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effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guidance-tests-metaanalysis_methods.pdf
July 01, 2012 - Methods Guide for Medical Test Reviews
8-1
Chapter 8
Meta-Analysis of Test Performance
When There Is a “Gold Standard”
Thomas A. Trikalinos, M.D., Tufts Evidence-based Practice Center, Boston, MA
Cynthia M. Balion, Ph.D., Hamilton General Hospital and McMaster Evidence-based
Practice Center, Hamilton, …
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/prostate-cancer-surveillance_research-protocol.pdf
May 19, 2011 - www.effectivehealthcare.ahrq.gov
Published Online: May 19, 2011
Specifically, for KQ 1, we will use studies that analyzed … These systematic reviews, collectively, analyzed a small number of randomized
controlled trials and
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/gastric-cancers-supplementary-app-i.xlsx
January 01, 2019 - Many adverse events analyzed for potential modification.
40905 CRITICS Age Yes Grade 3 to 5 adverse … Many adverse events analyzed for potential modification.
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/kidney-stones-draft-appendi-c.xlsx
January 01, 2024 - Intervention 5 Description Intervention Duration Followup Duration Co-Interventions N Randomized N Analyzed … Primary care clinic No NA Persons ages 20 to 60 years with a documented single calcium oxalate stone analyzed … NA NA NA NA NA NA NA Calcium (oxalate or phosphate) Only 1 Documented single calcium oxalate stone analyzed … in the groups to which they were assigned NI Unclear whether the N analyzed (384) represents all who … ; but characteristics for N analyzed were NR No None No None NA None NA None NA None Probably yes ITT
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/nppv-respiratory-failure_disposition-comments.pdf
July 01, 2012 - Peer Reviewer 5 Abstract Indicate the total number of patients included overall and for each
subgroup analyzed … We have added the number of subjects analyzed
for each KQ. … Severity of illness is also
mentioned, but not otherwise analyzed in this report.
Noted. … intubation rates
and the rate of those meeting prespecified
criteria for intubation, we preferentially analyzed … However the
Conclusions regarding post-extubation NIV might change if the data are
analyzed differently
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/crohns-disease_research-protocol.pdf
September 01, 2010 - Adults and children will be analyzed separately. … Adults and children will be analyzed separately. … Adults and children will be analyzed separately.
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/gastric-cancers-protocol.pdf
January 01, 2024 - Combinations
of these interventions, including the sequence of administration, will also be analyzed
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/urinary-incontinence-update_research-protocol.pdf
June 06, 2017 - high-
impact physical activities
• older women (whether “elderly” or just
older than a younger analyzed … address population characteristics;
descriptions of the interventions, exposures, and comparators analyzed … ; outcome
definitions; effect modifiers; enrolled and analyzed sample sizes; study design features; … Specific methods and
metrics (summary measures) to be meta-analyzed will depend on available, reported
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/migraine-prevention_disposition-comments.pdf
April 18, 2013 - We clarified this sentence as follows: “We
analyzed adjusted relative risk from
observational studies … and key messages
and the report with detailed and transparent
information about all available and analyzed … We also analyzed availability of the results
from the NIH funded studies and registered
trials. … We rechecked all excluded studies to make
sure that migraine prevention trials were
analyzed. … We
suspected but had no way to prove that the
FDA review and the articles by Aposotol
analyzed the
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-273-anal-cancer-disposition-comments.pdf
August 20, 2024 - was not preplanned, was assessed at higher risk of
bias compared with the parent trial report, and analyzed
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/cell-free-dna-appendix-c-prepub-final.xlsx
January 01, 2025 - Resulting data was analyzed by machine learning modules. … (outlier results) 24 or 21 (numbers do not add up correctly in the source PDF) 171 110 NR NR 0 (was analyzed … Yes Yes Yes Unclear Unclear Only number analyzed is described; it is unclear whether other participants … Yes Yes Yes Unclear Unclear Only the number analyzed were reported; unclear if others who were eligible … Sekiguchi, 2020 Unclear Yes Yes Unclear Unclear whether a random or consecutive samples was analyzed
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/cell-free-dna-final-app-c.xlsx
January 01, 2025 - Resulting data was analyzed by machine learning modules. … (outlier results) 24 or 21 (numbers do not add up correctly in the source PDF) 171 110 NR NR 0 (was analyzed … Yes Yes Yes Unclear Unclear Only number analyzed is described; it is unclear whether other participants … Yes Yes Yes Unclear Unclear Only the number analyzed were reported; unclear if others who were eligible … Sekiguchi, 2020 Unclear Yes Yes Unclear Unclear whether a random or consecutive samples was analyzed
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/gastric-cancers-protocol-amended.pdf
February 07, 2025 - Combinations
of these interventions, including the sequence of administration, will also be analyzed
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/gastric-cancers-protocol-amendment.pdf
May 02, 2025 - Combinations
of these interventions, including the sequence of administration, will also be analyzed
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/dietary-protein-intake-protocol-amendment.pdf
November 28, 2023 - power for
crossover studies
● Other studies with N < 50
participants (for RCTs -
25 participants analyzed … for crossover
studies
● Other studies
with N < 50
participants (for
RCTs - 25
participants
analyzed … participants and
without power for
crossover studies
and N<50
participants (for
RCTs – 25
participants
analyzed
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-204-obesity-disposition-comments.pdf
December 01, 2017 - #5: General The authors point out the poor quality of the methods used in
most of the studies they analyzed … is not undertaken for the purposes
of research, and 2) the variation in exposure and outcomes is
analyzed … Page 53, lines 36-37: Not sure why only a subset of, instead of
all, natural experiment studies was analyzed … authors are to be commended as the results section is
clear and concise considering the amount of data analyzed
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/colon-cancer-gene-profiling_research-protocol.pdf
March 13, 2012 - GEP tests use
defined protocols to evaluate the specimens to be analyzed: preparing the RNA samples, … What types of tissue specimens (e.g., frozen tissue) are analyzed for the GEP?
c. … In summarizing the published studies, this report will indicate whether GEP was
analyzed using all patients
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/thromboembolism-update_research-protocol.pdf
February 17, 2016 - address population characteristics; descriptions of the interventions, exposures, and
comparators analyzed … ; outcome definitions; effect modifiers; enrolled and analyzed
sample sizes; study design features; … Specific methods and
metrics (summary measures) to be meta-analyzed will depend on available, reported
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effectivehealthcare.ahrq.gov/sites/default/files/s96.pdf
October 01, 2007 - Data are collected, man-
aged, analyzed, and interpreted under public health surveil-
lance authority … remaining 4 attributes �timeliness, data quality, positive pre-
dictive value (PPV), and sensitivity�, we analyzed … After collection of data,
cases are analyzed by the Centers for Disease Control and
Prevention, the Food
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/community-health-worker-protocol.pdf
March 26, 2019 - o Do these results differ when only asthma interventions or programs are
analyzed? … o Do these results differ when only asthma interventions or programs are
analyzed?