibiotics have … Promotion of antibiotic resistance
c. Systemic absorption (rare)
3. … of antibiotics. … regimens
No systemic
antibiotics
Wound dressings
Systemic
antibiotics
Oral antimicrobials
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effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/fiber-intake-draft-report-appendix-c.xlsx
January 01, 2024 - constipation or diarrhoea, regular use of NSAID, antacids, proton pump inhibitors, or H2 blockers, antibiotic … constipation or diarrhoea, regular use of NSAID, antacids, proton pump inhibitors, or H2 blockers, antibiotic … planned influenza vaccination or vaccination during the previous 12 mo, prebiotics or probiotics, or antibiotic … RCT cross-over < 1992 No industry funding NR Community Healthy smoking, antibiotic use within 6 mo 3 … home), **90 d before the study for antibiotic use and 14 d before the study for the (pro-, prebiotics
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effectivehealthcare-admin.ahrq.gov/products/colorectal-surgery-preparation/research-protocol
December 01, 2019 - Antibiotics
Oral and/or intravenous antibiotics may also be given perioperatively. … A common oral antibiotic regimen is the Nichols-Condon bowel prep and consists of neomycin and erythromycin … Differences in antibiotic regimens between trials may complicate comparisons of postoperative infection … Decreased infection rates have been reported when oral antibiotics are added to intravenous antibiotics … Combination of oral non-absorbable and intravenous antibiotics versus intravenous antibiotics alone in
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effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/cer-233-diverticulitis-evidence-summary.pdf
October 01, 2020 - o Antibiotic treatment: For patients with uncomplicated diverticulitis, antibiotic
treatment may not … For patients who do receive antibiotics, the evidence is insufficient to
guide choice of antibiotic … imaging; (2) the effectiveness and
harms of hospitalization for acute uncomplicated diverticulitis, antibiotics … Antibiotic treatment of acute diverticulitis: With low SoE, studies did not find that
antibiotic treatment … For patients who
do receive antibiotics, the evidence is insufficient to guide choice of antibiotic